Abstract: Bones are dynamic and responsive organs, they
regulate their strength and mass according to the loads which they are subjected. Because, the Wnt/β-catenin pathway has profound
effects on the regulation of bone mass, we hypothesized that mechanical loading of bone cells stimulates Wnt/β-catenin signaling, which results in the generation of new bone mass.
Mechanical loading triggers the secretion of the Wnt molecule, which after binding to transmembrane proteins, causes GSK-3β (Glycogen synthase kinase 3 beta) to cease the phosphorylation of β-catenin. β-catenin accumulation in the cytoplasm, followed by its
transport into the nucleus, binding to transcription factors (TCF/LEF)
that initiate transcription of genes related to bone formation. To test this hypothesis, we used TOPGAL (Tcf Optimal Promoter
β-galactosidase) mice in an experiment in which cyclic loads were
applied to the forearm. TOPGAL mice are reporters for cells effected
by the Wnt/β-catenin signaling pathway. TOPGAL mice are genetically engineered mice in which transcriptional activation of β-
catenin, results in the production of an enzyme, β-galactosidase. The
presence of this enzyme allows us to localize transcriptional
activation of β-catenin to individual cells, thereby, allowing us to quantify the effects that mechanical loading has on the Wnt/β-catenin pathway and new bone formation. The ulnae of loaded TOPGAL
mice were excised and transverse slices along different parts of the
ulnar shaft were assayed for the presence of β-galactosidase.
Our results indicate that loading increases β-catenin transcriptional
activity in regions where this pathway is already primed (i.e. where basal activity is already higher) in a load magnitude dependent
manner. Further experiments are needed to determine the temporal and spatial activation of this signaling in relation to bone formation.
Abstract: Fatigue cracking continues to be the main challenges in
improving the performance of bituminous mixture pavements. The
purpose of this paper is to look at some aspects of the effects of fine
aggregate properties on the fatigue behaviour of hot mixture asphalt.
Two types of sand (quarry and mining sand) with two conventional
bitumen (PEN 50/60 & PEN 80/100) and four polymers modified
bitumen PMB (PM1_82, PM1_76, PM2_82 and PM2_76) were used.
Physical, chemical and mechanical tests were performed on the sands
to determine their effect when incorporated with a bituminous
mixture. According to the beam fatigue results, quarry sand that has
more angularity, rougher, higher shear strength and a higher
percentage of Aluminium oxide presented higher resistance to
fatigue. Also a PMB mixture gives better fatigue results than
conventional mixtures, this is due to the PMB having better viscosity
property than that of the conventional bitumen.
Abstract: Crime is a major societal problem for most of the
world's nations. Consequently, the police need to develop new
methods to improve their efficiency in dealing with these ever increasing crime rates. Two of the common difficulties that the police
face in crime control are crime investigation and the provision of crime information to the general public to help them protect themselves. Crime control in police operations involves the use of
spatial data, crime data and the related crime data from different organizations (depending on the nature of the analysis to be made).
These types of data are collected from several heterogeneous sources
in different formats and from different platforms, resulting in a lack of standardization. Moreover, there is no standard framework for
crime data collection, integration and dissemination through mobile
devices. An investigation into the current situation in crime control was carried out to identify the needs to resolve these issues. This
paper proposes and investigates the use of service oriented
architecture (SOA) and the mobile spatial information service in crime control. SOA plays an important role in crime control as an
appropriate way to support data exchange and model sharing from
heterogeneous sources. Crime control also needs to facilitate mobile
spatial information services in order to exchange, receive, share and release information based on location to mobile users anytime and
anywhere.
Abstract: Polyurethane foam (PUF) were prepared by
reacting polyols synthesized from soy-oil into mixture of 2,4-
Toluene diisocyanate (TDI) with 4,4--Methylene Diamine
Isocyanate (MDI) with ratio of 70:30. The polyols obtained
via esterification reaction were categorize into different
temperature of reaction and by used of varied concentration
of phosphoric acid catalyst. The purpose of catalysts is to
shifting selectivity to a desired and value added of product.
The effect of stoichiometric balance (molar ratio of
epoxide/ethylene glycol) to the concentration of the catalyst
on the final properties was evaluated.
Abstract: The aim of this paper is to express the input-output
matrix as a linear ordering problem which is classified as an NP-hard
problem. We then use a Tabu search algorithm to find the best
permutation among sectors in the input-output matrix that will give
an optimal solution. This optimal permutation can be useful in
designing policies and strategies for economists and government in
their goal of maximizing the gross domestic product.
