Abstract: Heme oxygenase-1 (HO-1), an enzyme degrading heme to carbon monoxide, iron, and biliverdin, has been recognized as playing a crucial role in cellular defense against stressful conditions, not only related to heme release. In the present study, the effects of TNF-a on the expression of heme oxygenase-1 (HO-1) in human aortic endothelial cells (HAECs) as well as the related mechanisms were investigated. 10 ng/mL TNF-α treatment significantly increased HO-1 expression after 6h, then a further increase at 12h and declined at 24h. Treatment with 2 ng/mL of TNF-a after 12 h resulted in a significant increase in HO-1 expression, which peaked at 10 ng/mL, then declined at 20 ng/mL. TNF-α induced HO-1 expression and then HO-1 expression reduced vascular cell adhesion molecule-1 (VCAM-1) expression. Phosphorylation studies of ERK1/2, JNK, and p38, three subgroups of mitogen-activated protein kinases (MAPKs) demonstrated TNF-α-induced ERK1/2, JNK, and p38 phosphorylation. The increase in HO-1 expression in response to TNF-α treatment was affected by pretreatment with SP600125 (a JNK inhibitor) and SB203580 (a p38 inhibitor), not with PD98059 (an ERK1/2 inhibitor). The expression of HO-1 was stronger in aortas of TNF-α-treated apo-E deficient mice when compared with control mice. These results suggest that low dose of TNF-α treatment notably induced HO-1 expression was mediated through JNK/p38 phosphorylation and may have a protective potential in cardiovascular diseases and inflammatory response through the regulation of HO-1 expression.
Abstract: This paper describes an approach to the adsorption
phenomena modeling aimed at specifying the adsorption mechanisms
on localized or nonlocalized adsorbent sites, when applied to the
nanocarbons. The concept comes from the fundamental
thermodynamic description of adsorption equilibrium and is based on
numerical calculations of the hydrogen adsorbed particles volume on
the surface of selected nanocarbons: single-walled nanotube and
nanocone. This approach enables to obtain information on adsorption
mechanism and then as a consequence to take appropriate
mathematical adsorption model, thus allowing for a more reliable
identification of the material porous structure. Theoretical basis of the
approach is discussed and newly derived results of the numerical
calculations are presented for the selected nanocarbons.
Abstract: The aim of this study is to describe the differences between women and men in the phenomena of feeling of knowing/know (FOK), tip of the tongue (TOT), and verbal fluency. Two studies are presented. The first included a group of 60 participants and focused on the analysis of FOK and TOT in men and women. The second study described the performance of 302 participants in verbal fluency tasks. Both studies showed that sex is not a significant predictor of linguistic abilities. Rather, the main factors influencing one’s linguistic ability were Vocabulary and education. This study enriches the knowledge on mechanisms of memory and verbal production.
Abstract: Takerbucht is the only cultivar of date palm known as being resistant to the bayoud disease, caused by Fusarium oxysporum f. sp. albedinis (F.o.a.). In the aim to understand more about the defense mechanisms implied, we realized phytochemical analyses of this cultivar leaflets and roots and this, for the first time, using gas chromatography-mass spectrometry (GC-MS).The examination of our results shows that fifty-four molecules have been detected, fourteen of which are common to leaflets and roots. This study revealed also the organs' richness in derivatives fatty acids: both saturated and unsaturated are represented mainly by methyl esters of Hexadecanoic and 9,12,15-Octadecatrienoic acids. 1-Dodecanethiol, derivative Dodecanoic acid is only present in roots. It’s of great interest to note that the screening revealed the steroidal saponins abundance, among which Yamogenin acetate and Diosgenin, exclusively detected in Takerbucht. They may play an essential role, in the date palm resistance to the bayoud disease.
