Abstract: The PAX6, a transcription factor, is essential for the morphogenesis of the eyes, brain, pituitary and pancreatic islets. In rodents, the loss of Pax6 function leads to central nervous system defects, anophthalmia, and nasal hypoplasia. The haplo-insufficiency of Pax6 causes microphthalmia, aggression and other behavioral abnormalities. It is also required in brain patterning and neuronal plasticity. In human, heterozygous mutation of Pax6 causes loss of iris [aniridia], mental retardation and glucose intolerance. The 3- deletion in Pax6 leads to autism and aniridia. The phenotypes are variable in peneterance and expressivity. However, mechanism of function and interaction of PAX6 with other proteins during development and associated disease are not clear. It is intended to explore interactors of PAX6 to elucidated biology of PAX6 function in the tissues where it is expressed and also in the central regulatory pathway. This report describes In-silico approaches to explore interacting proteins of PAX6. The models show several possible proteins interacting with PAX6 like MITF, SIX3, SOX2, SOX3, IPO13, TRIM, and OGT. Since the Pax6 is a critical transcriptional regulator and master control gene of eye and brain development it might be interacting with other protein involved in morphogenesis [TGIF, TGF, Ras etc]. It is also presumed that matricelluar proteins [SPARC, thrombospondin-1 and osteonectin etc] are likely to interact during transport and processing of PAX6 and are somewhere its cascade. The proteins involved in cell survival and cell proliferation can also not be ignored.
Abstract: A hybrid feature based adaptive particle filter algorithm is presented for object tracking in real scenarios with static camera.
The hybrid feature is combined by two effective features: the Grayscale Arranging Pairs (GAP) feature and the color histogram feature. The GAP feature has high discriminative ability even under conditions of severe illumination variation and dynamic background
elements, while the color histogram feature has high reliability to identify the detected objects. The combination of two features covers the shortage of single feature. Furthermore, we adopt an updating
target model so that some external problems such as visual angles can be overcame well. An automatic initialization algorithm is introduced which provides precise initial positions of objects. The experimental
results show the good performance of the proposed method.
Abstract: As part of national epidemiological survey on bovine
viral diarrhea virus (BVDV), a total of 274 dejecta samples were
collected from 14 cattle farms in 8 areas of Xinjiang Uygur
Autonomous Region in northwestern China. Total RNA was extracted
from each sample, and 5--untranslated region (UTR) of BVDV
genome was amplified by using two-step reverse
transcriptase-polymerase chain reaction (RT-PCR). The PCR products
were subsequently sequenced to study the genetic variations of BVDV
in these areas. Among the 274 samples, 33 samples were found
virus-positive. According to sequence analysis of the PCR products,
the 33 samples could be arranged into 16 groups. All the sequences,
however, were highly conserved with BVDV Osloss strains. The virus
possessed theses sequences belonged to BVDV-1b subtype by
phylogenetic analysis. Based on these data, we established a typing
tree for BVDV in these areas. Our results suggested that BVDV-1b
was a predominant subgenotype in northwestern China and no
correlation between the genetic and geographical distances could be
observed above the farm level.
Abstract: The usage of internet is rapidly increasing and the usage of mobile agent technology in internet environment has a great demand. The security issue one of main obstacles that restrict the mobile agent technology to spread. This paper proposes Secure-Image Mechanism (SIM) as a new mechanism to protect mobile agents against malicious hosts. . SIM aims to protect mobile agent by using the symmetric encryption and hash function in cryptography science. This mechanism can prevent the eavesdropping and alteration attacks. It assists the mobile agents to continue their journey normally incase attacks occurred.
Abstract: The use of power system stabilizers (PSSs) to damp
power system swing mode of oscillations is practical important. Our
purpose is to retune the power system stabilizer (PSS1A) parameters
in Unitrol D produced by ABB– was installed in 1995in Benghazi
North Power Plants (BNPPs) at General Electricity Company of
Libya (GECOL). The optimal values of the power system stabilizer
(PSS1A) parameters are determined off-line by a particle swarm
optimization technique (PSO). The objective is to damp the local and
inter-area modes of oscillations that occur following power system
disturbances. The retuned power system stabilizer (PSS1A) can cope
with large disturbance at different operating points and has enhanced
power system stability.
