Abstract: Bones are dynamic and responsive organs, they
regulate their strength and mass according to the loads which they are subjected. Because, the Wnt/β-catenin pathway has profound
effects on the regulation of bone mass, we hypothesized that mechanical loading of bone cells stimulates Wnt/β-catenin signaling, which results in the generation of new bone mass.
Mechanical loading triggers the secretion of the Wnt molecule, which after binding to transmembrane proteins, causes GSK-3β (Glycogen synthase kinase 3 beta) to cease the phosphorylation of β-catenin. β-catenin accumulation in the cytoplasm, followed by its
transport into the nucleus, binding to transcription factors (TCF/LEF)
that initiate transcription of genes related to bone formation. To test this hypothesis, we used TOPGAL (Tcf Optimal Promoter
β-galactosidase) mice in an experiment in which cyclic loads were
applied to the forearm. TOPGAL mice are reporters for cells effected
by the Wnt/β-catenin signaling pathway. TOPGAL mice are genetically engineered mice in which transcriptional activation of β-
catenin, results in the production of an enzyme, β-galactosidase. The
presence of this enzyme allows us to localize transcriptional
activation of β-catenin to individual cells, thereby, allowing us to quantify the effects that mechanical loading has on the Wnt/β-catenin pathway and new bone formation. The ulnae of loaded TOPGAL
mice were excised and transverse slices along different parts of the
ulnar shaft were assayed for the presence of β-galactosidase.
Our results indicate that loading increases β-catenin transcriptional
activity in regions where this pathway is already primed (i.e. where basal activity is already higher) in a load magnitude dependent
manner. Further experiments are needed to determine the temporal and spatial activation of this signaling in relation to bone formation.
Abstract: Fatigue cracking continues to be the main challenges in
improving the performance of bituminous mixture pavements. The
purpose of this paper is to look at some aspects of the effects of fine
aggregate properties on the fatigue behaviour of hot mixture asphalt.
Two types of sand (quarry and mining sand) with two conventional
bitumen (PEN 50/60 & PEN 80/100) and four polymers modified
bitumen PMB (PM1_82, PM1_76, PM2_82 and PM2_76) were used.
Physical, chemical and mechanical tests were performed on the sands
to determine their effect when incorporated with a bituminous
mixture. According to the beam fatigue results, quarry sand that has
more angularity, rougher, higher shear strength and a higher
percentage of Aluminium oxide presented higher resistance to
fatigue. Also a PMB mixture gives better fatigue results than
conventional mixtures, this is due to the PMB having better viscosity
property than that of the conventional bitumen.
Abstract: The data exchanged on the Web are of different nature
from those treated by the classical database management systems;
these data are called semi-structured data since they do not have a
regular and static structure like data found in a relational database;
their schema is dynamic and may contain missing data or types.
Therefore, the needs for developing further techniques and
algorithms to exploit and integrate such data, and extract relevant
information for the user have been raised. In this paper we present
the system OSIX (Osiris based System for Integration of XML
Sources). This system has a Data Warehouse model designed for the
integration of semi-structured data and more precisely for the
integration of XML documents. The architecture of OSIX relies on
the Osiris system, a DL-based model designed for the representation
and management of databases and knowledge bases. Osiris is a viewbased
data model whose indexing system supports semantic query
optimization. We show that the problem of query processing on a
XML source is optimized by the indexing approach proposed by
Osiris.
Abstract: The present paper considers the steady free convection
boundary layer flow of a viscoelastic fluid on solid sphere with
Newtonian heating. The boundary layer equations are an order higher
than those for the Newtonian (viscous) fluid and the adherence
boundary conditions are insufficient to determine the solution of
these equations completely. Thus, the augmentation an extra
boundary condition is needed to perform the numerical
computational. The governing boundary layer equations are first
transformed into non-dimensional form by using special
dimensionless group and then solved by using an implicit finite
difference scheme. The results are displayed graphically to illustrate
the influence of viscoelastic K and Prandtl Number Pr parameters on
skin friction, heat transfer, velocity profiles and temperature profiles.
Present results are compared with the published papers and are found
to concur very well.
Abstract: To compare Healing Effects of an
Ayurvedic Preparation and Silver Sulfadiazine on burn wounds in
Albino Rats.
Methods: Albino rats– 30 male / female rats weighing between
150-200 g were used in the study. They were individually housed and
maintained on normal diet and water ad libitum. Partial thickness
burn wounds were inflicted, on overnight-starved animals under
pentobarbitone (30mg/kg, i.p.) anaesthesia, by pouring hot molten
wax at 80oC into a plastic cylinder of 300 mm2 circular openings
placed on the shaven back of the animal. Apart from the drugs under
investigation no local/ systemic chemotherapeutic cover will be
provided to animals. All the animals were assessed for the percentage
of wound contraction, signs of infection, scab formation and
histopathological examination.