Abstract: With the rapid development in the field of life
sciences and the flooding of genomic information, the need for faster
and scalable searching methods has become urgent. One of the
approaches that were investigated is indexing. The indexing methods
have been categorized into three categories which are the lengthbased
index algorithms, transformation-based algorithms and mixed
techniques-based algorithms. In this research, we focused on the
transformation based methods. We embedded the N-gram method
into the transformation-based method to build an inverted index
table. We then applied the parallel methods to speed up the index
building time and to reduce the overall retrieval time when querying
the genomic database. Our experiments show that the use of N-Gram
transformation algorithm is an economical solution; it saves time and
space too. The result shows that the size of the index is smaller than
the size of the dataset when the size of N-Gram is 5 and 6. The
parallel N-Gram transformation algorithm-s results indicate that the
uses of parallel programming with large dataset are promising which
can be improved further.
Abstract: Recurrent event data is a special type of multivariate
survival data. Dynamic and frailty models are one of the approaches
that dealt with this kind of data. A comparison between these two
models is studied using the empirical standard deviation of the
standardized martingale residual processes as a way of assessing the
fit of the two models based on the Aalen additive regression model.
Here we found both approaches took heterogeneity into account and
produce residual standard deviations close to each other both in the
simulation study and in the real data set.
Abstract: The influence of viscosity on droplet diameter for
water-in-crude oil (w/o) emulsion with two different ratios; 20-80 %
and 50-50 % w/o emulsion was examined in the Brookfield
Rotational Digital Rheometer. The emulsion was prepared with
sorbitan sesquiolate (Span 83) act as emulsifier at varied temperature
and stirring speed in rotation per minute (rpm). Results showed that
the viscosity of w/o emulsion was strongly augmented by increasing
volume of water and decreased the temperature. The changing of
viscosity also altered the droplet size distribution. Changing of
droplet diameter was depends on the viscosity and the behavior of
emulsion either Newtonian or non-Newtonian.
Abstract: This paper discuss the separation of the miscible
liquids by means of fractional distillation. For complete separation of
liquids, the process of heating, condensation, separation and storage
is done automatically to achieve the objective. PIC micro-controller
has been used to control each and every process of the work. The
controller also controls the storage process by activating and deactivating
the conveyors. The liquids are heated which on reaching
their respective boiling points evaporate and enter the condensation
chamber where they convert into liquid. The liquids are then directed
to their respective tanks by means of stepper motor which moves in
three directions, each movement into different tank. The tank on
filling sends the signal to controller which then opens the solenoid
valves. The tank is emptied into the beakers below the nozzle. As the
beaker filled, the nozzle closes and the conveyors come into
operation. The filled beaker is replaced by an empty beaker from
behind. The work can be used in oil industries, chemical industries
and paint industries.
Abstract: The objective of this study is to propose an observer design for nonlinear systems by using an augmented linear system derived by application of a formal linearization method. A given nonlinear differential equation is linearized by the formal linearization method which is based on Taylor expansion considering up to the higher order terms, and a measurement equation is transformed into an augmented linear one. To this augmented dimensional linear system, a linear estimation theory is applied and a nonlinear observer is derived. As an application of this method, an estimation problem of transient state of electric power systems is studied, and its numerical experiments indicate that this observer design shows remarkable performances for nonlinear systems.
Abstract: Cameron Highlands is a mountainous area subjected
to torrential tropical showers. It extracts 5.8 million liters of water
per day for drinking supply from its rivers at several intake points.
The water quality of rivers in Cameron Highlands, however, has
deteriorated significantly due to land clearing for agriculture,
excessive usage of pesticides and fertilizers as well as construction
activities in rapidly developing urban areas. On the other hand, these
pollution sources known as non-point pollution sources are diverse
and hard to identify and therefore they are difficult to estimate.
Hence, Geographical Information Systems (GIS) was used to provide
an extensive approach to evaluate landuse and other mapping
characteristics to explain the spatial distribution of non-point sources
of contamination in Cameron Highlands. The method to assess
pollution sources has been developed by using Cameron Highlands
Master Plan (2006-2010) for integrating GIS, databases, as well as
pollution loads in the area of study. The results show highest annual
runoff is created by forest, 3.56 × 108 m3/yr followed by urban
development, 1.46 × 108 m3/yr. Furthermore, urban development
causes highest BOD load (1.31 × 106 kgBOD/yr) while agricultural
activities and forest contribute the highest annual loads for
phosphorus (6.91 × 104 kgP/yr) and nitrogen (2.50 × 105 kgN/yr),
respectively. Therefore, best management practices (BMPs) are
suggested to be applied to reduce pollution level in the area.
