Abstract: This study presents a mathematical modeling approach to the planning of HIV therapies on an individual basis. The model replicates clinical data from typical-progressors to AIDS for all stages of the disease with good agreement. Clinical data from rapid-progressors and long-term non-progressors is also matched by estimation of immune system parameters only. The ability of the model to reproduce these phenomena validates the formulation, a fact which is exploited in the investigation of effective therapies. The therapy investigation suggests that, unlike continuous therapy, structured treatment interruptions (STIs) are able to control the increase in both the drug-sensitive and drug-resistant virus population and, hence, prevent the ultimate progression from HIV to AIDS. The optimization results further suggest that even patients characterised by the same progression type can respond very differently to the same treatment and that the latter should be designed on a case-by-case basis. Such a methodology is presented here.
Abstract: In this paper, a PSO-based approach is proposed to
derive a digital controller for redesigned digital systems having an interval plant based on resemblance of the extremal gain/phase
margins. By combining the interval plant and a controller as an interval system, extremal GM/PM associated with the loop transfer function
can be obtained. The design problem is then formulated as an optimization problem of an aggregated error function revealing the deviation on the extremal GM/PM between the redesigned digital
system and its continuous counterpart, and subsequently optimized by
a proposed PSO to obtain an optimal set of parameters for the digital controller. Computer simulations have shown that frequency
responses of the redesigned digital system having an interval plant bare a better resemblance to its continuous-time counter part by the incorporation of a PSO-derived digital controller in comparison to those obtained using existing open-loop discretization methods.
Abstract: This paper presents an optimal design of linear phase
digital high pass finite impulse response (FIR) filter using Improved
Particle Swarm Optimization (IPSO). In the design process, the filter
length, pass band and stop band frequencies, feasible pass band and
stop band ripple sizes are specified. FIR filter design is a multi-modal
optimization problem. An iterative method is introduced to find the
optimal solution of FIR filter design problem. Evolutionary
algorithms like real code genetic algorithm (RGA), particle swarm
optimization (PSO), improved particle swarm optimization (IPSO)
have been used in this work for the design of linear phase high pass
FIR filter. IPSO is an improved PSO that proposes a new definition
for the velocity vector and swarm updating and hence the solution
quality is improved. A comparison of simulation results reveals the
optimization efficacy of the algorithm over the prevailing
optimization techniques for the solution of the multimodal, nondifferentiable,
highly non-linear, and constrained FIR filter design
problems.
Abstract: A nucleotide sequence can be expressed as a numerical sequence when each nucleotide is assigned its proton number. A resulting gene numerical sequence can be investigated for its fractal dimension in terms of evolution and chemical properties for comparative studies. We have investigated such nucleotide fluctuation in the 16S rRNA gene of archaea thermophiles. The studied archaea thermophiles were archaeoglobus fulgidus, methanothermobacter thermautotrophicus, methanocaldococcus jannaschii, pyrococcus horikoshii, and thermoplasma acidophilum. The studied five archaea-euryarchaeota thermophiles have fractal dimension values ranging from 1.93 to 1.97. Computer simulation shows that random sequences would have an average of about 2 with a standard deviation about 0.015. The fractal dimension was found to correlate (negative correlation) with the thermophile-s optimal growth temperature with R2 value of 0.90 (N =5). The inclusion of two aracheae-crenarchaeota thermophiles reduces the R2 value to 0.66 (N = 7). Further inclusion of two bacterial thermophiles reduces the R2 value to 0.50 (N =9). The fractal dimension is correlated (positive) to the sequence GC content with an R2 value of 0.89 for the five archaea-euryarchaeota thermophiles (and 0.74 for the entire set of N = 9), although computer simulation shows little correlation. The highest correlation (positive) was found to be between the fractal dimension and di-nucleotide Shannon entropy. However Shannon entropy and sequence GC content were observed to correlate with optimal growth temperature having an R2 of 0.8 (negative), and 0.88 (positive), respectively, for the entire set of 9 thermophiles; thus the correlation lacks species specificity. Together with another correlation study of bacterial radiation dosage with RecA repair gene sequence fractal dimension, it is postulated that fractal dimension analysis is a sensitive tool for studying the relationship between genotype and phenotype among closely related sequences.
