Determination of Volatile Organic Compounds in Human Breath by Optical Fiber Sensing
This work proposes an optical fiber system (OF) for
sensing various volatile organic compounds (VOCs) in human breath
for the diagnosis of some metabolic disorders as a non-invasive
methodology. The analyzed VOCs are alkanes (i.e., ethane, pentane,
heptane, octane, and decane), and aromatic compounds (i.e., benzene,
toluene, and styrene). The OF displays high analytical performance
since it provides near real-time responses, rapid analysis, and low
instrumentation costs, as well as it exhibits useful linear range and
detection limits; the developed OF sensor is also comparable to a
reference methodology (gas chromatography-mass spectrometry) for
the eight tested VOCs.
[1] K.-H. Kim, S.A. Jahan, and E. Kabir, "A review of breath analysis for
diagnosis of human health", Trends Anal. Chem., vol. 33, p. 1-8, 2012.
[2] P.J. Mazzone, "Analysis of volatile organic compounds in the exhaled
breath for the diagnosis of lung cancer", J. Thorac. Oncol., vol. 3, p.
774-780, 2008.
[3] C. Wang, P. Sahay, "Breath analysis using laser spectroscopic
techniques: breath biomarkers, spectral fingertips, and detection limits",
Sensors, vol. 9, p. 8230-8262, 2009.
[4] F. Biasoli, C. Yeretzian, T.D. Märk, J. Dewulf, H.V. Langenhove,
"Direct-injection mass spectrometry adds the time dimension to (B)
VOC analysis", Trends Anal. Chem., vol. 30, p. 1003-1017, 2011.
[5] M. Biniecka, S. Caroli, "Analytical methods for the quantification of
volatile aromatic compounds", Trends Anal. Chem., vol. 30, p. 1756-
1770, 2011.
[6] J. Luo, J. Luo, L. Wang, X. Shi, J. Yin, E. Crew, S. Lu, L.M.
Lesperance, C.-J. Zhong, "Nanoparticle-structured thin film sensor
arrays for breath sensing", Sens. Actuators B, vol. 161, p. 845-854, 2012.
[7] G. Magma, M. Santonico, A. Catini, R. Capuano, C. Di Natale, A.
D-Amico, R. Paolesse, L. Tortora, "Detection of bretah alcohol
concentrations using a gas sensor array", Lect. Notes Electr. Eng., vol.
109, p. 127-132.
[8] F.D.P. Ferreira, L.I.B. Silva, A.C. Freitas, T.A.P. Rocha-Santos, A.C.
Duarte, "High performance liquid chromatography coupled to an optical
fiber detector coated with laccase for screening catecholamines in
plasma and urine", J. Chrom. A, vol. 1216, p. 7049-7054, 2009.
[9] L.I.B. Silva, F.D.P. Ferreira, A.C. Freitas, T.A.P. Rocha-Santos, A.C.
Duarte, "Optical fiber biosensor coupled to chromatographic separation
for screening of dopamine, norepinephrine and epinephrine in human
urine and plasma", Talanta, vol. 80, p. 853-857, 2009.
[10] L.I.B. Silva, T.A.P. Rocha-Santos, A.C. Duarte, "Comparison of a gas
chromatography-optical fibre (GC-OF) detector with a gas
chromatography-flame ionization detector (GC-FID) for determination
of alcoholic compounds in industrial atmospheres", Talanta, vol. 76, p.
395-399, 2008.
[11] L.I.B. Silva, T.A.P. Rocha-Santos, A.C. Duarte, "Remote optical fibre
microsensor for monitoring BTEX in confined industrial atmospheres",
Talanta, vol. 78, p. 548-552, 2009.
[12] C.I.L. Justino, T.A. Rocha-Santos, A.C. Duarte, "Review of analytical
figures of merit of sensors and biosensors in clinical applications", TrAC
Trends Anal. Chem., vol. 29, 1172-1183, 2010.
[13] D. Poli, P. Carbognani, M. Corradi, M. Goldoni, O. Acampa, B. Balbi,
L. Bianchi, M. Rusca, A. Mutti, "Exhaled volatile organic compounds in
patients with non-small cell lung cancer: cross sectional and nested
short-term follow-up study", Respir. Res., vol. 6:71, 2005.
[1] K.-H. Kim, S.A. Jahan, and E. Kabir, "A review of breath analysis for
diagnosis of human health", Trends Anal. Chem., vol. 33, p. 1-8, 2012.
