Abstract: It is believed that DNA damaging toxic metabolites contributes to the development of different pathological conditions. To prevent harmful influence of toxic agents, cells developed number of protecting mechanisms, such as enzymatic reaction of detoxification of reactive metabolites and repair of DNA damage. The aim of the study was to examine the association between polymorphism of GSTT1/GSTM1 and XRCC1/3 genes and coronary artery disease (CAD) incidence. To examine a polymorphism of these genes in CAD susceptibility in patients and controls, PCR based genotyping assay was performed. For GST genes, frequency of GSTM1 null genotype among CAD affected group was significantly increased than in control group (P0.1). We found that neither XRCC1 Arg399Gln nor XRCC3 Thr241Met were associated with CAD risk. Obtained data suggests that GSTM1 null genotype carriers are more susceptible to CAD development.
Abstract: In this paper, we address the problem of adaptive radio
resource allocation (RRA) and packet scheduling in the downlink of a
cellular OFDMA system, and propose a downlink multi-carrier
proportional fair (MPF) scheduler and its joint with adaptive RRA
algorithm to distribute radio resources among multiple users according
to their individual QoS requirements. The allocation and scheduling
objective is to maximize the total throughput, while at the same time
maintaining the fairness among users. The simulation results
demonstrate that the methods presented provide for user more explicit
fairness relative to RRA algorithm, but the joint scheme achieves the
higher sum-rate capacity with flexible parameters setting compared
with MPF scheduler.
Abstract: Non-viral gene carriers composed of biodegradable
polymers or lipids have been considered as a safer alternative for gene
carriers over viral vectors. We have developed multi-functional
nano-micelles for both drug and gene delivery application.
Polyethyleneimine (PEI) was modified by grafting stearic acid (SA)
and formulated to polymeric micelles (PEI-SA) with positive surface
charge for gene and drug delivery. Our results showed that PEI-SA
micelles provided high siRNA binding efficiency. In addition, siRNA
delivered by PEI-SA carriers also demonstrated significantly high
cellular uptake even in the presence of serum proteins. The
post-transcriptional gene silencing efficiency was greatly improved by
the polyplex formulated by 10k PEI-SA/siRNA. The amphiphilic
structure of PEI-SA micelles provided advantages for multifunctional
tasks; where the hydrophilic shell modified with cationic charges can
electrostatically interact with DNA or siRNA, and the hydrophobic
core can serve as payloads for hydrophobic drugs, making it a
promising multifunctional vehicle for both genetic and chemotherapy
application.
Abstract: This paper considers the influence of promotion
instruments for renewable energy sources (RES) on a multi-energy
modeling framework. In Europe, so called Feed-in Tariffs are
successfully used as incentive structures to increase the amount of
energy produced by RES. Because of the stochastic nature of large
scale integration of distributed generation, many problems have
occurred regarding the quality and stability of supply. Hence, a
macroscopic model was developed in order to optimize the power
supply of the local energy infrastructure, which includes electricity,
natural gas, fuel oil and district heating as energy carriers. Unique
features of the model are the integration of RES and the adoption of
Feed-in Tariffs into one optimization stage. Sensitivity studies are
carried out to examine the system behavior under changing profits
for the feed-in of RES. With a setup of three energy exchanging
regions and a multi-period optimization, the impact of costs and
profits are determined.
Abstract: The Carrier Frequency Offset (CFO) due to timevarying
fading channel is the main cause of the loss of orthogonality
among OFDM subcarriers which is linked to inter-carrier interference
(ICI). Hence, it is necessary to precisely estimate and compensate the
CFO. Especially for mobile broadband communications, CFO and
channel gain also have to be estimated and tracked to maintain the
system performance. Thus, synchronization pilots are embedded in
every OFDM symbol to track the variations. In this paper, we present
the pilot scheme for both channel and CFO estimation where channel
estimation process can be carried out with only one OFDM symbol.
Additional, the proposed pilot scheme also provides better
performance in CFO estimation comparing with the conventional
orthogonal pilot scheme due to the increasing of signal-tointerference
ratio.
Abstract: The effect of the number of quantum dot (QD) layers
on the saturated gain of doped QD semiconductor optical amplifiers
(SOAs) has been studied using multi-population coupled rate
equations. The developed model takes into account the effect of
carrier coupling between adjacent layers. It has been found that
increasing the number of QD layers (K) increases the unsaturated
optical gain for K
Abstract: Pattern recognition is the research area of Artificial Intelligence that studies the operation and design of systems that recognize patterns in the data. Important application areas are image analysis, character recognition, fingerprint classification, speech analysis, DNA sequence identification, man and machine diagnostics, person identification and industrial inspection. The interest in improving the classification systems of data analysis is independent from the context of applications. In fact, in many studies it is often the case to have to recognize and to distinguish groups of various objects, which requires the need for valid instruments capable to perform this task. The objective of this article is to show several methodologies of Artificial Intelligence for data classification applied to biomedical patterns. In particular, this work deals with the realization of a Computer-Aided Detection system (CADe) that is able to assist the radiologist in identifying types of mammary tumor lesions. As an additional biomedical application of the classification systems, we present a study conducted on blood samples which shows how these methods may help to distinguish between carriers of Thalassemia (or Mediterranean Anaemia) and healthy subjects.
