Abstract: Growing world population has fundamental impacts
and often catastrophic on natural habitat. The immethodical
consumption of energy, destruction of the forests and extinction of
plant and animal species are the consequence of this experience.
Urban sustainability and sustainable urban development, that is so
spoken these days, should be considered as a strategy, goal and
policy, beyond just considering environmental issues and protection.
The desert-s climate has made a bunch of problems for its residents.
Very hot and dry climate in summers of the Iranian desert areas,
when there was no access to modern energy source and mechanical
cooling systems in the past, made Iranian architects to design a
natural ventilation system in their buildings. The structure, like a
tower going upward the roof, besides its ornamental application and
giving a beautiful view to the building, was used as a spontaneous
ventilation system. In this paper, it has been tried to name the
problems of the area and it-s inconvenience, then some answers has
pointed out in order to solve the problems and as an alternative
solution BADGIR (wind-catcher) has been introduced as a solution
knowing that it has been playing a major role in dealing with the
problems.
Abstract: Female breast cancer is the second in frequency after cervical cancer. Surgery is the most common treatment for breast cancer, followed by chemotherapy as a treatment of choice. Although effective, it causes serious side effects. Controlled-release drug delivery is an alternative method to improve the efficacy and safety of the treatment. It can release the dosage of drug between the minimum effect concentration (MEC) and minimum toxic concentration (MTC) within tumor tissue and reduce the damage of normal tissue and the side effect. Because an in vivo experiment of this system can be time-consuming and labor-intensive, a mathematical model is desired to study the effects of important parameters before the experiments are performed. Here, we describe a 3D mathematical model to predict the release of doxorubicin from pluronic gel to treat human breast cancer. This model can, ultimately, be used to effectively design the in vivo experiments.
Abstract: The standard investigational method for obstructive
sleep apnea syndrome (OSAS) diagnosis is polysomnography (PSG),
which consists of a simultaneous, usually overnight recording of
multiple electro-physiological signals related to sleep and
wakefulness. This is an expensive, encumbering and not a readily
repeated protocol, and therefore there is need for simpler and easily
implemented screening and detection techniques. Identification of
apnea/hypopnea events in the screening recordings is the key factor
for the diagnosis of OSAS. The analysis of a solely single-lead
electrocardiographic (ECG) signal for OSAS diagnosis, which may
be done with portable devices, at patient-s home, is the challenge of
the last years. A novel artificial neural network (ANN) based
approach for feature extraction and automatic identification of
respiratory events in ECG signals is presented in this paper. A
nonlinear principal component analysis (NLPCA) method was
considered for feature extraction and support vector machine for
classification/recognition. An alternative representation of the
respiratory events by means of Kohonen type neural network is
discussed. Our prospective study was based on OSAS patients of the
Clinical Hospital of Pneumology from Iaşi, Romania, males and
females, as well as on non-OSAS investigated human subjects. Our
computed analysis includes a learning phase based on cross signal
PSG annotation.
Abstract: Lignocellulosic materials are new targeted source to
produce second generation biofuels like biobutanol. However, this
process is significantly resisted by the native structure of biomass.
Therefore, pretreatment process is always essential to remove
hemicelluloses and lignin prior to the enzymatic hydrolysis.
The goals of pretreatment are removing hemicelluloses and
lignin, increasing biomass porosity, and increasing the enzyme
accessibility. The main goal of this research is to study the important
variables such as pretreatment temperature and time, which can give
the highest total sugar yield in pretreatment step by using dilute
phosphoric acid. After pretreatment, the highest total sugar yield of
13.61 g/L was obtained under an optimal condition at 140°C for 10
min of pretreatment time by using 1.75% (w/w) H3PO4 and at 15:1
liquid to solid ratio. The total sugar yield of two-stage process
(pretreatment+enzymatic hydrolysis) of 27.38 g/L was obtained.
Abstract: To solve the problem of multisensor data fusion under
non-Gaussian channel noise. The advanced M-estimates are known
to be robust solution while trading off some accuracy. In order to
improve the estimation accuracy while still maintaining the equivalent
robustness, a two-stage robust fusion algorithm is proposed using
preliminary rejection of outliers then an optimal linear fusion. The
numerical experiments show that the proposed algorithm is equivalent
to the M-estimates in the case of uncorrelated local estimates and
significantly outperforms the M-estimates when local estimates are
correlated.
