Modeling and Validation of Microspheres Generation in the Modified T-Junction Device
This paper presents a model for a modified T-junction
device for microspheres generation. The numerical model is
developed using a commercial software package: COMSOL
Multiphysics. In order to test the accuracy of the numerical model,
multiple variables, such as the flow rate of cross-flow, fluid properties,
structure, and geometry of the microdevice are applied. The results
from the model are compared with the experimental results in the
diameter of the microsphere generated. The comparison shows a good
agreement. Therefore the model is useful in further optimization of the
device and feedback control of microsphere generation if any.
[1] L. Amaya bower and T. Lee, "Lattice Boltzmann simulations of bubble
formation in a microfluidic T-junction," Philosophical Transactions of
the Royal Society A: Mathematical, Physical and Engineering Sciences,
vol. 369, pp. 2405-2413, 2011.
[2] S. Arias, D. Legendre, and R. Gonzalez-Cinca, "Numerical simulation of
bubble generation in a T-junction," Computers & Fluids, vol. 56, pp.
49-60, Mar 2012.
[3] N. C. Chen, J. Z. Wu, H. M. Jiang, and L. C. Dong, "CFD Simulation of
Droplet Formation in a Wide-Type Microfluidic T-Junction," Journal of
Dispersion Science and Technology, vol. 33, pp. 1635-1641, 2012.
[4] T. Glawdel and C. L. Ren, "Droplet formation in microfluidic T-junction
generators operating in the transitional regime. III. Dynamic surfactant
effects," Physical Review E, vol. 86, Aug 13 2012.
[5] X. Li, F. Li, J. Yang, H. Kinoshita, M. Oishi, and M. Oshima, "Study on
the mechanism of droplet formation in T-junction microchannel,"
Chemical Engineering Science, vol. 69, pp. 340-351, Feb 13 2012.
[6] M. B. Mbanjwa, K. Land, L. L. Jewell, and I. M. Gledhill, "Experimental
and numerical studies of emulsion formation in a microfluidic
T-junction," presented at the AfriCOMP11: Second African Conference
on Computational Mechanics, University of Cape Town, Cape Town,
2011.
[7] J. Sivasamy, T. N. Wong, N. T. Nguyen, and L. T. H. Kao, "An
investigation on the mechanism of droplet formation in a microfluidic
T-junction," Microfluidics and Nanofluidics, vol. 11, pp. 1-10, Jul 2011. [8] K. Wang, Y. C. Lu, J. Tan, B. D. Yang, and G. S. Luo, "Generating
gas/liquid/liquid three-phase microdispersed systems in double
T-junctions microfluidic device," Microfluidics and Nanofluidics, vol. 8,
pp. 813-821, Jun 2010.
[9] J. Wehking, M. Gabany, L. Chew, and R. Kumar, "Effects of viscosity,
interfacial tension, and flow geometry on droplet formation in a
microfluidic T-junction," Microfluidics and Nanofluidics, vol. 16, pp.
441-453, 2014/03/01 2014.
[10] S. Yeom and S. Y. Lee, "Size prediction of drops formed by dripping at a
micro T-junction in liquid-liquid mixing," Experimental Thermal and
Fluid Science, vol. 35, pp. 387-394, Feb 2011.
[11] R. F. Meyer, W. B. Rogers, M. T. McClendon, and J. C. Crocker,
"Producing Monodisperse Drug-Loaded Polymer Microspheres via
Cross-Flow Membrane Emulsification: The Effects of Polymers and
Surfactants," Langmuir, vol. 26, pp. 14479-14487, Sep 2010.
[12] M. Pathak, "Numerical simulation of membrane emulsification: Effect of
flow properties in the transition from dripping to jetting," Journal of
Membrane Science, vol. 382, pp. 166-176, Oct 15 2011.
[13] R. D. Hancocks, F. Spyropoulos, and I. T. Norton, "Comparisons between
membranes for use in cross flow membrane emulsification," Journal of
Food Engineering, vol. 116, pp. 382-389, 2013.
[14] T. Schneider, G. H. Chapman, and U. O. Häfeli, "Effects of chemical and
physical parameters in the generation of microspheres by hydrodynamic
flow focusing," Colloids and surfaces B: biointerfaces, vol. 87, pp.
361-368, 2011.
[15] Q. J. Zhang, G. Y. Lin, Y. Wang, F. J. Yang, L. Ba, and D. G. Fu,
"Formation of monodisperse cross-linked nanospherial condensates
based on flow-focusing and droplet diffusion techniques," Colloids and
Surfaces a-Physicochemical and Engineering Aspects, vol. 384, pp.
53-57, Jul 2011.
[16] K. Song, "Design and fabrication of novel microfluidic systems for
microsphere generation," Doctor of Philosophy, Department of
Biomedical Engineering, University of Saskatchewan, 2011.
[17] L. Lei, H. Zhang, D. J. Bergstrom, B. Zhang, and W. Zhang, "Modeling of
droplet generation by a modified T-junction device using COMSOL,"
presented at the International Conference on Mechanical Design and
Manufacturing, Hong Kong, 2014.
[18] K. Song and W. Zhang, "Design of a microchannel system using
axiomatic design theory for size-controllable and monodispersed
microspheres by enhanced perturbation," The International Journal of
Advanced Manufacturing Technology, vol. 64, pp. 769-779, 2013.
[19] S. Osher and J. A. Sethian, "Fronts propagating with curvature-dependent
speed-algorithms based on Hamilton-Jacobi formulations," Journal of
Computational Physics, vol. 79, pp. 12-49, Nov 1988.
[1] L. Amaya bower and T. Lee, "Lattice Boltzmann simulations of bubble
formation in a microfluidic T-junction," Philosophical Transactions of
the Royal Society A: Mathematical, Physical and Engineering Sciences,
vol. 369, pp. 2405-2413, 2011.
