Abstract: Purpose: The study aimed to assess the depressant or
antidepressant effects of several Nonsteroidal Anti-Inflammatory
Drugs (NSAIDs) in mice: the selective cyclooxygenase-2 (COX-2)
inhibitor meloxicam, and the non-selective COX-1 and COX-2
inhibitors lornoxicam, sodium metamizole, and ketorolac. The
current literature data regarding such effects of these agents are
scarce.
Materials and methods: The study was carried out on NMRI mice
weighing 20-35 g, kept in a standard laboratory environment. The
study was approved by the Ethics Committee of the University of
Medicine and Pharmacy „Carol Davila”, Bucharest. The study agents
were injected intraperitoneally, 10 mL/kg body weight (bw) 1 hour
before the assessment of the locomotor activity by cage testing (n=10
mice/ group) and 2 hours before the forced swimming tests (n=15).
The study agents were dissolved in normal saline (meloxicam,
sodium metamizole), ethanol 11.8% v/v in normal saline (ketorolac),
or water (lornoxicam), respectively. Negative and positive control
agents were also given (amitryptilline in the forced swimming test).
The cage floor used in the locomotor activity assessment was divided
into 20 equal 10 cm squares. The forced swimming test involved
partial immersion of the mice in cylinders (15/9cm height/diameter)
filled with water (10 cm depth at 28C), where they were left for 6
minutes. The cage endpoint used in the locomotor activity assessment
was the number of treaded squares. Four endpoints were used in the
forced swimming test (immobility latency for the entire 6 minutes,
and immobility, swimming, and climbing scores for the final 4
minutes of the swimming session), recorded by an observer that was
„blinded” to the experimental design. The statistical analysis used the
Levene test for variance homogeneity, ANOVA and post-hoc
analysis as appropriate, Tukey or Tamhane tests.
Results: No statistically significant increase or decrease in the
number of treaded squares was seen in the locomotor activity
assessment of any mice group. In the forced swimming test,
amitryptilline showed an antidepressant effect in each experiment, at
the 10 mg/kg bw dosage. Sodium metamizole was depressant at 100
mg/kg bw (increased the immobility score, p=0.049, Tamhane test),
but not in lower dosages as well (25 and 50 mg/kg bw). Ketorolac
showed an antidepressant effect at the intermediate dosage of 5
mg/kg bw, but not so in the dosages of 2.5 and 10 mg/kg bw,
respectively (increased the swimming score, p=0.012, Tamhane test).
Meloxicam and lornoxicam did not alter the forced swimming
endpoints at any dosage level.
Discussion: 1) Certain NSAIDs caused changes in the forced
swimming patterns without interfering with locomotion. 2) Sodium
metamizole showed a depressant effect, whereas ketorolac proved
antidepressant. Conclusion: NSAID-induced mood changes are not
class effects of these agents and apparently are independent of the
type of inhibited cyclooxygenase (COX-1 or COX-2).
Disclosure: This paper was co-financed from the European Social
Fund, through the Sectorial Operational Programme Human Resources Development 2007-2013, project number POSDRU /159
/1.5 /S /138907 "Excellence in scientific interdisciplinary research,
doctoral and postdoctoral, in the economic, social and medical fields
-EXCELIS", coordinator The Bucharest University of Economic
Studies.
Abstract: Here, we study the characteristic feature of
conventional (ON-OFF keying) and soliton based transmission
system. We consider 20Gbps transmission system implemented with
Conventional Single Mode Fiber (C-SMF) to examine the role of
Gaussian pulse which is the characteristic of conventional
propagation and Hyperbolic-secant pulse which is the characteristic
of soliton propagation in it. We note the influence of these pulses
with respect to different dispersion lengths and soliton period in
conventional and soliton system respectively and evaluate the system
performance in terms of Quality factor. From the analysis, we could
prove that the soliton pulse has the consistent performance even for
long distance without dispersion compensation than the conventional
system as it is robust to dispersion. For the length of transmission of
200Km, soliton system yielded Q of 33.958 while the conventional
system totally exhausted with Q=0.
