Feasibility of Leukemia Cancer Treatment (K562) by Atmospheric Pressure Plasma Jet
A new and novel approach in medicine is the use of
cold plasma for various applications such as sterilization blood
coagulation and cancer cell treatment. In this paper a pin-to-hole
plasma jet suitable for biological applications is investigated and
characterized and the possibility and feasibility of cancer cell
treatment is evaluated. The characterization includes power
consumption via Lissajous method, thermal behavior of plasma using
Infra-red camera as a novel method, Optical Emission Spectroscopy
(OES) to determine the species that are generated. Treatment of
leukemia cancer cells is also implemented and MTT assay is used to
evaluate viability.
[1] Y.Akishev, M. Grushin, A. Napartovich, and N. Turshkin,”Novel ac and
dc non-thermal plasma source for cold surface treatment of polymer
films and fabrics at atmospheric pressure,” Plasmas Polym., vol7, no.3,
pp. 261-289, sep 2002.W.-K. Chen, Linear Networks and Systems (Book
style). Belmont, CA: Wadsworth, 1993, pp. 123–135.
[2] T.I.Lee, K. W.Park, H. K. Baik, and S.-M. Lee “Dielectric Barrier
Hollow cathode discharge snd its enhanced performance for light
source,” Appl. Phys. Lett., vol 87, no. 26, pp. 261 502-1-261 502-3, Dec.
26, 2005.
[3] G. Fridman, G. Friedman, A. Gustol, A. B. Shekhter, V. N. Vasilets, and
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[4] R. M. Sankaran and K. P. Giapis, “Maskless etching of silicon using
patterned microdischarges,” Appl. Phys. Lett., vol. 79, no. 5, pp. 593-
595. Jul.30, 2001.
[5] M. Thiyagarajan, A. Sarani, X. Gonzales, “Characterization of Portable
Resistive Barrier Plasma Jet and Its Direct and Indirect Treatment for
Antibiotic Resistant Bacteria and THP-1 Luekemia Cancer cells” IEEE
Transaction on Plasma Science, vol. 40, no. 12, December 2012.
[6] Ulrich Kogelschatz; “Dielectric-barrier Discharges: Their History,
Discharge Physics, and Industrial Applications”; Plasma Chemistry and
Plasma Processing, 23, No.1, (2003)..
[7] Ehlbeck J, Schnbel U, Polak M, Winter J, Von Woedtke T, Brandenburg
R, von dem Hagen T and Weltmann K 2011 J.Phys. D: Appl. Phys. 44
013002M. Young, TheTechincal Writers Handbook.Mill Valley, CA:
University Science, 1989.
[8] Fridman G, Shereshevsky A, Jost M M, Brooks A D, Fridman A, Gutsol
A, Vasilets V and Friedman G 2007 Plasma Chem. Plasma Process S.
Chen, B. Mulgrew, and P. M. Grant, “A clustering technique for digital
communications channel equalization using radial basis function
networks,” IEEE Trans. Neural Networks, vol. 4, pp. 570–578, July
1993.
[9] Kalghatgi S U, Fridman G, Cooper M, Nagaraj G, Peddinghaus M,
Balasubramanian M, Vasilets V N, Gutsol A F, Fridman A and
Friedman G 2007; IEEE Trans. Plasma Sci 115016S. P. Bingulac, “On
the compatibility of adaptive controllers (Published Conference
Proceedings style),” in Proc. 4th Annu. Allerton Conf. Circuits and
Systems Theory, New York, 1994, pp. 8–16.
[10] Lloyd G, Friedman G, Jafri S, Schultz G, Fridman A and Harding K;
Plasma Process. Polym. (2010)
[11] Sun P, Pan J, Tian Y, Bai N, Wu H, Wang L, Yu C, Zhang J, Zhu W and
Beckerr K H; IEEE Trans. Plasma Sci, (2010).
[12] E. Stoffels, I. E. Keift, R. E. J. Sladek, L. J. M. van den Bedem, E. P.
vander Laan, and M. Steinbuch, “Plasma needle for in vivo medical
treatment: Recent developments and perspectives,”Plasma Sources Sci.
Technol. 15, S169-S180 (2006).
[1] Y.Akishev, M. Grushin, A. Napartovich, and N. Turshkin,”Novel ac and
dc non-thermal plasma source for cold surface treatment of polymer
films and fabrics at atmospheric pressure,” Plasmas Polym., vol7, no.3,
pp. 261-289, sep 2002.W.-K. Chen, Linear Networks and Systems (Book
style). Belmont, CA: Wadsworth, 1993, pp. 123–135.
