Differentiation of Gene Expression Profiles Data for Liver and Kidney of Pigs

Using DNA microarrays the comparative analysis of a gene expression profiles is carried out in a liver and kidneys of pigs. The hypothesis of a cross hybridization of one probe with different cDNA sites of the same gene or different genes is checked up, and it is shown, that cross hybridization can be a source of essential errors at revealing of a key genes in organ-specific transcriptome. It is reveald that distinctions in profiles of a gene expression are well coordinated with function, morphology, biochemistry and histology of these organs.

Authors:

• Khlopova N.S.
• Glazko V.I.
• Glazko T.T.

Keywords:

• Microarray
• gene expression profiles
• key genes.

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