Abstract: Bones are dynamic and responsive organs, they
regulate their strength and mass according to the loads which they are subjected. Because, the Wnt/β-catenin pathway has profound
effects on the regulation of bone mass, we hypothesized that mechanical loading of bone cells stimulates Wnt/β-catenin signaling, which results in the generation of new bone mass.
Mechanical loading triggers the secretion of the Wnt molecule, which after binding to transmembrane proteins, causes GSK-3β (Glycogen synthase kinase 3 beta) to cease the phosphorylation of β-catenin. β-catenin accumulation in the cytoplasm, followed by its
transport into the nucleus, binding to transcription factors (TCF/LEF)
that initiate transcription of genes related to bone formation. To test this hypothesis, we used TOPGAL (Tcf Optimal Promoter
β-galactosidase) mice in an experiment in which cyclic loads were
applied to the forearm. TOPGAL mice are reporters for cells effected
by the Wnt/β-catenin signaling pathway. TOPGAL mice are genetically engineered mice in which transcriptional activation of β-
catenin, results in the production of an enzyme, β-galactosidase. The
presence of this enzyme allows us to localize transcriptional
activation of β-catenin to individual cells, thereby, allowing us to quantify the effects that mechanical loading has on the Wnt/β-catenin pathway and new bone formation. The ulnae of loaded TOPGAL
mice were excised and transverse slices along different parts of the
ulnar shaft were assayed for the presence of β-galactosidase.
Our results indicate that loading increases β-catenin transcriptional
activity in regions where this pathway is already primed (i.e. where basal activity is already higher) in a load magnitude dependent
manner. Further experiments are needed to determine the temporal and spatial activation of this signaling in relation to bone formation.
Abstract: This paper presents application artificial intelligent (AI) techniques, namely artificial neural network (ANN), adaptive neuro fuzzy interface system (ANFIS), to estimate the real power transfer between generators and loads. Since these AI techniques adopt supervised learning, it first uses modified nodal equation method (MNE) to determine real power contribution from each generator to loads. Then the results of MNE method and load flow information are utilized to estimate the power transfer using AI techniques. The 25-bus equivalent system of south Malaysia is utilized as a test system to illustrate the effectiveness of both AI methods compared to that of the MNE method. The mean squared error of the estimate of ANN and ANFIS power transfer allocation methods are 1.19E-05 and 2.97E-05, respectively. Furthermore, when compared to MNE method, ANN and ANFIS methods computes generator contribution to loads within 20.99 and 39.37msec respectively whereas the MNE method took 360msec for the calculation of same real power transfer allocation.
Abstract: Structural behavior of ring stiffened thick walled
cylinders made of functionally graded materials (FGMs) is
investigated in this paper. Functionally graded materials are inhomogeneous composites which are usually made from a mixture
of metal and ceramic. The gradient compositional variation of the
constituents from one surface to the other provides an elegant solution to the problem of high transverse shear stresses that are
induced when two dissimilar materials with large differences in material properties are bonded. FGM formation of the cylinder is
modeled by power-law exponent and the variation of characteristics is supposed to be in radial direction.
A finite element formulation is derived for the analysis. According to the property variation of the constituent materials in the radial
direction of the wall, it is not convenient to use conventional elements to model and analyze the structure of the stiffened FGM
cylinders. In this paper a new cylindrical super-element is used to model the finite element formulation and analyze the static and
modal behavior of stiffened FGM thick walled cylinders. By using
this super-element the number of elements, which are needed for
modeling, will reduce significantly and the process time is less in comparison with conventional finite element formulations. Results for static and modal analysis are evaluated and verified by
comparison to finite element formulation with conventional
elements. Comparison indicates a good conformity between results.
Abstract: In this article, a method has been offered to classify
normal and defective tiles using wavelet transform and artificial
neural networks. The proposed algorithm calculates max and min
medians as well as the standard deviation and average of detail
images obtained from wavelet filters, then comes by feature vectors
and attempts to classify the given tile using a Perceptron neural
network with a single hidden layer. In this study along with the
proposal of using median of optimum points as the basic feature and
its comparison with the rest of the statistical features in the wavelet
field, the relational advantages of Haar wavelet is investigated. This
method has been experimented on a number of various tile designs
and in average, it has been valid for over 90% of the cases. Amongst
the other advantages, high speed and low calculating load are
prominent.
Abstract: Nowadays, OCR systems have got several
applications and are increasingly employed in daily life. Much
research has been done regarding the identification of Latin,
Japanese, and Chinese characters. However, very little investigation
has been performed regarding Farsi/Arabic characters recognition.
Probably the reason is difficulty and complexity of those characters
identification compared to the others and limitation of IT activities in
Farsi and Arabic speaking countries. In this paper, a technique has
been employed to identify isolated Farsi/Arabic characters. A chain
code based algorithm along with other significant peculiarities such
as number and location of dots and auxiliary parts, and the number of
holes existing in the isolated character has been used in this study to
identify Farsi/Arabic characters. Experimental results show the
relatively high accuracy of the method developed when it is tested on
several standard Farsi fonts.