Abstract: It is sometimes difficult to differentiate between
innocent murmurs and pathological murmurs during auscultation. In
these difficult cases, an intelligent stethoscope with decision support
abilities would be of great value. In this study, using a dog model,
phonocardiographic recordings were obtained from 27 boxer dogs
with various degrees of aortic stenosis (AS) severity. As a reference
for severity assessment, continuous wave Doppler was used. The data
were analyzed with recurrence quantification analysis (RQA) with
the aim to find features able to distinguish innocent murmurs from
murmurs caused by AS. Four out of eight investigated RQA features
showed significant differences between innocent murmurs and
pathological murmurs. Using a plain linear discriminant analysis
classifier, the best pair of features (recurrence rate and entropy)
resulted in a sensitivity of 90% and a specificity of 88%. In
conclusion, RQA provide valid features which can be used for
differentiation between innocent murmurs and murmurs caused by
AS.
Abstract: Laser soldering is based on applying some soldering material (albumin) onto the approximated edges of the cut and heating the solder (and the underlying tissues) by a laser beam. Endogenous and exogenous materials such as indocyanine green (ICG) are often added to solders to enhance light absorption. Gold nanoshells are new materials which have an optical response dictated by the plasmon resonance. The wavelength at which the resonance occurs depends on the core and shell sizes, allowing nanoshells to be tailored for particular applications. The purposes of this study was use combination of ICG and different concentration of gold nanoshells for skin tissue soldering and also to examine the effect of laser soldering parameters on the properties of repaired skin. Two mixtures of albumin solder and different combinations of ICG and gold nanoshells were prepared. A full thickness incision of 2×20 mm2 was made on the surface and after addition of mixtures it was irradiated by an 810nm diode laser at different power densities. The changes of tensile strength σt due to temperature rise, number of scan (Ns), and scan velocity (Vs) were investigated. The results showed at constant laser power density (I), σt of repaired incisions increases by increasing the concentration of gold nanoshells in solder, Ns and decreasing Vs. It is therefore important to consider the tradeoff between the scan velocity and the surface temperature for achieving an optimum operating condition. In our case this corresponds to σt =1800 gr/cm2 at I~ 47 Wcm-2, T ~ 85ºC, Ns =10 and Vs=0.3mms-1.
Abstract: The ITE Project is a project that has 1800 km length
and across the Turkey's land through east to west. The project of
pipeline enters geographically from Iran to Doğubayazit (Turkey) in
the east, exits to Greece from Ipsala province of Turkey in the west.
This project is the one of the international projects in such scale that
provides the natural gas of Iran and Caspian Sea through the
European continent. In this investigation, some information will be
given about the methods used to verify the direction of the pipeline
and the technical properties of the results obtained. The cost of
project itself entirely depends on the direction of the pipeline which
would be as short as possible and the specifications of the land cover.
Production standards of 1/2000 scaled digital orthophoto and vectoral
maps as a results of the use of map production materials and methods
(such as high resolution satellite images, and digital aerial images
captured from digital aerial cameras), will also be given in this report.
According to Turkish national map production standards, TM
((Transversal Mercator, 3 degree) projection is used for large scale
map and UTM (Universal Transversal Mercator, 6 degree) is used for
small scale map production standards. Some information is also given
about the projection used in the ITE natural gas pipeline project.
Abstract: In this study, the effect of nanofluids on the pool film
boiling was experimentally investigated at saturated condition under
atmospheric pressure. For this purpose, four different water-based
nanofluids (Al2O3, SiO2, TiO2 and CuO) with 0.1% particle volume
fraction were prepared. To investigate the boiling heat transfer, a
cylindrical rod with high temperature was used. The rod heated up to
high temperatures was immersed into nanofluids. The center
temperature of rod during the cooling process was recorded by using
a K-type thermocouple. The quenching curves showed that the pool
boiling heat transfer was strongly dependent on the nanoparticle
materials. During the repetitive quenching tests, the cooling time
decreased and thus, the film boiling vanished. Consequently, the
primary reason of this was the change of the surface characteristics
due to the nanoparticles deposition on the rod-s surface.
Abstract: In this paper, we propose a hardware and software
design method for automotive Electronic Control Units (ECU)
considering the functional safety. The proposed ECU is considered for
the application to Electro-Mechanical Actuator systems and the
validity of the design method is shown by the application to the
Electro-Mechanical Brake (EMB) control system which is used as a
brake actuator in Brake-By-Wire (BBW) systems. The importance of a
functional safety-based design approach to EMB ECU design has been
emphasized because of its safety-critical functions, which are executed
with the aid of many electric actuators, sensors, and application
software. Based on hazard analysis and risk assessment according to
ISO26262, the EMB system should be ASIL-D-compliant, the highest
ASIL level. To this end, an external signature watchdog and an
Infineon 32-bit microcontroller TriCore are used to reduce risks
considering common-cause hardware failure. Moreover, a software
design method is introduced for implementing functional
safety-oriented monitoring functions based on an asymmetric dual
core architecture considering redundancy and diversity. The validity
of the proposed ECU design approach is verified by using the EMB
Hardware-In-the-Loop (HILS) system, which consists of the EMB
assembly, actuator ECU, a host PC, and a few debugging devices.
