New Complexes of Nickel (II) Using 4-Hydroxy-2-Oxo-2H-Chromene-3-Carboxamide as Ligand

New complexes of nickel (II) have been synthesized in the reaction mixture of nickel (II) acetate and 4-hydroxy-2-oxo-2H-chromene-3-carboxamide. Bis(4-hydroxy-2-oxo-2H-chromene-3-carboxamidato-O,O)nickel (II) and diaquabis(4-hydroxy-2-oxo-2H-chromene-3-carboxamidato-O,O)nickel (II) were characterized by elemental analysis, IR spectroscopy and ESI mass spectrometry. Elemental analysis and mass spectrometry data of the complexes suggests the stoichiometry of 1:2 (metal-ligand).

• Dije Dehari
• Ahmed Jashari
• Shefket Dehari
• Agim Shabani

• Nickel complexes
• 4-hydroxy-2-oxo-2H-chromene-3-carboxamide
• IR spectroscopy
• mass spectrometry.

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<li value="NaN">H. Scarborough, W. Gould, The Reaction of Urea with Cyclic 1,3-Dicarbonyl and Other Active Hydrogen Compounds. <em>J. Org. Chem.</em>, vol. 26, no.10, pp. 3720-3723, 1961.</li>
<li value="NaN">M. Al-Haiza, M. Mostafa, M. El-Kady, Synthesis and Biological Evaluation of Some New Coumarin Derivatives. <em>Molecules</em>, vol. 8, pp. 275-286, 2003.</li>
<li value="NaN">C. Dutton, J. Sutcliffe, B. Yang, 4-Hydroxy coumarin derivatives with antibacterial activity. PCT Int. Appl. US1993/006308, 1994.</li>
<li value="NaN">V. Parmar, K. Bisht, R. Jain, S. Singh, S. Sharma, S. Gupta, S. Malhotra, O.Tyagi, A. Vardhan, H. Pati, D. Berghe, A. Vlietinck, Synthesis, Antimicrobial and Antiviral Activities of Novel Polyphenolic Compounds. <em>Ind. J. Chem.</em> Sec. B, vol. 35, pp. 220-232, 1996.</li>
<li value="NaN">T. Ishikawa, K. Kotake, H. Ishii, Synthesis of Toddacoumaquinone, a Coumarin-Naphthoquinone Dimer and Its Antiviral Activities. <em>Chemical &amp; Pharmaceutical Bulletin</em>, vol. 43, no. 6, pp. 1039-1041, 1995.</li>
<li value="NaN">A. El-Sayed, O. Abd-Allah, Synthetic and biological studies on coumarinhydrazone derivatives. <em>Phosporus, Sulfur and Silicon Relat. Elem., </em>vol. 170, pp. 75-86, 2001.</li>
<li value="NaN">A. El-Agrody, M. Abd El-Latif, N. El-Hady, A. Fakery, A. Bedair, Heteroaromatization with 4-Hydroxycoumarin Part II: Synthesis of Some New Pyrano[2,3-d]pyrimidines,[1,2,4]triazolo[1,5-c]pyrimidines and Pyrimido[1,6-b]-[1,2,4]triazine Derivatives. <em>Molecules,</em> vol. 6, pp. 519-527, 2001.</li>
<li value="NaN">A. Emmanuel-Giota, K. Fylaktakidou, D. Litina, K. Litinas, D. Nicolaides, Synthesis and biological evaluation of several 3-(coumarin-4-yl)tetrahydroisoxazole and 3-(coumarin-4-yl)dihydropyrazole derivatives. <em>J. Heterocyclic Chem.,</em> vol. 38, pp. 717-722, 2001.</li>
<li value="NaN">W. Barker, M. Hermodson, K. Link, 4-Hydroxycoumarins. Synthesis of the metabolites and some other derivatives of warfarin. <em>J. Med. Chem.</em>, vol. 14, pp. 167-169, 1971.</li>
<li value="NaN">Z. Nofal, M. El-Zahar, S. El-Karim, Novel Coumarin Derivatives with Expected Biological Activity. <em>Molecules, </em>vol. 5, pp. 99-113, 2000.</li>
