Synthesis and Use of Thiourea Derivative (1-Phenyl-3- Benzoyl-2-Thiourea) for Extraction of Cadmium Ion
The environmental pollution by heavy metals became
more problematic nowadays. To solve the problem of Cadmium
accumulation in human organs which lead to dangerous effects on
human health, and to determine its concentration, the organic legand
1-phenyl-3-benzoyl-2-thiourea was used to extract the cadmium ions
from its solution. This legand as one of thiourea derivatives was
successfully synthesized. The legand was characterized by NMR and
CHN elemental analysis, and used to extract the cadmium from its
solutions by formation of a stable complex at neutral pH. The
complex was characterized by elemental analysis and melting point.
The concentrations of cadmium ions before and after the extraction
were determined by Atomic Absorption Spectrophotometer (AAS).
The data show the percentage of the extract was more than 98.7% of
the concentration of cadmium used in the study
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[5] M. Kodomari, M. Suzuki, K. Tanigawa and T. Aoyama, Tetrahedron
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[6] J. S. Ren, J. Diprose, J. Warren, R.M. Esnouf, L.E. Bird, S. Ikemizu, M.
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[7] F. T. Elmali, U. Avciata and N. Demirhan, Main Group Chemistry 2011,
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[9] M. Struga, J. Kossakowski, E. Kedzierska, S. Fidecka, and J. Stefanska,
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[10] A. D. Desai, D. H. Mahajan, and K. H. Chikhalia, Ind. J. of Chem.,
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[11] R. B. Patel, K. H. Chikhalia, C. Pannecouque, and E. D. Clercq, J. Braz.
Chem. Soc., 2007, 18(2): 312-321.
[12] G. A. Kilcigil, and N. Altanlar, Turk J. Chem., 2006, 30: 223-228.
[13] S. Xue, J. Shan Zou, and H. Yong, Chin. Chem. Letters, 2000, 11(1), 19-
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[14] C. Fengling, C. Yanrui, L. Hongxia, Y. Xiaojun, F. Jing, and L. Yan,
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[15] K. R. Koch, Coord. Chem. Rev., 2001, vol. 216-217, pp. 473–488,.
[16] S. Saeed, N. Rashid, M. H. Bhatti, and P. G. Jones, Turk J. Chem., 2010,
34(5),761–770.
[17] H. Arslan, U. Florke, N. Kulcu, and E. Kayhan, Turk J. Chem., 2006, 30:
429-440.
[18] G. Avsar, H. Arslan, H. J. Haupt, and N. Kulcu, Turk J. Chem., 2003,
27: 281-285.
[19] H. Arsalan, and N. kuku, Transition metal Chemistry, 2003, 28: 816-
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[20] B. H. Abdullah and Y. M. Salh, Oriental J. Chem., 2010, 26(3), 763-
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[21] C. W. Sun and X. D. Zhang, Chin. J. Struc. Chem., 2007, 26(2), 153–
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[22] A. Saeed, R. A. Khera, N. Abbas, M. Latif, I. Sajid, and U. Flörke, Turk
J. Chem., 2010, 34(3), 335–345,.
[23] S. Saeed, N. Rashid, M. Ali, and R. Hussain, Europ. J. Chem., 2010,
1(3), 200–205.
[24] M. Eweis, S. S. Elkholy, and M. Z. Elsabee, Inter. J. Biol. Macromolec,
2006, 38(1), 1–8.
[25] D. Sriram, P. Yogeeswari, M. Dinakaran, and R. irumurugan, Journal of
Antimicrobial Chemotherapy, 2007, 59(6), 1194–1196.
[26] B. K. Kaymakcioglu, S. Rollas, and F. Kartal-Aricioglu, Europ. J. Drug
Metabo. and Pharmacokinetics, 2003, 28(4), 273–278,.
[27] M. G. Soung, K. Y. Park, J. H. Song, and N. D. Sung, J. Kore. Soc.
Appl. Biolo. Chem., 2008, 51(3), 219–222.
[28] A. Saeed and M. Batool, Medic. Chem. Res., 2007, 16(3), 143–154.
[29] S. Saeed, N. Rashid, M. Ali, R. Hussain, and P. G. Jones, Europ. J.
Chem., 2010, 1(3), 221–227.
