Evaluation of the Possible Effect of Gender, Age and Duration of Diabetes on the Serum Zinc Levels of Diabetic Patients in Murzuk Area-Libya
The aim of this study was to demonstrate the possible
effect of some variables such as age, gender, blood sugar level, and
duration of diabetes on the serum level of zinc in diabetic individuals
from Murzuk area. Serum zinc (Zn), Fasting blood sugar (FBS),
hemoglobin HbA1c (HbA1c) were evaluated in 46 type I diabetic
subjects (group 1), 48 type II diabetic subjects (group 2) and 43
healthy individuals (control) of both genders aged (30-81) years. Data
showed that both diabetic groups have significantly higher (P<0.05)
serum levels of Zn, FBS and HbA1c compared with controls. No
significant (p>0.05) differences in serum Zn levels were observed
between Males and Females. Serum Zn levels were non-significantly
decreased with increasing age. In type II diabetic subjects, serum Zn
levels were non-significantly decreased with increasing duration of
disease whereas those in type I were non-significantly increased.
[1] WHO, www.who.int/features, 2010.
[2] D. B. Chiranjib and K. P. Kumar, "A potential medical importance of
zinc in human health and chronic disease," Int. J. Pharm. Biomed. Sci.,
vol. 1,no. 1, pp.05-11, 2010.
[3] A. B. Chausmer, "Zinc, insulin and diabetes," J. Am. Collg. Nutr., vol.
17, no. 2, pp. 109-115, 1998.
[4] A. El-Yazigi, N. Hannan, and D. A. Raines, "Effect of diabetic state and
related disorders on the urinary excretion of magnesium and zinc in
patients," Diab. Res., vol. 22, no. 2, pp. 67-75, 1993.
[5] I. Nourmohammadi, I. Kocheki-shalmani, and M. Shaabani," Zinc,
copper, chromium, manganese and magnesium levels in serum and hair
of insulin-dependent diabetics," Arch. Irn. Med., vol. 3, pp. 129-29,
2000.
[6] A. Syogren, C. Floren, and A. Nilsson,"Magnesium, potassium, and zinc
deficiency in subjects with type II diabetes mellitus," Acta. Med. Scand.,
vol. 224, pp. 461-465, 1988.
[7] J. D. Kruse-Jerres, M. Rukgauer,"Trace elements in diabetes mellitus.
Peculiarities and clinical validity of determinations in blood cells," J.
Trace Elements Med. Biol., vol. 14, no. 1, pp. 21-27, 2000.
[8] A. H. Zargar, N. A. Shah, and S.R. Massodi, "Copper, zinc, and
magnesium levels in non-insulin dependent diabetes mellitus," Postgard.
Med. J., vol. 74, pp.665-668, 1998.
[9] M. Estakhari, A. Djazayery, M. R. Eshraghian, R. Majdzadeh, M. Jalali,
et al.,"Serum zinc levels in Children and adolescents with type I diabetes
mellitus," Iranian J. Publ. Health, vol. 40, no. 4, pp. 83-88, 2011.
[10] R. D. Rohn, P. Pleban, and L. L. Jenkins, "Magnesium, zink and copper
in plasma and blood cellular components in children with IDDM," Clin.
Chim. Acta, vol. 215, no. 1, pp. 21-28, 1993.
[11] D. Barham and P. Trinder, "An improved colour reagent for the
determination of blood glucose by the oxidase system," Analyst, vol. 97,
pp. 142 - 145, 1972.
[12] K. Spencer, "Analytical reviews in clinical biochemistry. The estimation
of creatinine," Ann. Clin. Biochem.,vol. 23, pp. 1-25,1986.
[13] M. P. Veniamin and C. Vakirtz-lemonias, "Chemical basis of the
carbamido diacetyl micro method for estimation of urea, citrulline and
carbamyl derivatives," Clin. Chem., vol. 16, pp. 3-6, 1970.
[14] American Diabetes Association (ADA), "Executive summary; Standards
of medical care in diabetes," Diabetic Care, vol. 32, pp. S6-S12, 2009.
[15] K. I. Akhuemokhan, A. Eregie, and O. A. Fasanmade, "Trace mineral
status and glycaemic control in Nigerians with type 2 diabetes," Afri. J.
Med., pp. 20-22, July 2010.
[16] A. C. Nsonwu, C. A. Usoro, M. H. Etukudo, and I. N. Usoro, "Influence
of age, gender and duration of diabetes on serum and urine levels of
zinc, magnesium, selenium and chromium in type 2 diabetics in Calabar,
Nigeria," Turk. J. Bioch., vol. 31, no. 3, pp. 107-114, 2006.
[1] WHO, www.who.int/features, 2010.