Abstract: In this paper we are interested in Moufang-Klingenberg
planesM(A) defined over a local alternative ring A of dual numbers.
We show that a collineation of M(A) preserve cross-ratio. Also, we
obtain some results about harmonic points.
Abstract: CONWIP (constant work-in-process) as a pull
production system have been widely studied by researchers to date.
The CONWIP pull production system is an alternative to pure push
and pure pull production systems. It lowers and controls inventory
levels which make the throughput better, reduces production lead
time, delivery reliability and utilization of work. In this article a
CONWIP pull production system was simulated. It was simulated
push and pull planning system. To compare these systems via a
production planning system (PPS) game were adjusted parameters of
each production planning system. The main target was to reduce the
total WIP and achieve throughput and delivery reliability to
minimum values. Data was recorded and evaluated. A future state
was made for real production of plastic components and the setup of
the two indicators with CONWIP pull production system which can
greatly help the company to be more competitive on the market.
Abstract: Decisions are regularly made during a project or
daily life. Some decisions are critical and have a direct impact on
project or human success. Formal evaluation is thus required,
especially for crucial decisions, to arrive at the optimal solution
among alternatives to address issues. According to microeconomic
theory, all people-s decisions can be modeled as indifference curves.
The proposed approach supports formal analysis and decision by
constructing indifference curve model from the previous experts-
decision criteria. These knowledge embedded in the system can be
reused or help naïve users select alternative solution of the similar
problem. Moreover, the method is flexible to cope with unlimited
number of factors influencing the decision-making. The preliminary
experimental results of the alternative selection are accurately
matched with the expert-s decisions.
Abstract: Hysitron TriboIndenterTM TI 950 system has been
used for studying the local viscoelastic properties of porcine
intervertebral disc end plate by means of nanoscale mechanical
dynamic analysis. The specimen of an endplate was cut from fresh
porcine vertebra dissected from 16 month animal. The lumbar spine
motion segments were dissected and 5 millimeter thick plates of
vertebral body, endplate and annulus fibrosus were prepared for
nanoindentation. The surface of the sample was kept in physiological
solution during nanoindentation experiment. We obtained mechanical
characteristics of different areas of native endplate (endplate middle
and vertebra and annulus fibrosus boundary).
Abstract: Motor imagery classification provides an important basis for designing Brain Machine Interfaces [BMI]. A BMI captures and decodes brain EEG signals and transforms human thought into actions. The ability of an individual to control his EEG through imaginary mental tasks enables him to control devices through the BMI. This paper presents a method to design a four state BMI using EEG signals recorded from the C3 and C4 locations. Principle features extracted through principle component analysis of the segmented EEG are analyzed using two novel classification algorithms using Elman recurrent neural network and functional link neural network. Performance of both classifiers is evaluated using a particle swarm optimization training algorithm; results are also compared with the conventional back propagation training algorithm. EEG motor imagery recorded from two subjects is used in the offline analysis. From overall classification performance it is observed that the BP algorithm has higher average classification of 93.5%, while the PSO algorithm has better training time and maximum classification. The proposed methods promises to provide a useful alternative general procedure for motor imagery classification
Abstract: Aurein 1.2 is a 13-residue amphipathic peptide with antibacterial and anticancer activity. Aurein1.2 and its retro analog were synthesized to study the activity of the peptides in relation to their structure. The antibacterial test result showed the retro-analog is inactive. The secondary structural analysis by CD spectra indicated that both of the peptides at TFE/Water adopt alpha-helical conformation. MD simulation was performed on aurein 1.2 and retro-analog in water and TFE in order to analyse the factors that are involved in the activity difference between retro and the native peptide. The simulation results are discussed and validated in the light of experimental data from the CD experiment. Both of the peptides showed a relatively similar pattern for their hydrophobicity, hydrophilicity, solvent accessible surfaces, and solvent accessible hydrophobic surfaces. However, they showed different in directions of dipole moment of peptides. Also, Our results further indicate that the reversion of the amino acid sequence affects flexibility .The data also showed that factors causing structural rigidity may decrease the activity. Consequently, our finding suggests that in the case of sequence-reversed peptide strategy, one has to pay attention to the role of amino acid sequence order in making flexibility and role of dipole moment direction in peptide activity. KeywordsAntimicrobial peptides, retro, molecular dynamic, circular dichroism.
