Abstract: The literature reports a large number of approaches for
measuring the similarity between protein sequences. Most of these
approaches estimate this similarity using alignment-based techniques
that do not necessarily yield biologically plausible results, for two
reasons.
First, for the case of non-alignable (i.e., not yet definitively aligned
and biologically approved) sequences such as multi-domain, circular
permutation and tandem repeat protein sequences, alignment-based
approaches do not succeed in producing biologically plausible results.
This is due to the nature of the alignment, which is based on the
matching of subsequences in equivalent positions, while non-alignable
proteins often have similar and conserved domains in non-equivalent
positions.
Second, the alignment-based approaches lead to similarity measures
that depend heavily on the parameters set by the user for the alignment
(e.g., gap penalties and substitution matrices). For easily alignable
protein sequences, it's possible to supply a suitable combination of
input parameters that allows such an approach to yield biologically
plausible results. However, for difficult-to-align protein sequences,
supplying different combinations of input parameters yields different
results. Such variable results create ambiguities and complicate the
similarity measurement task.
To overcome these drawbacks, this paper describes a novel and
effective approach for measuring the similarity between protein
sequences, called SAF for Substitution and Alignment Free. Without
resorting either to the alignment of protein sequences or to substitution
relations between amino acids, SAF is able to efficiently detect the
significant subsequences that best represent the intrinsic properties of
protein sequences, those underlying the chronological dependencies of
structural features and biochemical activities of protein sequences.
Moreover, by using a new efficient subsequence matching scheme,
SAF more efficiently handles protein sequences that contain similar
structural features with significant meaning in chronologically
non-equivalent positions. To show the effectiveness of SAF, extensive
experiments were performed on protein datasets from different
databases, and the results were compared with those obtained by
several mainstream algorithms.
Abstract: This work proposes a novel market-based air traffic flow control model considering competitive airlines in air traffic network. In the flow model, an agent based framework for resources (link/time pair) pricing is described. Resource agent and auctioneer for groups of resources are also introduced to simulate the flow management in Air Traffic Control (ATC). Secondly, the distributed group pricing algorithm is introduced, which efficiently reflect the competitive nature of the airline industry. Resources in the system are grouped according to the degree of interaction, and each auctioneer adjust s the price of one group of resources respectively until the excess demand of resources becomes zero when the demand and supply of resources of the system changes. Numerical simulation results show the feasibility of solving the air traffic flow control problem using market mechanism and pricing algorithms on the air traffic network.
Abstract: The harmonic Arnoldi method can be used to find interior eigenpairs of large matrices. However, it has been shown that this method may converge erratically and even may fail to do so. In this paper, we present a new method for computing interior eigenpairs of large nonsymmetric matrices, which is called weighted harmonic Arnoldi method. The implementation of the method has been tested by numerical examples, the results show that the method converges fast and works with high accuracy.
Abstract: In this work, the physical based device model of
AlGaN/GaN high electron mobility transistors (HEMTs) has been
established and the corresponding device operation behavior has
been investigated also by using Sentaurus TCAD from Synopsys.
Advanced AlGaN/GaN hetero-structures with GaN cap layer and AlN
spacer have been considered and the GaN cap layer and AlN spacer
are found taking important roles on the gate leakage blocking and
off-state breakdown voltage enhancement.
Abstract: As part of national epidemiological survey on bovine
viral diarrhea virus (BVDV), a total of 274 dejecta samples were
collected from 14 cattle farms in 8 areas of Xinjiang Uygur
Autonomous Region in northwestern China. Total RNA was extracted
from each sample, and 5--untranslated region (UTR) of BVDV
genome was amplified by using two-step reverse
transcriptase-polymerase chain reaction (RT-PCR). The PCR products
were subsequently sequenced to study the genetic variations of BVDV
in these areas. Among the 274 samples, 33 samples were found
virus-positive. According to sequence analysis of the PCR products,
the 33 samples could be arranged into 16 groups. All the sequences,
however, were highly conserved with BVDV Osloss strains. The virus
possessed theses sequences belonged to BVDV-1b subtype by
phylogenetic analysis. Based on these data, we established a typing
tree for BVDV in these areas. Our results suggested that BVDV-1b
was a predominant subgenotype in northwestern China and no
correlation between the genetic and geographical distances could be
observed above the farm level.