[30] D. K. Das, Fres. J. Anal. Chem., 1984, 318(8), 612.
[31] S. C. Shome, M. Mazumdar, and P. K. Haldar, J. Ind. Chem. Soc., 1980,
57(2), 139–141.
[32] G. Binzet, B. Zeybek, E. Kılıç, N. Külcü, and H. Arslan, J. Chem., 2013,
7 pages.
[33] A. Hakan, K. Nevzat, F. Ulrich. Spectrochimica Acta, 2006, Part A 64,
1065.
[34] O. A. Hassan, A. M. Otaiwi and A. Abeer, Natio. J. Chem., 2008: 31,
501-513.
[35] H. Arslan, N. Duran, G. Borekci, C. K. Ozer, and C. Akbay, Molecul.,
2009, 14: 519-527.
[36] H. A. Dondas, Y. Nural, N. Duran, and C. Kilner, Turk J. Chem., 2006,
30: 573-583.
[37] M. S. Rathod and S. Z. Jadhao, J. Chem. and Pharm. Res., 2012, 4(3),
1629-1631.
[38] W. Henderson, B. K. Nicholson, and C. E. F. Rickard, Inorg. Chim.
Acta, 2001, 320: 101- 109.
[39] C. D. Badiceanu, C. Draghici and A. Missir Rev. Roum. Chim., 2010,
55(6), 307-311
[40] G. Y. Sarkis and E. D. Faisal, J. Heteerocyclic chem., 1985, 22, 137.
J. Gilbert, 1984. Analysis of food contamination. Elsevier App. Sci.
Pups., London 1.
[2] S. Edrah, J. Appl. Scien. R, 2010, 4(8): 1014-1018.
[3] W. Rabb, J. Appl. Cosmetol, 1997, 15(4): 115-123.
[4] C. Alkan, Y. Tek and D. Kahraman, Turk J Chem, 2011, 35, 769 – 777.
[5] M. Kodomari, M. Suzuki, K. Tanigawa and T. Aoyama, Tetrahedron
Lett, 2005, 46, 5841.
[6] J. S. Ren, J. Diprose, J. Warren, R.M. Esnouf, L.E. Bird, S. Ikemizu, M.
Slater, J. Milton, J. Balzarini, D.L. Stuart and D.K. Stammers, J Biol
Chem 2000, 275, 5633.
[7] F. T. Elmali, U. Avciata and N. Demirhan, Main Group Chemistry 2011,
10: 17–23
[8] A. R. Katritzky and M. F. Gordeev, J. Chem. Soc., Perkin 1991, 1: 2199-
2203.
[9] M. Struga, J. Kossakowski, E. Kedzierska, S. Fidecka, and J. Stefanska,
Chem. Pharm. Bull, 2007, 55(5): 796-799.
[10] A. D. Desai, D. H. Mahajan, and K. H. Chikhalia, Ind. J. of Chem.,
2007, 46B: 1169-1173.
[11] R. B. Patel, K. H. Chikhalia, C. Pannecouque, and E. D. Clercq, J. Braz.
Chem. Soc., 2007, 18(2): 312-321.
[12] G. A. Kilcigil, and N. Altanlar, Turk J. Chem., 2006, 30: 223-228.
[13] S. Xue, J. Shan Zou, and H. Yong, Chin. Chem. Letters, 2000, 11(1), 19-
20.
[14] C. Fengling, C. Yanrui, L. Hongxia, Y. Xiaojun, F. Jing, and L. Yan,
Chinese Science Bulletin, 2006, 51(18): 2201-2207.
[15] K. R. Koch, Coord. Chem. Rev., 2001, vol. 216-217, pp. 473–488,.
[16] S. Saeed, N. Rashid, M. H. Bhatti, and P. G. Jones, Turk J. Chem., 2010,
34(5),761–770.
[17] H. Arslan, U. Florke, N. Kulcu, and E. Kayhan, Turk J. Chem., 2006, 30:
429-440.
[18] G. Avsar, H. Arslan, H. J. Haupt, and N. Kulcu, Turk J. Chem., 2003,
27: 281-285.
[19] H. Arsalan, and N. kuku, Transition metal Chemistry, 2003, 28: 816-
819.