Abstract: Both the minimum energy consumption and
smoothness, which is quantified as a function of jerk, are generally
needed in many dynamic systems such as the automobile and the
pick-and-place robot manipulator that handles fragile equipments.
Nevertheless, many researchers come up with either solely
concerning on the minimum energy consumption or minimum jerk
trajectory. This research paper proposes a simple yet very interesting
when combining the minimum energy and jerk of indirect jerks
approaches in designing the time-dependent system yielding an
alternative optimal solution. Extremal solutions for the cost functions
of the minimum energy, the minimum jerk and combining them
together are found using the dynamic optimization methods together
with the numerical approximation. This is to allow us to simulate
and compare visually and statistically the time history of state inputs
employed by combining minimum energy and jerk designs. The
numerical solution of minimum direct jerk and energy problem are
exactly the same solution; however, the solutions from problem of
minimum energy yield the similar solution especially in term of
tendency.
Abstract: This paper aims to develop a NOx emission model of
an acid gas incinerator using Nelder-Mead least squares support
vector regression (LS-SVR). Malaysia DOE is actively imposing the
Clean Air Regulation to mandate the installation of analytical
instrumentation known as Continuous Emission Monitoring System
(CEMS) to report emission level online to DOE . As a hardware
based analyzer, CEMS is expensive, maintenance intensive and often
unreliable. Therefore, software predictive technique is often
preferred and considered as a feasible alternative to replace the
CEMS for regulatory compliance. The LS-SVR model is built based
on the emissions from an acid gas incinerator that operates in a LNG
Complex. Simulated Annealing (SA) is first used to determine the
initial hyperparameters which are then further optimized based on the
performance of the model using Nelder-Mead simplex algorithm.
The LS-SVR model is shown to outperform a benchmark model
based on backpropagation neural networks (BPNN) in both training
and testing data.
Abstract: The Pulsed Compression Reactor promises to be a
compact, economical and energy efficient alternative to conventional
chemical reactors.
In this article, the production of synthesis gas using the Pulsed
Compression Reactor is investigated. This is done experimentally as
well as with simulations. The experiments are done by means of a
single shot reactor, which replicates a representative, single
reciprocation of the Pulsed Compression Reactor with great control
over the reactant composition, reactor temperature and pressure and
temperature history. Simulations are done with a relatively simple
method, which uses different models for the chemistry and
thermodynamic properties of the species in the reactor. Simulation
results show very good agreement with the experimental data, and
give great insight into the reaction processes that occur within the
cycle.
Abstract: The greenhouse effect and limitations on carbon
dioxide emissions concern engine maker and the future of the
internal combustion engines should go toward substantially and
improved thermal efficiency engine. Homogeneous charge
compression ignition (HCCI) is an alternative high-efficiency
technology for combustion engines to reduce exhaust emissions and
fuel consumption. However, there are still tough challenges in the
successful operation of HCCI engines, such as controlling the
combustion phasing, extending the operating range, and high
unburned hydrocarbon and CO emissions. HCCI and the exploitation
of ethanol as an alternative fuel is one way to explore new frontiers
of internal combustion engines with an eye towards maintaining its
sustainability. This study was done to extend database knowledge
about HCCI with ethanol a fuel.
Abstract: Recently electric vehicles are becoming popular as an
alternative of conventional fossil fuel vehicles. Conventional Internal
Combustion Engine (ICE) vehicle uses fossil fuel which contributing
a major part of overall carbon emission in the environment. Carbon
and other green house gas emission are responsible for global
warming and resulting climate change. It becomes vital to evaluate
performance of vehicle based on emission. In this paper an effort has
been made to depict the picture of emission caused by vehicle and
scenario of Australia has taken into account. Effort has been made to
compare the fossil based vehicle with electric vehicle in phases. The
study also evaluates advancement in electric vehicle technology,
required infrastructure for sustainability and future scope of
developments. This paper also includes the evaluation of electric
vehicle concept for pollution control and sustainable transport
systems in future. This study can be a benchmark for development of
electric vehicle as low carbon emission alternative for the cities of
tomorrow.
