Abstract: Human genome is not only the evolutionary
summation of all advantageous events, but also houses lesions of
deleterious foot prints. A single gene mutation sometimes may
express multiple consequences in numerous tissues and a linear
relationship of the genotype and the phenotype may often be obscure.
ß Thalassemia minor, a transfusion independent mild anaemia,
coupled with environment among other factors may articulate into
phenotypic pleotropy with Hypocholesterolemia, Vitamin D
deficiency, Tissue hypoxia, Hyper-parathyroidism and Psychological
alterations. Occurrence of Pancreatic insufficiency, resultant
steatorrhoea, Vitamin-D (25-OH) deficiency (13.86 ngm/ml) with
Hypocholesterolemia (85mg/dl) in a 30 years old male ß Thal-minor
patient (Hemoglobin 11mg/dl with Fetal Hemoglobin 2.10%, Hb A2
4.60% and Hb Adult 84.80% and altered Hemogram) with increased
Para thyroid hormone (62 pg/ml) & moderate Serum Ca+2
(9.5mg/ml) indicate towards a cascade of phenotypic pleotropy
where the ß Thalassemia mutation ,be it in the 5’ cap site of the
mRNA , differential splicing etc in heterozygous state is effecting
several metabolic pathways. Compensatory extramedulary
hematopoiesis may not coped up well with the stressful life style of
the young individual and increased erythropoietic stress with high
demand for cholesterol for RBC membrane synthesis may have
resulted in Hypocholesterolemia.Oxidative stress and tissue hypoxia
may have caused the pancreatic insufficiency, leading to Vitamin D
deficiency. This may in turn have caused the secondary
hyperparathyroidism to sustain serum Calcium level. Irritability and
stress intolerance of the patient was a cumulative effect of the vicious
cycle of metabolic compromises. From these findings we propose
that the metabolic deficiencies in the ß Thalassemia mutations may
be considered as the phenotypic display of the pleotropy to explain
the genetic epidemiology.
According to the recommendations from the NIH Workshop on
Gene-Environment Interplay in Common Complex Diseases: Forging
an Integrative Model, study design of observations should be
informed by gene-environment hypotheses and results of a study
(genetic diseases) should be published to inform future hypotheses.
Variety of approaches is needed to capture data on all possible
aspects, each of which is likely to contribute to the etiology of
disease. Speakers also agreed that there is a need for development of
new statistical methods and measurement tools to appraise
information that may be missed out by conventional method where
large sample size is needed to segregate considerable effect.
A meta analytic cohort study in future may bring about significant
insight on to the title comment.
Abstract: This paper aims to study decomposition behavior in
pyrolytic environment of four lignocellulosic biomass (oil palm shell,
oil palm frond, rice husk and paddy straw), and two commercial
components of biomass (pure cellulose and lignin), performed in a
thermogravimetry analyzer (TGA). The unit which consists of a
microbalance and a furnace flowed with 100 cc (STP) min-1 Nitrogen,
N2 as inert. Heating rate was set at 20⁰C min-1 and temperature
started from 50 to 900⁰C. Hydrogen gas production during the
pyrolysis was observed using Agilent Gas Chromatography Analyzer
7890A. Oil palm shell, oil palm frond, paddy straw and rice husk
were found to be reactive enough in a pyrolytic environment of up to
900°C since pyrolysis of these biomass starts at temperature as low as
200°C and maximum value of weight loss is achieved at about
500°C. Since there was not much different in the cellulose,
hemicelluloses and lignin fractions between oil palm shell, oil palm
frond, paddy straw and rice husk, the T-50 and R-50 values obtained
are almost similar. H2 productions started rapidly at this temperature
as well due to the decompositions of biomass inside the TGA.
Biomass with more lignin content such as oil palm shell was found to
have longer duration of H2 production compared to materials of high
cellulose and hemicelluloses contents.
Abstract: Leave of absence is important in maintaining a good
status of human resource quality. Allowing the employees temporarily
free from the routine assignments can vitalize the workers- morality
and productivity. This is particularly critical to secure a satisfactory
service quality for healthcare professionals of which were typically
featured with labor intensive and complicated works to perform. As
one of the veteran hospitals that were found and operated by the
Veteran Department of Taiwan, the nursing staff of the case hospital
was squeezed to an extreme minimum level under the pressure of a
tight budgeting. Leave of absence on schedule became extremely
difficult, especially for the intensive care units (ICU), in which
required close monitoring over the cared patients, and that had more
easily driven the ICU nurses nervous. Even worse, the deferred leaves
were more than 10 days at any time in the ICU because of a fluctuating
occupancy. As a result, these had brought a bad setback to this
particular nursing team, and consequently defeated the job
performance and service quality. To solve this problem and
accordingly to strengthen their morality, a project team was organized
across different departments specific for this. Sufficient information
regarding jobs and positions requirements, labor resources, and actual
working hours in detail were collected and analyzed in the team
meetings. Several alternatives were finalized. These included job
rotating, job combination, leave on impromptu and cross-departmental
redeployment. Consequently, the deferred leave days sharply reduced
70% to a level of 3 or less days. This improvement had not only
provided good shelter for the ICU nurses that improved their job
performance and patient safety but also encouraged the nurses active
participating of a project and learned the skills of solving problems
with colleagues.