Abstract: In the recent past Learning Classifier Systems have
been successfully used for data mining. Learning Classifier System
(LCS) is basically a machine learning technique which combines
evolutionary computing, reinforcement learning, supervised or
unsupervised learning and heuristics to produce adaptive systems. A
LCS learns by interacting with an environment from which it
receives feedback in the form of numerical reward. Learning is
achieved by trying to maximize the amount of reward received. All
LCSs models more or less, comprise four main components; a finite
population of condition–action rules, called classifiers; the
performance component, which governs the interaction with the
environment; the credit assignment component, which distributes the
reward received from the environment to the classifiers accountable
for the rewards obtained; the discovery component, which is
responsible for discovering better rules and improving existing ones
through a genetic algorithm. The concatenate of the production rules
in the LCS form the genotype, and therefore the GA should operate
on a population of classifier systems. This approach is known as the
'Pittsburgh' Classifier Systems. Other LCS that perform their GA at
the rule level within a population are known as 'Mitchigan' Classifier
Systems. The most predominant representation of the discovered
knowledge is the standard production rules (PRs) in the form of IF P
THEN D. The PRs, however, are unable to handle exceptions and do
not exhibit variable precision. The Censored Production Rules
(CPRs), an extension of PRs, were proposed by Michalski and
Winston that exhibit variable precision and supports an efficient
mechanism for handling exceptions. A CPR is an augmented
production rule of the form: IF P THEN D UNLESS C, where
Censor C is an exception to the rule. Such rules are employed in
situations, in which conditional statement IF P THEN D holds
frequently and the assertion C holds rarely. By using a rule of this
type we are free to ignore the exception conditions, when the
resources needed to establish its presence are tight or there is simply
no information available as to whether it holds or not. Thus, the IF P
THEN D part of CPR expresses important information, while the
UNLESS C part acts only as a switch and changes the polarity of D
to ~D. In this paper Pittsburgh style LCSs approach is used for
automated discovery of CPRs. An appropriate encoding scheme is
suggested to represent a chromosome consisting of fixed size set of
CPRs. Suitable genetic operators are designed for the set of CPRs
and individual CPRs and also appropriate fitness function is proposed
that incorporates basic constraints on CPR. Experimental results are
presented to demonstrate the performance of the proposed learning
classifier system.
Abstract: A Comparison and evaluation of the different
condition monitoring (CM) techniques was applied experimentally
on RC e.g. Dynamic cylinder pressure and crankshaft Instantaneous
Angular Speed (IAS), for the detection and diagnosis of valve faults
in a two - stage reciprocating compressor for a programme of
condition monitoring which can successfully detect and diagnose a
fault in machine. Leakage in the valve plate was introduced
experimentally into a two-stage reciprocating compressor. The effect
of the faults on compressor performance was monitored and the
differences with the normal, healthy performance noted as a fault
signature been used for the detection and diagnosis of faults.
The paper concludes with what is considered to be a unique
approach to condition monitoring. First, each of the two most useful
techniques is used to produce a Truth Table which details the
circumstances in which each method can be used to detect and
diagnose a fault. The two Truth Tables are then combined into a
single Decision Table to provide a unique and reliable method of
detection and diagnosis of each of the individual faults introduced
into the compressor. This gives accurate diagnosis of compressor
faults.
Abstract: The temporal nature of negative selection is an under exploited area. In a negative selection system, newly generated antibodies go through a maturing phase, and the survivors of the phase then wait to be activated by the incoming antigens after certain number of matches. These without having enough matches will age and die, while these with enough matches (i.e., being activated) will become active detectors. A currently active detector may also age and die if it cannot find any match in a pre-defined (lengthy) period of time. Therefore, what matters in a negative selection system is the dynamics of the involved parties in the current time window, not the whole time duration, which may be up to eternity. This property has the potential to define the uniqueness of negative selection in comparison with the other approaches. On the other hand, a negative selection system is only trained with “normal" data samples. It has to learn and discover unknown “abnormal" data patterns on the fly by itself. Consequently, it is more appreciate to utilize negation selection as a system for pattern discovery and recognition rather than just pattern recognition. In this paper, we study the potential of using negative selection in discovering unknown temporal patterns.
Abstract: For stable bipedal gait generation on the level floor,
efficient restoring of mechanical energy lost by heel collision at
the ground is necessary. Parametric excitation principle is one of
the solutions. We dealt with the robot-s total center of mass as
an inverted pendulum to consider the total dynamics of the robot.
