Magnetic Properties and Cytotoxicity of Ga-Mn Magnetic Ferrites Synthesized by the Citrate Sol-Gel Method
Magnetic spinel ferrites are materials that possess size, magnetic properties and heating ability adequate for their potential use in biomedical applications. The Mn0.5Ga0.5Fe2O4 magnetic nanoparticles (MNPs) were synthesized by sol-gel method using citric acid as chelating agent of metallic precursors. The synthesized samples were identified by X-Ray Diffraction (XRD) as an inverse spinel structure with no secondary phases. Saturation magnetization (Ms) of crystalline powders was 45.9 emu/g, which was higher than those corresponding to GaFe2O4 (14.2 emu/g) and MnFe2O4 (40.2 emu/g) synthesized under similar conditions, while the coercivity field (Hc) was 27.9 Oe. The average particle size was 18 ± 7 nm. The heating ability of the MNPs was enough to increase the surrounding temperature up to 43.5 °C in 7 min when a quantity of 4.5 mg of MNPs per mL of liquid medium was tested. Cytotoxic effect (hemolysis assay) of MNPs was determined and the results showed hemolytic values below 1% in all tested cases. According to the results obtained, these synthesized nanoparticles can be potentially used as thermoseeds for hyperthermia therapy.
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[1] Liu, X.L. & Fan, H.M., "Innovative magnetic nanoparticle platform for magnetic resonance imaging and magnetic fluid hyperthermia applications." Current Opinion in Chemical Engineering. 4, 38-46 (2014).
[2] Mornet, S., Vasseur, S., Grasset, F., Veverka, P., Goglio, G., Demourgues, A., Portier, J., Pollert, E. & Duguet, E., "Magnetic nanoparticle design for medical applications." Progress in Solid State Chemistry. 34, 237-247 (2006).
[3] Hergt, R., Dutz, S., Müller, R. & Zeisberger, M., "Magnetic particle hyperthermia: nanoparticle magnetism and materials development for cancer therapy." J. Phys.: Condens. Matter. 18, S2919-S2934 (2006).
[4] Lin, M., Huang, J. & Sha, M., "Recent advances in nanosized Mn–Zn ferrite magnetic fluid hyperthermia for cancer treatment." J. Nanosci. Nanotechnol. 14, 792-802 (2014).
[5] Makridis, A., Chatzitheodorou, I., Topouridou, K., Yavropoulou, M.P., Angelakeris, M. & Dendrinou-Samara, C. "A facile microwave synthetic route for ferrite nanoparticles with direct impact in magnetic particle hyperthermia." Materials Science and Engineering: C. 63, 663-670 (2016).
[6] Verma, S., Khollam, Y.B., Potdar, H.S. & Deshpande, S.B., "Synthesis of nanosized MgFe2O4 powders by microwave hydrothermal method." Materials letters. 58, 1092-1095 (2004).
[7] Kuznetsova, V., Almjasheva, O. & Gusarov, V., "Influence of microwave and ultrasonic treatment on the formation of CoFe2O4 under hydrothermal conditions." Glass Physics and Chemistry. 35, 205-209 (2009).
[8] Manikandan, A., Vijaya, J., Sundararajan, M., Meganathan, C., Kennedy, L. & Bououdina, M., "Optical and magnetic properties of Mg-doped ZnFe2O4 nanoparticles prepared by rapid microwave combustion method." Superlattices and Microstructures. 64, 118-131 (2013).
[9] Wang, Y.M., Cao, X., Liu, G.H., Hong, R.H., Chen, Y.M., & et al., "Synthesis of Fe3O4 magnetic fluid used for magnetic resonance imaging and hyperthermia." Journal of Magnetism and Magnetic Materials. 323, 2953-2959 (2011).
[10] Doaga, A., Cojocariu, A.M., Amin, W., Heib, F., Bender, P., Hempelmann, R. & Caltun, O.F., "Synthesis and characterizations of manganese ferrites for hyperthermia applications." Materials Chemistry and Physics. 143, 305-310 (2013).
[11] Mozaffari, M., B. Behdadfar, & J. Amighian, "Preparation and characterization of manganese ferrite nanoparticles via co-precipitation method for hyperthermia." Iranian Journal of Pharmaceutical Sciences. 4, 115-118 (2008).
[12] Iftikhar, A., Islam, M.U., Awan, M.S., Ahmad, M., Naseem, S. & Asif Iqbal, M., "Synthesis of super paramagnetic particles of Mn 1−xMgxFe2O4 ferrites for hyperthermia applications." Journal of Alloys and Compounds. 601, 116-119 (2014).
[13] Lungu, A., Malaescu, I., Marin, C.N., Vlazan, P., & Sfirloaga, P., "The electrical properties of manganese ferrite powders prepared by two different methods." Physica B. 462, 80-85 (2015).
[14] Sharifi, I. & Shokrollahi, H., "Structural, magnetic and Mössbauer evaluation of Mn substituted Co–Zn ferrite nanoparticles synthesized by co-precipitation." Journal of Magnetism and Magnetic Materials, 334, 36-40 (2013).