Abstract: Liposomal magnetofection is a simple, highly efficient
technology for cell transfection, demonstrating better outcome than a
number of other common gene delivery methods. However,
aggregate complexes distribution over the cell surface is non-uniform
due to the gradient of the permanent magnetic field. The aim of this
study was to estimate the efficiency of liposomal magnetofection for
prostate carcinoma PC3 cell line using newly designed device,
“DynaFECTOR", ensuring magnetofection in a dynamic gradient
magnetic field. Liposomal magnetofection in a dynamic gradient
magnetic field demonstrated the highest transfection efficiency for
PC3 cells – it increased for 21% in comparison with liposomal
magnetofection and for 42% in comparison with lipofection alone.
The optimal incubation time under dynamic magnetic field for PC3
cell line was 5 minutes and the optimal rotation frequency of
magnets – 5 rpm. The new approach also revealed lower cytotoxic
effect to cells than liposomal magnetofection.
Abstract: In competitive electricity markets all over the world, an adoption of suitable transmission pricing model is a problem as transmission segment still operates as a monopoly. Transmission pricing is an important tool to promote investment for various transmission services in order to provide economic, secure and reliable electricity to bulk and retail customers. The nodal pricing based on SRMC (Short Run Marginal Cost) is found extremely useful by researchers for sending correct economic signals. The marginal prices must be determined as a part of solution to optimization problem i.e. to maximize the social welfare. The need to maximize the social welfare subject to number of system operational constraints is a major challenge from computation and societal point of views. The purpose of this paper is to present a nodal transmission pricing model based on SRMC by developing new mathematical expressions of real and reactive power marginal prices using GA-Fuzzy based optimal power flow framework. The impacts of selecting different social welfare functions on power marginal prices are analyzed and verified with results reported in literature. Network revenues for two different power systems are determined using expressions derived for real and reactive power marginal prices in this paper.
Abstract: The fault current levels through the electric devices
have a significant impact on failure probability. New fault current
results in exceeding the rated capacity of circuit breaker and switching
equipments and changes operation characteristic of overcurrent relay.
In order to solve these problems, SFCL (Superconducting Fault
Current Limiter) has rising as one of new alternatives so as to improve
these problems. A fault current reduction differs depending on
installed location. Therefore, a location of SFCL is very important.
Also, SFCL decreases the fault current, and it prevents surrounding
protective devices to be exposed to fault current, it then will bring a
change of reliability. In this paper, we propose method which
determines the optimal location when SFCL is installed in power
system. In addition, the reliability about the power system which
SFCL was installed is evaluated. The efficiency and effectiveness of
this method are also shown by numerical examples and the reliability
indices are evaluated in this study at each load points. These results
show a reliability change of a system when SFCL was installed.
Abstract: The early diagnostic decision making in industrial processes is absolutely necessary to produce high quality final products. It helps to provide early warning for a special event in a process, and finding its assignable cause can be obtained. This work presents a hybrid diagnostic schmes for batch processes. Nonlinear representation of raw process data is combined with classification tree techniques. The nonlinear kernel-based dimension reduction is executed for nonlinear classification decision boundaries for fault classes. In order to enhance diagnosis performance for batch processes, filtering of the data is performed to get rid of the irrelevant information of the process data. For the diagnosis performance of several representation, filtering, and future observation estimation methods, four diagnostic schemes are evaluated. In this work, the performance of the presented diagnosis schemes is demonstrated using batch process data.
Abstract: In this paper we study the resource allocation problem
for an OFDMA based cooperative two-way relaying (TWR) network.
We focus on amplify and forward (AF) analog network coding
(ANC) protocol. An optimization problem for two basic resources
namely, sub-carrier and power is formulated for multi-user TWR
networks. A joint optimal optimization problem is investigated and
two-step low complexity sub-optimal resource allocation algorithm is
proposed for multi-user TWR networks with ANC protocol. The
proposed algorithm has been evaluated in term of total achievable
system sum-rate and achievable individual sum-rate for each userpair.
The good tradeoff between system sum-rate and fairness is
observed in the two-step proportional resource allocation scheme.