Abstract: In this research article of modeling Underwater
Wireless Sensor Network Simulators, we provide a comprehensive
overview of the various currently available simulators used in UWSN
modeling. In this work, we compare their working environment,
software platform, simulation language, key features, limitations and
corresponding applications. Based on extensive experimentation and
performance analysis, we provide their efficiency for specific
applications. We have also provided guidelines for developing
protocols in different layers of the protocol stack, and finally these
parameters are also compared and tabulated. This analysis is
significant for researchers and designers to find the right simulator
for their research activities.
Abstract: Fruit juices play important roles in human health as
being a key part of nutrition. Juice and nectar are two categories of
drinks with so many variations for consumers, regardless of age,
lifestyle and taste preferences, which they can find their favorites.
Juices contain 100% pulp when pulp content of ‘nectar’ changes
between 25%-50%. In this study, potassium (K), magnesium (Mg),
and phosphorus (P) contents in orange juice and nectar is determined
for conscious consumption. For this purpose inductively coupled
plasma optical emission spectrometry (ICP-OES) is used to find out
potassium (K), magnesium (Mg), and phosphorus (P) contents in
orange juices and nectar. Furthermore, the daily intake of elements
from orange juice and nectar that affects human health is also
investigated. From the results of experiments K, Mg and P contents
are found in orange juice as 1351; 73,25; 89,27 ppm and in orange
nectar as 986; 33,76; 51,30 respectively.
Abstract: This paper deals with various questions related to
functionality and providing banking services in the European union
on the Internet. Due to the fact that we live in the information
technologies era, the Internet become a new space for doing
economic and business activities in all areas, and especially important
in banking. Accepting the busy tempo of life, in the past several years
electronic banking has become necessity and a must for most users of
banking services. On a sample of 300 web sites of the banks
operating in European Union (EU) we conduct the research on the
functionality of e-banking services offered through banks web sites
with the key objective to reveal to what extent the information
technologies are used in their business operations. Characteristics of
EU banks websites will be examined and compared to the basic
groups of business activities on the web. Also some
recommendations for the successful bank web sites will be provided.
Abstract: The relationship between the state and the religion is
different based on the fact that how powerful is the religion faith in a
state and of the influences that affected the views of the constitution
drafters according to the constitutional system they were based to
draft their constitution. This paper aims at providing, through a
comparative methodology, how it is regulated by the constitution the
relationship between the state and the religion. The object of this
study are the constitutions of Italy as a nation with catholic religious
tradition, Greece as a nation with orthodox religion tradition, and
Turkey as a nation which represents Muslim religion, while Albania
as a nation known for its religious plurality. In particular, the analysis
will be focused on the secular or religious principle provided in the
constitution of each respective state. This comparative overview
intends to discern which of the states analyzed is more tolerant and
fully respects the freedom of religion. It results that most of the states
subject of this study, despite their religious tradition have chosen the
secular principle in their constitutions, but the religious freedom is
differently guaranteed.
Abstract: One of the key aspects of power quality improvement
in power system is the mitigation of voltage sags/swells and flicker.
Custom power devices have been known as the best tools for voltage
disturbances mitigation as well as reactive power compensation.
Dynamic Voltage Restorer (DVR) which is the most efficient and
effective modern custom power device can provide the most
commercial solution to solve several problems of power quality in
distribution networks. This paper deals with analysis and simulation
technique of DVR based on instantaneous power theory which is a
quick control to detect signals. The main purpose of this work is to
remove three important disturbances including voltage sags/swells
and flicker. Simulation of the proposed method was carried out on
two sample systems by using Matlab software environment and the
results of simulation show that the proposed method is able to
provide desirable power quality in the presence of wide range of
disturbances.
