Abstract: The aim of this article is to narrate the utility of novel simulation approach i.e. convolution method to predict blood concentration of drug utilizing dissolution data of salbutamol sulphate microparticulate formulations with different release patterns (1:1, 1:2 and 1:3, drug:polymer). Dissolution apparatus II USP 2007 and 900 ml double distilled water stirrd at 50 rpm was employed for dissolution analysis. From dissolution data, blood drug concentration was determined, and in return predicted blood drug concentration data was used to calculate the pharmacokinetic parameters i.e. Cmax, Tmax, and AUC. Convolution is a good biwaiver technique; however its better utility needs it application in the conditions where biorelevant dissolution media are used.
Abstract: Knowledge capabilities are increasingly important for
the innovative technology enterprises to enhance the business
performance in terms of product competitiveness, innovation and
sales. Recognition of the company capability by auditing allows them
to further pursue advancement, strategic planning and hence gain
competitive advantages. This paper attempts to develop an
Organizations- Knowledge Capabilities Assessment (OKCA) method
to assess the knowledge capabilities of technology companies. The
OKCA is a questionnaire-based assessment tool which has been
developed to uncover the impact of various knowledge capabilities on
different organizational performance. The collected data is then
analyzed to find out the crucial elements for different technological
companies. Based on the results, innovative technology enterprises are
able to recognize the direction for further improvement on business
performance and future development plan. External environmental
factors affecting organization performance can be found through the
further analysis of some selected reference companies.
Abstract: The implementation of electronic government started since the initiation of Multimedia Super Corridor (MSC) by the Malaysia government. The introduction of ICT in the public sector especially e-Government initiatives opens up a new book in the government administration throughout the world. The aim or this paper is to discuss the implementation of e-government in Malaysia, covering the result of public user self assessment on Malaysia's electronic government applications. E-services, e-procurement, Generic Office Environment (GOE), Human Resources Management Information System (HRMIS), Project Monitoring System (PMS), Electronic Labor Exchange (ELX) and e-syariah(religion) were the seven flagship application assessed. The study adopted a crosssectional survey research approach and information system literature were used. The analysis was done for 35 responden in pilot test and there was evidence from public user's perspective to suggest that the e-government applications were generally successful.
Abstract: The high temperature degree and uniform
Temperature Distribution (TD) on surface of cookware which contact
with food are effective factors for improving cookware application.
Additionally, the ability of pan material in retaining the heat and nonreactivity
with foods are other significant properties. It is difficult for
single material to meet a wide variety of demands such as superior
thermal and chemical properties. Multi-Layer Plate (MLP) makes
more regular TD. In this study the main objectives are to find the best
structure (single or multi-layer) and materials to provide maximum
temperature degree and uniform TD up side surface of pan. And also
heat retaining of used metals with goal of improving the thermal
quality of pan to economize the energy. To achieve this aim were
employed Finite Element Method (FEM) for analyzing transient
thermal behavior of applied materials. The analysis has been
extended for different metals, we achieved the best temperature
profile and heat retaining in Copper/ Stainless Steel MLP.
Abstract: Despite the relatively large number of studies that
have examined the use of appeals in advertisements, research on the
use of appeals in green advertisements is still underdeveloped and
needs to be investigated further, as it is definitely a tool for marketers
to create illustrious ads. In this study, content analysis was employed
to examine the nature of green advertising appeals and to match the
appeals with the green advertisements. Two different types of green
print advertisings, product orientation and organizational image
orientation were used. Thirty highly educated participants with
different backgrounds were asked individually to ascertain three
appeals out of thirty-four given appeals found among forty real green
advertisements. To analyze participant responses and to group them
based on common appeals, two-step K-mean clustering is used. The
clustering solution indicates that eye-catching graphics and
imaginative appeals are highly notable in both types of green ads.
Depressed, meaningful and sad appeals are found to be highly used in
organizational image orientation ads, whereas, corporate image,
informative and natural appeals are found to be essential for product
orientation ads.
Abstract: Due to the legacy of apartheid segregation South Africa remains a divided society where most voters live in politically homogenous social environments. This paper argues that political discussion within one’s social context plays a primary role in shaping political attitudes and vote choice. Using data from the Comparative National Elections Project 2004 and 2009 South African post-election surveys, the paper explores the extent of social context partisan homogeneity in South Africa and finds that voters are not overly embedded in homogenous social contexts. It then demonstrates the consequences of partisan homogeneity on voting behavior. Homogenous social contexts tend to encourage stronger partisan loyalties and fewer defections in vote choice while voters in more heterogeneous contexts show less consistency in their attitudes and behaviour. Finally, the analysis shows how momentous sociopolitical events at the time of a particular election can change the social context, with important consequences for electoral outcomes.
Abstract: Most real world systems express themselves formally
as a set of nonlinear algebraic equations. As applications grow, the
size and complexity of these equations also increase. In this work, we
highlight the key concepts in using the homotopy analysis method
as a methodology used to construct efficient iteration formulas for
nonlinear equations solving. The proposed method is experimentally
characterized according to a set of determined parameters which
affect the systems. The experimental results show the potential and
limitations of the new method and imply directions for future work.