Abstract: This paper provides a replacement policy for warranty products with different failure rate from the consumer-s viewpoint. Assume that the product is replaced once within a finite planning horizon, and the failure rate of the second product is lower than the failure rate of the first product. Within warranty period (WP), the failed product is corrected by minimal repair without any cost to the consumers. After WP, the failed product is repaired with a fixed repair cost to the consumers. However, each failure incurs a fixed downtime cost to the consumers over a finite planning horizon. In this paper, we derive the model of the expected total disbursement cost within a finite planning horizon and some properties of the optimal replacement policy under some reasonable conditions are obtained. Finally, numerical examples are given to illustrate the features of the optimal replacement policy under various maintenance costs.
Abstract: In this paper a real-time trajectory generation algorithm for computing 2-D optimal paths for autonomous aerial vehicles has been discussed. A dynamic programming approach is adopted to compute k-best paths by minimizing a cost function. Collision detection is implemented to detect intersection of the paths with obstacles. Our contribution is a novel approach to the problem of trajectory generation that is computationally efficient and offers considerable gain over existing techniques.
Abstract: Cassava bagasse is one of major biomass wastes in Thailand from starch processing industry, which contains high starch content of about 60%. The object of this study was to investigate the optimal condition for hydrothermally pretreating cassava baggasses with or without acid addition. The pretreated samples were measured reducing sugar yield directly or after enzymatic hydrolysis (alpha-amylase). In enzymatic hydrolysis, the highest reducing sugar content was obtained under hydrothermal conditions for at 125oC for 30 min. The result shows that pretreating cassava baggasses increased the efficiency of enzymatic hydrolysis. For acid hydrolysis, pretreating cassava baggasses with sulfuric acid at 120oC for 60 min gave a maximum reducing sugar yield. In this study, sulfuric acid had a greater capacity for hydrolyzing cassava baggasses than phosphoric acid. In comparison, dilute acid hydrolysis to provide a higher yield of reducing sugar than the enzymatic hydrolysis combined hydrothermal pretreatment. However, enzymatic hydrolysis in a combination with hydrothermal pretreatment was an alternative to enhance efficiency reducing sugar production from cassava bagasse.
Abstract: This paper presents a heuristic approach to solve the Generalized Assignment Problem (GAP) which is NP-hard. It is worth mentioning that many researches used to develop algorithms for identifying the redundant constraints and variables in linear programming model. Some of the algorithms are presented using intercept matrix of the constraints to identify redundant constraints and variables prior to the start of the solution process. Here a new heuristic approach based on the dominance property of the intercept matrix to find optimal or near optimal solution of the GAP is proposed. In this heuristic, redundant variables of the GAP are identified by applying the dominance property of the intercept matrix repeatedly. This heuristic approach is tested for 90 benchmark problems of sizes upto 4000, taken from OR-library and the results are compared with optimum solutions. Computational complexity is proved to be O(mn2) of solving GAP using this approach. The performance of our heuristic is compared with the best state-ofthe- art heuristic algorithms with respect to both the quality of the solutions. The encouraging results especially for relatively large size test problems indicate that this heuristic approach can successfully be used for finding good solutions for highly constrained NP-hard problems.
Abstract: Optimal cultural site selection is one of the ways that
can lead to the promotion of citizenship culture in addition to
ensuring the health and leisure of city residents. This study examines
the social and cultural needs of the community and optimal cultural
site allocation and after identifying the problems and shortcomings,
provides a suitable model for finding the best location for these
centers where there is the greatest impact on the promotion of
citizenship culture. On the other hand, non-scientific methods cause
irreversible impacts to the urban environment and citizens. But
modern efficient methods can reduce these impacts. One of these
methods is using geographical information systems (GIS). In this
study, Analytical Hierarchy Process (AHP) method was used to
locate the optimal cultural site. In AHP, three principles
(decomposition), (comparative analysis), and (combining
preferences) are used. The objectives of this research include
providing optimal contexts for passing time and performing cultural
activities by Shiraz residents and also proposing construction of some
cultural sites in different areas of the city. The results of this study
show the correct positioning of cultural sites based on social needs of
citizens. Thus, considering the population parameters and radii
access, GIS and AHP model for locating cultural centers can meet
social needs of citizens.