Results: Percentage of wound healing was significantly better in
the test ointment group compared to the standard. Signs of infection
were observed in more animals in the test ointment group compared
to the standard. Scab formation also took place earlier in the test
ointment group compared to standard. Epithelial regeneration and
healing profile was better in the test ointment compared to the
standard. Moreover the test ointment group did not show any raised
margins in the wound or blackish discoloration as was observed in
silver sulfadiazine group.
Conclusion: The burn wound healing effect of the ayurvedic
ointment under study is better in comparison to standard therapy of
silver sulfadiazine. The problem of infection encountered with the
test ointment can be overcome by changing the concentrations and
proportions of the ingredients in the test ointment which constitutes
the further plan of the study.
Abstract: Dengue disease is an infectious vector-borne viral
disease that is commonly found in tropical and sub-tropical regions,
especially in urban and semi-urban areas, around the world and
including Malaysia. There is no currently available vaccine or
chemotherapy for the prevention or treatment of dengue disease.
Therefore prevention and treatment of the disease depend on vector
surveillance and control measures. Disease risk mapping has been
recognized as an important tool in the prevention and control
strategies for diseases. The choice of statistical model used for
relative risk estimation is important as a good model will
subsequently produce a good disease risk map. Therefore, the aim of
this study is to estimate the relative risk for dengue disease based
initially on the most common statistic used in disease mapping called
Standardized Morbidity Ratio (SMR) and one of the earliest
applications of Bayesian methodology called Poisson-gamma model.
This paper begins by providing a review of the SMR method, which
we then apply to dengue data of Perak, Malaysia. We then fit an
extension of the SMR method, which is the Poisson-gamma model.
Both results are displayed and compared using graph, tables and
maps. Results of the analysis shows that the latter method gives a
better relative risk estimates compared with using the SMR. The
Poisson-gamma model has been demonstrated can overcome the
problem of SMR when there is no observed dengue cases in certain
regions. However, covariate adjustment in this model is difficult and
there is no possibility for allowing spatial correlation between risks in
adjacent areas. The drawbacks of this model have motivated many
researchers to propose other alternative methods for estimating the
risk.
Abstract: This study investigated the relationship between
exercise imagery use and level of physical activity within a wide
range of exercisers in Klang valley, Malaysia. One hundred and
twenty four respondents (Mage = 28.92, SD = 9.34) completed two
sets of questionnaires (Exercise Imagery Inventory and Leisure-Time
Exercise Questionnaire) that measure the use of imagery and exercise
frequency of participants. From the result obtained, exercise imagery
is found to be significantly correlated to level of physical activity.
Besides that, variables such as gender, age and ethnicity that may
affect the use of imagery and exercise frequency were also being
assessed in this study. Among all variables, only ethnicity showed
significant difference in level of physical activity (p < 0.05). Findings
in this study suggest that further investigation should be done on
other variables such as socioeconomic, educational level, and selfefficacy
that may affect the imagery use and frequency of physical
activity among exercisers.
Abstract: Cameron Highlands is a mountainous area subjected
to torrential tropical showers. It extracts 5.8 million liters of water
per day for drinking supply from its rivers at several intake points.
The water quality of rivers in Cameron Highlands, however, has
deteriorated significantly due to land clearing for agriculture,
excessive usage of pesticides and fertilizers as well as construction
activities in rapidly developing urban areas. On the other hand, these
pollution sources known as non-point pollution sources are diverse
and hard to identify and therefore they are difficult to estimate.
Hence, Geographical Information Systems (GIS) was used to provide
an extensive approach to evaluate landuse and other mapping
characteristics to explain the spatial distribution of non-point sources
of contamination in Cameron Highlands. The method to assess
pollution sources has been developed by using Cameron Highlands
Master Plan (2006-2010) for integrating GIS, databases, as well as
pollution loads in the area of study. The results show highest annual
runoff is created by forest, 3.56 × 108 m3/yr followed by urban
development, 1.46 × 108 m3/yr. Furthermore, urban development
causes highest BOD load (1.31 × 106 kgBOD/yr) while agricultural
activities and forest contribute the highest annual loads for
phosphorus (6.91 × 104 kgP/yr) and nitrogen (2.50 × 105 kgN/yr),
respectively. Therefore, best management practices (BMPs) are
suggested to be applied to reduce pollution level in the area.
