Mirror Neuron System Study on Elderly Using Dynamic Causal Modeling fMRI Analysis
Dynamic Causal Modeling (DCM) functional
Magnetic Resonance Imaging (fMRI) is a promising technique to
study the connectivity among brain regions and effects of stimuli
through modeling neuronal interactions from time-series
neuroimaging. The aim of this study is to study characteristics of a
mirror neuron system (MNS) in elderly group (age: 60-70 years old).
Twenty volunteers were MRI scanned with visual stimuli to study a
functional brain network. DCM was employed to determine the
mechanism of mirror neuron effects. The results revealed major
activated areas including precentral gyrus, inferior parietal lobule,
inferior occipital gyrus, and supplementary motor area. When visual
stimuli were presented, the feed-forward connectivity from visual
area to conjunction area was increased and forwarded to motor area.
Moreover, the connectivity from the conjunction areas to premotor
area was also increased. Such findings can be useful for future
diagnostic process for elderly with diseases such as Parkinson-s and
Alzheimer-s.
[1] Friston, K.J., Harrison, L., and Penny, W., 2003, "Dynamic Causal
Modelling", NeuroImage, Vol. 19, pp. 1273-1302.
[2] Friston, K.J., 2002, "What Can Neuroimaging Tell Us Abut Distributed
Circuitry? Ann. Rev", Neuroscience, Vol. 25, pp. 221-250.
[3] Friston, K.J., B├╝chel, C., Fink, G.R., Morris, J., Rolls, E., and Dolan,
R.J., 1997, "Psychophysiological and Modulatory Interactions in
Neuroimaging", NeuroImage, Vol. 6, pp. 218-229.
[4] McIntosh, A.R., Grady, C., Ungerleider, L.G., Haxby, J.V., Rapoport,
S.I., and Horwitz, B., 1994, "Network Analysis of Cortical Visual
Pathways Mapped with Pet", neuroscience, Vol. 14, pp. 655-666.
[5] Fogassi, L., 2011, "The Mirror Neuron System: How Cognitive
Functions Emerge from Motor Organization", Journal of Economic
Behavior & Organization, Vol. 77, pp. 66-75.
[6] Fogassi, L., Ferrari, P.F., Gesierich, B., Rozzi, S., Chersi, F., and
Rizzolatti, G., 2005, "Parietal Lobe: From Action Organization to
Intention Understanding", Science, Vol. 308, pp. 662-667.
[7] Fogassi, L. and Luppino, G., 2005, "Motor Functions of the Parietal
Lobe", Current Opinion in Neurobiology, Vol. 15, pp. 626-631.
[8] Galati, G., Committeri, G., Spitoni, G., Aprile, T., Russo, F.D., Pitzalis,
S., and Pizzamiglio, L., 2008, "A Selective Representation of the
Meaning of Actions in the Auditory Mirror System", NeuroImage, Vol.
40, pp. 1274-1286.
[9] Gallese, V., Fadiga, L., Fogassi, L., and Rizzolatti, G., 1996, "Action
Recognition in the Premotor Cortex", Brain, Vol. 119, 2, pp. 593-609.
[10] Iacoboni, M., 2005, "Neural Mechanisms of Imitation", Current Opinion
in Neurobiology, Vol. 15, 6, pp. 632-637.
[11] Iacoboni, M. and Dapretto, M., 2006, "The Mirror Neuron System and
the Consequences of Its Dysfunction", Nature Reviews Neuroscience,
Vol. 7, 12, pp. 942-951.
[12] Iacoboni, M., Woods, R.P., Brass, M., Bekkering, H., Mazziotta, J.C.,
and Rizzolatti, G., 1999, "Cortical Mechanisms of Human Imitation",
Science, Vol. 286, pp. 2526-2528.
[13] Decety, J., Chaminade, T., Grezes, J., and Meltzoff, A.N., 2002, "A Pet
Exploration of the Neural Mechanisms Involved in Reciprocal
Imitation", NeuroImage, Vol. 15, pp. 265-272.
[14] Fabbri-Destro, M. and Rizzolatti, G., 2008, "Mirror Neurons and Mirror
Systems in Monkeys and Humans", Physiology, Vol. 23, pp. 171-179.
[15] Grafton, S.T., Arbib, M.A., Fadiga, L., and Rizzolatti, G., 1996,
"Localization of Grasp Representations in Humans by Positron Emission
Tomography. 2. Observation Compared with Imagination", Exp. Brain
Res, Vol. 112, pp. 103-111.
[16] Grezes, J., Armony, J.L., Rowe, J., and Passingham, R.E., 2003,
"Activations Related to "Mirror" and "Canonical" Neurones in the
Human Brain: An Fmri Study", NeuroImage, Vol. 18, pp. 928-937.
[17] Lamm, C., Fischer, M.H., and Decety, J., 2007, "Predicting the Actions
of Others Taps into One's Own Somatosensory RepresentationsÔÇöa
Functional Mri Study", Neuropsychologia, Vol. 44, pp. 2480-2491.
[18] Rizzolatti, G., Fogassi, L., and Gallese, V., 2001, "Neurophysiological
Mechanisms Underlying the Understanding and Imitation of Action",
Nat. Rev. Neurosci, Vol. 2, pp. 661-670.
[19] Marreiros, A.C., Kiebel, S.J., and Friston, K.J., 2008, "Dynamic Causal
Modelling for Fmri: A Two-State Model", NeuroImage, Vol., pp. 269-
278.
[1] Friston, K.J., Harrison, L., and Penny, W., 2003, "Dynamic Causal
Modelling", NeuroImage, Vol. 19, pp. 1273-1302.