Furthermore, it is shown that the existing sensor fault tolerant control
system can be used more effectively for mitigating the effects of
hardware and software faults by applying the proposed ECU design
method.
Abstract: Technology transfer by international trade and
foreign direct investment is the most important positive
outcome of open economy. It is widely accepted that new
technology and knowledge have an important role in
enhancing economic growth. Human capital is the other
important factor assisting economic growth. In this study, the
role of human capital in the growth process is examined in a
view of new endogenous growth theory emphasizing on the
technology transfer resulting from international trade. Using
the panel data of 10 developed and 10 developing countries,
impact of human capital and openness on the rate of economic
growth of different countries is analysed. Evidence suggests
the view that human capital and openness contribute to the
economic growth in both developing and developed countries,
but with different rates.
Abstract: Prickly pear fruit (Opuntia ficus indica L. Miller) belongs to the Cactaceae family. This species is very sensitive to low storage temperatures (< 5°C) which cause damages. The fruits can be peeled, suitably packaged and successfully commercialized as a ready-to-eat product. The main limit to the extension of the shelf life is the production of off-flavors due to different factors, the growth of microorganisms and the action of endogenous enzymes. Lipoxygenase (LOX) and Pectinesterase (PE) are involved in fruit degradation. In particular, LOX pathway is directly responsible for lipid oxidation, and the subsequent production of off-flavours, while PE causes the softening of fruit during maturation. They act on the texture and shelf-life of post-harvest, packaged fruits, as a function of the the grown of microorganisms and packaging technologies used. The aim of this work is to compare the effect of different packaging technologies on the shelf life extension of ready-to-eat prickly pear fruits with regards for the enzymes activities.
Abstract: In Multiple Sclerosis, pathological changes in the
brain results in deviations in signal intensity on Magnetic Resonance
Images (MRI). Quantitative analysis of these changes and their
correlation with clinical finding provides important information for
diagnosis. This constitutes the objective of our work. A new approach
is developed. After the enhancement of images contrast and the brain
extraction by mathematical morphology algorithm, we proceed to the
brain segmentation. Our approach is based on building statistical
model from data itself, for normal brain MRI and including clustering
tissue type. Then we detect signal abnormalities (MS lesions) as a
rejection class containing voxels that are not explained by the built
model. We validate the method on MR images of Multiple Sclerosis
patients by comparing its results with those of human expert
segmentation.
Abstract: Candida albicans ATCC 10231 had low endogenous activity of the alternative oxidase compared with that of C. albicans ATCC 10261. In C. albicans ATCC 10231 the endogenous activity declined as the cultures aged. Alternative oxidase activity could be induced in C. albicans ATCC 10231 by treatment with cyanide, but the induction of this activity required the presence of oxygen which could be replaced, at least in part, with high concentrations of potassium ferricyanide. We infer from this that the expression of the gene encoding the alternative oxidase is under the control of a redoxsensitive transcription factor.
Abstract: This paper is a continuation of our daily energy peak load forecasting approach using our modified network which is part of the recurrent networks family and is called feed forward and feed back multi context artificial neural network (FFFB-MCANN). The inputs to the network were exogenous variables such as the previous and current change in the weather components, the previous and current status of the day and endogenous variables such as the past change in the loads. Endogenous variable such as the current change in the loads were used on the network output. Experiment shows that using endogenous and exogenous variables as inputs to the FFFBMCANN rather than either exogenous or endogenous variables as inputs to the same network produces better results. Experiments show that using the change in variables such as weather components and the change in the past load as inputs to the FFFB-MCANN rather than the absolute values for the weather components and past load as inputs to the same network has a dramatic impact and produce better accuracy.
Abstract: An alarming emergence of multidrug-resistant strains
of the tuberculosis pathogen Mycobacterium tuberculosis and
continuing high worldwide incidence of tuberculosis has invigorated
the search for novel drug targets. The enzyme glutamate racemase
(MurI) in bacteria catalyzes the stereoconversion of L-glutamate to
D-glutamate which is a component of the peptidoglycan cell wall of
the bacterium. The inhibitors targeted against MurI from several
bacterial species have been patented and are advocated as promising
antibacterial agents. However there are none available against MurI
from Mycobacterium tuberculosis, due to the lack of its threedimensional
structure. This work accomplished two major objectives.
First, the tertiary structure of MtMurI was deduced computationally
through homology modeling using the templates from bacterial
homologues. It is speculated that like in other Gram-positive bacteria,
MtMurI exists as a dimer and many of the protein interactions at the
dimer interface are also conserved. Second, potent candidate
inhibitors against MtMurI were identified through docking against
already known inhibitors in other organisms.