Abstract: When the foundations of structures under cyclic
loading with amplitudes less than their permissible load, the concern exists often for the amount of uniform and non-uniform settlement of
such structures. Storage tank foundations with numerous filling and discharging and railways ballast course under repeating
transportation loads are examples of such conditions. This paper
deals with the effects of using the new generation of reinforcements,
Grid-Anchor, for the purpose of reducing the permanent settlement
of these foundations under the influence of different proportions of
the ultimate load. Other items such as the type and the number of
reinforcements as well as the number of loading cycles are studied numerically. Numerical models were made using the Plaxis3D
Tunnel finite element code. The results show that by using gridanchor
and increasing the number of their layers in the same
proportion as that of the cyclic load being applied, the amount of
permanent settlement decreases up to 42% relative to unreinforced
condition depends on the number of reinforcement layers and percent
of applied load and the number of loading cycles to reach a constant
value of dimensionless settlement decreases up to 20% relative to
unreinforced condition.
Abstract: Minimally invasive surgery (MIS) is now being widely used as a preferred choice for various types of operations. The need to detect various tactile properties, justifies the key role of tactile sensing that is currently missing in MIS. In this regard, Laparoscopy is one of the methods of minimally invasive surgery that can be used in kidney stone removal surgeries. At this moment, determination of the exact location of stone during laparoscopy is one of the limitations of this method that no scientific solution has been found for so far. Artificial tactile sensing is a new method for obtaining the characteristics of a hard object embedded in a soft tissue. Artificial palpation is an important application of artificial tactile sensing that can be used in different types of surgeries. In this study, a new method for determining the exact location of stone during laparoscopy is presented. In the present study, the effects of stone existence on the surface of kidney were investigated using conceptual 3D model of kidney containing a simulated stone. Having imitated palpation and modeled it conceptually, indications of stone existence that appear on the surface of kidney were determined. A number of different cases were created and solved by the software and using stress distribution contours and stress graphs, it is illustrated that the created stress patterns on the surface of kidney show not only the existence of stone inside, but also its exact location. So three-dimensional analysis leads to a novel method of predicting the exact location of stone and can be directly applied to the incorporation of tactile sensing in artificial palpation, helping surgeons in non-invasive procedures.
Abstract: This article presents the simulation, parameterization and optimization of an electromagnet with the C–shaped configuration, intended for the study of magnetic properties of materials. The electromagnet studied consists of a C-shaped yoke, which provides self–shielding for minimizing losses of magnetic flux density, two poles of high magnetic permeability and power coils wound on the poles. The main physical variable studied was the static magnetic flux density in a column within the gap between the poles, with 4cm2 of square cross section and a length of 5cm, seeking a suitable set of parameters that allow us to achieve a uniform magnetic flux density of 1x104 Gaussor values above this in the column, when the system operates at room temperature and with a current consumption not exceeding 5A. By means of a magnetostatic analysis by the finite element method, the magnetic flux density and the distribution of the magnetic field lines were visualized and quantified. From the results obtained by simulating an initial configuration of electromagnet, a structural optimization of the geometry of the adjustable caps for the ends of the poles was performed. The magnetic permeability effect of the soft magnetic materials used in the poles system, such as low– carbon steel (0.08% C), Permalloy (45% Ni, 54.7% Fe) and Mumetal (21.2% Fe, 78.5% Ni), was also evaluated. The intensity and uniformity of the magnetic field in the gap showed a high dependence with the factors described above. The magnetic field achieved in the column was uniform and its magnitude ranged between 1.5x104 Gauss and 1.9x104 Gauss according to the material of the pole used, with the possibility of increasing the magnetic field by choosing a suitable geometry of the cap, introducing a cooling system for the coils and adjusting the spacing between the poles. This makes the device a versatile and scalable tool to generate the magnetic field necessary to perform magnetic characterization of materials by techniques such as vibrating sample magnetometry (VSM), Hall-effect, Kerr-effect magnetometry, among others. Additionally, a CAD design of the modules of the electromagnet is presented in order to facilitate the construction and scaling of the physical device.
