Optimization of Extraction of Phenolic Compounds from Avicennia marina (Forssk.)Vierh using Response Surface Methodology
Optimization of extraction of phenolic compounds
from Avicennia marina using response surface methodology was
carried out during the present study. Five levels, three factors
rotatable design (CCRD) was utilized to examine the optimum
combination of extraction variables based on the TPC of Avicennia
marina leaves. The best combination of response function was 78.41
°C, drying temperature; 26.18°C; extraction temperature and 36.53
minutes of extraction time. However, the procedure can be promptly
extended to the study of several others pharmaceutical processes like
purification of bioactive substances, drying of extracts and
development of the pharmaceutical dosage forms for the benefit of
consumers.
[1] P. B. Tomlinson, The Botany of Mangroves, Cambridge University
Press. New York, USA, 163-170, 1994.
[2] W. M. Bandarnayake, "Bioactivities, bioactive compounds and chemical
constituents of mangrove plants", Wetlands Ecol. Manage, 10: 421-452,
2002.
[3] D. H. Miles, U. Kokpol, V. Chittawong, S. Tip-Pyang, K. Tunsuwan,
and C. Nguyen, "Mangrove forests-The importance of conservation as a
bioresource for ecosystem diversity and utilization as a source of
chemical constituents with potential medicinal and agricultural value",
1999 IUPAC 70 (11): 1-9, 1998.
[4] P. Maisuthisakul, M. Suttajit, and R. Pongsawatmanit, "Assessment of
phenolic content and free radical-scavenging capacity of some Thai
indigenous plants", Food Chem., 100: 1409-1418, 2007.
[5] C. Vioux-Chagnoleau, F. Lejeune, J. Sok, C. Pierrard, C. Marionnet,
and F. Bernerd, "Reconstructed human skin: from photodamage to
sunscreen photoprotection and anti-aging molecules", J. Dermatol. Sci.
(Supplement), 2(1): S1-S12, 2006.
[6] S. Surveswaran, Y. Z. Cai, H. Corke, and M. Sun, "Systematic
evaluation of natural phenolic antioxidants from 133 Indian medicinal
plants", Journal of Food Chemistry 102: 938-953, 2007.
[7] C. Alasalvar, M. Karamac, R. Amarowicz, and F. Shahidi, "Antioxidant
and Antiradical Activities in Extracts of Hazelnut Kernel (Corylus
avellana L.) And Hazelnut Green Leafy Cover", Journal of Agriculture
and Food Chemistry 54: 4826-4832, 2006.
[8] E. A. Audi, E. J. V. Campos, M. Rufino, D.G. Cortez, C. A. Bersani-
Amado, L. A. L. Soares, P. R. Petrovick, and J. C. P. Mello, "Petiveria
alliacea L.: Plant drug quality control, hydroalcoholic extract
standardization and pharmacological assay of lyophilized extract", Acta
Farmaceutica Bonaerense, 20 (3), 225-232, 2001.
[9] W. Cui, G. Mazza, B. D. Oomah, and C. G. Billiaderis, "Optimization
of anaqueous extraction process for flaxseed gum by response surface
methodology", Lebensmittel-Wissenschaft und-Technologie, 27, 363-
369, 1994.
[10] P.O. Haaland, Experimental Design in Biotechnology, Marcel Dekker,
New York. PP. 1-18, 1989.
[11] G.E.P. Box, W.G. Hunter, and J.S. Hunter, Statistics for Experimenters:
an introduction to design, data analysis, and model building, New York,
John Wiley, 1978.
[12] R. H. Myers, and D. C. Montgomery, "Response surface methodology,
process and product optimization using designed experiments (2nd Ed.).
New York, NY: John Wiley and Sons, 1995.
[13] M. H. Canteri-Schemin, H. C. R. Fertonani, N. Waszczynskyj, and G.
Wosiacki, "Extraction of pectin from apple pomace", Brazilian Archives
of Biology and Technology, 48 (2), 259-266, 2005.
[14] L. A. L. Soares, G. González Ortega, P. R. Petrovick, and P. C. Schmidt,
"Optimization of Tablets Containing a High Dose of Spray-Dried Plant
Extract: A Technical Note. AAPSPharmSciTech 6(3), 368-371, 2005.
[15] Y.Y. Lim, T. T. Lim, and J. J. Tee, "Antioxidant properties of several
tropical fruits: A comparative studies", Food Chemistry 103: 1003-1008,
2007.
[16] R. H. Myers, and D. C. Montgomery, "Response surface methodology:
Process and product optimization using designed experiments," p. 32.
New York, USA: Wiley, 2002.
[17] N. Peatciyammal, B. Balachandar, M. Dinesh Kumar, K. Tamilarasan,
and C. Muthukumaran, "Statistical Optimization of Enzymatic
Hydrolysis of Potato (Solanum tuberosum) Starch by Immobilized ╬▒-
amylase", International Journal of Chemical and Biological
Engineering, 3:3, 2010.
[18] A.M. Joglekar, and A.T. May, "Product excellence through design of
experiments", Cereal Food World, 32: 857-868, 1987.
[1] P. B. Tomlinson, The Botany of Mangroves, Cambridge University
Press. New York, USA, 163-170, 1994.
