Abstract: The increasing importance of FlexRay systems in
automotive domain inspires unceasingly relative researches. One
primary issue among researches is to verify the reliability of FlexRay
systems either from protocol aspect or from system design aspect.
However, research rarely discusses the effect of network topology on
the system reliability. In this paper, we will illustrate how to model
the reliability of FlexRay systems with various network topologies by
a well-known probabilistic reasoning technology, Bayesian Network.
In this illustration, we especially investigate the effectiveness of error
containment built in star topology and fault-tolerant midpoint
synchronization algorithm adopted in FlexRay communication
protocol. Through a FlexRay steer-by-wire case study, the influence
of different topologies on the failure probability of the FlexRay steerby-
wire system is demonstrated. The notable value of this research is
to show that the Bayesian Network inference is a powerful and
feasible method for the reliability assessment of FlexRay systems.
Abstract: Reverse engineering of full-genomic interaction networks based on compendia of expression data has been successfully applied for a number of model organisms. This study adapts these approaches for an important non-model organism: The major human fungal pathogen Candida albicans. During the infection process, the pathogen can adapt to a wide range of environmental niches and reversibly changes its growth form. Given the importance of these processes, it is important to know how they are regulated. This study presents a reverse engineering strategy able to infer fullgenomic interaction networks for C. albicans based on a linear regression, utilizing the sparseness criterion (LASSO). To overcome the limited amount of expression data and small number of known interactions, we utilize different prior-knowledge sources guiding the network inference to a knowledge driven solution. Since, no database of known interactions for C. albicans exists, we use a textmining system which utilizes full-text research papers to identify known regulatory interactions. By comparing with these known regulatory interactions, we find an optimal value for global modelling parameters weighting the influence of the sparseness criterion and the prior-knowledge. Furthermore, we show that soft integration of prior-knowledge additionally improves the performance. Finally, we compare the performance of our approach to state of the art network inference approaches.