Modeling of Sensitivity for SPR Biosensors- New Aspects

The computer modeling is carried out for parameter of sensitivity of optoelectronic chemical and biosensors, using phenomena of surface plasmon resonance (SPR). The physical model of SPR-sensor-s is described with (or without) of modifications of sensitive gold film surface by a dielectric layer. The variants of increasing of sensitivity for SPR-biosensors, constructed on the principle gold – dielectric – biomolecular layer are considered. Two methods of mathematical treatment of SPR-curve are compared – traditional, with estimation of sensor-s response as shift of the SPRcurve minimum and proposed, for system with dielectric layer, using calculating of the derivative in the point of SPR-curve half-width.

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References:
[1] J. Homola, "Model of a chemo-optical sensor based on plasmon
excitation in thin silver films", Sensors and actuators B, vol. 11, pp.
481-485, 1993.
[2] B. Liedberg, I. Lundstrom, E. Stenberg, "Principles of biosensing with
an extended coupling matrix and surface plasmon resonance, "Sensors
and Actuators B, vol. 11, pp. 63-72, 1993.
[3] R. M. A. Azzam and N. M. Bashara, "Ellipsometry and Polarized
Light", North-Holland, Amsterdam, 1977.
[4] P. T. Leung, D. Pollard-Knight, G. P. Molan, M. F. Finlan, "Modelling
of particle-enhanced sentitivity of the surface-plasmon resonance
biosensor, "Sensors and actuators B, vol. 22, pp. 175-180, 1994.