Abstract: Synchronization is a difficult problem in CDMA
satellite communications. Due to the influence of additive noise and
fading in the mobile channel, it is not easy to keep up with the
attenuation and offset. This paper considers a recently proposed
approach to solve the problem of synchronization chaotic Chen
system in CDMA satellite communication in the presence of constant
attenuation and offset. An analytic algorithm that provides closed
form channel and carrier offset estimates is presented. The principle
of this approach is based on adding a compensation block before the
receiver to compensate the distortion of the imperfect channel by
using genetic algorithm.
The resultants presented, show that the receiver is able to recover
rapidly the synchronization with the transmitter.
Abstract: In this paper we propose a new criterion for solving
the problem of channel shortening in multi-carrier systems. In a
discrete multitone receiver, a time-domain equalizer (TEQ) reduces
intersymbol interference (ISI) by shortening the effective duration of
the channel impulse response. Minimum mean square error (MMSE)
method for TEQ does not give satisfactory results. In [1] a new
criterion for partially equalizing severe ISI channels to reduce the
cyclic prefix overhead of the discrete multitone transceiver (DMT),
assuming a fixed transmission bandwidth, is introduced. Due to
specific constrained (unit morm constraint on the target impulse
response (TIR)) in their method, the freedom to choose optimum
vector (TIR) is reduced. Better results can be obtained by avoiding
the unit norm constraint on the target impulse response (TIR). In
this paper we change the cost function proposed in [1] to the cost
function of determining the maximum of a determinant subject to
linear matrix inequality (LMI) and quadratic constraint and solve the
resulting optimization problem. Usefulness of the proposed method
is shown with the help of simulations.
Abstract: This paper proposes a synchronized random switching frequency pulse width modulation (SRSFPWM). In this technique, the clock signal is used to control the random noise frequency which is produced by the feedback voltage of a hysteresis circuit. These make the triangular carrier frequency equaling to the random noise frequency in each switching period with the symmetrical positive and negative slopes of triangular carrier. Therefore, there is no error voltage in PWM signal. The PSpice simulated results shown the proposed technique improved the performance in case of low frequency harmonics of PWM signal comparing with conventional random switching frequency PWM.
Abstract: Extraction of lactic acid by emulsion liquid membrane technology (ELM) using n-trioctyl amine (TOA) in n-heptane as carrier within the organic membrane along with sodium carbonate as acceptor phase was optimized by using response surface methodology (RSM). A three level Box-Behnken design was employed for experimental design, analysis of the results and to depict the combined effect of five independent variables, vizlactic acid concentration in aqueous phase (cl), sodium carbonate concentration in stripping phase (cs), carrier concentration in membrane phase (ψ), treat ratio, and batch extraction time (τ)
with equal volume of organic and external aqueous phase on lactic acid extraction efficiency. The maximum lactic acid extraction efficiency (ηext) of 98.21%from aqueous phase in a batch reactor using ELM was found at the optimized values for test variables, cl, cs, ψ, and τ as 0.06 [M], 0.18 [M], 4.72 (%,v/v), 1.98 (v/v) and 13.36 min respectively.
Abstract: The paper presents the design concept of a unitselection
text-to-speech synthesis system for the Slovenian language.
Due to its modular and upgradable architecture, the system can be
used in a variety of speech user interface applications, ranging from
server carrier-grade voice portal applications, desktop user interfaces
to specialized embedded devices.
Since memory and processing power requirements are important
factors for a possible implementation in embedded devices, lexica
and speech corpora need to be reduced. We describe a simple and
efficient implementation of a greedy subset selection algorithm that
extracts a compact subset of high coverage text sentences. The
experiment on a reference text corpus showed that the subset
selection algorithm produced a compact sentence subset with a small
redundancy.
The adequacy of the spoken output was evaluated by several
subjective tests as they are recommended by the International
Telecommunication Union ITU.
Abstract: The range of the output power is a very important and evident limitation of two-level inverters. In order to overcome this disadvantage, multilevel inverters are introduced. Recently, Cascade H-Bridge inverters have emerged as one of the popular converter topologies used in numerous industrial applications. The modulation switching strategies such as phase shifted carrier based Pulse Width Modulation (PWM) technique and Stair case modulation with Selective Harmonic Elimination (SHE) PWM technique are generally used. NR method is used to solve highly non linear transcendental equations which are formed by SHEPWM method. Generally NR method has a drawback of requiring good initial guess but in this paper a new approach is implemented for NR method with any random initial guess. A three phase CHB 11-level inverter is chosen for analysis. MATLAB/SIMULINK programming environment and harmonic profiles are compared. Finally this paper presents a method at fundamental switching frequency with least % THDV.
