Abstract: 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) catalyzes the conversion of HMG-CoA to mevalonate using NADPH and the enzyme is involved in rate-controlling step of mevalonate. Inhibition of HMGR is considered as effective way to lower cholesterol levels so it is drug target to treat hypercholesterolemia, major risk factor of cardiovascular disease. To discover novel HMGR inhibitor, we performed structure-based pharmacophore modeling combined with molecular dynamics (MD) simulation. Four HMGR inhibitors were used for MD simulation and representative structure of each simulation were selected by clustering analysis. Four structure-based pharmacophore models were generated using the representative structure. The generated models were validated used in virtual screening to find novel scaffolds for inhibiting HMGR. The screened compounds were filtered by applying drug-like properties and used in molecular docking. Finally, four hit compounds were obtained and these complexes were refined using energy minimization. These compounds might be potential leads to design novel HMGR inhibitor.
Abstract: Traffic Engineering (TE) is the process of controlling
how traffic flows through a network in order to facilitate efficient and
reliable network operations while simultaneously optimizing network
resource utilization and traffic performance. TE improves the
management of data traffic within a network and provides the better
utilization of network resources. Many research works considers intra
and inter Traffic Engineering separately. But in reality one influences
the other. Hence the effective network performances of both inter and
intra Autonomous Systems (AS) are not optimized properly. To
achieve a better Joint Optimization of both Intra and Inter AS TE, we
propose a joint Optimization technique by considering intra-AS
features during inter – AS TE and vice versa. This work considers the
important criterion say latency within an AS and between ASes. and
proposes a Bi-Criteria Latency optimization model. Hence an overall
network performance can be improved by considering this jointoptimization
technique in terms of Latency.
Abstract: Existing literature ondesign reasoning seems to give
either one sided accounts on expert design behaviour based on
internal processing. In the same way ecological theoriesseem to
focus one sidedly on external elementsthat result in a lack of unifying
design cognition theory. Although current extended design cognition
studies acknowledge the intellectual interaction between internal and
external resources, there still seems to be insufficient understanding
of the complexities involved in such interactive processes. As
such,this paper proposes a novelmulti-directional model for design
researchers tomap the complex and dynamic conduct controlling
behaviour in which both the computational and ecological
perspectives are integrated in a vertical manner. A clear distinction
between identified intentional and emerging physical drivers, and
relationships between them during the early phases of experts- design
process, is demonstrated by presenting a case study in which the
model was employed.
Abstract: Drilling of glass sheets with different thicknesses have
been carried out by Abrasive Jet Machining process (AJM) in order
to determine its machinability under different controlling parameters
of the AJM process. The present study has been introduced a
mathematical model and the obtained results have been compared
with that obtained from other models published earlier [1-6]. The
experimental results of the present work are used to discuss the
validity of the proposed model as well as the other models.
Abstract: Texture classification is a trendy and a catchy
technology in the field of texture analysis. Textures, the repeated
patterns, have different frequency components along different
orientations. Our work is based on Texture Classification and its
applications. It finds its applications in various fields like Medical
Image Classification, Computer Vision, Remote Sensing,
Agricultural Field, and Textile Industry. Weed control has a major
effect on agriculture. A large amount of herbicide has been used for
controlling weeds in agriculture fields, lawns, golf courses, sport
fields, etc. Random spraying of herbicides does not meet the exact
requirement of the field. Certain areas in field have more weed
patches than estimated. So, we need a visual system that can
discriminate weeds from the field image which will reduce or even
eliminate the amount of herbicide used. This would allow farmers to
not use any herbicides or only apply them where they are needed. A
machine vision precision automated weed control system could
reduce the usage of chemicals in crop fields. In this paper, an
intelligent system for automatic weeding strategy Multi Resolution
Combined Statistical & spatial Frequency is used to discriminate the
weeds from the crops and to classify them as narrow, little and broad
weeds.