Abstract: Microorganisms can be removed, inhibited or killed by physical agents, physical processes or chemical agents but they have their inherent disadvantages such as increased resistance against antibiotics etc. Since, plants have endless ability to synthesize aromatic substances which act as the master agents for plant defense mechanisms against microorganisms, insects and herbivores. Thus, secondary metabolites or phytochemicals obtained from plants can be used as agents of disease control nowadays. In the present study effect of different concentrations of acetone fraction of leaves and alcohol fraction of inflorescence of Euphorbia pulcherrima on various cytomorphological parameters i.e. cell number, mycelium width, conidial size, conidiophore size etc. of Aspergillus fumigatus has been studied. Change in mycelium/ hyphal cell width, conidium size, conidiophore size etc. was measured with the help of a previously calibrated oculometer. To study effect on morphology, fungal mycelium along with conidiophore and conidia were stained with cotton blue and mounted in lactophenol and observed microscopically. Inhibitory action of the acetone extract of Euphorbia pulcherrima leaf on growth of Aspergillus fumigatus was investigated. Control containing extract free medium supported profuse growth of the fungus. Although decrease in growth was observed even at 3.95μg/ml but significant inhibition of growth was started at7.81μg/ml concentration of the extract. Complete inhibition was observed at 15.62μg/ml and above. Microscopic examination revealed that at 3.95, 7.81 and 15.62μg/ml extract concentration hyphal cell width was found to be increased from 1.44μm in control to 3.86, 5.24 and 8.98 μm respectively giving a beaded appearance to the mycelium. Vesicle size was reduced from 24.78x20.08μm (control) to 11.34x10.06μm at 3.95μg/ml concentration. At 7.81 and 15.62μg/ml concentration no phialides and sterigmata were observed. Inhibitory action of the alcohol extract of inflorescence on the growth of Aspergillus fumigatus was also studied. Control containing extract free medium supported profuse growth of the fungus. Although decrease in growth was observed even at 3.95μg/ml but complete inhibition was observed at 62.5μg/ml and above. Microscopic examination revealed that hyphal cell width of Aspergillus fumigatus was found to be increased from 1.67μm in control to 5.84μm at MIC i.e. at 62.5μg/ml. Vesicle size was reduced from 44.76x 24.22μm (control) to 11.36x 6.80μm at 15.62μg/ml concentrations. At 31.25 μg/ml and 62.5μg/ml concentration no phialides and sterigmata was found. Spore germination was completely found to be inhibited at 3.95μg/ml concentration. Similarly 92.87% reduction in vesicle size was observed at 15.62μg/ml concentration. It is evident from the results that plant extracts inhibit fungal growth and this inhibition is concentration dependent.
Abstract: Nowadays, more engineering systems are using some
kind of Artificial Intelligence (AI) for the development of their
processes. Some well-known AI techniques include artificial neural
nets, fuzzy inference systems, and neuro-fuzzy inference systems
among others. Furthermore, many decision-making applications base
their intelligent processes on Fuzzy Logic; due to the Fuzzy
Inference Systems (FIS) capability to deal with problems that are
based on user knowledge and experience. Also, knowing that users
have a wide variety of distinctiveness, and generally, provide
uncertain data, this information can be used and properly processed
by a FIS. To properly consider uncertainty and inexact system input
values, FIS normally use Membership Functions (MF) that represent
a degree of user satisfaction on certain conditions and/or constraints.
In order to define the parameters of the MFs, the knowledge from
experts in the field is very important. This knowledge defines the MF
shape to process the user inputs and through fuzzy reasoning and
inference mechanisms, the FIS can provide an “appropriate" output.
However an important issue immediately arises: How can it be
assured that the obtained output is the optimum solution? How can it
be guaranteed that each MF has an optimum shape? A viable solution
to these questions is through the MFs parameter optimization. In this
Paper a novel parameter optimization process is presented. The
process for FIS parameter optimization consists of the five simple
steps that can be easily realized off-line. Here the proposed process
of FIS parameter optimization it is demonstrated by its
implementation on an Intelligent Interface section dealing with the
on-line customization / personalization of internet portals applied to
E-commerce.
