Abstract: HIV-1 genome is highly heterogeneous. Due to this
variation, features of HIV-I genome is in a wide range. For this
reason, the ability to infection of the virus changes depending on
different chemokine receptors. From this point of view, R5 HIV
viruses use CCR5 coreceptor while X4 viruses use CXCR5 and
R5X4 viruses can utilize both coreceptors. Recently, in
Bioinformatics, R5X4 viruses have been studied to classify by using
the experiments on HIV-1 genome.
In this study, R5X4 type of HIV viruses were classified using
Auto Regressive (AR) model through Artificial Neural Networks
(ANNs). The statistical data of R5X4, R5 and X4 viruses was
analyzed by using signal processing methods and ANNs. Accessible
residues of these virus sequences were obtained and modeled by AR
model since the dimension of residues is large and different from
each other. Finally the pre-processed data was used to evolve various
ANN structures for determining R5X4 viruses. Furthermore ROC
analysis was applied to ANNs to show their real performances. The
results indicate that R5X4 viruses successfully classified with high
sensitivity and specificity values training and testing ROC analysis
for RBF, which gives the best performance among ANN structures.