Abstract: Nowadays, one of the most important problems of the
metropolises and the world large cities is the habitant traffic difficulty
and lack of sufficient parking site for the vehicles. Esfahan city as the
third metropolis of Iran has encountered with the vehicles parkingplace
problems in the most parts of fourteen regions of the city. The
non principled and non systematic dispersal and lack of parking sites
in the city has created an unfavorable status for its traffic and has
caused the air and sound pollutions increase; in addition, it wastes the
most portions of the citizenship and travelers' charge and time in
urban pathways and disturbs their mental and psychical calmness,
thus leads to their intensive dissatisfaction. In this study, by the usage
of AHP model in GIS environment, the effective criteria in selecting
the public parking sites have been combined with each other, and the
results of the created layers overlapping represent the parking
utilitarian vastness and widths. The achieved results of this research
indicate the pretty appropriate public parking sites selection in region
number 3 of Esfahan; but inconsequential dispersal and lack of these
parking sites in this region have caused abundant transportation
problems in Esfahan city.
Abstract: Nowadays, manufacturers are facing great challenges
with regard to the production of green products due to the emerging issue of hazardous substance management (HSM). In particular,
environmental legislation pressures have yielded to increased risk,
manufacturing complexity and green components demands. The green principles were expanded to many departments within
organization, including supply chain. Green supply chain
management (GSCM) was emerging in the last few years. This idea
covers every stage in manufacturing from the first to the last stage of
life cycle. From product lifecycle concept, the cycle starts at the design of a product. QFD is a customer-driven product development
tool, considered as a structured management approach for efficiently
translating customer needs into design requirements and parts deployment, as well as manufacturing plans and controls in order to
achieve higher customer satisfaction. This paper develops an Eco-
QFD to provide a framework for designing Eco-mobile phone by integrating the life cycle analysis LCA into QFD throughout the entire product development process.
Abstract: In this paper, an analysis of a target location estimation
system using the best linear unbiased estimator (BLUE) for high
performance radar systems is presented. In synthetic environments,
we are here concerned with three key elements of radar system
modeling, which makes radar systems operates accurately in strategic
situation in virtual ground. Radar Cross Section (RCS) modeling
is used to determine the actual amount of electromagnetic waves
that are reflected from a tactical object. Pattern Propagation Factor
(PPF) is an attenuation coefficient of the radar equation that contains
the reflection from the surface of the earth, the diffraction, the
refraction and scattering by the atmospheric environment. Clutter is
the unwanted echoes of electronic systems. For the data fusion of
output results from radar detection in synthetic environment, BLUE
is used and compared with the mean values of each simulation results.
Simulation results demonstrate the performance of the radar system.
Abstract: Plackett-Burman statistical screening of media
constituents and operational conditions for extracellular lipase
production from isolate Trichoderma viride has been carried out in
submerged fermentation. This statistical design is used in the early
stages of experimentation to screen out unimportant factors from a
large number of possible factors. This design involves screening of
up to 'n-1' variables in just 'n' number of experiments. Regression
coefficients and t-values were calculated by subjecting the
experimental data to statistical analysis using Minitab version 15.
The effects of nine process variables were studied in twelve
experimental trials. Maximum lipase activity of 7.83 μmol /ml /min
was obtained in the 6th trail. Pareto chart illustrates the order of
significance of the variables affecting the lipase production. The
present study concludes that the most significant variables affecting
lipase production were found to be palm oil, yeast extract, K2HPO4,
MgSO4 and CaCl2.
Abstract: This paper presents a new general technique for analysis of noise in static log-domain translinear circuits. It is demonstrated that employing this technique, leads to a general, simple and routine method of the noise analysis. The circuit has been simulated by HSPICE. The simulation results are seen to conform to the theoretical analysis and shows benefits of the proposed circuit.
Abstract: This paper describes the crashworthiness assessment and improvement of tlting train made of sandwich composites. The crashworhiness assessment of tilting train was conducted according to four collision scenarios of the Korean railway safety law. Collision analysis was carried out using explicit finite element analysis code LS-DYNA 3D. The finite element model consists of 3-D finite element model and 1-D equivalent model to save the finite element modeling and calculation time. It found that the crashworthiness analysis results were satisfied with the performance requirements except the crash scenario-2. In order to meet the crashworthiness requirements for crash scenario-2, the stiffness reinforcement for the laminate composite cover and metal frames of cabmask structure were proposed. Consequentially, it has satisfied the requirement for crash scenario-2.
Abstract: Analytical investigation of the sedimentation
processes in the river engineering and hydraulic structures is of vital
importance as this can affect water supply for the cultivating lands in
the command area. The reason being that gradual sediment formation
behind the reservoir can reduce the nominal capacity of these dams.
