Abstract: Sense-antisense gene pair (SAGP) is a pair of two oppositely transcribed genes sharing a common region on a chromosome. In the mammalian genomes, SAGPs can be organized in more complex sense-antisense gene architectures (CSAGA) in which at least one gene could share loci with two or more antisense partners. Many dozens of CSAGAs can be found in the human genome. However, CSAGAs have not been systematically identified and characterized in context of their role in human diseases including cancers. In this work we characterize the structural-functional properties of a cluster of 5 genes –TMEM97, IFT20, TNFAIP1, POLDIP2 and TMEM199, termed TNFAIP1 / POLDIP2 module. This cluster is organized as CSAGA in cytoband 17q11.2. Affymetrix U133A&B expression data of two large cohorts (410 atients, in total) of breast cancer patients and patient survival data were used. For the both studied cohorts, we demonstrate (i) strong and reproducible transcriptional co-regulatory patterns of genes of TNFAIP1/POLDIP2 module in breast cancer cell subtypes and (ii) significant associations of TNFAIP1/POLDIP2 CSAGA with amplification of the CSAGA region in breast cancer, (ii) cancer aggressiveness (e.g. genetic grades) and (iv) disease free patient-s survival. Moreover, gene pairs of this module demonstrate strong synergetic effect in the prognosis of time of breast cancer relapse. We suggest that TNFAIP1/ POLDIP2 cluster can be considered as a novel type of structural-functional gene modules in the human genome.
Abstract: Turbulence modeling of large-scale flow over a vegetated surface is complex. Such problems involve large scale computational domains, while the characteristics of flow near the surface are also involved. In modeling large scale flow, surface roughness including vegetation is generally taken into account by mean of roughness parameters in the modified law of the wall. However, the turbulence structure within the canopy region cannot be captured with this method, another method which applies source/sink terms to model plant drag can be used. These models have been developed and tested intensively but with a simple surface geometry. This paper aims to compare the use of roughness parameter, and additional source/sink terms in modeling the effect of plant drag on wind flow over a complex vegetated surface. The RNG k-ε turbulence model with the non-equilibrium wall function was tested with both cases. In addition, the k-ω turbulence model, which is claimed to be computationally stable, was also investigated with the source/sink terms. All numerical results were compared to the experimental results obtained at the study site Mason Bay, Stewart Island, New Zealand. In the near-surface region, it is found that the results obtained by using the source/sink term are more accurate than those using roughness parameters. The k-ω turbulence model with source/sink term is more appropriate as it is more accurate and more computationally stable than the RNG k-ε turbulence model. At higher region, there is no significant difference amongst the results obtained from all simulations.
Abstract: Aluminum alloy sheets have several advantages such
as the lightweight, high-specific strength and recycling efficiency.
Therefore, aluminum alloy sheets in sheet forming have been used in various areas as automotive components and so forth. During the
process of sheet forming, wrinkling which is caused by compression stress might occur and the formability of sheets was affected by
occurrence of wrinkling. A few studies of uniaxial compressive test by
using square tubes, pipes and sheets were carried out to clarify the each wrinkling behavior. However, on uniaxial compressive test,
deformation behavior of the sheets hasn-t be cleared. Then, it is necessary to clarify the relationship between the buckling behavior
and the forming conditions. In this study, the effect of dimension of the sheet in the buckling behavior on compression test of aluminum alloy sheet was cleared by experiment and FEA. As the results, the buckling
deformation was classified by three modes in terms of the distribution of equivalent plastic strain.
Abstract: Recently, majors of doctors are divided into terribly lots of detailed areas. However, it is actually not a rare case that a doctor has a patient who is not in his/her major. He/She must judge an assessment and make a medical treatment plan for this patient. According to our investigation, conventional approaches such as image diagnosis cooperation are insufficient. This paper proposes an 'Assessment / Medical Treatment Plan Consulting System'. We have implemented a pilot system based on our proposition. Its effectiveness is clarified by an evaluation.
Abstract: The integral form of equations of motion of composite
beams subjected to varying time loads are discretized using a
developed finite element model. The model consists of a straight five
node twenty-two degrees of freedom beam element. The stability
analysis of the beams is studied by solving the matrix form
characteristic equations of the system. The principle of virtual work
and the first order shear deformation theory are employed to analyze
the beams with large deformation and small strains. The regions of
dynamic instability of the beam are determined by solving the
obtained Mathieu form of differential equations. The effects of nonconservative
loads, shear stiffness, and damping parameters on
stability and response of the beams are examined. Several numerical
calculations are presented to compare the results with data reported
by other researchers.
