Morphology and Magnetic Properties of Fe3O4 and Au@Fe3O4 Nanoparticles Synthesized by Pulsed Plasma in Liquid

Spherical shaped magnetite (Fe3O4) and Au@Fe3O4 nanoparticles were successfully synthesized from Fe electrodes immersed in water with CTAB surfactant and HAuCl4 solution using simple method-pulsed plasma in liquid, without the use of dopants or special conditions for stabilization. Vibrating sample magnetometer indicated ferromagnetic behavior of particles at room temperature with coercivity and saturation magnetization of (Hc=105 Oe, Ms=6.83 emu/g) for Fe3O4 and (Hc=175, Ms=3.56emu/g) for Au@Fe3O4 nanoparticles. Structure and morphology of nanoparticles were characterized by X-ray Diffraction analysis and HR-TEM measurements. The cytotoxicity of nanoparticles was indicated using a XTT assay to be very low (cell viability: 98-89% with Fe3O4 and 99-91% for Au@Fe3O4 NPs).

Authors:

• Zhazgul Kelgenbaeva
• Emil Omurzak
• Saadat Sulaimankulova
• Tsutomu Mashimo

Keywords:

• Magnetite
• Gold coated magnetite
• Nanoparticles
• Pulsed Plasma in Liquid
• Cytotoxicity.

References:

[1] T. Matsunaga, Yoshiko Okamura and Tsuyoshi Tanaka
"Biotechnological application of nano-scale engineered bacterial
magnetic particles" J. Mater. Chem. 14 (2004) 2099-2105.
[2] S. Bucak, D. A. Jones, P. E. Laibinis and T. A. Halton "Protein separation
using colloidal magnetic nanoparticles" Biotech Prog. 2 (2003) 477-84.
[3] M. Koneracka, P. Kopcansky, M. Timko and C. N. Ramshand "Direct
binding procedure of proteins and enzymes to fine magnetic particles" J
Magn Magn Mater 252 (2002) 409-11.
[4] Z. G. Forbes, B. B. Yellen, K. A. Barbee and G. Friedman "AN approach
to targeted drug delivery based on uniform magnetic fields" IEEE trans
Mag 39 (2003) 3372-2 .
[5] R. B. Gupta, U. B. Kompella "Nanoparticle technology for drug delivery"
Taylor and Francis Group, New York, 2006, 416p.
[6] E. Iglesias-Silva, J. L. Vilas-Vilela et al "Synthesis of gold-coated iron
oxide nanoparticles" J Non-Crystalline Solids 356 (2010) 1233-35.
[7] A. J. Wagstaff et al "Cisplatin drug delivery using gold-coated iron oxide
nanoparticles for enhanced tumor targeting with external magnetic fields"
Inorganica Chimica Acta xxx (2012).
[8] E. Omurzak et al "Synthesis method of nanomaterials by pulsed plasma in
liquid" J Nanosci. Nanotechnol 7 (2007) 3157-9.
[9] A. E. Berkowitz, W. J. Schuele and P. J. Flanders "Influence of crystallite
size on the magnetic properties of acicular ╬│−Fe2O3 particles" J Appl Phys
39 (1968) 1261-64.
[10] Z. Li, M. Kawashita, T. Kudo and H. Kanetaka "Sol-gel synthesis,
characterization and in vitro compatibility evaluation of iron nanoparticle
encapsulating - silica microspheres for hyperthermia of cancer" J Mater
Sci. Mater Med 23 (2012) 2461-9.
[11] J. M. Landry et al "The genomic and transcriptomic landscape of a HeLa
cell line" G3: Genes/Genomes/ Genetics. (Early online published) 2013
doi: 10.1534g3.113.005777.