Abstract: The increasing importance of data stream arising in a
wide range of advanced applications has led to the extensive study of
mining frequent patterns. Mining data streams poses many new
challenges amongst which are the one-scan nature, the unbounded
memory requirement and the high arrival rate of data streams. In this
paper, we propose a new approach for mining itemsets on data
stream. Our approach SFIDS has been developed based on FIDS
algorithm. The main attempts were to keep some advantages of the
previous approach and resolve some of its drawbacks, and
consequently to improve run time and memory consumption. Our
approach has the following advantages: using a data structure similar
to lattice for keeping frequent itemsets, separating regions from each
other with deleting common nodes that results in a decrease in search
space, memory consumption and run time; and Finally, considering
CPU constraint, with increasing arrival rate of data that result in
overloading system, SFIDS automatically detect this situation and
discard some of unprocessing data. We guarantee that error of results
is bounded to user pre-specified threshold, based on a probability
technique. Final results show that SFIDS algorithm could attain
about 50% run time improvement than FIDS approach.
Abstract: Performance of a cobalt doped sol-gel derived silica (Co/SiO2) catalyst for Fischer–Tropsch synthesis (FTS) in slurryphase reactor was studied using paraffin wax as initial liquid media. The reactive mixed gas, hydrogen (H2) and carbon monoxide (CO) in a molar ratio of 2:1, was flowed at 50 ml/min. Braunauer-Emmett- Teller (BET) surface area and X-ray diffraction (XRD) techniques were employed to characterize both the specific surface area and crystallinity of the catalyst, respectively. The reduction behavior of Co/SiO2 catalyst was investigated using the Temperature Programmmed Reduction (TPR) method. Operating temperatures were varied from 493 to 533K to find the optimum conditions to maximize liquid fuels production, gasoline and diesel.
Abstract: This paper describes an algorithm to estimate realtime vehicle velocity using image processing technique from the known camera calibration parameters. The presented algorithm involves several main steps. First, the moving object is extracted by utilizing frame differencing technique. Second, the object tracking method is applied and the speed is estimated based on the displacement of the object-s centroid. Several assumptions are listed to simplify the transformation of 2D images from 3D real-world images. The results obtained from the experiment have been compared to the estimated ground truth. From this experiment, it exhibits that the proposed algorithm has achieved the velocity accuracy estimation of about ± 1.7 km/h.
Abstract: This work consists of three parts. First, the alias-free
condition for the conventional two-channel quadrature mirror filter
bank is analyzed using complex arithmetic. Second, the approach
developed in the first part is applied to the complex quadrature mirror
filter bank. Accordingly, the structure is simplified and the theory is
easier to follow. Finally, a new class of complex quadrature mirror
filter banks is proposed. Interesting properties of this new structure
are also discussed.
Abstract: This paper presents modeling and optimization of two NP-hard problems in flexible manufacturing system (FMS), part type selection problem and loading problem. Due to the complexity and extent of the problems, the paper was split into two parts. The first part of the papers has discussed the modeling of the problems and showed how the real coded genetic algorithms (RCGA) can be applied to solve the problems. This second part discusses the effectiveness of the RCGA which uses an array of real numbers as chromosome representation. The novel proposed chromosome representation produces only feasible solutions which minimize a computational time needed by GA to push its population toward feasible search space or repair infeasible chromosomes. The proposed RCGA improves the FMS performance by considering two objectives, maximizing system throughput and maintaining the balance of the system (minimizing system unbalance). The resulted objective values are compared to the optimum values produced by branch-and-bound method. The experiments show that the proposed RCGA could reach near optimum solutions in a reasonable amount of time.
Abstract: This study deals with evaluation of influence of salinity (NaCl) onto equilibrium of Cu and Ni removal from aqueous solutions by natural sorbent – zeolite. Equilibrium data were obtained by batch experiments. The salinity of the aqueous solution was influenced by dissolving NaCl in distilled water. It was studied in the range of NaCl concentrations from 1 g.l-1 to 100g.l-1. For Cu sorption there is a significant influence of salinity. The maximum capacity of zeolite for Cu was decreasing with growing concentration of NaCl. For Ni sorption there is not so significant influence of salinity as for Cu. The maximum capacity of zeolite for Ni was slightly decreasing with growing concentration of NaCl.