Abstract: This paper presents a numerical analysis of the
performance of a five-bladed Darrieus vertical-axis water turbine,
based on the NACA 0025 blade profile, for both bare and shrouded
configurations. A complete campaign of 2-D simulations, performed
for several values of tip speed ratio and based on RANS unsteady
calculations, has been performed to obtain the rotor torque and power
curves. Also the effect of a NACA-shaped central hydrofoil has been
investigated, with the aim of evaluating the impact of a solid
blockage on the performance of the shrouded rotor configuration.
The beneficial effect of the shroud on rotor overall performances
has clearly been evidenced, while the adoption of the central
hydrofoil has proved to be detrimental, being the resulting flow slow
down (due to the presence of the obstacle) much higher with respect
to the flow acceleration (due to the solid blockage effect).
Abstract: Border Gateway Protocol (BGP) is the standard routing protocol between various autonomous systems (AS) in the internet. In the event of failure, a considerable delay in the BGP convergence has been shown by empirical measurements. During the convergence time the BGP will repeatedly advertise new routes to some destination and withdraw old ones until it reach a stable state. It has been found that the KEEPALIVE message timer and the HOLD time are tow parameters affecting the convergence speed. This paper aims to find the optimum value for the KEEPALIVE timer and the HOLD time that maximally reduces the convergence time without increasing the traffic. The KEEPALIVE message timer optimal value founded by this paper is 30 second instead of 60 seconds, and the optimal value for the HOLD time is 90 seconds instead of 180 seconds.
Abstract: This paper describes an algorithm to estimate realtime vehicle velocity using image processing technique from the known camera calibration parameters. The presented algorithm involves several main steps. First, the moving object is extracted by utilizing frame differencing technique. Second, the object tracking method is applied and the speed is estimated based on the displacement of the object-s centroid. Several assumptions are listed to simplify the transformation of 2D images from 3D real-world images. The results obtained from the experiment have been compared to the estimated ground truth. From this experiment, it exhibits that the proposed algorithm has achieved the velocity accuracy estimation of about ± 1.7 km/h.
Abstract: This paper presents modeling and optimization of two NP-hard problems in flexible manufacturing system (FMS), part type selection problem and loading problem. Due to the complexity and extent of the problems, the paper was split into two parts. The first part of the papers has discussed the modeling of the problems and showed how the real coded genetic algorithms (RCGA) can be applied to solve the problems. This second part discusses the effectiveness of the RCGA which uses an array of real numbers as chromosome representation. The novel proposed chromosome representation produces only feasible solutions which minimize a computational time needed by GA to push its population toward feasible search space or repair infeasible chromosomes. The proposed RCGA improves the FMS performance by considering two objectives, maximizing system throughput and maintaining the balance of the system (minimizing system unbalance). The resulted objective values are compared to the optimum values produced by branch-and-bound method. The experiments show that the proposed RCGA could reach near optimum solutions in a reasonable amount of time.
Abstract: This paper presents the convergence analysis
of a prediction based blind equalizer for IIR channels.
Predictor parameters are estimated by using the recursive
least squares algorithm. It is shown that the prediction
error converges almost surely (a.s.) toward a scalar
multiple of the unknown input symbol sequence. It is
also proved that the convergence rate of the parameter
estimation error is of the same order as that in the iterated
logarithm law.
Abstract: In many buildings we rely on large footings to offer
structural stability. Designers often compensate for the lack of
knowledge available with regard to foundation-soil interaction by
furnishing structures with overly large footings. This may lead to a
significant increase in building expenditures if many large
foundations are present. This paper describes the interface material
law that governs the behavior along the contact surface of adjacent
materials, and the behavior of a large foundation under ultimate limit
loading. A case study is chosen that represents a common
foundation-soil system frequently used in general practice and
therefore relevant to other structures. Investigations include
compressing versus uplifting wind forces, alterations to the
foundation size and subgrade compositions, the role of the slab
stiffness and presence and the effect of commonly used structural
joints and connections. These investigations aim to provide the
reader with an objective design approach, efficiently preventing
structural instability.
Abstract: Biological Ammonia removal (nitrification), the
oxidation of ammonia to nitrate catalyzed by bacteria, is a key part of
global nitrogen cycling. In the first step of nitrification,
chemolithoautotrophic ammonia oxidizer transform ammonia to
nitrite, this subsequently oxidized to nitrate by nitrite oxidizing
bacteria. This process can be affected by several factors. In this study
the effect of influent COD on biological ammonia removal in a
bench-scale biological reactor was investigated. Experiments were
carried out using synthetic wastewater. The initial ammonium
concentration was 25mgNH4
+-N L-1. The effect of COD between
247.55±1.8 and 601.08±3.24mgL-1 on biological ammonia removal
was investigated by varying the COD loading supplied to reactor.