[15] Farooq, H., Ahmad, M.R., Jamil, Y., Hafeez, A., Mahmood, Z. & Mahmood, T., "Structural and Dielectric Properties of Manganese Ferrite Nanoparticles." J. Basic Appl. Sci. 8, 597-601 (2012).
[16] Aakash, Choubey, R., Das D., & Mukherjee, S., "Effect of doping of manganese ions on the structural and magnetic properties of nickel ferrite." Journal of Alloys and Compounds. 668, 33-39 (2016).
[17] Cao, X., Liu, G., Wang, Y., Li, J. & Hong, R., "Preparation of octahedral shaped Mn0.8Zn0.2Fe2O4 ferrites via co-precipitation." Journal of Alloys and Compounds. 497, L9-L12 (2010).
[18] Kang, E., Park, J., Hwang, Y., Kang, M., Park, J.G., & Hyeon, T., "Direct synthesis of highly crystalline and monodisperse manganese ferrite nanocrystals." J. Phys. Chem. B. 108, 13932-13935 (2004).
[19] Monfared, A.H., Zamanian, A., Beygzadeh, M., Sharif, I. & Mozafari, M., "A rapid and efficient thermal decomposition approach for the synthesis of manganese-zinc/oleylamine core/shell ferrite nanoparticles." Journal of Alloys and Compounds. 693, 1090-1095 2(017).
[20] Vamvakidis, K., Sakellari, D., Angelakeris, M. & Dendrinou-Samara, C., "Size and compositionally controlled manganese ferrite nanoparticles with enhanced magnetization." J Nanopart Res. 15, 1-11 (2013).
[21] Stoia, M., Barvinsch, P., Barbu, L., Barbu, M. & Stefanescu, M., "Synthesis of nanocrystalline nickel ferrite by thermal decomposition of organic precursors." J Therm Anal Calorim. 108, 1033-1039 (2011).
[22] Yang, H., Zhang, C., Shi, X., Hu, H., Du, X., et al. "Water-soluble superparamagnetic manganese ferrite nanoparticles for magnetic resonance imaging." Biomaterials. 31, 3667-3673 (2010).
[23] Bellusci, M., Aliotta, C., Fiorani, D., La Barbera, A., Padella, F., et al "Manganese iron oxide superparamagnetic powder by mechanochemical processing. Nanoparticles functionalization and dispersion in a nanofluid." J Nanopart Res. 14, 1-11 (2012).
[24] Arana, M., Bercoff, P., Jacobo, S., Mendoza, P. & Pasquevich, G., "Mechanochemical synthesis of MnZn ferrite nanoparticles suitable for biocompatible ferrofluids." Ceramics International. 42, 1545-1551 (2016).
[25] Iwasaki, T., Nakatsuka, R., Murase, K., Takata, H., Nakamura, H. & Watano, S., "Simple and rapid synthesis of magnetite/hydroxyapatite composites for hyperthermia treatments via a mechanochemical route." Int. J. Mol. Sci. 14, 9365-9378 (2013).
[26] Bėčytė, V., Mažeika, K., Rakickas, T. & Pakštas, V., "Study of magnetic and structural properties of cobalt-manganese ferrite nanoparticles obtained by mechanochemical synthesis." Materials Chemistry and Physics. 172, 6-10 (2016).
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@article{"International Journal of Chemical, Materials and Biomolecular Sciences:76167", author = "Javier Sánchez and Laura Elena De León Prado and Dora Alicia Cortés Hernández", title = "Magnetic Properties and Cytotoxicity of Ga-Mn Magnetic Ferrites Synthesized by the Citrate Sol-Gel Method", abstract = "Magnetic spinel ferrites are materials that possess size, magnetic properties and heating ability adequate for their potential use in biomedical applications. The Mn0.5Ga0.5Fe2O4 magnetic nanoparticles (MNPs) were synthesized by sol-gel method using citric acid as chelating agent of metallic precursors. The synthesized samples were identified by X-Ray Diffraction (XRD) as an inverse spinel structure with no secondary phases. Saturation magnetization (Ms) of crystalline powders was 45.9 emu/g, which was higher than those corresponding to GaFe2O4 (14.2 emu/g) and MnFe2O4 (40.2 emu/g) synthesized under similar conditions, while the coercivity field (Hc) was 27.9 Oe. The average particle size was 18 ± 7 nm. The heating ability of the MNPs was enough to increase the surrounding temperature up to 43.5 °C in 7 min when a quantity of 4.5 mg of MNPs per mL of liquid medium was tested. Cytotoxic effect (hemolysis assay) of MNPs was determined and the results showed hemolytic values below 1% in all tested cases. According to the results obtained, these synthesized nanoparticles can be potentially used as thermoseeds for hyperthermia therapy.
", keywords = "Cytotoxicity, heating ability, manganese-gallium ferrite, magnetic hyperthermia.", volume = "11", number = "8", pages = "590-6", }