Abstract: This paper proposes a modeling method of the laws controlling manufacturing systems with temporal and non temporal constraints. A methodology of robust control construction generating the margins of passive and active robustness is being elaborated. Indeed, two paramount models are presented in this paper. The first utilizes the P-time Petri Nets which is used to manage the flow type disturbances. The second, the quality model, exploits the Intervals Constrained Petri Nets (ICPN) tool which allows the system to preserve its quality specificities. The redundancy of the robustness of the elementary parameters between passive and active is also used. The final model built allows the correlation of temporal and non temporal criteria by putting two paramount models in interaction. To do so, a set of definitions and theorems are employed and affirmed by applicator examples.
Abstract: In this paper, we proposed a method to design a
model-following adaptive controller for linear/nonlinear plants.
Radial basis function neural networks (RBF-NNs), which are known
for their stable learning capability and fast training, are used to
identify linear/nonlinear plants. Simulation results show that the
proposed method is effective in controlling both linear and nonlinear
plants with disturbance in the plant input.
Abstract: Induction motors are being used in greater numbers
throughout a wide variety of industrial and commercial applications
because it provides many benefits and reliable device to convert the
electrical energy into mechanical motion. In some application it-s
desired to control the speed of the induction motor. Because of the
physics of the induction motor the preferred method of controlling its
speed is to vary the frequency of the AC voltage driving the motor. In
recent years, with the microcontroller incorporated into an appliance
it becomes possible to use it to generate the variable frequency AC
voltage to control the speed of the induction motor.
This study investigates the microcontroller based variable
frequency power inverter. the microcontroller is provide the variable
frequency pulse width modulation (PWM) signal that control the
applied voltage on the gate drive, which is provides the required
PWM frequency with less harmonics at the output of the power
inverter.
The fully controlled bridge voltage source inverter has been
implemented with semiconductors power devices isolated gate
bipolar transistor (IGBT), and the PWM technique has been
employed in this inverter to supply the motor with AC voltage.
The proposed drive system for three & single phase power inverter
is simulated using Matlab/Simulink. The Matlab Simulation Results
for the proposed system were achieved with different SPWM. From
the result a stable variable frequency inverter over wide range has
been obtained and a good agreement has been found between the
simulation and hardware of a microcontroller based single phase
inverter.
Abstract: Fuel cell's system requires regulating circuit for
voltage and current in order to control power in case of connecting to
other generative devices or load. In this paper Fuel cell system and
convertor, which is a multi-variable system, are controlled using
sliding mode method. Use of weighting matrix in design procedure
made it possible to regulate speed of control. Simulation results show
the robustness and accuracy of proposed controller for controlling
desired of outputs.
Abstract: The purpose of this study was to present a reliable mean for human-computer interfacing based on finger gestures made in two dimensions, which could be interpreted and adequately used in controlling a remote robot's movement. The gestures were captured and interpreted using an algorithm based on trigonometric functions, in calculating the angular displacement from one point of touch to another as the user-s finger moved within a time interval; thereby allowing for pattern spotting of the captured gesture. In this paper the design and implementation of such a gesture based user interface was presented, utilizing the aforementioned algorithm. These techniques were then used to control a remote mobile robot's movement. A resistive touch screen was selected as the gesture sensor, then utilizing a programmed microcontroller to interpret them respectively.
Abstract: The implicit block methods based on the backward
differentiation formulae (BDF) for the solution of stiff initial value
problems (IVPs) using variable step size is derived. We construct a
variable step size block methods which will store all the coefficients
of the method with a simplified strategy in controlling the step size
with the intention of optimizing the performance in terms of
precision and computation time. The strategy involves constant,
halving or increasing the step size by 1.9 times the previous step size.
Decision of changing the step size is determined by the local
truncation error (LTE). Numerical results are provided to support the
enhancement of method applied.
