Thermo-Sensitive Hydrogel: Control of Hydrophilic-Hydrophobic Transition
The study investigated the hydrophilic to hydrophobic
transition of modified polyacrylamide hydrogel with the inclusion of
N-isopropylacrylamide (NIAM). The modification was done by
mimicking micellar polymerization, which resulted in better
arrangement of NIAM chains in the polyacrylamide network. The
degree of NIAM arrangement is described by NH number. The
hydrophilic to hydrophobic transition was measured through the
partition coefficient, K, of Orange II and Methylene Blue in hydrogel
and in water. These dyes were chosen as a model for solutes with
different degree of hydrophobicity. The study showed that the
hydrogel with higher NH values resulted in better solubility of both
dyes. Moreover, in temperature above the lower critical solution
temperature (LCST) of Poly(N-isopropylacrylamide) (PNIAM)also
caused the collapse of NIPAM chains which results in a more
hydrophobic environment that increases the solubility of Methylene
Blue and decreases the solubility of Orange II in the hydrogels with
NIPAM present.
[1] N. A. Peppas, in Biomaterials Science, edited by B. D. Ratner et al.
(Elsevier Academic Press, 2004), pp. 100.
[2] M. R. Guilherme et al., Polymer 44, 4213 (2003).
[3] C. C. Lin, and A. T. Metters, Advanced Drug Delivery Reviews 58,
1379 (2006).
[4] A. Khademhosseini, and R. Langer, Biomaterials 28, 5087 (2007).
[5] N. A. Peppas et al., European Journal of Pharmaceutical Formulations
50, 27 (2000).
[6] N. A. Peppas et al., Advanced Materials 18, 1345 (2006).
[7] J. T. Zhang et al., Colloid and Polymer Science 283, 461 (2005).
[8] B. Jeong, S. W. Kim, and Y. H. Bae, Advanced Drug Delivery Reviews
54, 37 (2002).
[9] W. Xue, and I. W. Hamley, Polymer 43, 3069 (2002).
[10] L. C. Dong, and A. S. Hoffman, Journal of Controlled Release 4, 223
(1986).
[11] L. Brannon-Peppas, and N. A. Peppas, Chemical Engineering Science
46, 715 (1991).
[12] J. Ricka, and T. Tanaka, Macromolecules 17, 2916 (1984).
[13] M. Mahkam, Journal of Bioactive and Compatible Polymers 19, 209
(2004).
[14] W. Xue et al., European Polymer Journal 40, 47 (2004).
[15] H. G. Schild, Progress in Polymer Science 17, 163 (1992).
[16] S. Biggs, J. Selb, and F. Candau, Langmuir 8, 838 (1992).
[17] F. Candau et al., Prog. Org. Coat. 24, 11 (1994).
[18] W. Siriwatwechakul, in Chemical Engineering Department (Princeton
University, Princeton NJ, 2005), p. 173.
[19] S. R. Turner, D. B. Siano, and J. Bock, (Exxon Research & Engineering
Company, United States, 1985).
[20] F. Candau, and J. Selb, Advances in Colloid and Interface Science 79,
149 (1999).
[21] S. Biggs et al., J. Phys. Chem. 96, 1505 (1992).
[22] E. Volpert, J. Selb, and F. Candau, Polymer 39, 1025 (1998).
[23] S. Panmai, R. K. Prud'homme, and D. G. Peiffer, Colloid Surf. APhysicochem.
Eng. Asp. 147, 3 (1999).
[24] C. Tanford, The Effect of Temperature (Joh Wiley & Sons, Inc., New
York, 1980), pp. 21.
[25] F. Candau, E. J. Regalado, and J. Selb, Macromolecules 31, 5550
(1998).
[1] N. A. Peppas, in Biomaterials Science, edited by B. D. Ratner et al.
(Elsevier Academic Press, 2004), pp. 100.
[2] M. R. Guilherme et al., Polymer 44, 4213 (2003).