[2] P.J. Mazzone, "Analysis of volatile organic compounds in the exhaled
breath for the diagnosis of lung cancer", J. Thorac. Oncol., vol. 3, p.
774-780, 2008.
[3] C. Wang, P. Sahay, "Breath analysis using laser spectroscopic
techniques: breath biomarkers, spectral fingertips, and detection limits",
Sensors, vol. 9, p. 8230-8262, 2009.
[4] F. Biasoli, C. Yeretzian, T.D. Märk, J. Dewulf, H.V. Langenhove,
"Direct-injection mass spectrometry adds the time dimension to (B)
VOC analysis", Trends Anal. Chem., vol. 30, p. 1003-1017, 2011.
[5] M. Biniecka, S. Caroli, "Analytical methods for the quantification of
volatile aromatic compounds", Trends Anal. Chem., vol. 30, p. 1756-
1770, 2011.
[6] J. Luo, J. Luo, L. Wang, X. Shi, J. Yin, E. Crew, S. Lu, L.M.
Lesperance, C.-J. Zhong, "Nanoparticle-structured thin film sensor
arrays for breath sensing", Sens. Actuators B, vol. 161, p. 845-854, 2012.
[7] G. Magma, M. Santonico, A. Catini, R. Capuano, C. Di Natale, A.
D-Amico, R. Paolesse, L. Tortora, "Detection of bretah alcohol
concentrations using a gas sensor array", Lect. Notes Electr. Eng., vol.
109, p. 127-132.
[8] F.D.P. Ferreira, L.I.B. Silva, A.C. Freitas, T.A.P. Rocha-Santos, A.C.
Duarte, "High performance liquid chromatography coupled to an optical
fiber detector coated with laccase for screening catecholamines in
plasma and urine", J. Chrom. A, vol. 1216, p. 7049-7054, 2009.
[9] L.I.B. Silva, F.D.P. Ferreira, A.C. Freitas, T.A.P. Rocha-Santos, A.C.
Duarte, "Optical fiber biosensor coupled to chromatographic separation
for screening of dopamine, norepinephrine and epinephrine in human
urine and plasma", Talanta, vol. 80, p. 853-857, 2009.
[10] L.I.B. Silva, T.A.P. Rocha-Santos, A.C. Duarte, "Comparison of a gas
chromatography-optical fibre (GC-OF) detector with a gas
chromatography-flame ionization detector (GC-FID) for determination
of alcoholic compounds in industrial atmospheres", Talanta, vol. 76, p.
395-399, 2008.
[11] L.I.B. Silva, T.A.P. Rocha-Santos, A.C. Duarte, "Remote optical fibre
microsensor for monitoring BTEX in confined industrial atmospheres",
Talanta, vol. 78, p. 548-552, 2009.
[12] C.I.L. Justino, T.A. Rocha-Santos, A.C. Duarte, "Review of analytical
figures of merit of sensors and biosensors in clinical applications", TrAC
Trends Anal. Chem., vol. 29, 1172-1183, 2010.
[13] D. Poli, P. Carbognani, M. Corradi, M. Goldoni, O. Acampa, B. Balbi,
L. Bianchi, M. Rusca, A. Mutti, "Exhaled volatile organic compounds in
patients with non-small cell lung cancer: cross sectional and nested
short-term follow-up study", Respir. Res., vol. 6:71, 2005.
@article{"International Journal of Earth, Energy and Environmental Sciences:54402", author = "C. I. L. Justino and L. I. B. Silva and K. Duarte and A. C. Freitas and T. A. P. Rocha-Santos and A. C. Duarte", title = "Determination of Volatile Organic Compounds in Human Breath by Optical Fiber Sensing", abstract = "This work proposes an optical fiber system (OF) for
sensing various volatile organic compounds (VOCs) in human breath
for the diagnosis of some metabolic disorders as a non-invasive
methodology. The analyzed VOCs are alkanes (i.e., ethane, pentane,
heptane, octane, and decane), and aromatic compounds (i.e., benzene,
toluene, and styrene). The OF displays high analytical performance
since it provides near real-time responses, rapid analysis, and low
instrumentation costs, as well as it exhibits useful linear range and
detection limits; the developed OF sensor is also comparable to a
reference methodology (gas chromatography-mass spectrometry) for
the eight tested VOCs.", keywords = "Breath analysis, gas chromatography-mass
spectrometry, optical fiber sensor, volatile organic compounds", volume = "6", number = "8", pages = "497-4", }