Abstract: Topical photodynamic therapy (PDT) with
5-aminolevulinic acid (ALA) is an alternative therapy for treating
superficial cancer, especially for skin or oral cancer. ALA, a precursor
of the photosensitizer protoporphyrin IX (PpIX), is present as
zwitterions and hydrophilic property which make the low permeability
through the cell membrane. Collagen is a traditional carrier; its
molecular composed various amino acids which bear positive charge
and negative charge. In order to utilize the ion-pairs with ALA and
collagen, the study employed various pH values adjusting the net
charge. The aim of this study was to compare a series collagen form,
including solution, gel and sponge to investigate the topical delivery
behavior of ALA. The in vivo confocal laser scanning microscopy
(CLSM) study demonstrated that PpIX generation ability was different
pattern after apply for 6 h. Gel type could generate high PpIX, and
archived more deep of skin depth.
Abstract: This work presents a multiple objective linear programming (MOLP) model based on the desirability function approach for solving the aggregate production planning (APP) decision problem upon Masud and Hwang-s model. The proposed model minimises total production costs, carrying or backordering costs and rates of change in labor levels. An industrial case demonstrates the feasibility of applying the proposed model to the APP problems with three scenarios of inventory levels. The proposed model yields an efficient compromise solution and the overall levels of DM satisfaction with the multiple combined response levels. There has been a trend to solve complex planning problems using various metaheuristics. Therefore, in this paper, the multi-objective APP problem is solved by hybrid metaheuristics of the hunting search (HuSIHSA) and firefly (FAIHSA) mechanisms on the improved harmony search algorithm. Results obtained from the solution of are then compared. It is observed that the FAIHSA can be used as a successful alternative solution mechanism for solving APP problems over three scenarios. Furthermore, the FAIHSA provides a systematic framework for facilitating the decision-making process, enabling a decision maker interactively to modify the desirability function approach and related model parameters until a good optimal solution is obtained with proper selection of control parameters when compared.
Abstract: Herein, we report the different types of surface morphology due to the interaction between the pure protein Insulin (INS) and catanionic surfactant mixture of Sodium Dodecyl Sulfate (SDS) and Cetyl Trimethyl Ammonium Bromide (CTAB) at air/water interface obtained by the Langmuir-Blodgett (LB) technique. We characterized the aggregations by Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM) and Fourier transform infrared spectroscopy (FTIR) in LB films. We found that the INS adsorption increased in presence of catanionic surfactant at air/water interface. The presence of small amount of surfactant induces two-stage growth kinetics due to the pure protein absorption and protein-catanionic surface micelle interaction. The protein remains in native state in presence of small amount of surfactant mixture. Smaller amount of surfactant mixture with INS is producing surface micelle type structure. This may be considered for drug delivery system. On the other hand, INS becomes unfolded and fibrillated in presence of higher amount of surfactant mixture. In both the cases, the protein was successfully immobilized on a glass substrate by the LB technique. These results may find applications in the fundamental science of the physical chemistry of surfactant systems, as well as in the preparation of drug-delivery system.
Abstract: Perth will run out of available sustainable natural
water resources by 2015 if nothing is done to slow usage rates,
according to a Western Australian study [1]. Alternative water
technology options need to be considered for the long-term
guaranteed supply of water for agricultural, commercial, domestic
and industrial purposes. Seawater is an alternative source of water for
human consumption, because seawater can be desalinated and
supplied in large quantities to a very high quality.
While seawater desalination is a promising option, the technology
requires a large amount of energy which is typically generated from
fossil fuels. The combustion of fossil fuels emits greenhouse gases
(GHG) and, is implicated in climate change. In addition to
environmental emissions from electricity generation for desalination,
greenhouse gases are emitted in the production of chemicals and
membranes for water treatment. Since Australia is a signatory to the
Kyoto Protocol, it is important to quantify greenhouse gas emissions
from desalinated water production.
A life cycle assessment (LCA) has been carried out to determine
the greenhouse gas emissions from the production of 1 gigalitre (GL)
of water from the new plant. In this LCA analysis, a new desalination
plant that will be installed in Bunbury, Western Australia, and known
as Southern Seawater Desalinization Plant (SSDP), was taken as a
case study. The system boundary of the LCA mainly consists of three
stages: seawater extraction, treatment and delivery. The analysis
found that the equivalent of 3,890 tonnes of CO2 could be emitted
from the production of 1 GL of desalinated water. This LCA analysis
has also identified that the reverse osmosis process would cause the
most significant greenhouse emissions as a result of the electricity
used if this is generated from fossil fuels