Parametrically excited walking requires the use of continuous target
trajectory that is close to discontinuous optimal trajectory. In this
paper, we proposed the new target trajectory based on a position
in the walking direction. We surveyed relations between walking
performance and the parameters that form the target trajectory via
numerical simulations. As a result, it was found that our target
trajectory has the similar characteristics of a parametrically excited
inverted pendulum.
Abstract: Heat-inducible gene expression vectors are useful for hyperthermia-induced cancer gene therapy, because the combination
of hyperthermia and gene therapy can considerably improve the therapeutic effects. In the present study, we developed an enhanced
heat-inducible transgene expression system in which a heat-shock
protein (HSP) promoter and tetracycline-responsive transactivator
were combined. When the transactivator plasmid containing the
tetracycline-responsive transactivator gene was co-transfected with
the reporter gene expression plasmid, a high level of heat-induced gene expression was observed compared with that using the HSP
promoter without the transactivator. In vitro evaluation of the
therapeutic effect using HeLa cells showed that heat-induced therapeutic gene expression caused cell death in a high percentage of
these cells, indicating that this strategy is promising for cancer gene therapy.
Abstract: Recently studies in area of supply chain network
(SCN) have focused on the disruption issues in distribution systems.
Also this paper extends the previous literature by providing a new biobjective
model for cost minimization of designing a three echelon
SCN across normal and failure scenarios with considering multi
capacity option for manufacturers and distribution centers. Moreover,
in order to solve the problem by means of LINGO software, novel
model will be reformulated through a branch of LP-Metric method
called Min-Max approach.
Abstract: Buildings and associated construction methods have a significant impact on the environment. As construction activity increases in Kuwait, there is a need to create design and construction strategies which will minimize the environmental impact of new buildings. Green construction is a design philosophy intended to improve the sustainability of construction by the minimization of resource depletion and CO2 emissions throughout the life cycle of buildings. This paper presents and discusses the results of a survey that was conducted in Kuwait, with the objective of investigating the awareness of developers and other stakeholders regarding their understanding and use of green construction strategies. The results of the survey demonstrate that whilst there seems to be a reasonable level of awareness amongst the stakeholders, this awareness is not currently well reflected in the design and construction practices actually being applied. It is therefore concluded is there is a pressing need for intervention from Government in order that the use of sustainable green design and construction strategies becomes the norm in Kuwait.
Abstract: During the year 1999, Serbia (ex Yugoslavia) and their northern province, Vojvodina, has been bombarded. Because of that general public believe is that this region was contaminated by depleted uranium and that there is a potential contaminant of agricultural products due to soil radioactivity. This paper presents the repeated analysis of agricultural soil samples in Vojvodina. The same investigation was carried out during the year 2001, and it was concluded that, based on the gamma-spectrometric analysis of 50 soil samples taken from the region of Vojvodina, there haven-t been registered any increase of radioactivity that could endanger the food production. We continue with the monitoring of this region. The comparison between those two sets of results is presented.
Abstract: The study of interaction among the grain, moisture,
and the surrounding space (air) is key to understanding the graindrying
process. In Iran, rice (mostly Indica type) is dried by flat
bed type dryer until the final MC reaches to 6 to 8%. The
experiments were conducted to examine the effect of application of
discharge fan with different heights of paddy on the drying
efficiency. Experiments were designed based on two different
configurations of the drying methods; with and without discharge
fan with three different heights of paddy including; 5, 10, and 15
cm. The humid heated air will be going out immediately by the
suction of discharge fan. The drying time is established upon the
average final MC to achieve about 8%. To save energy and reduce
the drying time, the distribution of temperature between layers
should be fast and uniform with minimum difference; otherwise
the difference of MC gradient between layers will be high and will
induce grain breakage. The difference of final MC between layers
in the two methods was 48-73%. The steady state of temperature
between the two methods has saved time in the range of 10-20%,
and the efficiency of temperature distribution increased 17-26% by
the use of discharge fan.
Abstract: Coverage is one of the main research interests in wireless sensor networks (WSN), it is used to determine the quality of service (QoS) of the networks. Therefore this paper aims to review the common strategies use in solving coverage problem in WSN. The strategies studied are used during deployment phase where the coverage is calculated based on the placement of the sensors on the region of interest (ROI). The strategies reviewed are categorized into three groups based on the approaches used, namely; force based, grid based or computational geometry based approach.
Abstract: Herein, the organic semiconductor methyl orange
(MO), is investigated for the first time for its electronic applications.