Abstract: Since the beginning of human history, human
activities have caused many changes in the environment. Today, a
particular attention should be paid to gaining knowledge about water
quality of wetlands which are pristine natural environments rich in
genetic reserves. If qualitative conditions of industrial areas (in terms
of both physicochemical and biological conditions) are not addressed
properly, they could cause disruption in natural ecosystems,
especially in rivers. With regards to the quality of water resources,
determination of pollutant sources plays a pivotal role in engineering
projects as well as designing water quality control systems. Thus,
using different methods such as flow duration curves, dischargepollution
load model and frequency analysis by HYFA software
package, risk of various industrial pollutants in international and
ecologically important Gavkhoni wetland is analyzed. In this study, a
station located at Varzaneh City is used as the last station on
Zayanderud River, from where the river water is discharged into the
wetland. Results showed that elements- concentrations often
exceeded the allowed level and river water can endanger regional
ecosystem. In addition, if the river discharge is managed on Q25
basis, this basis can lower concentrations of elements, keeping them
within the normal level.
Abstract: This paper presents the prediction of kidney
dysfunction using different neural network (NN) approaches. Self
organization Maps (SOM), Probabilistic Neural Network (PNN) and
Multi Layer Perceptron Neural Network (MLPNN) trained with Back
Propagation Algorithm (BPA) are used in this study. Six hundred and
sixty three sets of analytical laboratory tests have been collected from
one of the private clinical laboratories in Baghdad. For each subject,
Serum urea and Serum creatinin levels have been analyzed and tested
by using clinical laboratory measurements. The collected urea and
cretinine levels are then used as inputs to the three NN models in
which the training process is done by different neural approaches.
SOM which is a class of unsupervised network whereas PNN and
BPNN are considered as class of supervised networks. These
networks are used as a classifier to predict whether kidney is normal
or it will have a dysfunction. The accuracy of prediction, sensitivity
and specificity were found for each type of the proposed networks
.We conclude that PNN gives faster and more accurate prediction of
kidney dysfunction and it works as promising tool for predicting of
routine kidney dysfunction from the clinical laboratory data.
Abstract: Reinforced concrete crash barriers used in road traffic
must meet a number of criteria. Crash barriers are laid lengthwise,
one behind another, and joined using specially designed steel locks.
While developing BSV reinforced concrete crash barriers (type
ŽPSV), experiments and calculations aimed to optimize the shape of
a newly designed lock and the reinforcement quantity and
distribution in a crash barrier were carried out. The tension carrying
capacity of two parallelly joined locks was solved experimentally.
Based on the performed experiments, adjustments of nonlinear
properties of steel were performed in the calculations. The obtained
results served as a basis to optimize the lock design using a
computational model that takes into account the plastic behaviour of
steel and the influence of the surrounding concrete [6]. The response
to the vehicle impact has been analyzed using a specially elaborated
complex computational model, comprising both the nonlinear model
of the damping wall or crash barrier and the detailed model of the
vehicle [7].
Abstract: the data quality is a kind of complex and unstructured concept, which is concerned by information systems managers. The reason of this attention is the high amount of Expenses for maintenance and cleaning of the inefficient data. Such a data more than its expenses of lack of quality, cause wrong statistics, analysis and decisions in organizations. Therefor the managers intend to improve the quality of their information systems' data. One of the basic subjects of quality improvement is the evaluation of the amount of it. In this paper, we present a precautionary method, which with its application the data of information systems would have a better quality. Our method would cover different dimensions of data quality; therefor it has necessary integrity. The presented method has tested on three dimensions of accuracy, value-added and believability and the results confirm the improvement and integrity of this method.
Abstract: A different concept for designing and detailing of
reinforced concrete precast frame structures is analyzed in this paper.
