Abstract: This study is conducted to investigate the disparity of between learning styles and cognitive abilities specifically in Vocational Education. Felder and Silverman Learning Styles Model (FSLSM) was applied to measure the students’ learning styles while the content in Building Construction Subject consists; knowledge, skills and problem solving were taken into account in constructing the elements of cognitive abilities. Building Construction is one of the vocational courses offered in Vocational Education structure. There are four dimension of learning styles proposed by Felder and Silverman intended to capture student learning preferences with regards to processing either active or reflective, perception based on sensing or intuitive, input of information used visual or verbal and understanding information represent with sequential or global learner. Felder-Solomon Learning Styles Index was developed based on FSLSM and the questions were used to identify what type of student learning preferences. The index consists 44 item-questions characterize for learning styles dimension in FSLSM. The achievement test was developed to determine the students’ cognitive abilities. The quantitative data was analyzed in descriptive and inferential statistic involving Multivariate Analysis of Variance (MANOVA). The study discovered students are tending to be visual learners and each type of learner having significant difference whereas cognitive abilities there are different finding for each type of learners in knowledge, skills and problem solving. This study concludes the gap between type of learner and the cognitive abilities in few illustrations and it explained how the connecting made. The finding may help teachers to facilitate students more effectively and to boost the student’s cognitive abilities.
Abstract: Quantitative Structure-Activity Relationship (QSAR)
approach for discovering novel more active Calanone derivative as
anti-leukemia compound has been conducted. There are 6
experimental activities of Calanone compounds against leukemia cell
L1210 that are used as material of the research. Calculation of
theoretical predictors (independent variables) was performed by
AM1 semiempirical method. The QSAR equation is determined by
Principle Component Regression (PCR) analysis, with Log IC50 as
dependent variable and the independent variables are atomic net
charges, dipole moment (μ), and coefficient partition of noctanol/
water (Log P). Three novel Calanone derivatives that
obtained by this research have higher activity against leukemia cell
L1210 than pure Calanone.