Abstract: In this paper, based on linear matrix inequality (LMI), by using Lyapunov functional theory, the exponential stability criterion is obtained for a class of uncertain Takagi-Sugeno fuzzy Hopfield neural networks (TSFHNNs) with time delays. Here we choose a generalized Lyapunov functional and introduce a parameterized model transformation with free weighting matrices to it, these techniques lead to generalized and less conservative stability condition that guarantee the wide stability region. Finally, an example is given to illustrate our results by using MATLAB LMI toolbox.
Abstract: This paper presents a experiment to estimate the
influences of cutting conditions in microstructure changes of
machining austenitic 304 stainless steel, especially for wear insert. The
wear insert were prefabricated with a width of 0.5 mm. And the forces,
temperature distribution, RS, and microstructure changes were
measured by force dynamometer, infrared thermal camera, X-ray
diffraction, XRD, SEM, respectively. The results told that the different
combinations of machining condition have a significant influence on
machined surface microstructure changes. In addition to that, the
ANOVA and AOMwere used to tell the different influences of cutting
speed, feed rate, and wear insert.
Abstract: In this study we investigate silica nanoparticle (SiO2- NP) effects on the structure and phase properties of supported lipid monolayers and bilayers, coupling surface pressure measurements, fluorescence microscopy and atomic force microscopy. SiO2-NPs typically in size range of 10nm to 100 nm in diameter are tested. Our results suggest first that lipid molecules organization depends to their nature. Secondly, lipid molecules in the vinicity of big aggregates nanoparticles organize in liquid condensed phase whereas small aggregates are localized in both fluid liquid-expanded (LE) and liquid-condenced (LC). We demonstrated also by atomic force microscopy that by measuring friction forces it is possible to get information as if nanoparticle aggregates are recovered or not by lipid monolayers and bilayers.
Abstract: In this paper, we present parallel alternating two-stage methods for solving linear system Ax = b, where A is a monotone matrix or an H-matrix. And we give some convergence results of these methods for nonsingular linear system.
Abstract: This paper applies fuzzy AHP to evaluate the service
quality of online auction. Service quality is a composition of various
criteria. Among them many intangible attributes are difficult to
measure. This characteristic introduces the obstacles for respondents
on reply in the survey. So as to overcome this problem, we invite
fuzzy set theory into the measurement of performance and use AHP in
obtaining criteria. We found the most concerned dimension of service
quality is Transaction Safety Mechanism and the least is Charge Item.
Other criteria such as information security, accuracy and information
are too vital.
Abstract: Since hyaluronic acid (HA) receptor such as CD44 is
over-expressed at sites of cancer cells, HA can be used as a targeting
vehicles for anti-cancer drugs. The aim of this study is to synthesize
block copolymer composed of hyaluronic acid and
poly(ε-caprolactone) (HAPCL) and to fabricate polymeric micelles for
anticancer drug targeting against CD44 receptor of tumor cells.
Chemical composition of HAPCL was confirmed using 1H NMR
spectroscopy. Doxorubicin (DOX) was incorporated into polymeric
micelles of HAPCL. The diameters of HAPHS polymeric micelles
were changed around 80nm and have spherical shapes. Targeting
potential was investigated using CD44-overexpressing. When
DOX-incorporated polymeric micelles was added to KB cells, they
revealed strong red fluorescence color while blocking of CD44
receptor by pretreatment of free HA resulted in reduced intensity,
indicating that HAPCL polymeric micelles have targetability against
CD44 receptor.
Abstract: To extract the important physiological factors related to
diabetes from an oral glucose tolerance test (OGTT) by mathematical
modeling, highly informative but convenient protocols are required.
Current models require a large number of samples and extended
period of testing, which is not practical for daily use. The purpose
of this study is to make model assessments possible even from a
reduced number of samples taken over a relatively short period.
For this purpose, test values were extrapolated using a support
vector machine. A good correlation was found between reference and
extrapolated values in evaluated 741 OGTTs. This result indicates
that a reduction in the number of clinical test is possible through a
computational approach.
Abstract: In the era of great competition, understanding and satisfying
customers- requirements are the critical tasks for a company
to make a profits. Customer relationship management (CRM) thus
becomes an important business issue at present. With the help of
the data mining techniques, the manager can explore and analyze
from a large quantity of data to discover meaningful patterns and
rules. Among all methods, well-known association rule is most
commonly seen. This paper is based on Apriori algorithm and uses
genetic algorithms combining a data mining method to discover fuzzy
classification rules. The mined results can be applied in CRM to
help decision marker make correct business decisions for marketing
strategies.
Abstract: In this paper, delay-dependent stability analysis for
neutral type neural networks with uncertain paramters and
time-varying delay is studied. By constructing new
Lyapunov-Krasovskii functional and dividing the delay interval into
multiple segments, a novel sufficient condition is established to
guarantee the globally asymptotically stability of the considered
system. Finally, a numerical example is provided to illustrate the
usefulness of the proposed main results.
