Abstract: Aim of this work was to compare the efficacy of two
loading methods of proteins onto polymeric nanocarriers: adsorption
and encapsulation methods. Preliminary studies of protein loading
were done using Bovine Serum Albumin (BSA) as model protein.
Nanocarriers were prepared starting from polylactic co-glycolic acid
(PLGA) polymer; production methods used are two different variants
of emulsion evaporation method. Nanoparticles obtained were
analyzed in terms of dimensions by Dynamic Light Scattering and
Loading Efficiency of BSA by Bradford Assay. Loaded
nanoparticles were then submitted to in-vitro protein dissolution test
in order to study the effect of the delivery system on the release rate
of the protein.
Abstract: In this paper, we focused primarily on Istanbul data
that is gathered by using intelligent transportation systems (ITS), and
considered the developments in traffic information delivery and
future applications that are being planned for implementation. Since
traffic congestion is increasing and travel times are becoming less
consistent and less predictable, traffic information delivery has
become a critical issue. Considering the fuel consumption and wasted
time in traffic, advanced traffic information systems are becoming
increasingly valuable which enables travelers to plan their trips more
accurately and easily.
Abstract: Transferring patient information between medical care
sites is necessary to deliver better patient care and to reduce medical
cost. So developing of electronic medical records is an important trend
for the world.The Continuity of Care Document (CCD) is product of
collaboration between CDA and CCR standards. In this study, we will
develop a system to generate medical records with entry level based on
CCD template module.
Abstract: This research attempts to explore gaps in Information
Systems (IS) and innovation literatures by developing a model of
Information Technology (IT) capability in enabling innovation. The
research was conducted by using semi-structured interview with six
innovators in business consulting, financial, healthcare and academic
organizations. The interview results suggest four elements of ITenabled
innovation capability which are information (ability to
capture ideas and knowledge), connectivity (ability to bridge
geographical boundary and mobilize human resources),
communication (ability to attain and engage relationships between
human resources) and transformation (ability to change the functions
and process integrations) in defining IT-enabled innovation platform.
The results also suggests innovators- roles and IT capability.
Abstract: The two-dimensional gel electrophoresis method
(2-DE) is widely used in Proteomics to separate thousands of proteins
in a sample. By comparing the protein expression levels of proteins in
a normal sample with those in a diseased one, it is possible to identify
a meaningful set of marker proteins for the targeted disease. The major
shortcomings of this approach involve inherent noises and irregular
geometric distortions of spots observed in 2-DE images. Various
experimental conditions can be the major causes of these problems. In
the protein analysis of samples, these problems eventually lead to
incorrect conclusions. In order to minimize the influence of these
problems, this paper proposes a partition based pair extension method
that performs spot-matching on a set of gel images multiple times and
segregates more reliable mapping results which can improve the
accuracy of gel image analysis. The improved accuracy of the
proposed method is analyzed through various experiments on real
2-DE images of human liver tissues.
Abstract: A new dual-fluid concept was studied that could eventually find application for cold-gas propulsion for small space satellites or other constant flow applications. In basic form, the concept uses two different refrigerant working fluids, each having a different saturation vapor pressure. The higher vapor pressure refrigerant remains in the saturation phase and is used to pressurize the lower saturation vapor pressure fluid (the propellant) which remains in the compressed liquid phase. A demonstration thruster concept based on this principle was designed and built to study its operating characteristics. An automotive-type electronic fuel injector was used to meter and deliver the propellant. Ejected propellant mass and momentum were measured for several combinations of refrigerants and hydrocarbon fluids. The thruster has the advantage of delivering relatively large total impulse at low tank pressure within a small volume.
Abstract: Product Lead Time (PLT) is the period of time from
receiving a customer's order to delivering the final product. PLT is an
indicator of the manufacturing controllability, efficiency and
performance. Due to the explosion in the rate of technological
innovations and the rapid changes in the nature of manufacturing
processes, manufacturing firms can bring the new products to market
quicker only if they can reduce their PLT and speed up the rate at
which they can design, plan, control, and manufacture. Although
there is a substantial body of research on manufacturing relating to
cost and quality issues, there is no much specific research conducted
in relation to the formulation of PLT, despite its significance and
importance. This paper analyzes and formulates PLT which can be
used as a guideline for achieving the shorter PLT. Further more this
paper identifies the causes of delay and factors that contributes to the
increased product lead-time.
Abstract: Detecting protein-protein interactions is a central problem in computational biology and aberrant such interactions may have implicated in a number of neurological disorders. As a result, the prediction of protein-protein interactions has recently received considerable attention from biologist around the globe. Computational tools that are capable of effectively identifying protein-protein interactions are much needed. In this paper, we propose a method to detect protein-protein interaction based on substring similarity measure. Two protein sequences may interact by the mean of the similarities of the substrings they contain. When applied on the currently available protein-protein interaction data for the yeast Saccharomyces cerevisiae, the proposed method delivered reasonable improvement over the existing ones.