Abstract: The aim of this paper is to emphasize and alleviate the effect of phase noise due to imperfect local oscillators on the performances of a Multi-Carrier CDMA system. After the cancellation of Common Phase Error (CPE), an iterative approach is introduced which iteratively estimates Inter-Carrier Interference (ICI) components in the frequency domain and cancels their contribution in the time domain. Simulation are conducted in order to investigate the achievable performances for several parameters, such as the spreading factor, the modulation order, the phase noise power and the transmission Signal-to-Noise Ratio.
Abstract: One of the disadvantages of using OFDM is the larger
peak to averaged power ratio (PAPR) in its time domain signal. The
larger PAPR signal would course the fatal degradation of bit error
rate performance (BER) due to the inter-modulation noise in the nonlinear
channel. This paper proposes an improved DSI (Dummy
Sequence Insertion) method, which can achieve the better PAPR and
BER performances. The feature of proposed method is to optimize
the phase of each dummy sub-carrier so as to reduce the PAPR
performance by changing all predetermined phase coefficients in the
time domain signal, which is calculated for data sub-carriers and
dummy sub-carriers separately. To achieve the better PAPR
performance, this paper also proposes to employ the time-frequency
domain swapping algorithm for fine adjustment of phase coefficient
of the dummy subcarriers, which can achieve the less complexity of
processing and achieves the better PAPR and BER performances
than those for the conventional DSI method. This paper presents
various computer simulation results to verify the effectiveness of
proposed method as comparing with the conventional methods in the
non-linear channel.
Abstract: A new supported liquid membrane (SLM) system for
the selective transport of VO2
+ ions was prepared in this present
work. The SLM was a thin porous polyvinylidene difluoride
(PVDF) membrane soaked with Di-(2-ethylhexyl) phosphoric acid
(D2EHPA) as mobile carrier in Xylene as organic solvent.
D2EHPA acts as a highly selective carrier for the uphill transport of
VO2
+ ions through the SLM. The transport of VO2
+ ions reached to
64%. In the presence of P2O7-2 ion as suitable masking agent in the
feed solution, the interfering effects of other cations were eliminated.
Abstract: In this paper we propose a blind algorithm for peakto- average power ratio (PAPR) reduction in OFDM systems, based on selected mapping (SLM) algorithm as a distortionless method. The main drawback of the conventional SLM technique is the need for transmission of several side information bits, for each data block, which results in loss in data rate transmission. In the proposed method some special number of carriers in the OFDM frame is reserved to be rotated with one of the possible phases according to the number of phase sequence blocks in SLM algorithm. Reserving some limited number of carriers wont effect the reduction in PAPR of OFDM signal. Simulation results show using ML criteria at the receiver will lead to the same system-performance as the conventional SLM algorithm, while there is no need to send any side information to the receiver.
Abstract: This article discusses the questions concerning of creating small packet networks for energy companies with application of high voltage power line carrier equipment (PLC) with functionality of IP traffic transmission. The main idea is to create converged PLC links between substations and dispatching centers where packet data and voice are transmitted in one data flow. The article contents description of basic conception of the network, evaluation of voice traffic transmission parameters, and discussion of header compression techniques in relation to PLC links. The results of exploration show us, that convergent packet PLC links can be very useful in the construction of small packet networks between substations in remote locations, such as deposits or low populated areas.
Abstract: In this paper, we proposed the effects of Mo thickness
on the properties of AZO/Mo/AZO multilayer thin films for
opto-electronics applications. The structural, optical and electrical
properties of AZO/Mo/AZO thin films were investigated.
Optimization of the thin films coatings resulted with low resistivity of
9.98 × 10-5 )-cm, mobility of 12.75 cm2/V-s, carrier concentration of
1.05 × 1022 cm-3, maximum transmittance of 79.13% over visible
spectrum of 380 – 780 nm and Haacke figure of merit (FOM) are 5.95
× 10-2 )-1 under Mo layer thickness of 15 nm. These results indicate an
alternative candidate for use as a transparent electrode in solar cells
and various displays applications.
Abstract: Polymeric microreactors have emerged as a new
generation of carriers that hold tremendous promise in the areas of
cancer therapy, controlled delivery of drugs, for removal of
pollutants etc. Present work reports a simple and convenient
methodology for synthesis of polystyrene and poly caprolactone
microreactors. An aqueous suspension of carboxylated (1μm)
polystyrene latex particles was mixed with toluene solution followed
by freezing with liquid nitrogen. Freezed particles were incubated at
-20°C and characterized for formation of voids on the surface of
polymer microspheres by Field Emission Scanning Electron
Microscope. The hollow particles were then overnight incubated at
40ºC with unfunctionalized quantum dots (QDs) in 5:1 ratio. QDs
Encapsulated polystyrene microcapsules were characterized by
fluorescence microscopy.
Likewise Poly ε-caprolactone microreactors were prepared by
micro-volcanic rupture of freeze dried microspheres synthesized
using emulsification of polymer with aqueous Poly vinyl alcohol and
freezed with liquid nitrogen. Microreactors were examined with Field
Emission Scanning Electron Microscope for size and morphology.
Current study is an attempt to create hollow polymer particles which
can be employed for microencapsulation of nanoparticles and drug
molecules.