Abstract: The aim of this research is to identify the key factors in shipping company’s port selection in order to providing their requirement. To identify and rank factors that play the main role in selecting port for providing the ship requirement, at the first step, data were collected via Semi-structured interviews, the aim was to generate knowledge on how shipping company select the port and suppliers for providing their needs. 37 port selection factors were chosen from the previous researches and field interviews and have been categorized into two groups of port's factor and the factors of services of suppliers companies. The current study adopts a questionnaire survey to the main shipping companies' operators in Iran. Their responses reveal that level of services of supplying companies and customs rules play the important role in selecting the ports. Our findings could affect decisions made by port authorities to consider that supporting the privet sections for ship chandelling business could have the best result in attracting ships.
Abstract: Agro-industry is one of major industries that have
strong impacts on national economic incomes, growth, stability, and
sustainable development. Moreover, this industry also has strong
influences on social, cultural and political issues. Furthermore, this
industry, as producing primary and secondary products, is facing
challenges from such diverse factors such as demand inconsistency,
intense international competition, technological advancements and
new competitors. In order to maintain and to improve industry’s
competitiveness in both domestics and international markets, science
and technology are key factors. Besides hard sciences and
technologies, modern industrial engineering concepts such as Just in
Time (JIT) Total Quality Management (TQM), Quick Response
(QR), Supply Chain Management (SCM) and Lean can be very
effective to support to increase efficiency and effectiveness of these
agricultural products on world stage. Onion is one of Thailand’s
major export products which bring back national incomes. But, it is
also facing challenges in many ways. This paper focused its interests
in onion packing process and its related activities such as storage and
shipment from one of major packing plant and storage in Mae Wang
District, Chiang Mai, Thailand, by applying Toyota Production
System (TPS) or Lean concepts, to improve process capability
throughout the entire packing and distribution process which will be
profitable for the whole onion supply chain. And it will be beneficial
to other related agricultural products in Thailand and other ASEAN
countries.
Abstract: Roadway planning and design is a very complex
process involving five key phases before a project is completed;
planning, project development, final design, right-of-way, and
construction. The planning phase for a new roadway transportation
project is a very critical phase as it greatly affects all latter phases of
the project. A location study is usually performed during the
preliminary planning phase in a new roadway project. The objective
of the location study is to develop alignment alternatives that are cost
efficient considering land acquisition and construction costs. This
paper describes a methodology to develop optimal preliminary
roadway alignments utilizing spatial-data. Four optimization criteria
are taken into consideration; roadway length, land cost, land slope,
and environmental impacts. The basic concept of the methodology is
to convert the proposed project area into a grid, which represents the
search space for an optimal alignment. The aforementioned
optimization criteria are represented in each of the grid’s cells. A
spatial-data optimization technique is utilized to find the optimal
alignment in the search space based on the four optimization criteria.
Two case studies for new roadway projects in Duval County in the
State of Florida are presented to illustrate the methodology. The
optimization output alignments are compared to the proposed Florida
Department of Transportation (FDOT) alignments. The comparison is
based on right-of-way costs for the alignments. For both case studies,
the right-of-way costs for the developed optimal alignments were
found to be significantly lower than the FDOT alignments.
Abstract: The coaxial transformer-coupled push-pull circuitry
has been used widely in HF and VHF amplifiers for many decades
without significant changes in the topology of the transformers. Basic
changes over the years concerned the construction and turns ratio of
the transformers as has been imposed upon the newer technologies
active devices demands. The balun transmission line transformers
applied in push-pull amplifiers enable input/output impedance
transformation, but are mainly used to convert the balanced output
into unbalanced and the input unbalanced into balanced. A simple
and affordable alternative solution over the traditional coaxial
transformer is the coreless planar balun. A key advantage over the
traditional approach lies in the high specifications repeatability;
simplifying the amplifier construction requirements as the planar
balun constitutes an integrated part of the PCB copper layout. This
paper presents the performance analysis of a planar LDMOS
MRFE6VP5600 Push-Pull amplifier that enables robust operation in
Band III, DVB-T, DVB-T2 standards but functions equally well in
Band II, for DRM+ new generation transmitters.
Abstract: Recently, there is a lot of interest in the field of under
water optical wireless communication for short range because of
its high bandwidth. But in most of the previous works line of
sight propagation or single scattering of photons only considered.
