Impact of Tuberculosis Co-infection on Cytokine Expression in HIV-Infected Individuals

Year: 2016 Volume: 10 Issue: 4 183 - 187 Pages

• Authors:
• M. Nosik
• I. Rymanova
• N. Adamovich
• S. Sevostyanihin
• K. Ryzhov
• Y. Kuimova
• A. Kravtchenko
• N. Sergeeva
• A. Sobkin

Abstract: HIV and Tuberculosis (TB) infections each speed the other's progress. HIV-infection increases the risk of TB disease. At the same time, TB infection is associated with clinical progression of HIV-infection. HIV+TB co-infected patients are also at higher risk of acquiring new opportunistic infections. An important feature of disease progression and clinical outcome is the innate and acquired immune responses. HIV and TB, however, have a spectrum of dysfunctions of the immune response. As cytokines play a crucial role in the immunopathology of both infections, it is important to study immune interactions in patients with dual infection HIV+TB. Plasma levels of proinflammatory cytokines IL-2, IFN-γ and immunoregulating cytokines IL-4, IL-10 were evaluated in 75 patients with dual infection HIV+TB, 58 patients with HIV monoinfection and 50 patients with TB monoinfection who were previously naïve for HAART. The decreased levels of IL-2, IFN-γ, IL-4 and IL-10 were observed in patients with dual infection HIV+TB in comparison with patients who had only HIV or TB which means the profound suppression of Th1 and Th2 cytokine secretion. Thus, those cytokines could possibly serve as immunological markers of progression of HIV-infection in patients with TB.

• Keywords:
• HIV
• Tuberculosis
• TB
• HIV associated with TB
• Th1/ Th2 cytokine expression.

Regulation of Transfer of 137cs by Polymeric Sorbents for Grow Ecologically Sound Biomass

Year: 2014 Volume: 8 Issue: 3 213 - 216 Pages

• Authors:
• A. H. Tadevosyan
• S. K. Mayrapetyan
• N. B. Tavakalyan
• K. I. Pyuskyulyan
• A. H. Hovsepyan
• S. N. Sergeeva

Abstract: Soil contamination with radiocesium has a long-term radiological impact due to its long physical half-life (30.1 years for 137Cs and 2 years for 134Cs) and its high biological availability. 137Cs causes the largest concerns because of its deleterious effect on agriculture and stock farming, and, thus, human life for decades. One of the important aspects of the problem of contaminated soils remediation is understand of protective actions aimed at the reduction of biological migration of radionuclides in soil-plant system. The most effective way to bind radionuclides is the use of selective sorbents. The proposed research mainly aims to achieve control on transfer of 137Cs in a system growing media – plant due to counter ions variation in the polymeric sorbents. As research object Japanese basil - Perilla frutescens was chosen. Productivity of plants depending on the presence (control-without presence of polymer) and type of polymer material, as well as content of 137Cs in plant material has been determined. The character of different polymers influences on the 137Cs migration in growing media – plant system as well as accumulation in the plants has been cleared up.

• Keywords:
• Radioceaseum
• Japanese basil
• polymer
• soil-plant system.