Abstract: IVE toolkit has been created for facilitating research,education and development in the ?eld of virtual storytelling andcomputer games. Primarily, the toolkit is intended for modellingaction selection mechanisms of virtual humans, investigating level-of-detail AI techniques for large virtual environments, and for exploringjoint behaviour and role-passing technique (Sec. V). Additionally, thetoolkit can be used as an AI middleware without any changes. Themain facility of IVE is that it serves for prototyping both the AI andvirtual worlds themselves. The purpose of this paper is to describeIVE?s features in general and to present our current work - includingan educational game - on this platform.Keywords? AI middleware, simulation, virtual world.
Abstract: One of the major pollutants in the environment is arsenic (As). Due to the toxic effects of As to all organisms, its remediation is necessary. Conventional technologies used in the remediation of As contaminated soils are expensive and may even compromise the structure of the soil. An attractive alternative is phytoremediation, which is the use of plants which can take up the contaminant in their tissues. Plant growth promoting bacteria (PGPB) has been known to enhance growth of plants through several mechanisms such as phytohormone production, phosphate solubilization, siderophore production and 1-aminocyclopropane-1- carboxylate (ACC) deaminase production, which is an essential trait that aids plants especially under stress conditions such as As stress. Twenty one bacteria were isolated from As-contaminated soils in the vicinity of the Janghang Smelter in Chungnam Province, South Korea. These exhibited high tolerance to either arsenite (As III) or arsenate (As V) or both. Most of these isolates possess several plant growth promoting traits which can be potentially exploited to increase phytoremediation efficiency. Among the identified isolates is Pseudomonas sp. JS1215, which produces ACC deaminase, indole acetic acid (IAA), and siderophore. It also has the ability to solubilize phosphate. Inoculation of JS1215 significantly enhanced root and shoot length and biomass accumulation of maize under normal conditions. In the presence of As, particularly in lower As level, inoculation of JS1215 slightly increased root length and biomass. Ethylene increased with increasing As concentration, but was reduced by JS1215 inoculation. JS1215 can be a potential bioinoculant for increasing phytoremediation efficiency.
Abstract: The ongoing effort to develop an in-house
compressible solver with multi-disciplinary physics is presented in
this paper. Basic compressible solver combined with IBM technique
provides us an effective numerical tool able to tackle the physics
phenomena and especially physic phenomena involved in Solid
Rocket Motors (SRMs). Main principles are introduced step by step
describing its implementation. This paper sheds light on the whole
potentiality of our proposed numerical model and we strongly believe
a way to introduce multi-physics mechanisms strongly coupled is
opened to ablation in nozzle, fluid/structure interaction and burning
propellant surface with time.
Abstract: The purpose of this paper is to present the design and
instrumentation of a new benchmark multivariable nonlinear control
laboratory. The mathematical model of this system may be used to
test the applicability and performance of various nonlinear control
procedures. The system is a two degree-of-freedom robotic arm with
soft and hard (discontinuous) nonlinear terms. Two novel
mechanisms are designed to allow the implementation of adjustable
Coulomb friction and backlash.
Abstract: The persistent nature of perfluorochemicals (PFCs) has attracted global concern in recent years. Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) are the most commonly found PFC compounds, and thus their fate and transport play key roles in PFC distribution in the natural environment. The kinetic behavior of PFOS or PFOA on boehmite consists of a fast adsorption process followed by a slow adsorption process which may be attributed to the slow transport of PFOS or PFOA into the boehmite pore surface. The adsorption isotherms estimated the maximum adsorption capacities of PFOS and PFOA on boehmite as 0.877 μg/m2 and 0.633 μg/m2, with the difference primarily due to their different functional groups. The increase of solution pH led to a moderate decrease of PFOS and PFOA adsorption, owing to the increase of ligand exchange reactions and the decrease of electrostatic interactions. The presence of NaCl in solution demonstrated negative effects for PFOS and PFOA adsorption on boehmite surfaces, with potential mechanisms being electrical double layer compression, competitive adsorption of chloride.
Abstract: Intrusion detection systems (IDS)are crucial components
of the security mechanisms of today-s computer systems.