In practical case this is not applicable because of beam blockage in
underwater and multiple scattering also occurred during the photons
propagation through water. In this paper we consider a non-line
of sight underwater wireless optical communication system with
multiple scattering and examine the performance of the system using
monte carlo simulation. The distribution scattering angle of photons
are modeled by Henyey-Greenstein method. The average bit error
rate is calculated using on-off keying modulation for different water
types.
Abstract: Ulexite (Na2O.2CaO.5B2O3.16H2O) is boron mineral
that is found in large quantities in the Turkey and world. In this
study, the dissolution of this mineral in the disodium hydrogen
phosphate solutions has been studied. Temperature, concentration,
stirring speed, solid liquid ratio and particle size were selected as
parameters. The experimental results were successfully correlated by
linear regression using Statistica program. Dissolution curves were
evaluated shrinking core models for solid-fluid systems. It was
observed that increase in the reaction temperature and decrease in the
solid/liquid ratio causes an increase the dissolution rate of ulexite.
The activation energy was found to be 63.4 kJ/mol. The leaching of
ulexite was controlled by chemical reaction.
Abstract: A central element of higher education today is the
“core” or “general education” curriculum: that configuration of
courses that often encompasses the essence of liberal arts education.
Ensuring that such offerings reflect the mission and values of the
institution is a challenge faced by most college and universities, often
more than once. This paper presents an action model of program
planning designed to structure the processes of developing,
implementing and revising core curricula in a manner consistent with
key institutional goals and objectives. Through presentation of a case
study from a university in the United States, the elements of needs
assessment, stakeholder investment and collaborative compromise
are shown as key components of a planning strategy that can produce
a general education program that is comprehensive, academically
rigorous, assessable, and mission consistent. The paper concludes
with recommendations for both the implementation and evaluation of
such programs in practice.
Abstract: One of the crucial parameters of digital cryptographic
systems is the selection of the keys used and their distribution. The
randomness of the keys has a strong impact on the system’s security
strength being difficult to be predicted, guessed, reproduced, or
discovered by a cryptanalyst. Therefore, adequate key randomness
generation is still sought for the benefit of stronger cryptosystems.
This paper suggests an algorithm designed to generate and test
pseudo random number sequences intended for cryptographic
applications. This algorithm is based on mathematically manipulating
a publically agreed upon information between sender and receiver
over a public channel. This information is used as a seed for
performing some mathematical functions in order to generate a
sequence of pseudorandom numbers that will be used for
encryption/decryption purposes. This manipulation involves
permutations and substitutions that fulfill Shannon’s principle of
“confusion and diffusion”. ASCII code characters were utilized in the
generation process instead of using bit strings initially, which adds
more flexibility in testing different seed values. Finally, the obtained
results would indicate sound difficulty of guessing keys by attackers.
Abstract: The efficiency of the actuation system of exoskeletons
and active orthoses for lower limbs is a significant aspect of the
design of such devices because it affects their efficacy. The F-IVT is
an innovative actuation system to power artificial knee joint with
energy recovery capabilities. Its key and non-conventional elements
are a flywheel that acts as a mechanical energy storage system, and
an Infinitely Variable Transmission (IVT). The design of the F-IVT
can be optimized for a certain walking condition, resulting in a heavy
reduction of both the electric energy consumption and of the electric
peak power. In this work, by means of simulations of level ground
walking at different speeds, it is demonstrated that the F-IVT is still
an advantageous actuator which permits to save energy consumption
and to downsize the electric motor even when it does not work in
nominal conditions.
Abstract: Transmission system performance analysis is vital to
proper planning and operations of power systems in the presence of
deregulation. Key performance indicators (KPIs) are often used as
measure of degree of performance. This paper gives a novel method
to determine the transmission efficiency by evaluating the ratio of
real power losses incurred from a specified transfer direction.
Available Transmission Transfer Efficiency (ATTE) expresses the
percentage of real power received resulting from inter-area available
power transfer. The Tie line (Rated system path) performance is seen
to differ from system wide (Network response) performance and
ATTE values obtained are transfer direction specific. The required
sending end quantities with specified receiving end ATC and the
receiving end power circle diagram are obtained for the tie line
analysis. The amount of real power loss load relative to the available
transfer capability gives a measure of the transmission grid
efficiency.