Abstract: In the LFC problem, the interconnections among some areas are the input of disturbances, and therefore, it is important to suppress the disturbances by the coordination of governor systems. In contrast, tie-line power flow control by TCPS located between two areas makes it possible to stabilize the system frequency oscillations positively through interconnection, which is also expected to provide a new ancillary service for the further power systems. Thus, a control strategy using controlling the phase angle of TCPS is proposed for provide active control facility of system frequency in this paper. Also, the optimum adjustment of PID controller's parameters in a robust way under bilateral contracted scenario following the large step load demands and disturbances with and without TCPS are investigated by Particle Swarm Optimization (PSO), that has a strong ability to find the most optimistic results. This newly developed control strategy combines the advantage of PSO and TCPS and has simple stricture that is easy to implement and tune. To demonstrate the effectiveness of the proposed control strategy a three-area restructured power system is considered as a test system under different operating conditions and system nonlinearities. Analysis reveals that the TCPS is quite capable of suppressing the frequency and tie-line power oscillations effectively as compared to that obtained without TCPS for a wide range of plant parameter changes, area load demands and disturbances even in the presence of system nonlinearities.
Abstract: This paper presents a new ultra-wideband (UWB) bandpass filter (BPF) with sharp roll-off and dual-notched bands. The filter consists of a triangle ring multi-mode resonator (MMR) with the stub-loaded resonator (SLR) for controlling the two transmission zeros at 2.8 / 11 GHz, the embedded open-circuited stub and the asymmetric tight coupled input/output (I/O) lines for introducing the dual notched bands at 5.2 / 6.8 GHz. The attenuation slope in the lower and higher passband edges of the proposed filter show 160- and 153-dB/GHz, respectively. This study mainly provides a simple method to design a UWB bandpass filter with high passband selectivity and dual-notched bands for satisfying the Federal Communications Commission (FCC-defined) indoor UWB specification
Abstract: The problem of manipulator control is a highly
complex problem of controlling a system which is multi-input, multioutput,
non-linear and time variant. In this paper some adaptive
fuzzy, and a new hybrid fuzzy control algorithm have been
comparatively evaluated through simulations, for manipulator
control. The adaptive fuzzy controllers consist of self-organizing,
self-tuning, and coarse/fine adaptive fuzzy schemes. These
controllers are tested for different trajectories and for varying
manipulator parameters through simulations. Various performance
indices like the RMS error, steady state error and maximum error are
used for comparison. It is observed that the self-organizing fuzzy
controller gives the best performance. The proposed hybrid fuzzy
plus integral error controller also performs remarkably well, given its
simple structure.
Abstract: We identify clawback triggers from firms- proxy
statements (Form DEF 14A) and use the likelihood of restatements to
proxy for financial reporting quality. Based on a sample of 578 U.S.
firms that voluntarily adopt clawback provisions during 2003-2009,
when restatement-based triggers could be decomposed into two types:
fraud and unintentional error, and we do observe the evidence that
using fraud triggers is associated with high financial reporting quality.
The findings support that fraud triggers can enhance deterrent effect of
clawback provision by establishing a viable disincentive against fraud,
misconduct, and otherwise harmful acts. These results are robust to
controlling for the compensation components, to different sample
specifications and to a number of sensitivity.
Abstract: The increased use of biodiesel implies variations on both greenhouse gases and air pollutant emissions. Some studies point out that the use of biodiesel blends on diesel can help in controlling air pollution and promote a reduction of CO2 emissions. Reductions on PM, SO2, VOC and CO emissions are also expected, however NOx emissions may increase, which may potentiate O3 formation. This work aims to assess the impact of the biodiesel use on air quality, through a numerical modeling study, taking the Northern region of Portugal as a case study. The emission scenarios are focused on 2008 (baseline year) and 2020 (target year of Renewable Energy Directive-RED) and on three biodiesel blends (B0, B10 and B20). In a general way the use of biodiesel by 2020 will reduce the CO2 and air pollutants emissions in the Northern Portugal, improving air quality. However it will be in a very small extension.