<li value="NaN">L. Raev, E. Voinov, I. Ivanov, D. Popov, Antitumor activity of some coumarin derivatives. <em>Pharmazie,</em> vol. 45, pp. 696-698, 1990.</li>
<li value="NaN">P. Valenti, A. Rampa, M. Recanatini, A. Bisi, F. Belluti, P. Da Re, M. Carrara, L. Cima, Synthesis, cytotoxicity and SAR of simple geiparvarin analogues. <em>Anticancer Drug Des.,</em> vol. 12, no. 6, pp. 443-451, 1997.</li>
<li value="NaN">A. Shah, Y. Naliapara, D. Sureja, N. Motohashi, M. Kawase, C. Miskolci, D. Szabo, J. Molnar, 6,12-Dihydro-1-Benzopyrano[3,4-b][1,4]Benzothiazin-6-ones. Synthesis and MDR Reversal in Tumor Cells. <em>Anticancer research,</em> vol. 18, pp. 3001-3004, 1998.</li>
<li value="NaN">H. Skulnick, P. Johnson, P. Aristoff, J. Morris, K. Lovasz, Structure-Based Design of Nonpeptidic HIV Protease Inhibitors: The Sulfonamide-Substituted Cyclooctylpyranones. <em>J. Med. Chem.,</em> vol. 40, pp. 1149-1164, 1997.</li>
<li value="NaN">C. Spino, M. Dodier, S. Sotheeswaren, Anti-HIV coumarins from calophyllum seed oil. <em>Bioinorg. &amp; Med. Chem. lett.,</em> vol. 8, pp. 3475-3478, 1998.</li>
<li value="NaN">D. Jiang, R. Deng, J. Wu, Synthesis and properties of lanthanide compounds of 3-sulfo-4-hydroxycoumarin. <em>Wuji Huaxue,</em> vol. 5, pp. 21-28, 1989.</li>
<li value="NaN">R. Deng, J. Wu, L. Long, Lanthanide complexes of bis(4-hydroxy-3-coumarinyl) acetic acid and their anticoagulant action. <em>Bull. Soc. Chim. Belg</em>., vol. 101, pp. 439-443, 1992.</li>
<li value="NaN">I. Kostova, I. Manolov, S. Konstantinov, M. Karaivanova. Synthesis, physicochemical characterisation and cytotoxic screening of new complexes of cerium, lanthanum and neodymium with Warfarin and Coumachlor sodium salts. <em>Eur. J. Med. Chem.,</em> vol. 34, pp. 63-68, 1999.</li>
<li value="NaN"> I. Manolov, I. Kostova, T. Netzeva, S. Konstantinov, M. Karaivanova, Cytotoxic activity of cerium complexes with coumarin derivatives. Molecular modeling of the ligands. <em>Arch. Pharm.,</em> vol. 333, pp. 93-98, 2000.</li>
<li value="NaN"> I. Kostova, G. Momekov, M. Zaharieva, M. Karaivanova, Cytotoxic activity of new lanthanum complexes of bis-coumarins. <em>Eur. J. Med. Chem.,</em> vol. 40, pp. 542&ndash;551, 2005.</li>
<li value="NaN"> I. Kostova, I. Manolov, G. Momekov, Cytotoxic activity of new neodymium (III) complexes of bis-coumarins. <em>Eur. J. Med. Chem., </em>vol. 39, pp. 765&ndash;775, 2004.</li>
<li value="NaN">I. Kostova, I. Manolov, M. Karaivanova, Synthesis, physicchemical characterization, and cytotoxic screening of new zirconium complexes with coumarin derivatives. <em>Arch Pharm.,</em> vol. 334, pp. 157&ndash;162, 2001.</li>
<li value="NaN">E. Pretsch, P. Buhlmann, M. Badertscher, <em>Structure Determination of Organic Compounds,</em> Berlin Heidelberg: Springer-Verlag, 2009, p. 292.</li>
<li value="NaN">E. Pretsch, P. Buhlmann, M. Badertscher, <em>Structure Determination of Organic Compounds,</em> Berlin Heidelberg: Springer-Verlag, 2009, p. 317.</li>
</ol>