Kinetic Study of Gluconic Acid Batch Fermentation by Aspergillus niger
Gluconic acid is one of interesting chemical products
in industries such as detergents, leather, photographic, textile, and
especially in food and pharmaceutical industries. Fermentation is an
advantageous process to produce gluconic acid. Mathematical
modeling is important in the design and operation of fermentation
process. In fact, kinetic data must be available for modeling. The
kinetic parameters of gluconic acid production by Aspergillus niger
in batch culture was studied in this research at initial substrate
concentration of 150, 200 and 250 g/l. The kinetic models used were
logistic equation for growth, Luedeking-Piret equation for gluconic
acid formation, and Luedeking-Piret-like equation for glucose
consumption. The Kinetic parameters in the model were obtained by
minimizing non linear least squares curve fitting.
[1] J.Z. Liu, L.P. Weng, Q.L. Zhang, H. Xu, L. N. Ji, "A mathematical
model for gluconinc acid fermentation by Aspergillus niger",
Biochemical Engineering Journal, vol. 14, pp. 15-64, 2003.
[2] S. Velizarov, V. Beschkov, "Biotransformation of glucose to free
gluconic acid by Gluconobacter oxydans: substrate and product
inhibition situations", Process Biochemistry, vol. 33, no. 5, pp.527-534,
1998.
[3] H. Znad, J. Markos, V. Bales, "Production of gluconic acid from glucose
by Aspergillus niger: growth and non-growth conditions", Process
Biochemistry, vol. 39, pp. 1341-1345, 2004.
[4] M.L. Shuler, F. Kargi, Bioprocess Engineering Basic Concept. New
Jersey: Prentice-Hall Inc., 1992, pp.176.
[5] T. Takamatsu, S. Shioya, T. Furuya, "Mathematical model of gluconic
acid fermentation by Aspergillus niger", J. Chem.. Technol. Biotechnol.,
vol. 31, pp. 697-704, 1981.
[6] H. Znad, M. Blazej, V. Bales, J. Markos, "A kinetic model for gluconic
acid production by Aspergillus niger", Chem. Pap., vol. 58, no. 1, pp.
23-28, 2004.
[1] J.Z. Liu, L.P. Weng, Q.L. Zhang, H. Xu, L. N. Ji, "A mathematical
model for gluconinc acid fermentation by Aspergillus niger",
Biochemical Engineering Journal, vol. 14, pp. 15-64, 2003.
[2] S. Velizarov, V. Beschkov, "Biotransformation of glucose to free
gluconic acid by Gluconobacter oxydans: substrate and product
inhibition situations", Process Biochemistry, vol. 33, no. 5, pp.527-534,
1998.
[3] H. Znad, J. Markos, V. Bales, "Production of gluconic acid from glucose
by Aspergillus niger: growth and non-growth conditions", Process
Biochemistry, vol. 39, pp. 1341-1345, 2004.
[4] M.L. Shuler, F. Kargi, Bioprocess Engineering Basic Concept. New
Jersey: Prentice-Hall Inc., 1992, pp.176.
[5] T. Takamatsu, S. Shioya, T. Furuya, "Mathematical model of gluconic
acid fermentation by Aspergillus niger", J. Chem.. Technol. Biotechnol.,
vol. 31, pp. 697-704, 1981.
[6] H. Znad, M. Blazej, V. Bales, J. Markos, "A kinetic model for gluconic
acid production by Aspergillus niger", Chem. Pap., vol. 58, no. 1, pp.
23-28, 2004.
@article{"International Journal of Chemical, Materials and Biomolecular Sciences:58669", author = "Akbarningrum Fatmawati and Rudy Agustriyanto and Lindawati", title = "Kinetic Study of Gluconic Acid Batch Fermentation by Aspergillus niger", abstract = "Gluconic acid is one of interesting chemical products
in industries such as detergents, leather, photographic, textile, and
especially in food and pharmaceutical industries. Fermentation is an
advantageous process to produce gluconic acid. Mathematical
modeling is important in the design and operation of fermentation
process. In fact, kinetic data must be available for modeling. The
kinetic parameters of gluconic acid production by Aspergillus niger
in batch culture was studied in this research at initial substrate
concentration of 150, 200 and 250 g/l. The kinetic models used were
logistic equation for growth, Luedeking-Piret equation for gluconic
acid formation, and Luedeking-Piret-like equation for glucose
consumption. The Kinetic parameters in the model were obtained by
minimizing non linear least squares curve fitting.", keywords = "Aspergillus niger, fermentation, gluconic acid,kinetic.", volume = "3", number = "9", pages = "498-5", }