Abstract: This study is aimed to investigate feasibility of the
aerobic biological process to treat oily wastewater from palm oil food
industry. Effect of aeration and sludge concentrations are studied.
Raw sludge and raw wastewater was mixed and acclimatized for five
days in a stirred tank reactor. The aeration rate (no aeration, low;
1.5L/min and high rate; 2L/min) and sludge concentration (3675,
7350, and 11025mg/L of VSS) were varied. Responses of process
were pH, COD, oil and grease, VSS, and PHB content. It was found
that the treatment can remove 85.1 to 97.1 % of COD and remove
12.9 to 54.8% of oil & grease. The PHB yield was found to be within
0.15% to 2.4% as PHB/VSS ratio and 0.01% to 0.12% as PHB/COD
removed. The higher aeration results a high COD removal and oil &
grease removal, while experiment without aeration gives better PHB
yield. Higher sludge concentrations (11025mg/L VSS) give higher
removal of oil & grease while moderate sludge concentration
(7350mg/L VSS) give better result in COD removal. Higher PHB
yield is obtained in low sludge concentration (3675mg/L).
Abstract: Estimation of natural frequency of structures is very
important and isn-t usually calculated simply and sometimes
complicated. Lack of knowledge about that caused hard damage and
hazardous effects.
In this paper, with using from two different models in FEM
method and based on hydrodynamic mass of fluids, natural frequency
of an especial bearing (Fig. 1) in an electric field (or, a periodic
force) is calculated in different stiffness and different geometric. In
final, the results of two models and analytical solution are compared.
Abstract: In this paper the complete rotor system including
elastic shaft with distributed mass, allowing for the effects of oil film
in bearings. Also, flexibility of foundation is modeled. As a whole
this article is a relatively complete research in modeling and
vibration analysis of rotor considering gyroscopic effect, damping,
dependency of stiffness and damping coefficients on frequency and
solving the vibration equations including these parameters. On the
basis of finite element method and utilizing four element types
including element of shaft, disk, bearing and foundation and using
MATLAB, a computer program is written. So the responses in
several cases and considering different effects are obtained. Then the
results are compared with each other, with exact solutions and results
of other papers.
Abstract: In this investigation, anatase TiO2 thin films were
grown by radio frequency magnetron sputtering on glass substrates at
a high sputtering pressure and room temperature. The anatase films
were then annealed at 300-600 °C in air for a period of 1 hour. To
examine the structure and morphology of the films, X-ray diffraction
(XRD) and atomic force microscopy (AFM) methods were used
respectively. From X-ray diffraction patterns of the TiO2 films, it was
found that the as-deposited film showed some differences compared
with the annealed films and the intensities of the peaks of the
crystalline phase increased with the increase of annealing
temperature. From AFM images, the distinct variations in the
morphology of the thin films were also observed. The optical
constants were characterized using the transmission spectra of the
films obtained by UV-VIS-IR spectrophotometer. Besides, optical
thickness of the film deposited at room temperature was calculated
and cross-checked by taking a cross-sectional image through SEM.
The optical band gaps were evaluated through Tauc model. It was
observed that TiO2 films produced at room temperatures exhibited
high visible transmittance and transmittance decreased slightly with
the increase of annealing temperatures. The films were found to be
crystalline having anatase phase. The refractive index of the films
was found from 2.31-2.35 in the visible range. The extinction
coefficient was nearly zero in the visible range and was found to
increase with annealing temperature. The allowed indirect optical
band gap of the films was estimated to be in the range from 3.39 to
3.42 eV which showed a small variation. The allowed direct band
gap was found to increase from 3.67 to 3.72 eV. The porosity was
also found to decrease at a higher annealing temperature making the
film compact and dense.
Abstract: Fertilization plays an important role in crop growth and soil improvement. This study was conducted to determine the best fertilization system for wheat production. Experiments were arranged in a complete block design with three replications in two years. Main plots consisted of six methods of fertilization including (N1): farmyard manure; (N2): compost; (N3): chemical fertilizers; (N4): farmyard manure + compost; (N5): farmyard manure + compost + chemical fertilizers and (N6): control were arranged in sub plots. The addition of compost or farm yard manure significantly increased the soil microbial biomass carbon in comparison to the chemical fertilizer. The dehydrogenase, phosphatase and urease activities in the N3 treatment were significantly lower than in the farm yard manure and compost treatments.