[3] C. C. Lin, and A. T. Metters, Advanced Drug Delivery Reviews 58,
1379 (2006).
[4] A. Khademhosseini, and R. Langer, Biomaterials 28, 5087 (2007).
[5] N. A. Peppas et al., European Journal of Pharmaceutical Formulations
50, 27 (2000).
[6] N. A. Peppas et al., Advanced Materials 18, 1345 (2006).
[7] J. T. Zhang et al., Colloid and Polymer Science 283, 461 (2005).
[8] B. Jeong, S. W. Kim, and Y. H. Bae, Advanced Drug Delivery Reviews
54, 37 (2002).
[9] W. Xue, and I. W. Hamley, Polymer 43, 3069 (2002).
[10] L. C. Dong, and A. S. Hoffman, Journal of Controlled Release 4, 223
(1986).
[11] L. Brannon-Peppas, and N. A. Peppas, Chemical Engineering Science
46, 715 (1991).
[12] J. Ricka, and T. Tanaka, Macromolecules 17, 2916 (1984).
[13] M. Mahkam, Journal of Bioactive and Compatible Polymers 19, 209
(2004).
[14] W. Xue et al., European Polymer Journal 40, 47 (2004).
[15] H. G. Schild, Progress in Polymer Science 17, 163 (1992).
[16] S. Biggs, J. Selb, and F. Candau, Langmuir 8, 838 (1992).
[17] F. Candau et al., Prog. Org. Coat. 24, 11 (1994).
[18] W. Siriwatwechakul, in Chemical Engineering Department (Princeton
University, Princeton NJ, 2005), p. 173.
[19] S. R. Turner, D. B. Siano, and J. Bock, (Exxon Research & Engineering
Company, United States, 1985).
[20] F. Candau, and J. Selb, Advances in Colloid and Interface Science 79,
149 (1999).
[21] S. Biggs et al., J. Phys. Chem. 96, 1505 (1992).
[22] E. Volpert, J. Selb, and F. Candau, Polymer 39, 1025 (1998).
[23] S. Panmai, R. K. Prud'homme, and D. G. Peiffer, Colloid Surf. APhysicochem.
Eng. Asp. 147, 3 (1999).
[24] C. Tanford, The Effect of Temperature (Joh Wiley & Sons, Inc., New
York, 1980), pp. 21.
[25] F. Candau, E. J. Regalado, and J. Selb, Macromolecules 31, 5550
(1998).
@article{"International Journal of Chemical, Materials and Biomolecular Sciences:59099", author = "Wanwipa Siriwatwechakul and Nutte Teraphongphom and Vatcharani Ngaotheppitak and Sureeporn
Kunataned", title = "Thermo-Sensitive Hydrogel: Control of Hydrophilic-Hydrophobic Transition", abstract = "The study investigated the hydrophilic to hydrophobic
transition of modified polyacrylamide hydrogel with the inclusion of
N-isopropylacrylamide (NIAM). The modification was done by
mimicking micellar polymerization, which resulted in better
arrangement of NIAM chains in the polyacrylamide network. The
degree of NIAM arrangement is described by NH number. The
hydrophilic to hydrophobic transition was measured through the
partition coefficient, K, of Orange II and Methylene Blue in hydrogel
and in water. These dyes were chosen as a model for solutes with
different degree of hydrophobicity. The study showed that the
hydrogel with higher NH values resulted in better solubility of both
dyes. Moreover, in temperature above the lower critical solution
temperature (LCST) of Poly(N-isopropylacrylamide) (PNIAM)also
caused the collapse of NIPAM chains which results in a more
hydrophobic environment that increases the solubility of Methylene
Blue and decreases the solubility of Orange II in the hydrogels with
NIPAM present.", keywords = "Thermo-sensitive hydrogel, partition coefficient, the
lower critical solution temperature (LCST), micellar polymerization.", volume = "2", number = "11", pages = "323-6", }