The aim of the present paper is to analytically investigate
sedimentation process along the river course and behind the storage
reservoirs in general and the Eastern Intake of the Dez Diversion weir
in particular using the SHARC software. Results of the model
indicated the water level at 115.97m whereas the real time
measurement from the river cross section was 115.98 m which
suggests a significantly close relation between them. The average
transported sediment load in the river was measured at 0.25mm ,
from which it can be concluded that nearly 100% of the suspended
loads in river are moving which suggests no sediment settling but
indicates that almost all sediment loads enters into the intake. It was
further showed the average sediment diameter entering the intake to
be 0.293 mm which in turn suggests that about 85% of suspended
sediments in the river entre the intake. Comparison of the results
from the SHARC model with those obtained form the SSIIM
software suggests quite similar outputs but distinguishing the
SHARC model as more appropriate for the analysis of simpler
problems than other model.
Abstract: The Tropical Data Hub (TDH) is a virtual research environment that provides researchers with an e-research infrastructure to congregate significant tropical data sets for data reuse, integration, searching, and correlation. However, researchers often require data and metadata synthesis across disciplines for crossdomain analyses and knowledge discovery. A triplestore offers a semantic layer to achieve a more intelligent method of search to support the synthesis requirements by automating latent linkages in the data and metadata. Presently, the benchmarks to aid the decision of which triplestore is best suited for use in an application environment like the TDH are limited to performance. This paper describes a new evaluation tool developed to analyze both features and performance. The tool comprises a weighted decision matrix to evaluate the interoperability, functionality, performance, and support availability of a range of integrated and native triplestores to rank them according to requirements of the TDH.
Abstract: Thrombosis can be life threatening, necessitating therefore its instant treatment. Hydergine, a nootropic agent is used as a cognition enhancer in stroke patients but relatively little is known about its anti-thrombolytic effect. To investigate this aspect, in vivo and ex vivo experiments were designed and conducted. Three groups of rats were injected 1.5mg, 3.0mg and 4.5mg hydergine intraperitonealy with and without prior exposure to fresh plasma. Positive and negative controls were run in parallel. Animals were sacrificed after 1.5hrs and BT, CT, PT, INR, APTT, plasma calcium levels were estimated. For ex vivo analyses, each 1ml blood aspirated was exposed to 0.1mg, 0.2mg, 0.3mg dose of hydergine with parallel controls. Parameters analyzed were as above. Statistical analysis was through one-way ANOVA. Dunken-s and Tukey-s tests provided intra-group variance. BT, CT, PT, INR and APTT increased while calcium levels dropped significantly (P
Abstract: The paper presents the Romanian realities and perspectives from the point of view of reaching the sustainable development model in the context of the recent accession to the European Union, based on the analysis of the indicators listed in the EU Sustainable Development Strategy. The analysis of the economic-social potential for sustainable development and of the environment aspects show that the objectives stipulated in the renewed EU Sustainable Development Strategy of 2006 can be reached, but an extra effort must be put-in in order to overcome the existing substantial gaps in several areas in relation to the developed countries of the EU. The paper-s conclusions show that even if sustainable development is not an easy target to reach in Romania, there are resources and a growing potential, which can lead to sustainable development if used rationally.
Abstract: In this paper, Fabless Prototyping Methodology is
introduced for the design and analysis of MEMS devices.
Conventionally Finite Element Analysis (FEA) is performed before
system level simulation. In our proposed methodology, system level
simulation is performed earlier than FEA as it is computationally less
extensive and low cost. System level simulations are based on
equivalent behavioral models of MEMS device. Electrostatic
actuation based MEMS Microgripper is chosen as case study to
implement this methodology. This paper addresses the behavioral
model development and simulation of actuator part of an
electrostatically actuated Microgripper. Simulation results show that
the actuator part of Microgripper works efficiently for a voltage range
of 0-45V with the corresponding jaw displacement of 0-4.5425μm.
With some minor changes in design, this range can be enhanced to
15μm at 85V.
Abstract: The present work deals with thermodynamic analysis
of cascade refrigeration system using ozone friendly refrigerants pair
R507A and R23. R507A is azeotropic mixture composed of HFC
refrigerants R125/R143a (50%/50% wt.). R23 is a single component
HFC refrigerant used as replacement to CFC refrigerant R13 in low
temperature applications. These refrigerants have zero ozone
depletion potential and are non-flammable and as R507A an
azeotropic mixture there is no problem of temperature glide. This
study thermodynamically analyzed R507A-R23 cascade refrigeration
system to optimize the design and operating parameters of the
system. The design and operating parameters include: Condensing,
evaporating, subcooling and superheating temperatures in the high
temperature circuit, temperature difference in the cascade heat
exchanger, Condensing, evaporating, subcooling and superheating
temperatures in the low temperature circuit.
Abstract: This study proposes novel hybrid social network analysis and collaborative filtering approach to enhance the performance of recommender systems. The proposed model selects subgroups of users in Internet community through social network analysis (SNA), and then performs clustering analysis using the information about subgroups. Finally, it makes recommendations using cluster-indexing CF based on the clustering results. This study tries to use the cores in subgroups as an initial seed for a conventional clustering algorithm. This model chooses five cores which have the highest value of degree centrality from SNA, and then performs clustering analysis by using the cores as initial centroids (cluster centers). Then, the model amplifies the impact of friends in social network in the process of cluster-indexing CF.