[20] B. H. Abdullah and Y. M. Salh, Oriental J. Chem., 2010, 26(3), 763-
773.
[21] C. W. Sun and X. D. Zhang, Chin. J. Struc. Chem., 2007, 26(2), 153–
156.
[22] A. Saeed, R. A. Khera, N. Abbas, M. Latif, I. Sajid, and U. Flörke, Turk
J. Chem., 2010, 34(3), 335–345,.
[23] S. Saeed, N. Rashid, M. Ali, and R. Hussain, Europ. J. Chem., 2010,
1(3), 200–205.
[24] M. Eweis, S. S. Elkholy, and M. Z. Elsabee, Inter. J. Biol. Macromolec,
2006, 38(1), 1–8.
[25] D. Sriram, P. Yogeeswari, M. Dinakaran, and R. irumurugan, Journal of
Antimicrobial Chemotherapy, 2007, 59(6), 1194–1196.
[26] B. K. Kaymakcioglu, S. Rollas, and F. Kartal-Aricioglu, Europ. J. Drug
Metabo. and Pharmacokinetics, 2003, 28(4), 273–278,.
[27] M. G. Soung, K. Y. Park, J. H. Song, and N. D. Sung, J. Kore. Soc.
Appl. Biolo. Chem., 2008, 51(3), 219–222.
[28] A. Saeed and M. Batool, Medic. Chem. Res., 2007, 16(3), 143–154.
[29] S. Saeed, N. Rashid, M. Ali, R. Hussain, and P. G. Jones, Europ. J.
Chem., 2010, 1(3), 221–227.
[30] D. K. Das, Fres. J. Anal. Chem., 1984, 318(8), 612.
[31] S. C. Shome, M. Mazumdar, and P. K. Haldar, J. Ind. Chem. Soc., 1980,
57(2), 139–141.
[32] G. Binzet, B. Zeybek, E. Kılıç, N. Külcü, and H. Arslan, J. Chem., 2013,
7 pages.
[33] A. Hakan, K. Nevzat, F. Ulrich. Spectrochimica Acta, 2006, Part A 64,
1065.
[34] O. A. Hassan, A. M. Otaiwi and A. Abeer, Natio. J. Chem., 2008: 31,
501-513.
[35] H. Arslan, N. Duran, G. Borekci, C. K. Ozer, and C. Akbay, Molecul.,
2009, 14: 519-527.
[36] H. A. Dondas, Y. Nural, N. Duran, and C. Kilner, Turk J. Chem., 2006,
30: 573-583.
[37] M. S. Rathod and S. Z. Jadhao, J. Chem. and Pharm. Res., 2012, 4(3),
1629-1631.
[38] W. Henderson, B. K. Nicholson, and C. E. F. Rickard, Inorg. Chim.
Acta, 2001, 320: 101- 109.
[39] C. D. Badiceanu, C. Draghici and A. Missir Rev. Roum. Chim., 2010,
55(6), 307-311
[40] G. Y. Sarkis and E. D. Faisal, J. Heteerocyclic chem., 1985, 22, 137.
@article{"International Journal of Chemical, Materials and Biomolecular Sciences:66196", author = "Abdulfattah M. Alkherraz and Zaineb I. Lusta and Ahmed E. Zubi", title = "Synthesis and Use of Thiourea Derivative (1-Phenyl-3- Benzoyl-2-Thiourea) for Extraction of Cadmium Ion", abstract = "The environmental pollution by heavy metals became
more problematic nowadays. To solve the problem of Cadmium
accumulation in human organs which lead to dangerous effects on
human health, and to determine its concentration, the organic legand
1-phenyl-3-benzoyl-2-thiourea was used to extract the cadmium ions
from its solution. This legand as one of thiourea derivatives was
successfully synthesized. The legand was characterized by NMR and
CHN elemental analysis, and used to extract the cadmium from its
solutions by formation of a stable complex at neutral pH. The
complex was characterized by elemental analysis and melting point.
The concentrations of cadmium ions before and after the extraction
were determined by Atomic Absorption Spectrophotometer (AAS).
The data show the percentage of the extract was more than 98.7% of
the concentration of cadmium used in the study
", keywords = "Thiourea derivatives, cadmium extraction.", volume = "8", number = "2", pages = "99-3", }