[2] W. M. Bandarnayake, "Bioactivities, bioactive compounds and chemical
constituents of mangrove plants", Wetlands Ecol. Manage, 10: 421-452,
2002.
[3] D. H. Miles, U. Kokpol, V. Chittawong, S. Tip-Pyang, K. Tunsuwan,
and C. Nguyen, "Mangrove forests-The importance of conservation as a
bioresource for ecosystem diversity and utilization as a source of
chemical constituents with potential medicinal and agricultural value",
1999 IUPAC 70 (11): 1-9, 1998.
[4] P. Maisuthisakul, M. Suttajit, and R. Pongsawatmanit, "Assessment of
phenolic content and free radical-scavenging capacity of some Thai
indigenous plants", Food Chem., 100: 1409-1418, 2007.
[5] C. Vioux-Chagnoleau, F. Lejeune, J. Sok, C. Pierrard, C. Marionnet,
and F. Bernerd, "Reconstructed human skin: from photodamage to
sunscreen photoprotection and anti-aging molecules", J. Dermatol. Sci.
(Supplement), 2(1): S1-S12, 2006.
[6] S. Surveswaran, Y. Z. Cai, H. Corke, and M. Sun, "Systematic
evaluation of natural phenolic antioxidants from 133 Indian medicinal
plants", Journal of Food Chemistry 102: 938-953, 2007.
[7] C. Alasalvar, M. Karamac, R. Amarowicz, and F. Shahidi, "Antioxidant
and Antiradical Activities in Extracts of Hazelnut Kernel (Corylus
avellana L.) And Hazelnut Green Leafy Cover", Journal of Agriculture
and Food Chemistry 54: 4826-4832, 2006.
[8] E. A. Audi, E. J. V. Campos, M. Rufino, D.G. Cortez, C. A. Bersani-
Amado, L. A. L. Soares, P. R. Petrovick, and J. C. P. Mello, "Petiveria
alliacea L.: Plant drug quality control, hydroalcoholic extract
standardization and pharmacological assay of lyophilized extract", Acta
Farmaceutica Bonaerense, 20 (3), 225-232, 2001.
[9] W. Cui, G. Mazza, B. D. Oomah, and C. G. Billiaderis, "Optimization
of anaqueous extraction process for flaxseed gum by response surface
methodology", Lebensmittel-Wissenschaft und-Technologie, 27, 363-
369, 1994.
[10] P.O. Haaland, Experimental Design in Biotechnology, Marcel Dekker,
New York. PP. 1-18, 1989.
[11] G.E.P. Box, W.G. Hunter, and J.S. Hunter, Statistics for Experimenters:
an introduction to design, data analysis, and model building, New York,
John Wiley, 1978.
[12] R. H. Myers, and D. C. Montgomery, "Response surface methodology,
process and product optimization using designed experiments (2nd Ed.).
New York, NY: John Wiley and Sons, 1995.
[13] M. H. Canteri-Schemin, H. C. R. Fertonani, N. Waszczynskyj, and G.
Wosiacki, "Extraction of pectin from apple pomace", Brazilian Archives
of Biology and Technology, 48 (2), 259-266, 2005.
[14] L. A. L. Soares, G. González Ortega, P. R. Petrovick, and P. C. Schmidt,
"Optimization of Tablets Containing a High Dose of Spray-Dried Plant
Extract: A Technical Note. AAPSPharmSciTech 6(3), 368-371, 2005.
[15] Y.Y. Lim, T. T. Lim, and J. J. Tee, "Antioxidant properties of several
tropical fruits: A comparative studies", Food Chemistry 103: 1003-1008,
2007.
[16] R. H. Myers, and D. C. Montgomery, "Response surface methodology:
Process and product optimization using designed experiments," p. 32.
New York, USA: Wiley, 2002.
[17] N. Peatciyammal, B. Balachandar, M. Dinesh Kumar, K. Tamilarasan,
and C. Muthukumaran, "Statistical Optimization of Enzymatic
Hydrolysis of Potato (Solanum tuberosum) Starch by Immobilized ╬▒-
amylase", International Journal of Chemical and Biological
Engineering, 3:3, 2010.
[18] A.M. Joglekar, and A.T. May, "Product excellence through design of
experiments", Cereal Food World, 32: 857-868, 1987.
@article{"International Journal of Biological, Life and Agricultural Sciences:51225", author = "V.Bharathi and Jamila Patterson and R.Rajendiran", title = "Optimization of Extraction of Phenolic Compounds from Avicennia marina (Forssk.)Vierh using Response Surface Methodology", abstract = "Optimization of extraction of phenolic compounds
from Avicennia marina using response surface methodology was
carried out during the present study. Five levels, three factors
rotatable design (CCRD) was utilized to examine the optimum
combination of extraction variables based on the TPC of Avicennia
marina leaves. The best combination of response function was 78.41
°C, drying temperature; 26.18°C; extraction temperature and 36.53
minutes of extraction time. However, the procedure can be promptly
extended to the study of several others pharmaceutical processes like
purification of bioactive substances, drying of extracts and
development of the pharmaceutical dosage forms for the benefit of
consumers.", keywords = "Avicennia marina, Central Composite RotatableDesign (CCRD), Response Surface Methodology, Total Phenoliccontents (TPC)", volume = "5", number = "8", pages = "426-5", }