Abstract: Voltage collapse is instability of heavily loaded electric
power systems that cause to declining voltages and blackout. Power
systems are predicated to become more heavily loaded in the future
decade as the demand for electric power rises while economic and
environmental concerns limit the construction of new transmission
and generation capacity. Heavily loaded power systems are closer to
their stability limits and voltage collapse blackouts will occur if
suitable monitoring and control measures are not taken. To control
transmission lines, it can be used from FACTS devices.
In this paper Harmony search algorithm (HSA) and Genetic
Algorithm (GA) have applied to determine optimal location of
FACTS devices in a power system to improve power system stability.
Three types of FACTS devices (TCPAT, UPFS, and SVC) have been
introduced. Bus under voltage has been solved by controlling reactive
power of shunt compensator. Also a combined series-shunt
compensators has been also used to control transmission power flow
and bus voltage simultaneously.
Different scenarios have been considered. First TCPAT, UPFS, and
SVC are placed solely in transmission lines and indices have been
calculated. Then two types of above controller try to improve
parameters randomly. The last scenario tries to make better voltage
stability index and losses by implementation of three types controller
simultaneously. These scenarios are executed on typical 34-bus test
system and yields efficiency in improvement of voltage profile and
reduction of power losses; it also may permit an increase in power
transfer capacity, maximum loading, and voltage stability margin.
Abstract: Sarkhoon gas plant, located in south of Iran, has been installed to removal H2S contained in a high pressure natural gas stream. The solvent used for the H2S removal from gaseous stream is 34% by weight (wt%) Di-ethanol amine (DEA) solutions. Due to increasing concentration of heat stable salt (HSS) in solvent, corrosivity of amine solution had been increased. Reports indicated that there was corrosion on the shell of regeneration column. Because source formation of HSS was unknown, we decided to control the amount of HSS at the limit less than 3% wt amine solvent. Therefore, two small columns were filled by strong anionic base and carbon active, and then polluted amine was passed through beds. Finally a temporary amine recovery package on industrial scale was made based on laboratory’s results. From economical point of view we could save $700000 beside corrosion occurrence of the stripping column has been vigorously decreased.
Abstract: Nowadays, with the emerging of the new applications
like robot control in image processing, artificial vision for visual
servoing is a rapidly growing discipline and Human-machine
interaction plays a significant role for controlling the robot. This
paper presents a new algorithm based on spatio-temporal volumes for
visual servoing aims to control robots. In this algorithm, after
applying necessary pre-processing on video frames, a spatio-temporal
volume is constructed for each gesture and feature vector is extracted.
These volumes are then analyzed for matching in two consecutive
stages. For hand gesture recognition and classification we tested
different classifiers including k-Nearest neighbor, learning vector
quantization and back propagation neural networks. We tested the
proposed algorithm with the collected data set and results showed the
correct gesture recognition rate of 99.58 percent. We also tested the
algorithm with noisy images and algorithm showed the correct
recognition rate of 97.92 percent in noisy images.
Abstract: In this paper, acoustic techniques are used to detect hidden insect infestations of date palm tress (Phoenix dactylifera L.). In particular, we use an acoustic instrument for early discovery of the presence of a destructive insect pest commonly known as the Red Date Palm Weevil (RDPW) and scientifically as Rhynchophorus ferrugineus (Olivier). This type of insect attacks date palm tress and causes irreversible damages at late stages. As a result, the infected trees must be destroyed. Therefore, early presence detection is a major part in controlling the spread and economic damage caused by this type of infestation. Furthermore monitoring and early detection of the disease can asses in taking appropriate measures such as isolating or treating the infected trees. The acoustic system is evaluated in terms of its ability for early discovery of hidden bests inside the tested tree. When signal acquisitions is completed for a number of date palms, a signal processing technique known as time-frequency analysis is evaluated in terms of providing an estimate that can be visually used to recognize the acoustic signature of the RDPW. The testing instrument was tested in the laboratory first then; it was used on suspected or infested tress in the field. The final results indicate that the acoustic monitoring approach along with signal processing techniques are very promising for the early detection of presence of the larva as well as the adult pest in the date palms.