Intervention of Sambucus Nigra Polyphenolic Extract in Experimental Arterial Hypertension
The research focuses on the effects of polyphenols
extracted from Sambucus nigra fruit, using an experimental arterial
hypertension pattern, as well as their influence on the oxidative
stress. The results reveal the normalization of the reduced glutathion
concentration, as well as a considerable reduction in the
malondialdehide serum concentration by the polyphenolic protection.
The rat blood pressure values were recorded using a CODATM
system, which uses a non-invasive blood pressure measuring method.
All the measured blood pressure components revealed a biostatistically
significant (p<0.05) blood pressure drop between the
AHT and the AHT+P groups. The results prove that oxidative stress
is considerably lower, statistically speaking, in rats with hypertension
but also provided with natural polyphenolic protection from
Sambucus nigra fruits than in the rats belonging to the control group.
In addition to the demonstrated antioxidant effects, natural
polyphenols also have other biological properties that might
contribute to the cardioprotective effects.
[1] K. D. Setchell, Phytoestrogens: the biochemistry, physiology, and
implications for human health of soy isoflavones. Am J Clin Nutr. 68,
1998, pp. 1333S - 1346S.
[2] J. Burns, Relationship among antioxidant activity, vasodilatation
capacity, and phenolic content of red wine. J Agric and Food Chemistry
48, 2000, pp. 220 - 230.
[3] L. Z. Tosca, M. L. Fernandez, Cardioprotective effects of dietary
polyphenols. Recent Advances in Nutritional Sciences 135, 2005, pp.
2291 - 2295.
[4] V. Cheynier, Polyphenols in foods are more complex than often thought.
Am J Clin Nutr 81, 2005, pp. 223S - 229S.
[5] L. H. Yao, Y. M Jiang, J. Shi, F. A. Tomas-Barberan, N. Datta, R.
Singanusong, Flavonoids in food and their health benefits. Plant Foods
Hum Nutr, 59, 2004, pp. 113 - 122.
[6] S. Pascual-Teresa, M. T. Sanchez -Ballesta, Anthocyanins: from plant to
health. Phytochem Rev, 7, 2008, pp. 281 - 299.
[7] L. I. Mennen, D. Sapinho, A. De Bree, Consumption of foods rich in
flavonoids is related to a decreased cardiovascular risk in apparently
healthy French women. J Nutr 134, 2004, pp. 923 - 926.
[8] D. R. Bell, K. Gochenaur, Direct vasoactive and vasoprotective
properties of anthocyanin - rich extracts. J Appl Physiol 100, 2006, pp.
1164 - 1170.
[9] E. Beutler, O. Durion, B. J. Kelly, Diabetic heart and kidney exhibit
increased resistance to lipid peroxidation. Biochem Biophys Acta 1047,
1990, pp. 63 - 69.
[10] H. Ohkawa, N. Ohisin, K. Yadik, Assay for lipid peroxides in animals
tissues by thiobarbituric acid reaction. Annal Biochem 95, 1979, pp. 351 - 358.
[11] F. Nielsen, B. B. Mikkelsen, J. B. Nielsen, H. R. Andersen, P.
Grandjean, Plasma malondialdehyde as biomarker for oxidative stress:
reference interval and effects of life-style factors. Clin Chem 43(7),
1997, pp. 1209 - 1214.
[12] D. Steinberg, S. Parthasarthy, T. E. Carew, J. C. Khoo, J. L. Witztum,
Beyond cholesterol: modifications of low-density lipoprotein that
increase its atherogenicity. N Engl J Med 320, 1989, pp. 915 - 924.
[13] E. Anselm, M. Chataigneau, M. Ndiaye, T. Chataigneau, V. B. Schini-
Kerth, Grape juice causes endothelium-dependent relaxation via a
redox-sensitive Src- and Akt-dependent activation of eNOS. Cardiovasc
Res 73, 2007, pp. 404 - 413.
[14] J. E. Whittier, Y. Xiong, M. C. Rechsteiner, T. C. Squier, Hsp90
enhances degradation of oxidized calmodulin by the 20 S proteasome. J
Biol Chem 279, 2004, pp. 46135 - 46142.
[15] T. C. Squier, Redox modulation of cellular metabolism through targeted
degradation of signaling proteins by the proteasome. Antioxid Redox
Signal 8, 2006, pp. 217 - 228.
[16] Y. Y. Lee-Hilz, A. M. Boerboom, A. H. Westphal, W. J. Berkel, J. M.
Aarts, I. M. Rietjens, Pro-oxidant activity of flavonoids induces EpRE
mediated gene expression. Chem Res Toxicol 19, 2006, pp. 1499 -
1505.
[17] I. Rahman, S. K. Biswas, P. A. Kirkham, Regulation of inflammation
and redox signaling by dietary polyphenols. Biochem Pharmacol 72,
2006, pp. 1439 - 1452.
[18] E. Hernandez-Montes, S. E. Pollard, D. Vauzour, L. Jofre-Montseny, C.
Rota, G. Rimbach, Activation of glutathione peroxidase via Nrf1
mediates genistein's protection against oxidative endothelial cell injury.
Biochem Biophys Res Commun 346, 2006, pp. 851 - 859.
[19] R. Masella, R. Di Benedetto, R. Vari, C. Filesi, C. Giovannini, Novel
mechanisms of natural antioxidant compounds in biological systems:
involvement of glutathione and glutathione-related enzymes. J Nutr
Biochem 16, 10, 2005, pp. 577 - 586.
[20] M. Wro'blewska, J. Jus'kiewicz, S. Frejnagel, J. Oszmian'ski, Z.
Zdun'czyk, Physiological influence of chokeberry phenolics in model
diet. Acta Aliment Hung 37, 2008, pp. 221 - 232.
