Abstract: Matrix metalloproteinase-3 (MMP3) is key member
of the MMP family, and is known to be present in coronary
atherosclerotic. Several studies have demonstrated that MMP-3
5A/6A polymorphism modify each transcriptional activity in allele
specific manner. We hypothesized that this polymorphism may play
a role as risk factor for development of coronary stenosis. The aim of
our study was to estimate MMP-3 (5A/6A) gene polymorphism on
interindividual variability in risk for coronary stenosis in an Iranian
population.DNA was extracted from white blood cells and genotypes
were obtained from coronary stenosis cases (n=95) and controls
(n=100) by PCR (polymerase chain reaction) and restriction
fragment length polymorphism techniques. Significant differences
between cases and controls were observed for MMP3 genotype
frequencies (X2=199.305, p< 0.001); the 6A allele was less
frequently seen in the control group, compared to the disease group
(85.79 vs. 78%, 6A/6A+5A/6A vs. 5A/5A, P≤0.001). These data
imply the involvement of -1612 5A/6A polymorphism in coronary
stenosis, and suggest that probably the 6A/6A MMP-3 genotype is a
genetic susceptibility factor for coronary stenosis.
Abstract: Mammography is the most effective procedure for an
early diagnosis of the breast cancer. Nowadays, people are trying to
find a way or method to support as much as possible to the
radiologists in diagnosis process. The most popular way is now being
developed is using Computer-Aided Detection (CAD) system to
process the digital mammograms and prompt the suspicious region to
radiologist. In this paper, an automated CAD system for detection
and classification of massive lesions in mammographic images is
presented. The system consists of three processing steps: Regions-Of-
Interest detection, feature extraction and classification. Our CAD
system was evaluated on Mini-MIAS database consisting 322
digitalized mammograms. The CAD system-s performance is
evaluated using Receiver Operating Characteristics (ROC) and Freeresponse
ROC (FROC) curves. The archived results are 3.47 false
positives per image (FPpI) and sensitivity of 85%.