Abstract: In this study the mixed mode fracture mechanics
parameters were investigated for high tensile steel butt welded joint
based on modified Arcan test and finite element analysis was used to
evaluate the effect of crack length on fracture criterion. The nondimensional
stress intensity factors, strain energy release rates and Jintegral
energy on crack tip were obtained for various in-plane
loading combinations on Arcan specimen starting from pure mode-I
to pure mode-II loading conditions. The specimen and apparatus were
modeled by finite element method and analyzed under various
loading angles (between 0 to 90 degrees with 15 degree interval) to
simulate the pure mode-I, II and mixed mode fracture. Since the
analytical results are independent from elasticity modules for
isotropic materials, therefore the results in elastic fields can be used
for Arcan specimens. The main objective of this study was to
evaluate the geometric calibration factors for modified Arcan test
specimen in order to obtain fracture toughness under mixed mode
loading conditions.
Abstract: In this paper, in order to categorize ORL database face
pictures, principle Component Analysis (PCA) and Kernel Principal
Component Analysis (KPCA) methods by using Elman neural
network and Support Vector Machine (SVM) categorization methods
are used. Elman network as a recurrent neural network is proposed
for modeling storage systems and also it is used for reviewing the
effect of using PCA numbers on system categorization precision rate
and database pictures categorization time. Categorization stages are
conducted with various components numbers and the obtained results
of both Elman neural network categorization and support vector
machine are compared. In optimum manner 97.41% recognition
accuracy is obtained.
Abstract: This paper presents ageing experiments controlled by the evolution of junction parameters. The deterioration of the device is related to high injection effects which modified the transport mechanisms in the space charge region of the junction. Physical phenomena linked to the degradation of junction parameters that affect the devices reliability are reported and discussed. We have used the method based on numerical analysis of experimental current-voltage characteristic of the junction, in order to extract the electrical parameters. The simultaneous follow-up of the evolutions of the series resistance and of the transition voltage allow us to introduce a new parameter for reliability evaluation.
Abstract: Almost all Libyan industries (both private and public) have struggled with many difficulties during the past three decades due to many problems. These problems have created a strongly negative impact on the productivity and utilization of many companies within Libya. This paper studies the current awareness and implementation levels of Just-In-Time (JIT) within the Libyan Textile private industry. A survey has been applied in this study using an intensive detailed questionnaire. Based on the analysis of the survey responses, the results show that the management body within the surveyed companies has a modest strategy towards most of the areas that are considered as being very crucial in any successful implementation of JIT. The results also show a variation within the implementation levels of the JIT elements as these varies between Low and Acceptable levels. The paper has also identified limitations within the investigated areas within this industry, and has pointed to areas where senior managers within the Libyan textile industry should take immediate actions in order to achieve effective implementation of JIT within their companies.
Abstract: The paper considers the effect of feed plate location
on the interactions in a seven plate binary distillation column. The
mathematical model of the distillation column is deduced based on
the equations of mass and energy balances for each stage, detailed
model for both reboiler and condenser, and heat transfer equations.
The Dynamic Relative Magnitude Criterion, DRMC is used to assess
the interactions in different feed plate locations for a seven plate
(Benzene-Toluene) binary distillation column ( the feed plate is
originally at stage 4). The results show that whenever we go far from
the optimum feed plate position, the level of interaction augments.
Abstract: Food borne illnesses have been reported to be a global
health challenge. Annual incidences of food–related diseases involve
76 million cases, of which only 14 million can be traced to known
pathogens. Poor hygienic practices have contributed greatly to this. It
has been reported that in the year 2000 about 2.1 million people died
from diarrheal diseases, hence, there is a need to ensure food safety at
all level. This study focused on the sterility examination and
inhibitory effect of honey samples on selected gram negative and
gram positive food borne pathogen from South West Nigeria. The
laboratory examinations revealed the presence of some bacterial and
fungal contaminations of honey samples and that inhibitory activity
of the honey sample was more pronounced on the gram negative
bacteria than the gram positive bacterial isolates. Antibiotic
sensitivity test conducted on the different bacterial isolates also
showed that honey was able to inhibit the proliferation of the tested
bacteria than the employed antibiotics.