[2] S. Arias, D. Legendre, and R. Gonzalez-Cinca, "Numerical simulation of
bubble generation in a T-junction," Computers & Fluids, vol. 56, pp.
49-60, Mar 2012.
[3] N. C. Chen, J. Z. Wu, H. M. Jiang, and L. C. Dong, "CFD Simulation of
Droplet Formation in a Wide-Type Microfluidic T-Junction," Journal of
Dispersion Science and Technology, vol. 33, pp. 1635-1641, 2012.
[4] T. Glawdel and C. L. Ren, "Droplet formation in microfluidic T-junction
generators operating in the transitional regime. III. Dynamic surfactant
effects," Physical Review E, vol. 86, Aug 13 2012.
[5] X. Li, F. Li, J. Yang, H. Kinoshita, M. Oishi, and M. Oshima, "Study on
the mechanism of droplet formation in T-junction microchannel,"
Chemical Engineering Science, vol. 69, pp. 340-351, Feb 13 2012.
[6] M. B. Mbanjwa, K. Land, L. L. Jewell, and I. M. Gledhill, "Experimental
and numerical studies of emulsion formation in a microfluidic
T-junction," presented at the AfriCOMP11: Second African Conference
on Computational Mechanics, University of Cape Town, Cape Town,
2011.
[7] J. Sivasamy, T. N. Wong, N. T. Nguyen, and L. T. H. Kao, "An
investigation on the mechanism of droplet formation in a microfluidic
T-junction," Microfluidics and Nanofluidics, vol. 11, pp. 1-10, Jul 2011. [8] K. Wang, Y. C. Lu, J. Tan, B. D. Yang, and G. S. Luo, "Generating
gas/liquid/liquid three-phase microdispersed systems in double
T-junctions microfluidic device," Microfluidics and Nanofluidics, vol. 8,
pp. 813-821, Jun 2010.
[9] J. Wehking, M. Gabany, L. Chew, and R. Kumar, "Effects of viscosity,
interfacial tension, and flow geometry on droplet formation in a
microfluidic T-junction," Microfluidics and Nanofluidics, vol. 16, pp.
441-453, 2014/03/01 2014.
[10] S. Yeom and S. Y. Lee, "Size prediction of drops formed by dripping at a
micro T-junction in liquid-liquid mixing," Experimental Thermal and
Fluid Science, vol. 35, pp. 387-394, Feb 2011.
[11] R. F. Meyer, W. B. Rogers, M. T. McClendon, and J. C. Crocker,
"Producing Monodisperse Drug-Loaded Polymer Microspheres via
Cross-Flow Membrane Emulsification: The Effects of Polymers and
Surfactants," Langmuir, vol. 26, pp. 14479-14487, Sep 2010.
[12] M. Pathak, "Numerical simulation of membrane emulsification: Effect of
flow properties in the transition from dripping to jetting," Journal of
Membrane Science, vol. 382, pp. 166-176, Oct 15 2011.
[13] R. D. Hancocks, F. Spyropoulos, and I. T. Norton, "Comparisons between
membranes for use in cross flow membrane emulsification," Journal of
Food Engineering, vol. 116, pp. 382-389, 2013.
[14] T. Schneider, G. H. Chapman, and U. O. Häfeli, "Effects of chemical and
physical parameters in the generation of microspheres by hydrodynamic
flow focusing," Colloids and surfaces B: biointerfaces, vol. 87, pp.
361-368, 2011.
[15] Q. J. Zhang, G. Y. Lin, Y. Wang, F. J. Yang, L. Ba, and D. G. Fu,
"Formation of monodisperse cross-linked nanospherial condensates
based on flow-focusing and droplet diffusion techniques," Colloids and
Surfaces a-Physicochemical and Engineering Aspects, vol. 384, pp.
53-57, Jul 2011.
[16] K. Song, "Design and fabrication of novel microfluidic systems for
microsphere generation," Doctor of Philosophy, Department of
Biomedical Engineering, University of Saskatchewan, 2011.
[17] L. Lei, H. Zhang, D. J. Bergstrom, B. Zhang, and W. Zhang, "Modeling of
droplet generation by a modified T-junction device using COMSOL,"
presented at the International Conference on Mechanical Design and
Manufacturing, Hong Kong, 2014.
[18] K. Song and W. Zhang, "Design of a microchannel system using
axiomatic design theory for size-controllable and monodispersed
microspheres by enhanced perturbation," The International Journal of
Advanced Manufacturing Technology, vol. 64, pp. 769-779, 2013.
[19] S. Osher and J. A. Sethian, "Fronts propagating with curvature-dependent
speed-algorithms based on Hamilton-Jacobi formulations," Journal of
Computational Physics, vol. 79, pp. 12-49, Nov 1988.
@article{"International Journal of Mechanical, Industrial and Aerospace Sciences:69772", author = "Lei Lei and Hongbo Zhang and Donald J. Bergstrom and Bing Zhang and K. Y. Song and W. J. Zhang", title = "Modeling and Validation of Microspheres Generation in the Modified T-Junction Device", abstract = "This paper presents a model for a modified T-junction
device for microspheres generation. The numerical model is
developed using a commercial software package: COMSOL
Multiphysics. In order to test the accuracy of the numerical model,
multiple variables, such as the flow rate of cross-flow, fluid properties,
structure, and geometry of the microdevice are applied. The results
from the model are compared with the experimental results in the
diameter of the microsphere generated. The comparison shows a good
agreement. Therefore the model is useful in further optimization of the
device and feedback control of microsphere generation if any.
", keywords = "CFD modeling, validation, microsphere generation,
modified T-junction.", volume = "9", number = "5", pages = "756-5", }