Abstract: This paper contributes to the field of Environmental
Awareness Training (EAT) evaluation in terms of military activities.
Environmental management of military activities is a growing concern
for defence forces worldwide and the importance of EAT is becoming
widely recognized. As one of Australia-s largest landowners, the
Australian Defence Force (ADF) is extremely mindful of its duty as a
joint environmental manager. It has an integrated Environmental
Management System (EMS) to assist environmental management and
EAT is an essential part of the ADF EMS model. This paper examines
how EAT was conducted during the exercise Talisman Saber in 2009
(TS09) and evaluates its effectiveness, using Shoalwater Bay Training
Area (SWBTA), one of the most significant military training areas and
a significant protected area in Australia, as a case study. A
questionnaire survey conducted showed, overall, that EAT was
effective from the perspective of a sample of participants.
Recommendations are made for the ADF to refine EAT for future
exercises.
Abstract: Based on an analysis of the mechanism of degradation of optical characteristics of the ZnO-pigmented white paint by electron irradiation, a model of single molecular color centers is built. An equation that explains the relationship between the changes of variation of the ZnO-pigmented white paint-s spectrum absorptance and electron fluence is derived. The uncertain parameters in the equation can be calculated using the curve fitting by experimental data. The result indicates that the model can be applied to predict the degradation of optical characteristics of ZnO-pigmented white paint by electron radiation.
Abstract: Cloud computing is the innovative and leading
information technology model for enabling convenient, on-demand
network access to a shared pool of configurable computing resources
that can be rapidly provisioned and released with minimal
management effort. This paper presents our development on enabling
an individual user's desktop in a virtualized environment, which is
stored on a remote virtual machine rather than locally. We present the
initial work on the integration of virtual desktop and application
sharing with virtualization technology. Given the development of
remote desktop virtualization, this proposed effort has the potential to
positively provide an efficient, resilience and elastic environment for
online cloud service. Users no longer need to burden the cost of
software licenses and platform maintenances. Moreover, this
development also helps boost user productivity by promoting a
flexible model that lets users access their desktop environments from
virtually anywhere.
Abstract: An economic operation scheduling problem of a
hydro-thermal power generation system has been properly solved by
the proposed multipath adaptive tabu search algorithm (MATS). Four
reservoirs with their own hydro plants and another one thermal plant
are integrated to be a studied system used to formulate the objective
function under complicated constraints, eg water managements,
power balance and thermal generator limits. MATS with four subsearch
units (ATSs) and two stages of discarding mechanism (DM),
has been setting and trying to solve the problem through 25 trials
under function evaluation criterion. It is shown that MATS can
provide superior results with respect to single ATS and other
previous methods, genetic algorithms (GA) and differential evolution
(DE).
Abstract: Simultaneous recovery of copper and DCA from
simulated MEUF concentrated stream was investigated. Effects of
surfactant (DCA) and metal (copper) concentrations, surfactant to
metal molar ratio (S/M ratio), electroplating voltage, EDTA
concentration, solution pH, and salt concentration on metal recovery
and current efficiency were studied. Electric voltage of -0.5 V was
shown to be optimum operation condition in terms of Cu recovery,
current efficiency, and surfactant recovery. Increasing Cu recovery and
current efficiency were observed with increases of Cu concentration
while keeping concentration of DCA constant. However, increasing
both Cu and DCA concentration while keeping S/M ratio constant at
2.5 showed detrimental effect on Cu recovery at DCA concentration
higher than 15 mM. Cu recovery decreases with increasing pH while
current efficiency showed an opposite trend. It is believed that
conductivity is the main cause for discrepancy of Cu recovery and
current efficiency observed at different pH. Finally, it was shown that
EDTA had adverse effect on both Cu recovery and current efficiency
while addition of NaCl salt had negative impact on current efficiency
at concentration higher than 8000 mg/L.
Abstract: Tofurther advance research on immune-related genes
from T. molitor, we constructed acDNA library and analyzed
expressed sequence taq (EST) sequences from 1,056 clones. After
removing vector sequence and quality checkingthrough thePhred
program (trim_alt 0.05 (P-score>20), 1039 sequences were generated.
The average length of insert was 792 bp. In addition, we identified 162
clusters, 167 contigs and 391 contigs after clustering and assembling
process using a TGICL package. EST sequences were searchedagainst
NCBI nr database by local BLAST (blastx, E