For this purpose, Al/MO/n-Si heterojunction is fabricated through
economical cheap and simple “drop casting” technique. The currentvoltage
(I-V) measurements of the device are made at room
temperature under dark conditions. The I-V characteristics of
Al/MO/n-Si junction exhibits asymmetrical and rectifying behavior
that confirms the formation of diode. The diode parameters such as
rectification ratio (RR), turn on voltage (Vturn on), reverse saturation
current (I0), ideality factor (n), barrier height ( b
f ), series resistance
(Rs) and shunt resistance (Rsh) are determined from I-V curves using
Schottky equations. These values of these parameters are also
extracted and verified by applying Cheung’s functions. The
conduction mechanisms are explained from the forward bias I-V
characteristics using the power law.
Abstract: This paper investigates the development of weld zone
in Resistance Spot Welding (RSW) which focuses on weld nugget and Heat Affected Zone (HAZ). The effects of four factors namely
weld current, weld time, electrode force and hold time were studied using a general 24 factorial design augmented by five centre points. The results of the analysis showed that all selected factors except
hold time exhibit significant effect on weld nugget radius and HAZ size. Optimization of the welding parameters (weld current, weld
time and electrode force) to normalize weld nugget and to minimize
HAZ size was then conducted using Central Composite Design (CCD) in Response Surface Methodology (RSM) and the optimum
parameters were determined. A regression model for radius of weld nugget and HAZ size was developed and its adequacy was evaluated.
The experimental results obtained under optimum operating conditions were then compared with the predicted values and were
found to agree satisfactorily with each other
Abstract: The culture of riding heavy motorcycles originates
from advanced countries and mainly comes from Europe, North
America, and Japan. Heavy duty motorcycle riders are different from
people who view motorcycles as a convenient mean of transportation.
They regard riding them as a kind of enjoyment and high-level taste.
The activities of riding heavy duty motorcycles have formes a
distinctive landscape in domestic land in Taiwan. Previous studies
which explored motorcycle culture in Taiwan still focused on the
objects of motorcycle engine displacement under 50 cc.. The study
aims to study the heavy duty motorcycles of engine displacement over
550 cc. and explores where their attractiveness is. For finding the
attractiveness of heavy duty motorcycle, the study chooses Miryoku
Engineering (Preference-Based Design) approach. Two steps are
adopted to proceed the research. First, through arranging the letters
obtained from interviewing experts, EGM (The Evaluation Grid
Method) was applied to find out the structure of attractiveness. The
attractive styles are eye-dazzling, leisure, classic, and racing
competitive styles. Secondarily, Quantification Theory Type I analysis
was adopted as a tool for analyzing the importance of attractiveness.
The relationship between style and attractive parts was also discussed.
The results could contribute to the design and research development of
heavy duty motorcycle industry in Taiwan.
Abstract: Milk is a very important nutrient. Low productivity is
a problem of Turkish dairy farming. During recent years, Turkish government has supported cooperatives that assist milk producers and
encouraged farmers to become cooperative members. Turkish
government established several ways to support specially smallholders. For example Ministry of Agriculture and Rural Affairs
(MARA) provided two to four cows to villagers on a grant or loan basis with a long repayment period at low interest rates by
cooperatives. Social Support Project in Rural Areas (SSPRA) is
another support program targeting only disadvantaged people,
especially poor villager. Both programs have a very strong social
support component and similar objectives. But there are minor
differences between them in terms of target people, terms and conditions of the credit supplied Isparta province in Mediterranean region of Turkey is one of the
supported regions. MARA distributed dairy cows to 1072 farmers through 16 agricultural cooperatives in Isparta province in the context
of SSPRA. In this study, economic-social impacts on dairy cattle project
implemented through cooperatives were examined in Isparta. Primary data were collected from 12 cooperatives- president. The
data were obtained by personal interview through a questionnaire and
to cooperatives and given to farms benefiting from the project in
order to reveal the economic and social developments.
Finding of the study revealed that project provided new job
opportunities and improved quality of livestock. It was found that producers who benefited from the project were more willing to
participate in cooperative or other producer organizations.
Abstract: Steel made pipelines with different diameters are used
for transmitting oil and gas which in many cases are buried in soil
under the sea bed or immersed in sea water. External corrosion of
pipes is an important form of deterioration due to the aggressive
environment of sea water. Corrosion normally results in pits. Hence,
using the finite element method, namely ABAQUS software, this
paper estimates the amount of pressure capacity reduction of a pipecontaining
a semi-elliptical pitting corrosion and the rate of corrosion
during the pipeline life of 25 years.