[2] T.I.Lee, K. W.Park, H. K. Baik, and S.-M. Lee “Dielectric Barrier
Hollow cathode discharge snd its enhanced performance for light
source,” Appl. Phys. Lett., vol 87, no. 26, pp. 261 502-1-261 502-3, Dec.
26, 2005.
[3] G. Fridman, G. Friedman, A. Gustol, A. B. Shekhter, V. N. Vasilets, and
A. Fridman, “Applied plasma medicine,” Plasma Process. Polym., vol.
5, no. 6, pp. 503-533, Aug. 2008.
[4] R. M. Sankaran and K. P. Giapis, “Maskless etching of silicon using
patterned microdischarges,” Appl. Phys. Lett., vol. 79, no. 5, pp. 593-
595. Jul.30, 2001.
[5] M. Thiyagarajan, A. Sarani, X. Gonzales, “Characterization of Portable
Resistive Barrier Plasma Jet and Its Direct and Indirect Treatment for
Antibiotic Resistant Bacteria and THP-1 Luekemia Cancer cells” IEEE
Transaction on Plasma Science, vol. 40, no. 12, December 2012.
[6] Ulrich Kogelschatz; “Dielectric-barrier Discharges: Their History,
Discharge Physics, and Industrial Applications”; Plasma Chemistry and
Plasma Processing, 23, No.1, (2003)..
[7] Ehlbeck J, Schnbel U, Polak M, Winter J, Von Woedtke T, Brandenburg
R, von dem Hagen T and Weltmann K 2011 J.Phys. D: Appl. Phys. 44
013002M. Young, TheTechincal Writers Handbook.Mill Valley, CA:
University Science, 1989.
[8] Fridman G, Shereshevsky A, Jost M M, Brooks A D, Fridman A, Gutsol
A, Vasilets V and Friedman G 2007 Plasma Chem. Plasma Process S.
Chen, B. Mulgrew, and P. M. Grant, “A clustering technique for digital
communications channel equalization using radial basis function
networks,” IEEE Trans. Neural Networks, vol. 4, pp. 570–578, July
1993.
[9] Kalghatgi S U, Fridman G, Cooper M, Nagaraj G, Peddinghaus M,
Balasubramanian M, Vasilets V N, Gutsol A F, Fridman A and
Friedman G 2007; IEEE Trans. Plasma Sci 115016S. P. Bingulac, “On
the compatibility of adaptive controllers (Published Conference
Proceedings style),” in Proc. 4th Annu. Allerton Conf. Circuits and
Systems Theory, New York, 1994, pp. 8–16.
[10] Lloyd G, Friedman G, Jafri S, Schultz G, Fridman A and Harding K;
Plasma Process. Polym. (2010)
[11] Sun P, Pan J, Tian Y, Bai N, Wu H, Wang L, Yu C, Zhang J, Zhu W and
Beckerr K H; IEEE Trans. Plasma Sci, (2010).
[12] E. Stoffels, I. E. Keift, R. E. J. Sladek, L. J. M. van den Bedem, E. P.
vander Laan, and M. Steinbuch, “Plasma needle for in vivo medical
treatment: Recent developments and perspectives,”Plasma Sources Sci.
Technol. 15, S169-S180 (2006).
@article{"International Journal of Medical, Medicine and Health Sciences:53266", author = "Mashayekh Amir Shahriar and Akhlaghi Morteza and Rajaee Hajar and Khani Mohammad Reza and Shokri Babak", title = "Feasibility of Leukemia Cancer Treatment (K562) by Atmospheric Pressure Plasma Jet", abstract = "A new and novel approach in medicine is the use of
cold plasma for various applications such as sterilization blood
coagulation and cancer cell treatment. In this paper a pin-to-hole
plasma jet suitable for biological applications is investigated and
characterized and the possibility and feasibility of cancer cell
treatment is evaluated. The characterization includes power
consumption via Lissajous method, thermal behavior of plasma using
Infra-red camera as a novel method, Optical Emission Spectroscopy
(OES) to determine the species that are generated. Treatment of
leukemia cancer cells is also implemented and MTT assay is used to
evaluate viability.
", keywords = "Atmospheric Pressure Plasma Jet (APPJ), Plasma
Medicine, Cancer cell treatment, leukemia.", volume = "8", number = "10", pages = "700-4", }