The new detailing of the joints derives from the special hybrid
moment frame joints. The special reinforcements of this alternative
detailing, named modified special hybrid joint, are bondless with
respect to both column and beams. Full scale tests were performed on
a plan model, which represents a part of 5 story structure, cropped in
the middle of the beams and columns spans. Theoretical approach
was developed, based on testing results on twice repaired model,
subjected to lateral seismic type loading. Discussion regarding the
modified special hybrid joint behavior and further on widening
research needed concludes the presentation.
Abstract: Solution to unsteady Navier-Stokes equation by Splitting method in physical orthogonal algebraic curvilinear coordinate system, also termed 'Non-linear grid system' is presented. The linear terms in Navier-Stokes equation are solved by Crank- Nicholson method while the non-linear term is solved by the second order Adams-Bashforth method. This work is meant to bring together the advantage of Splitting method as pressure-velocity solver of higher efficiency with the advantage of consuming Non-linear grid system which produce more accurate results in relatively equal number of grid points as compared to Cartesian grid. The validation of Splitting method as a solution of Navier-Stokes equation in Nonlinear grid system is done by comparison with the benchmark results for lid driven cavity flow by Ghia and some case studies including Backward Facing Step Flow Problem.
Abstract: Recently, malware attacks have become more serious
over the Internet by e-mail, denial of service (DoS) or distributed
denial of service (DDoS). The Botnets have become a significant part
of the Internet malware attacks. The traditional botnets include three
parts – botmaster, command and control (C&C) servers and bots. The
C&C servers receive commands from botmaster and control the
distributions of computers remotely. Bots use DNS to find the
positions of C&C server. In this paper, we propose an advanced hybrid
peer-to-peer (P2P) botnet 2.0 (AHP2P botnet 2.0) using web 2.0
technology to hide the instructions from botmaster into social sites,
which are regarded as C&C servers. Servent bots are regarded as
sub-C&C servers to get the instructions from social sites. The AHP2P
botnet 2.0 can evaluate the performance of servent bots, reduce DNS
traffics from bots to C&C servers, and achieve harder detection bots
actions than IRC-based botnets over the Internet.
Abstract: In this paper, we study the application of Extreme
Learning Machine (ELM) algorithm for single layered feedforward
neural networks to non-linear chaotic time series problems. In this
algorithm the input weights and the hidden layer bias are randomly
chosen. The ELM formulation leads to solving a system of linear
equations in terms of the unknown weights connecting the hidden
layer to the output layer. The solution of this general system of
linear equations will be obtained using Moore-Penrose generalized
pseudo inverse. For the study of the application of the method we
consider the time series generated by the Mackey Glass delay
differential equation with different time delays, Santa Fe A and
UCR heart beat rate ECG time series. For the choice of sigmoid,
sin and hardlim activation functions the optimal values for the
memory order and the number of hidden neurons which give the
best prediction performance in terms of root mean square error are
determined. It is observed that the results obtained are in close
agreement with the exact solution of the problems considered
which clearly shows that ELM is a very promising alternative
method for time series prediction.
Abstract: The physical methods for RNA secondary structure prediction are time consuming and expensive, thus methods for computational prediction will be a proper alternative. Various algorithms have been used for RNA structure prediction including dynamic programming and metaheuristic algorithms. Musician's behaviorinspired harmony search is a recently developed metaheuristic algorithm which has been successful in a wide variety of complex optimization problems. This paper proposes a harmony search algorithm (HSRNAFold) to find RNA secondary structure with minimum free energy and similar to the native structure. HSRNAFold is compared with dynamic programming benchmark mfold and metaheuristic algorithms (RnaPredict, SetPSO and HelixPSO). The results showed that HSRNAFold is comparable to mfold and better than metaheuristics in finding the minimum free energies and the number of correct base pairs.
Abstract: This paper presents the work of signal discrimination
specifically for Electrocardiogram (ECG) waveform. ECG signal is
comprised of P, QRS, and T waves in each normal heart beat to
describe the pattern of heart rhythms corresponds to a specific
individual. Further medical diagnosis could be done to determine any
heart related disease using ECG information. The emphasis on QRS
Complex classification is further discussed to illustrate the
importance of it. Pan-Tompkins Algorithm, a widely known
technique has been adapted to realize the QRS Complex
classification process. There are eight steps involved namely
sampling, normalization, low pass filter, high pass filter (build a band
pass filter), derivation, squaring, averaging and lastly is the QRS
detection. The simulation results obtained is represented in a
Graphical User Interface (GUI) developed using MATLAB.
