Abstract: This study focuses on examining why the range of
experience with respect to HIV infection is so diverse, especially in
regard to the latency period. An agent-based approach in modelling
the infection is used to extract high-level behaviour which cannot be
obtained analytically from the set of interaction rules at the cellular
level. A prototype model encompasses local variation in baseline
properties, contributing to the individual disease experience, and is
included in a network which mimics the chain of lymph nodes. The
model also accounts for stochastic events such as viral mutations.
The size and complexity of the model require major computational
effort and parallelisation methods are used.
Abstract: We report on the development of a model to
understand why the range of experience with respect to HIV
infection is so diverse, especially with respect to the latency period.
To investigate this, an agent-based approach is used to extract highlevel
behaviour which cannot be described analytically from the set
of interaction rules at the cellular level. A network of independent
matrices mimics the chain of lymph nodes. Dealing with massively
multi-agent systems requires major computational effort. However,
parallelisation methods are a natural consequence and advantage of
the multi-agent approach and, using the MPI library, are here
implemented, tested and optimized. Our current focus is on the
various implementations of the data transfer across the network.
Three communications strategies are proposed and tested, showing
that the most efficient approach is communication based on the
natural lymph-network connectivity.