Abstract: Availability of different genetic tests after completion
of Human Genome Project increases the physicians’ responsibility to
keep themselves update on the potential implementation of these
genetic tests in their daily practice. However, due to numbers of
barriers, still many of physicians are not either aware of these tests or
are not willing to offer or refer their patients for genetic tests. This
study was conducted an anonymous, cross-sectional, mailed-based
survey to develop a primary data of Malaysian physicians’ level of
knowledge and perception of gene profiling. Questionnaire had 29
questions. Total scores on selected questions were used to assess the
level of knowledge. The highest possible score was 11. Descriptive
statistics, one way ANOVA and chi-squared test was used for
statistical analysis. Sixty three completed questionnaires were
returned by 27 general practitioners (GPs) and 36 medical specialists.
Responders’ age ranges from 24 to 55 years old (mean 30.2 ± 6.4).
About 40% of the participants rated themselves as having poor level
of knowledge in genetics in general whilst 60% believed that they
have fair level of knowledge; however, almost half (46%) of the
respondents felt that they were not knowledgeable about available
genetic tests. A majority (94%) of the responders were not aware of
any lab or company which is offering gene profiling services in
Malaysia. Only 4% of participants were aware of using gene profiling
for detection of dosage of some drugs. Respondents perceived greater
utility of gene profiling for breast cancer (38%) compared to the
colorectal familial cancer (3%). The score of knowledge ranged from
2 to 8 (mean 4.38 ± 1.67). Non- significant differences between score
of knowledge of GPs and specialists were observed, with score of
4.19 and 4.58 respectively. There was no significant association
between any demographic factors and level of knowledge. However,
those who graduated between years 2001 to 2005 had higher level of
knowledge. Overall, 83% of participants showed relatively high level
of perception on value of gene profiling to detect patient’s risk of
disease. However, low perception was observed for both statements
of using gene profiling for general population in order to alter their
lifestyle (25%) as well as having the full sequence of a patient
genome for the purpose of determining a patient’s best match for
treatment (18%). The lack of clinical guidelines, limited provider
knowledge and awareness, lack of time and resources to educate
patients, lack of evidence-based clinical information and cost of tests
were the most barriers of ordering gene profiling mentioned by
physicians. In conclusion Malaysian physicians who participate in
this study had mediocre level of knowledge and awareness in gene
profiling. The low exposure to the genetic questions and problems
might be a key predictor of lack of awareness and knowledge on
available genetic tests. Educational and training workshop might be useful in helping Malaysian physicians incorporate genetic profiling
into practice for eligible patients.
Abstract: The paper presents the trends of Georgian hazelnut market development and analyses the competitive advantages which will help Georgia to enter international hazelnut market using modern technologies. The history of hazelnut crop development and hazelnut varieties in Georgia are discussed. For hazelnut supply analysis trends in hazelnut production are considered, trends in export and import development is evaluated, domestic hazelnut market is studied and analysed based on expert interviews and initial accounting materials. In order to achieve and strengthen its position in international market, potential advantages and disadvantages of Georgian hazelnut are revealed, analysis of export and import possibilities of hazelnut is presented. Recommendations are developed based on the conclusions, which are made through identifying the key factors that hinder development of Georgian hazelnut market.
Abstract: A numerical model has been developed to investigate the thermally triggered release kinetics for drug delivery using phase change material as shell of microcapsules. Biocompatible material n-Eicosane is used as demonstration. PCM shell of microcapsule will remain in solid form after the drug is taken, so the drug will be encapsulated by the shell, and will not be released until the target body part of lesion is exposed to external heat source, which will thermally trigger the release kinetics, leading to solid-to-liquid phase change. The findings can lead to better understanding on the key effects influencing the phase change process for drug delivery applications. The facile approach to release drug from core/shell structure of microcapsule can be well integrated with organic solvent free fabrication of microcapsules, using double emulsion as template in microfluidic aqueous two phase system.