From the results obtained in this study it could be concluded in the
range of 247.55±1.8 to 351.35±2.05mgL-1, there is a direct
relationship between amount of COD and ammonia removal.
However more than 351.35±2.05 up to 601.08±3.24mgL-1 were
found an indirect relationship between them.
Abstract: This paper presents the comparison ageing deterioration of silicone rubber housing material for outdoor polymer insulators by using salt fog ageing test based on IEC 61109 and outdoor exposure test.Four types of high temperature silicone vulcanized silicone rubber sheet with different amount of ATH were used as testing specimen. For salt fog ageing test, the specimens were tested continuously 1000 hours with energized in test chamber. For outdoor exposure test, the specimens were hung continuously 18 months without energized. Physical and chemical analyses were conducted to evaluate degree of ageing deterioration of tested specimens. Slightly surface erosion was observed on specimen surface after salt fog ageing test and no erosion was observed on surface of outdoor exposure specimen. However, comparable degree of ageing deterioration can be seen from surface analysis results.
Abstract: A numerical simulation of micro Poiseuille flow has
performed for rarefied and compressible flow at slip flow regimes.
The wall roughness is simulated in two cases with triangular
microelements and random micro peaks distributed on wall surfaces
to study the effects of roughness shape and distribution on flow field.
Two values of Mach and Knudsen numbers have used to investigate
the effects of rarefaction as well as compressibility. The numerical
results have also checked with available theoretical and experimental
relations and good agreements has achieved. High influence of
roughness shape can be seen for both compressible and
incompressible rarefied flows. In addition it is found that rarefaction
has more significant effect on flow field in microchannels with
higher relative roughness. It is also found that compressibility has
more significant effects on Poiseuille number when relative
roughness increases.
Abstract: The study was conducted to investigate the profile of
hepatitis in Kingdom of Saudi Arabia, and to determine which age
group hepatitis viruses most commonly infect. The epidemiology of
viral hepatitis in Saudi Arabia has undergone major changes,
concurrent with major socioeconomic developments over the last two
to three decades. This disease represents a major public health
problem in Saudi Arabia resulting in the need for considerable
healthcare resources. A retrospective cross sectional analysis of the
reported cases of viral hepatitis was conducted based on the reports
of The Ministry of Health in Saudi Arabia about Hepatitis A, B and C
infections in all regions from the period of January 2006 to December
2010. The study demonstrated that incidence of viral Hepatitis is
decreasing, except for Hepatitis B that showed minimal increase. Of
hepatitis A, B, and C, Hepatitis B virus (HBV) was the most
predominant type, accounting for (53%) of the cases, followed by
Hepatitis C virus (HCV) (30%) and HAV (17%). HAV infection
predominates in children (5–14 years) with 60% of viral hepatitis
cases, HBV in young adults (15–44 years) with 69% of viral hepatitis
cases, and HCV in older adults (>45 years) with 59% of viral
hepatitis cases. Despite significant changes in the prevalence of viral
hepatitis A, B and C, it remains a major public health problem in
Saudi Arabia; however, it showed a significant decline in the last two
decades that could be attributed to the vaccination programs and the
improved health facilities. Further researches are needed to identify
the risk factors making a specific age group or a specific region in
Saudi Arabia targeted for a specific type of hepatitis viruses.
Abstract: This paper has been investigated a technique that predicts the performance of a bar-type unimorph piezoelectric vibration actuator depending on the frequency. This paper has been proposed an equivalent circuit that can be easily analyzed for the bar-type unimorph piezoelectric vibration actuator. In the dynamic analysis, rigidity and resonance frequency, which are important mechanical elements, were derived using the basic beam theory. In the equivalent circuit analysis, the displacement and bandwidth of the piezoelectric vibration actuator depending on the frequency were predicted. Also, for the reliability of the derived equations, the predicted performance depending on the shape change was compared with the result of a finite element analysis program.
Abstract: Undular hydraulic jumps are illustrated by a smooth
rise of the free surface followed by a train of stationary waves. They
are sometimes experienced in natural waterways and rivers. The
characteristics of undular hydraulic jumps are studied here. The
height, amplitude and the main characteristics of undular jump is
depended on the upstream Froude number and aspect ratio. The
experiments were done on the smooth bed flume. These results
compared with other researches and the main characteristics of the
undular hydraulic jump were studied in this article.