Abstract: Data Envelopment Analysis (DEA) is a methodology
that computes efficiency values for decision making units (DMU) in a
given period by comparing the outputs with the inputs. In many cases,
there are some time lag between the consumption of inputs and the
production of outputs. For a long-term research project, it is hard to
avoid the production lead time phenomenon. This time lag effect
should be considered in evaluating the performance of organizations.
This paper suggests a model to calculate efficiency values for the
performance evaluation problem with time lag. In the experimental
part, the proposed methods are compared with the CCR and an
existing time lag model using the data set of the 21st century frontier
R&D program which is a long-term national R&D program of Korea.
Abstract: This paper examined the influence of matching
students- learning preferences with the teaching methodology
adopted, on their academic performance in an accounting course in
two types of learning environment in one university in Lebanon:
classes with PowerPoint (PPT) vs. conventional classes. Learning
preferences were either for PPT or for Conventional methodology. A
statistically significant increase in academic achievement is found in
the conventionally instructed group as compared to the group taught
with PPT. This low effectiveness of PPT might be attributed to the
learning preferences of Lebanese students. In the PPT group, better
academic performance was found among students with
learning/teaching match as compared with students with
learning/teaching mismatch. Since the majority of students display a
preference for the conventional methodology, the result might
suggest that Lebanese students- performance is not optimized by PPT
in the accounting classrooms, not because of PPT itself, but because
it is not matching the Lebanese students- learning preferences in such
a quantitative course.
Abstract: In this paper we investigate the electrical
characteristics of a new structure of gate all around strained silicon
nanowire field effect transistors (FETs) with dual dielectrics by
changing the radius (RSiGe) of silicon-germanium (SiGe) wire and
gate dielectric. Indeed the effect of high-κ dielectric on Field Induced
Barrier Lowering (FIBL) has been studied. Due to the higher electron
mobility in tensile strained silicon, the n-type FETs with strained
silicon channel have better drain current compare with the pure Si
one. In this structure gate dielectric divided in two parts, we have
used high-κ dielectric near the source and low-κ dielectric near the
drain to reduce the short channel effects. By this structure short
channel effects such as FIBL will be reduced indeed by increasing
the RSiGe, ID-VD characteristics will be improved. The leakage
current and transfer characteristics, the threshold-voltage (Vt), the
drain induced barrier height lowering (DIBL), are estimated with
respect to, gate bias (VG), RSiGe and different gate dielectrics. For
short channel effects, such as DIBL, gate all around strained silicon
nanowire FET have similar characteristics with the pure Si one while
dual dielectrics can improve short channel effects in this structure.
Abstract: Background: Widespread use of chemotherapeutic
drugs in the treatment of cancer has lead to higher health hazards
among employee who handle and administer such drugs, so nurses
should know how to protect themselves, their patients and their work
environment against toxic effects of chemotherapy. Aim of this study
was carried out to examine the effect of chemotherapy safety protocol
for oncology nurses on their protective measure practices. Design: A
quasi experimental research design was utilized. Setting: The study
was carried out in oncology department of Menoufia university
hospital and Tanta oncology treatment center. Sample: A
convenience sample of forty five nurses in Tanta oncology treatment
center and eighteen nurses in Menoufiya oncology department.
Tools: 1. an interviewing questionnaire that covering sociodemographic
data, assessment of unit and nurses' knowledge about
chemotherapy. II: Obeservational check list to assess nurses' actual
practices of handling and adminestration of chemotherapy. A base
line data were assessed before implementing Chemotherapy Safety
protocol, then Chemotherapy Safety protocol was implemented, and
after 2 monthes they were assessed again. Results: reveled that 88.9%
of study group I and 55.6% of study group II improved to good total
knowledge scores after educating on the safety protocol, also 95.6%
of study group I and 88.9% of study group II had good total practice
score after educating on the safety protocol. Moreover less than half
of group I (44.4%) reported that heavy workload is the most barriers
for them, while the majority of group II (94.4%) had many barriers
for adhering to the safety protocol such as they didn’t know the
protocol, the heavy work load and inadequate equipment.
Conclusions: Safety protocol for Oncology Nurses seemed to have
positive effect on improving nurses' knowledge and practice.
Recommendation: chemotherapy safety protocol should be instituted
for all oncology nurses who are working in any oncology unit and/ or
center to enhance compliance, and this protocol should be done at
frequent intervals.