[2] D. B. Chiranjib and K. P. Kumar, "A potential medical importance of
zinc in human health and chronic disease," Int. J. Pharm. Biomed. Sci.,
vol. 1,no. 1, pp.05-11, 2010.
[3] A. B. Chausmer, "Zinc, insulin and diabetes," J. Am. Collg. Nutr., vol.
17, no. 2, pp. 109-115, 1998.
[4] A. El-Yazigi, N. Hannan, and D. A. Raines, "Effect of diabetic state and
related disorders on the urinary excretion of magnesium and zinc in
patients," Diab. Res., vol. 22, no. 2, pp. 67-75, 1993.
[5] I. Nourmohammadi, I. Kocheki-shalmani, and M. Shaabani," Zinc,
copper, chromium, manganese and magnesium levels in serum and hair
of insulin-dependent diabetics," Arch. Irn. Med., vol. 3, pp. 129-29,
2000.
[6] A. Syogren, C. Floren, and A. Nilsson,"Magnesium, potassium, and zinc
deficiency in subjects with type II diabetes mellitus," Acta. Med. Scand.,
vol. 224, pp. 461-465, 1988.
[7] J. D. Kruse-Jerres, M. Rukgauer,"Trace elements in diabetes mellitus.
Peculiarities and clinical validity of determinations in blood cells," J.
Trace Elements Med. Biol., vol. 14, no. 1, pp. 21-27, 2000.
[8] A. H. Zargar, N. A. Shah, and S.R. Massodi, "Copper, zinc, and
magnesium levels in non-insulin dependent diabetes mellitus," Postgard.
Med. J., vol. 74, pp.665-668, 1998.
[9] M. Estakhari, A. Djazayery, M. R. Eshraghian, R. Majdzadeh, M. Jalali,
et al.,"Serum zinc levels in Children and adolescents with type I diabetes
mellitus," Iranian J. Publ. Health, vol. 40, no. 4, pp. 83-88, 2011.
[10] R. D. Rohn, P. Pleban, and L. L. Jenkins, "Magnesium, zink and copper
in plasma and blood cellular components in children with IDDM," Clin.
Chim. Acta, vol. 215, no. 1, pp. 21-28, 1993.
[11] D. Barham and P. Trinder, "An improved colour reagent for the
determination of blood glucose by the oxidase system," Analyst, vol. 97,
pp. 142 - 145, 1972.
[12] K. Spencer, "Analytical reviews in clinical biochemistry. The estimation
of creatinine," Ann. Clin. Biochem.,vol. 23, pp. 1-25,1986.
[13] M. P. Veniamin and C. Vakirtz-lemonias, "Chemical basis of the
carbamido diacetyl micro method for estimation of urea, citrulline and
carbamyl derivatives," Clin. Chem., vol. 16, pp. 3-6, 1970.
[14] American Diabetes Association (ADA), "Executive summary; Standards
of medical care in diabetes," Diabetic Care, vol. 32, pp. S6-S12, 2009.
[15] K. I. Akhuemokhan, A. Eregie, and O. A. Fasanmade, "Trace mineral
status and glycaemic control in Nigerians with type 2 diabetes," Afri. J.
Med., pp. 20-22, July 2010.
[16] A. C. Nsonwu, C. A. Usoro, M. H. Etukudo, and I. N. Usoro, "Influence
of age, gender and duration of diabetes on serum and urine levels of
zinc, magnesium, selenium and chromium in type 2 diabetics in Calabar,
Nigeria," Turk. J. Bioch., vol. 31, no. 3, pp. 107-114, 2006.
@article{"International Journal of Medical, Medicine and Health Sciences:61925", author = "Mukhtar H. Hassan and Muhammed A. Basher and Elhadi E. Saad and Almahdi M. Almahdi", title = "Evaluation of the Possible Effect of Gender, Age and Duration of Diabetes on the Serum Zinc Levels of Diabetic Patients in Murzuk Area-Libya", abstract = "The aim of this study was to demonstrate the possible
effect of some variables such as age, gender, blood sugar level, and
duration of diabetes on the serum level of zinc in diabetic individuals
from Murzuk area. Serum zinc (Zn), Fasting blood sugar (FBS),
hemoglobin HbA1c (HbA1c) were evaluated in 46 type I diabetic
subjects (group 1), 48 type II diabetic subjects (group 2) and 43
healthy individuals (control) of both genders aged (30-81) years. Data
showed that both diabetic groups have significantly higher (P0.05) differences in serum Zn levels were observed
between Males and Females. Serum Zn levels were non-significantly
decreased with increasing age. In type II diabetic subjects, serum Zn
levels were non-significantly decreased with increasing duration of
disease whereas those in type I were non-significantly increased.", keywords = "Blood sugar, diabetes, HbA1c, zinc.", volume = "7", number = "3", pages = "159-3", }