[1] K. D. Setchell, Phytoestrogens: the biochemistry, physiology, and
implications for human health of soy isoflavones. Am J Clin Nutr. 68,
1998, pp. 1333S - 1346S.
[2] J. Burns, Relationship among antioxidant activity, vasodilatation
capacity, and phenolic content of red wine. J Agric and Food Chemistry
48, 2000, pp. 220 - 230.
[3] L. Z. Tosca, M. L. Fernandez, Cardioprotective effects of dietary
polyphenols. Recent Advances in Nutritional Sciences 135, 2005, pp.
2291 - 2295.
[4] V. Cheynier, Polyphenols in foods are more complex than often thought.
Am J Clin Nutr 81, 2005, pp. 223S - 229S.
[5] L. H. Yao, Y. M Jiang, J. Shi, F. A. Tomas-Barberan, N. Datta, R.
Singanusong, Flavonoids in food and their health benefits. Plant Foods
Hum Nutr, 59, 2004, pp. 113 - 122.
[6] S. Pascual-Teresa, M. T. Sanchez -Ballesta, Anthocyanins: from plant to
health. Phytochem Rev, 7, 2008, pp. 281 - 299.
[7] L. I. Mennen, D. Sapinho, A. De Bree, Consumption of foods rich in
flavonoids is related to a decreased cardiovascular risk in apparently
healthy French women. J Nutr 134, 2004, pp. 923 - 926.
[8] D. R. Bell, K. Gochenaur, Direct vasoactive and vasoprotective
properties of anthocyanin - rich extracts. J Appl Physiol 100, 2006, pp.
1164 - 1170.
[9] E. Beutler, O. Durion, B. J. Kelly, Diabetic heart and kidney exhibit
increased resistance to lipid peroxidation. Biochem Biophys Acta 1047,
1990, pp. 63 - 69.
[10] H. Ohkawa, N. Ohisin, K. Yadik, Assay for lipid peroxides in animals
tissues by thiobarbituric acid reaction. Annal Biochem 95, 1979, pp. 351 - 358.
[11] F. Nielsen, B. B. Mikkelsen, J. B. Nielsen, H. R. Andersen, P.
Grandjean, Plasma malondialdehyde as biomarker for oxidative stress:
reference interval and effects of life-style factors. Clin Chem 43(7),
1997, pp. 1209 - 1214.
[12] D. Steinberg, S. Parthasarthy, T. E. Carew, J. C. Khoo, J. L. Witztum,
Beyond cholesterol: modifications of low-density lipoprotein that
increase its atherogenicity. N Engl J Med 320, 1989, pp. 915 - 924.
[13] E. Anselm, M. Chataigneau, M. Ndiaye, T. Chataigneau, V. B. Schini-
Kerth, Grape juice causes endothelium-dependent relaxation via a
redox-sensitive Src- and Akt-dependent activation of eNOS. Cardiovasc
Res 73, 2007, pp. 404 - 413.
[14] J. E. Whittier, Y. Xiong, M. C. Rechsteiner, T. C. Squier, Hsp90
enhances degradation of oxidized calmodulin by the 20 S proteasome. J
Biol Chem 279, 2004, pp. 46135 - 46142.
[15] T. C. Squier, Redox modulation of cellular metabolism through targeted
degradation of signaling proteins by the proteasome. Antioxid Redox
Signal 8, 2006, pp. 217 - 228.
[16] Y. Y. Lee-Hilz, A. M. Boerboom, A. H. Westphal, W. J. Berkel, J. M.
Aarts, I. M. Rietjens, Pro-oxidant activity of flavonoids induces EpRE
mediated gene expression. Chem Res Toxicol 19, 2006, pp. 1499 -
1505.
[17] I. Rahman, S. K. Biswas, P. A. Kirkham, Regulation of inflammation
and redox signaling by dietary polyphenols. Biochem Pharmacol 72,
2006, pp. 1439 - 1452.
[18] E. Hernandez-Montes, S. E. Pollard, D. Vauzour, L. Jofre-Montseny, C.
Rota, G. Rimbach, Activation of glutathione peroxidase via Nrf1
mediates genistein's protection against oxidative endothelial cell injury.
Biochem Biophys Res Commun 346, 2006, pp. 851 - 859.
[19] R. Masella, R. Di Benedetto, R. Vari, C. Filesi, C. Giovannini, Novel
mechanisms of natural antioxidant compounds in biological systems:
involvement of glutathione and glutathione-related enzymes. J Nutr
Biochem 16, 10, 2005, pp. 577 - 586.
[20] M. Wro'blewska, J. Jus'kiewicz, S. Frejnagel, J. Oszmian'ski, Z.
Zdun'czyk, Physiological influence of chokeberry phenolics in model
diet. Acta Aliment Hung 37, 2008, pp. 221 - 232.
@article{"International Journal of Medical, Medicine and Health Sciences:50627", author = "Manuela Ciocoiu and Laur Badescu and Oana Badulescu and Magda Badescu", title = "Intervention of Sambucus Nigra Polyphenolic Extract in Experimental Arterial Hypertension", abstract = "The research focuses on the effects of polyphenols
extracted from Sambucus nigra fruit, using an experimental arterial
hypertension pattern, as well as their influence on the oxidative
stress. The results reveal the normalization of the reduced glutathion
concentration, as well as a considerable reduction in the
malondialdehide serum concentration by the polyphenolic protection.
The rat blood pressure values were recorded using a CODATM
system, which uses a non-invasive blood pressure measuring method.
All the measured blood pressure components revealed a biostatistically
significant (p", keywords = "Arterial hypertension, Oxidative stress, Sambucus nigra", volume = "6", number = "4", pages = "67-4", }