Abstract: In this work, an attempt is made to design an optimal
wind/pv/diesel hybrid power system for a village of Ain Merane,
Chlef, Algeria, where the wind speed and solar radiation
measurements were made. The aim of this paper is the optimization
of a hybrid wind/solar/diesel system applied in term of technical and
economic feasibility by simulation using HOMER. A comparison
was made between the performance of wind/pv/diesel system and the
classic connecting system.
Abstract: An optimal control problem for a mathematical model of efficiency of antiviral therapy in hepatitis B virus infections is considered. The aim of the study is to control the new viral production, block the new infection cells and maintain the number of uninfected cells in the given range. The optimal controls represent the efficiency of antiviral therapy in inhibiting viral production and preventing new infections. Defining the cost functional, the optimal control problem is converted into the constrained optimization problem and the first order optimality system is derived. For the numerical simulation, we propose the steepest descent algorithm based on the adjoint variable method. A computer program in MATLAB is developed for the numerical simulations.
Abstract: This paper deals with a periodic-review substitutable
inventory system for a finite and an infinite number of periods. Here
an upward substitution structure, a substitution of a more costly item
by a less costly one, is assumed, with two products. At the beginning
of each period, a stochastic demand comes for the first item only,
which is quality-wise better and hence costlier. Whenever an arriving
demand finds zero inventory of this product, a fraction of unsatisfied
customers goes for its substitutable second item. An optimal ordering
policy has been derived for each period. The results are illustrated
with numerical examples. A sensitivity analysis has been done to
examine how sensitive the optimal solution and the maximum profit
are to the values of the discount factor, when there is a large number
of periods.
Abstract: In this paper multi-objective genetic algorithms are
employed for Pareto approach optimization of ideal Turboshaft
engines. In the multi-objective optimization a number of conflicting
objective functions are to be optimized simultaneously. The
important objective functions that have been considered for
optimization are specific thrust (F/m& 0), specific fuel consumption
( P S ), output shaft power 0 (& /&) shaft W m and overall efficiency( ) O
η .
These objectives are usually conflicting with each other. The design
variables consist of thermodynamic parameters (compressor pressure
ratio, turbine temperature ratio and Mach number).
At the first stage single objective optimization has been
investigated and the method of NSGA-II has been used for multiobjective
optimization. Optimization procedures are performed for
two and four objective functions and the results are compared for
ideal Turboshaft engine. In order to investigate the optimal
thermodynamic behavior of two objectives, different set, each
including two objectives of output parameters, are considered
individually. For each set Pareto front are depicted. The sets of
selected decision variables based on this Pareto front, will cause the
best possible combination of corresponding objective functions.
There is no superiority for the points on the Pareto front figure,
but they are superior to any other point. In the case of four objective
optimization the results are given in tables.
Abstract: In this paper, the least-squares design of variable fractional-delay (VFD) finite impulse response (FIR) digital differentiators is proposed. The used transfer function is formulated so that Farrow structure can be applied to realize the designed system. Also, the symmetric characteristics of filter coefficients are derived, which leads to the complexity reduction by saving almost a half of the number of coefficients. Moreover, all the elements of related vectors or matrices for the optimal process can be represented in closed forms, which make the design easier. Design example is also presented to illustrate the effectiveness of the proposed method.
Abstract: Reverse engineering of full-genomic interaction networks based on compendia of expression data has been successfully applied for a number of model organisms. This study adapts these approaches for an important non-model organism: The major human fungal pathogen Candida albicans. During the infection process, the pathogen can adapt to a wide range of environmental niches and reversibly changes its growth form. Given the importance of these processes, it is important to know how they are regulated. This study presents a reverse engineering strategy able to infer fullgenomic interaction networks for C. albicans based on a linear regression, utilizing the sparseness criterion (LASSO). To overcome the limited amount of expression data and small number of known interactions, we utilize different prior-knowledge sources guiding the network inference to a knowledge driven solution. Since, no database of known interactions for C. albicans exists, we use a textmining system which utilizes full-text research papers to identify known regulatory interactions. By comparing with these known regulatory interactions, we find an optimal value for global modelling parameters weighting the influence of the sparseness criterion and the prior-knowledge. Furthermore, we show that soft integration of prior-knowledge additionally improves the performance. Finally, we compare the performance of our approach to state of the art network inference approaches.