Existing research on intrusion detection has focused on sequential
intrusions. However, intrusions can also be formed by concurrent
interactions of multiple processes. Some of the intrusions caused
by these interactions cannot be detected using sequential intrusion
detection methods. Therefore, there is a need for a mechanism that
views the distributed system as a whole. L-BIDS (Lattice-Based
Intrusion Detection System) is proposed to address this problem. In
the L-BIDS framework, a library of intrusions and distributed traces
are represented as lattices. Then these lattices are compared in order
to detect intrusions in the distributed traces.
Abstract: Based on different experiences in the historic centers
of Spain, we propose an global strategy for the regeneration of the
pre-tertiary fabrics and its application to the specific case of San
Mateo neighborhood, in Jerez de la Frontera (Andalusia), through a
diagnosis that focus particularly on the punishments the last-decade
economic situation (building boom and crisis) and shows the tragic
transition from economic center to an imminent disappearance with
an image similar to the ruins of war, due to the loss of their
traditional roles. From it we will learn their historically-tested
mechanisms of environment adaptation, which distill the vernacular
architecture essence and that we will apply to our strategy of action
based on a dotacional-and-free-space rhizome which rediscovers its
hidden character. The architectural fact will be crystallized in one of
the example-pieces proposed: The Artistic Revitalization Center.
Abstract: Objective: The objective of this paper is to assess the
hospitals preparedness for emergency using WHO standards.
Method: This is a cross-sectional study, consisted of site visit,
questionnaire survey, 16 health facilities were included. The WHO
standard for emergency preparedness of health facilities was used to
evaluate and assess the hospitals preparedness of health facilities.
Result: 13 hospitals were responded. They scored below average
in all measure >75%), while above average score was in 7 out 9 nine
measure with a range of 8%-25%. Un acceptable below average was
noted in two measures only.
Discussion: The biggest challenge facing the hospitals in their
emergency intervention is the lack of pre-emergency and emergency
preparedness plans as well as the coordination of the hospitals
response mechanisms.
Conclusion: The studied hospitals presently are far from
international disasters preparedness protocols. That necessitates
improvements in emergency preparedness, as well as in physician
skills for injury management.
Abstract: Fine alignment of main ship power plants mechanisms
and shaft lines provides long-term and failure-free performance of
propulsion system while fast and high-quality installation of
mechanisms and shaft lines decreases common labor intensity. For
checking shaft line allowed stress and setting its alignment it is
required to perform calculations considering various stages of life
cycle. In 2012 JSC SSTC developed special software complex
“Shaftline” for calculation of alignment of having its own I/O
interface and display of shaft line 3D model. Alignment of shaft line
as per bearing loads is rather labor-intensive procedure. In order to
decrease its duration, JSC SSTC developed automated alignment
system from ship power plants mechanisms. System operation
principle is based on automatic simulation of design load on bearings.
Initial data for shaft line alignment can be exported to automated
alignment system from PC “Shaft line”.
Abstract: In any trust model, the two information sources that a peer relies on to predict trustworthiness of another peer are direct experience as well as reputation. These two vital components evolve over time. Trust evolution is an important issue, where the objective is to observe a sequence of past values of a trust parameter and determine the future estimates. Unfortunately, trust evolution algorithms received little attention and the proposed algorithms in the literature do not comply with the conditions and the nature of trust. This paper contributes to this important problem in the following ways: (a) presents an algorithm that manages and models trust evolution in a P2P environment, (b) devises new mechanisms for effectively maintaining trust values based on the conditions that influence trust evolution , and (c) introduces a new methodology for incorporating trust-nurture incentives into the trust evolution algorithm. Simulation experiments are carried out to evaluate our trust evolution algorithm.
