Abstract: It is known that the heart interacts with and adapts to
its venous and arterial loading conditions. Various experimental
studies and modeling approaches have been developed to investigate
the underlying mechanisms. This paper presents a model of the left
ventricle derived based on nonlinear stress-length myocardial
characteristics integrated over truncated ellipsoidal geometry, and
second-order dynamic mechanism for the excitation-contraction
coupling system. The results of the model presented here describe the
effects of the viscoelastic damping element of the electromechanical
coupling system on the hemodynamic response. Different heart rates
are considered to study the pacing effects on the performance of the
left-ventricle against constant preload and afterload conditions under
various damping conditions. The results indicate that the pacing
process of the left ventricle has to take into account, among other
things, the viscoelastic damping conditions of the myofilament
excitation-contraction process.
Abstract: It is known that the heart interacts with and adapts to its venous and arterial loading conditions. Various experimental studies and modeling approaches have been developed to investigate the underlying mechanisms. This paper presents a model of the left ventricle derived based on nonlinear stress-length myocardial characteristics integrated over truncated ellipsoidal geometry, and second-order dynamic mechanism for the excitation-contraction coupling system. The results of the model presented here describe the effects of the viscoelastic damping element of the electromechanical coupling system on the hemodynamic response. Different heart rates are considered to study the pacing effects on the performance of the left-ventricle against constant preload and afterload conditions under various damping conditions. The results indicate that the pacing process of the left ventricle has to take into account, among other things, the viscoelastic damping conditions of the myofilament excitation-contraction process. The effects of left ventricular dimensions on the hemdynamic response have been examined. These effects are found to be different at different viscoelastic and pacing conditions.