Abstract: This research aimed to study on the potential of
recycling organic waste in Suan Sunandha Rajabhat University as
compost. In doing so, the composition of solid waste generated in the
campus was investigated while physical and chemical properties of
organic waste were analyzed in order to evaluate the portion of waste
suitable for recycling as compost. As a result of the study, it was
found that (1) the amount of organic waste was averaged at 299.8
kg/day in which mixed food wastes had the highest amount of 191.9
kg/day followed by mixed leave & yard wastes and mixed fruit &
vegetable wastes at the amount of 66.3 and 41.6 kg/day respectively;
(2) physical and chemical properties of organic waste in terms of
moisture content was between 69.54 to 78.15%, major elements for
plant as N, P and K were 0.14 to 0.17%, 0.46 to 0.52% and 0.16 to
0.18% respectively, and carbon/nitrogen ratio (C/N) was about 15:1
to 17.5:1; (3) recycling organic waste as compost was designed by
aerobic decomposition using mixed food wastes : mixed leave & yard
wastes : mixed fruit & vegetable wastes at the portion of 3:2:1 by
weight in accordance with the potential of their amounts and their
physical and chemical properties.
Abstract: In this paper we discuss a set of guidelines which
could be adapted when designing an audio user interface for the
visually impaired. It is based on an audio environment that is
focused on audio positioning. Unlike current applications which only
interpret Graphical User Interface (GUI) for the visually impaired,
this particular audio environment bypasses GUI to provide a direct
auditory output. It presents the capability of two dimensional (2D)
navigation on audio interfaces. This paper highlights the significance
of a 2D audio environment with spatial information in the context
of the visually impaired. A thorough usability study has been conducted
to prove the applicability of proposed design guidelines for
these auditory interfaces. While proving these guidelines, previously
unearthed design aspects have been revealed in this study.
Abstract: This paper deals with the problem of thermal and
mechanical shocks, which rising during operation, mostly at
interrupted cut. Here will be solved their impact on the cutting edge
tool life, the impact of coating technology on resistance to shocks
and experimental determination of tool life in heating flame.
Resistance of removable cutting edges against thermal and
mechanical shock is an important indicator of quality as well as its
abrasion resistance. Breach of the edge or its crumble may occur due
to cyclic loading. We can observe it not only during the interrupted
cutting (milling, turning areas abandoned hole or slot), but also in
continuous cutting. This is due to the volatility of cutting force on
cutting. Frequency of the volatility in this case depends on the type
of rising chips (chip size element). For difficult-to-machine materials
such as austenitic steel particularly happened at higher cutting speeds
for the localization of plastic deformation in the shear plane and for
the inception of separate elements substantially continuous chips.
This leads to variations of cutting forces substantially greater than for
other types of steel.
Abstract: This paper presents a new approach for the prob-ability density function estimation using the Support Vector Ma-chines (SVM) and the Expectation Maximization (EM) algorithms.In the proposed approach, an advanced algorithm for the SVM den-sity estimation which incorporates the Mean Field theory in the learning process is used. Instead of using ad-hoc values for the para-meters of the kernel function which is used by the SVM algorithm,the proposed approach uses the EM algorithm for an automatic optimization of the kernel. Experimental evaluation using simulated data set shows encouraging results.
Abstract: In this paper, we consider the control of time delay system
by Proportional-Integral (PI) controller. By Using the Hermite-
Biehler theorem, which is applicable to quasi-polynomials, we seek
a stability region of the controller for first order delay systems. The
essence of this work resides in the extension of this approach to
second order delay system, in the determination of its stability region
and the computation of the PI optimum parameters. We have used
the genetic algorithms to lead the complexity of the optimization
problem.
Abstract: In this article we present a methodology which
enables preschool and primary school unlanguaged children to
remember words, phrases and texts with the help of graphic signs -
letters, syllables and words. Reading for a child becomes a support
for speech development. Teaching is based on the principle "from
simple to complex", "a letter - a syllable - a word - a proposal - a
text." Availability of multi-level texts allows using this methodology
for working with children who have different levels of speech
development.
Abstract: A pilot project was carried out in 2007 by the senior
students of Cyprus International University, aiming to minimize the
total cost of waste collection in Northern Cyprus. Many developed
and developing countries have cut their transportation costs – which
lies between 30-40% – down at a rate of 40% percent, by
implementing network models for their route assignments.
Accordingly, a network model was implemented at Göçmenköy
district, to optimize and standardize waste collection works. The
work environment of the employees were also redesigned to provide
maximum ergonomy and to increase productivity, efficiency and
safety. Following the collection of the required data including waste
densities, lengths of roads and population, a model was constructed
to allocate the optimal route assignment for the waste collection
trucks at Göçmenköy district.