[2] Friston, K.J., 2002, "What Can Neuroimaging Tell Us Abut Distributed
Circuitry? Ann. Rev", Neuroscience, Vol. 25, pp. 221-250.
[3] Friston, K.J., B├╝chel, C., Fink, G.R., Morris, J., Rolls, E., and Dolan,
R.J., 1997, "Psychophysiological and Modulatory Interactions in
Neuroimaging", NeuroImage, Vol. 6, pp. 218-229.
[4] McIntosh, A.R., Grady, C., Ungerleider, L.G., Haxby, J.V., Rapoport,
S.I., and Horwitz, B., 1994, "Network Analysis of Cortical Visual
Pathways Mapped with Pet", neuroscience, Vol. 14, pp. 655-666.
[5] Fogassi, L., 2011, "The Mirror Neuron System: How Cognitive
Functions Emerge from Motor Organization", Journal of Economic
Behavior & Organization, Vol. 77, pp. 66-75.
[6] Fogassi, L., Ferrari, P.F., Gesierich, B., Rozzi, S., Chersi, F., and
Rizzolatti, G., 2005, "Parietal Lobe: From Action Organization to
Intention Understanding", Science, Vol. 308, pp. 662-667.
[7] Fogassi, L. and Luppino, G., 2005, "Motor Functions of the Parietal
Lobe", Current Opinion in Neurobiology, Vol. 15, pp. 626-631.
[8] Galati, G., Committeri, G., Spitoni, G., Aprile, T., Russo, F.D., Pitzalis,
S., and Pizzamiglio, L., 2008, "A Selective Representation of the
Meaning of Actions in the Auditory Mirror System", NeuroImage, Vol.
40, pp. 1274-1286.
[9] Gallese, V., Fadiga, L., Fogassi, L., and Rizzolatti, G., 1996, "Action
Recognition in the Premotor Cortex", Brain, Vol. 119, 2, pp. 593-609.
[10] Iacoboni, M., 2005, "Neural Mechanisms of Imitation", Current Opinion
in Neurobiology, Vol. 15, 6, pp. 632-637.
[11] Iacoboni, M. and Dapretto, M., 2006, "The Mirror Neuron System and
the Consequences of Its Dysfunction", Nature Reviews Neuroscience,
Vol. 7, 12, pp. 942-951.
[12] Iacoboni, M., Woods, R.P., Brass, M., Bekkering, H., Mazziotta, J.C.,
and Rizzolatti, G., 1999, "Cortical Mechanisms of Human Imitation",
Science, Vol. 286, pp. 2526-2528.
[13] Decety, J., Chaminade, T., Grezes, J., and Meltzoff, A.N., 2002, "A Pet
Exploration of the Neural Mechanisms Involved in Reciprocal
Imitation", NeuroImage, Vol. 15, pp. 265-272.
[14] Fabbri-Destro, M. and Rizzolatti, G., 2008, "Mirror Neurons and Mirror
Systems in Monkeys and Humans", Physiology, Vol. 23, pp. 171-179.
[15] Grafton, S.T., Arbib, M.A., Fadiga, L., and Rizzolatti, G., 1996,
"Localization of Grasp Representations in Humans by Positron Emission
Tomography. 2. Observation Compared with Imagination", Exp. Brain
Res, Vol. 112, pp. 103-111.
[16] Grezes, J., Armony, J.L., Rowe, J., and Passingham, R.E., 2003,
"Activations Related to "Mirror" and "Canonical" Neurones in the
Human Brain: An Fmri Study", NeuroImage, Vol. 18, pp. 928-937.
[17] Lamm, C., Fischer, M.H., and Decety, J., 2007, "Predicting the Actions
of Others Taps into One's Own Somatosensory RepresentationsÔÇöa
Functional Mri Study", Neuropsychologia, Vol. 44, pp. 2480-2491.
[18] Rizzolatti, G., Fogassi, L., and Gallese, V., 2001, "Neurophysiological
Mechanisms Underlying the Understanding and Imitation of Action",
Nat. Rev. Neurosci, Vol. 2, pp. 661-670.
[19] Marreiros, A.C., Kiebel, S.J., and Friston, K.J., 2008, "Dynamic Causal
Modelling for Fmri: A Two-State Model", NeuroImage, Vol., pp. 269-
278.
@article{"International Journal of Biological, Life and Agricultural Sciences:56487", author = "R. Keerativittatayut and B. Kaewkamnerdpong and J. Laothamatas and W. Sungkarat", title = "Mirror Neuron System Study on Elderly Using Dynamic Causal Modeling fMRI Analysis", abstract = "Dynamic Causal Modeling (DCM) functional
Magnetic Resonance Imaging (fMRI) is a promising technique to
study the connectivity among brain regions and effects of stimuli
through modeling neuronal interactions from time-series
neuroimaging. The aim of this study is to study characteristics of a
mirror neuron system (MNS) in elderly group (age: 60-70 years old).
Twenty volunteers were MRI scanned with visual stimuli to study a
functional brain network. DCM was employed to determine the
mechanism of mirror neuron effects. The results revealed major
activated areas including precentral gyrus, inferior parietal lobule,
inferior occipital gyrus, and supplementary motor area. When visual
stimuli were presented, the feed-forward connectivity from visual
area to conjunction area was increased and forwarded to motor area.
Moreover, the connectivity from the conjunction areas to premotor
area was also increased. Such findings can be useful for future
diagnostic process for elderly with diseases such as Parkinson-s and
Alzheimer-s.", keywords = "Mirror Neuron System (MNS), Dynamic Causal
Modeling (DCM), Functional Magnetic Resonance Imaging (fMRI)", volume = "5", number = "10", pages = "603-5", }
