Abstract: This paper focuses on the assessment of the air
pollution and morbidity relationship in Tunisia. Air pollution is
measured by ozone air concentration and the morbidity is measured
by the number of respiratory-related restricted activity days during
the 2-week period prior to the interview. Socioeconomic data are also
collected in order to adjust for any confounding covariates. Our
sample is composed by 407 Tunisian respondents; 44.7% are women,
the average age is 35.2, near 69% are living in a house built after
1980, and 27.8% have reported at least one day of respiratory-related
restricted activity. The model consists on the regression of the
number of respiratory-related restricted activity days on the air
quality measure and the socioeconomic covariates. In order to correct
for zero-inflation and heterogeneity, we estimate several models
(Poisson, negative binomial, zero inflated Poisson, Poisson hurdle,
negative binomial hurdle and finite mixture Poisson models).
Bootstrapping and post-stratification techniques are used in order to
correct for any sample bias. According to the Akaike information
criteria, the hurdle negative binomial model has the greatest goodness
of fit. The main result indicates that, after adjusting for
socioeconomic data, the ozone concentration increases the probability
of positive number of restricted activity days.
Abstract: The Roma (Gypsies) is a transnational minority with a
high degree of consanguineous marriages. Similar to other
genetically isolated founder populations, the Roma harbor a number
of unique or rare genetic disorders. This paper discusses about a rare
form of Charcot-Marie-Tooth disease – type 4G (CMT4G), also
called Hereditary Motor and Sensory Neuropathy type Russe, an
autosomal recessive disease caused by mutation private to Roma
characterized by abnormally increased density of non-myelinated
axons. CMT4G was originally found in Bulgarian Roma and in 2009
two putative causative mutations in the HK1 gene were identified.
Since then, several cases were reported in Roma families mainly
from Bulgaria and Spain. Here we present a Slovak Roma family in
which CMT4G was diagnosed on the basis of clinical examination
and genetic testing. This case is a further proof of the role of the HK1
gene in pathogenesis of the disease. It confirms that mutation in the
HK1 gene is a common cause of autosomal recessive CMT disease in
Roma and should be considered as a common part of a diagnostic
procedure.
Abstract: Monoamine oxidase A gene (MAOA) is suggested to
be a candidate gene implicated in many neuropsychiatric disorders,
including autism spectrum disorder (ASD). This meta-analytic review
evaluates the relationship between ASD and MAOA markers such as
30 bp variable number tandem repeats in the promoter region
(uVNTR) and single nucleotide polymorphisms (SNPs) by using
findings from recently published studies. It seems that in Caucasian
males, the risk of developing ASD increase with the presence of 4-
repeat allele in the promoter region of MAOA gene whereas no
differences were found between autistic patients and controls in
Egyptian, West Bengal and Korean population. Some studies point to
the importance of specific haplotype groups of SNPs and interaction
of MAOA with others genes (e. g. FOXP2 or SRY). The results of
existing studies are insufficient and further research is needed.
Abstract: Measurements and quantitative analysis of kinematic
parameters of human hand movements have an important role in
different areas such as hand function rehabilitation, modeling of
multi-digits robotic hands, and the development of machine-man
interfaces. In this paper the assessment and evaluation of the reachto-
grasp movement by using computerized and robot-assisted method
is described. Experiment involved the measurements of hand
positions of seven healthy subjects during grasping three objects of
different shapes and sizes. Results showed that three dominant phases
of reach-to-grasp movements could be clearly identified.
Abstract: It is difficult to study the effect of various variables on
cycle fitting through actual experiment. To overcome such difficulty,
the forward dynamics of a musculoskeletal model was applied to cycle
fitting in this study. The measured EMG data weres compared with the
muscle activities of the musculoskeletal model through forward
dynamics. EMG data were measured from five cyclists who do not
have musculoskeletal diseases during three minutes pedaling with a
constant load (150 W) and cadence (90 RPM). The muscles used for
the analysis were the Vastus Lateralis (VL), Tibialis Anterior (TA),
Bicep Femoris (BF), and Gastrocnemius Medial (GM). Person’s
correlation coefficients of the muscle activity patterns, the peak timing
of the maximum muscle activities, and the total muscle activities were
calculated and compared. BIKE3D model of AnyBody (Anybodytech,
Denmark) was used for the musculoskeletal model simulation. The
comparisons of the actual experiments with the simulation results
showed significant correlations in the muscle activity patterns (VL:
0.789, TA: 0.503, BF: 0.468, GM: 0.670). The peak timings of the
maximum muscle activities were distributed at particular phases. The
total muscle activities were compared with the normalized muscle
activities, and the comparison showed about 10% difference in the VL
(+10%), TA (+9.7%), and BF (+10%), excluding the GM (+29.4%).
Thus, it can be concluded that muscle activities of model &
experiment showed similar results. The results of this study indicated
that it was possible to apply the simulation of further improved
musculoskeletal model to cycle fitting.