Abstract: The drastic increase in the usage of SMS technology
has led service providers to seek for a solution that enable users of
mobile devices to access services through SMSs. This has resulted in
the proposal of solutions towards SMS-based service invocation in
service oriented environments. However, the dynamic nature of
service-oriented environments coupled with sudden load peaks
generated by service request, poses performance challenges to
infrastructures for supporting SMS-based service invocation. To
address this problem we adopt load balancing techniques. A load
balancing model with adaptive load balancing and load monitoring
mechanisms as its key constructs is proposed. The load balancing
model then led to realization of Least Loaded Load Balancing
Framework (LLLBF). Evaluation of LLLBF benchmarked with round
robin (RR) scheme on the queuing approach showed LLLBF
outperformed RR in terms of response time and throughput.
However, LLLBF achieved better result in the cost of high
processing power.
Abstract: The motion planning procedure described in this paper has been developed in order to eliminate or reduce the residual vibrations of electromechanical positioning systems, without augmenting the motion time (usually imposed by production requirements), nor introducing overtime for vibration damping. The proposed technique is based on a suitable choice of the motion law assigned to the servomotor that drives the mechanism. The reference profile is defined by a Bezier curve, whose shape can be easily changed by modifying some numerical parameters. By means of an optimization technique these parameters can be modified without altering the continuity conditions imposed on the displacement and on its time derivatives at the initial and final time instants.
Abstract: The Taiwan government has started to promote the “Plain Landscape Afforestation and Greening Program" since 2002. A key task of the program was the payment for environmental services (PES), entitled the “Plain Landscape Afforestation Policy" (PLAP), which was certificated by the Executive Yuan on August 31, 2001 and enacted on January 1, 2002. According to the policy, it is estimated that the total area of afforestation will be 25,100 hectares by December 31, 2007. Until the end of 2007, the policy had been enacted for six years in total and the actual area of afforestation was 8,919.18 hectares. Among them, Taiwan Sugar Corporation (TSC) was accounted for 7,960 hectares (with 2,450.83 hectares as public service area) which occupied 86.22% of the total afforestation area; the private farmland promoted by local governments was accounted for 869.18 hectares which occupied 9.75% of the total afforestation area. Based on the above, we observe that most of the afforestation area in this policy is executed by TSC, and the achievement ratio by TSC is better than by others. It implies that the success of the PLAP is seriously related to the execution of TSC. The objective of this study is to analyze the relevant policy planning of TSC's participation in the PLAP, suggest complementary measures, and draw up effective adjustment mechanisms, so as to improve the effectiveness of executing the policy. Our main conclusions and suggestions are summarized as follows: 1. The main reason for TSC’s participation in the PLAP is based on their passive cooperation with the central government or company policy. Prior to TSC’s participation in the PLAP, their lands were mainly used for growing sugarcane. 2. The main factors of TSC's consideration on the selection of tree species are based on the suitability of land and species. The largest proportion of tree species is allocated to economic forests, and the lack of technical instruction was the main problem during afforestation. Moreover, the method of improving TSC’s future development in leisure agriculture and landscape business becomes a key topic. 3. TSC has developed short and long-term plans on participating in the PLAP for the future. However, there is no great willingness or incentive on budgeting for such detailed planning. 4. Most people from TSC interviewed consider the requirements on PLAP unreasonable. Among them, an unreasonable requirement on the number of trees accounted for the greatest proportion; furthermore, most interviewees suggested that the government should continue to provide incentives even after 20 years. 5. Since the government shares the same goals as TSC, there should be sufficient cooperation and communication that support the technical instruction and reduction of afforestation cost, which will also help to improve effectiveness of the policy.
Abstract: The proliferation of web application and the pervasiveness of mobile technology make web-based attacks even more attractive and even easier to launch. Web Application Firewall (WAF) is an intermediate tool between web server and users that provides comprehensive protection for web application. WAF is a negative security model where the detection and prevention mechanisms are based on predefined or user-defined attack signatures and patterns. However, WAF alone is not adequate to offer best defensive system against web vulnerabilities that are increasing in number and complexity daily. This paper presents a methodology to automatically design a positive security based model which identifies and allows only legitimate web queries. The paper shows a true positive rate of more than 90% can be achieved.