Abstract: The nanosized polymeric micelles release the drug
due to acoustic cavitation, which is enhanced in dual frequency
ultrasonic fields. In this study, adult female Balb/C mice were
transplanted with spontaneous breast adenocarcinoma tumors and
were injected with a dose of 1.3 mg/kg doxorubicin in one of three
forms: free doxorubicin, micellar doxorubicin without sonication and
micellar doxorubicin with sonication. To increase cavitation yield,
the tumor region was sonicated with low level dual frequency of 3
MHz and 28 kHz. The animals were sacrificed 24 h after injection,
and their tumor, heart, spleen, liver, kidneys and plasma were
separated and homogenized. The drug content in their tumor, heart,
spleen, liver, kidneys and plasma was determined using tissue
fluorimetry. The results show that in the group that received micellar
doxorubicin with sonication, the drug concentration in the tumor
tissue was nine and three times higher than in the free doxorubicin
group and the micellar doxorubicin without sonication group,
respectively. In the micellar doxorubicin with sonication group, the
drug concentration in other tissues was lower than other groups
(p
Abstract: The wireless link can be unreliable in realistic wireless
sensor networks (WSNs). Energy efficient and reliable data
forwarding is important because each node has limited resources.
Therefore, we must suggest an optimal solution that considers using
the information of the node-s characteristics. Previous routing
protocols were unsuited to realistic asymmetric WSNs. In this paper,
we propose a Protocol that considers Both sides of Link-quality and
Energy (PBLE), an optimal routing protocol that balances modified
link-quality, distance and energy. Additionally, we propose a node
scheduling method. PBLE achieves a longer lifetime than previous
routing protocols and is more energy-efficient. PBLE uses energy,
local information and both sides of PRR in a 1-hop distance. We
explain how to send data packets to the destination node using the
node's information. Simulation shows PBLE improves delivery rate
and network lifetime compared to previous schemes. Moreover, we
show the improvement in various WSN environments.
Abstract: True integration of multimedia services over wired or
wireless networks increase the productivity and effectiveness in
today-s networks. IP Multimedia Subsystems are Next Generation
Network architecture to provide the multimedia services over fixed
or mobile networks. This paper proposes an extended SIP-based QoS
Management architecture for IMS services over underlying IP access
networks. To guarantee the end-to-end QoS for IMS services in
interconnection backbone, SIP based proxy Modules are introduced
to support the QoS provisioning and to reduce the handoff disruption
time over IP access networks. In our approach these SIP Modules
implement the combination of Diffserv and MPLS QoS mechanisms
to assure the guaranteed QoS for real-time multimedia services. To
guarantee QoS over access networks, SIP Modules make QoS
resource reservations in advance to provide best QoS to IMS users
over heterogeneous networks. To obtain more reliable multimedia
services, our approach allows the use of SCTP protocol over SIP
instead of UDP due to its multi-streaming feature. This architecture
enables QoS provisioning for IMS roaming users to differentiate IMS
network from other common IP networks for transmission of realtime
multimedia services. To validate our approach simulation
models are developed on short scale basis. The results show that our
approach yields comparable performance for efficient delivery of
IMS services over heterogeneous IP access networks.
Abstract: This paper explains how mobile learning assures sustainable e-education for multicultural group of students. This paper reports the impact of mobile learning on distance education in multicultural environment. The emergence of learning technologies through CD, internet, and mobile is increasingly adopted by distance institutes for quick delivery and cost-effective purposes. Their sustainability is conditioned by the structure of learners as well as the teaching community. The experimental study was conducted among the distant learners of Vinayaka Missions University located at Salem in India. Students were drawn from multicultural environment based on different languages, religions, class and communities. During the mobile learning sessions, the students, who are divided on language, religion, class and community, were dominated by play impulse rather than study anxiety or cultural inhibitions. This study confirmed that mobile learning improved the performance of the students despite their division based on region, language or culture. In other words, technology was able to transcend the relative deprivation in the multicultural groups. It also confirms sustainable e-education through mobile learning and cost-effective system of instruction. Mobile learning appropriates the self-motivation and play impulse of the young learners in providing sustainable e-education to multicultural social groups of students.
Abstract: This article is an extension and a practical application
approach of Wheeler-s NEBIC theory (Net Enabled Business
Innovation Cycle). NEBIC theory is a new approach in IS research
and can be used for dynamic environment related to new technology.
Firms can follow the market changes rapidly with support of the IT
resources. Flexible firms adapt their market strategies, and respond
more quickly to customers changing behaviors. When every leading
firm in an industry has access to the same IT resources, the way that
these IT resources are managed will determine the competitive
advantages or disadvantages of firm. From Dynamic Capabilities
Perspective and from newly introduced NEBIC theory by Wheeler,
we know that only IT resources cannot deliver customer value but
good configuration of those resources can guarantee customer value
by choosing the right emerging technology, grasping the right
economic opportunities through business innovation and growth. We
found evidences in literature that SOA (Service Oriented
Architecture) is a promising emerging technology which can deliver
the desired economic opportunity through modularity, flexibility and
loose-coupling. SOA can also help firms to connect in network which
can open a new window of opportunity to collaborate in innovation
and right kind of outsourcing. There are many articles and research
reports indicates that failure rate in outsourcing is very high but at the
same time research indicates that successful outsourcing projects
adds tangible and intangible benefits to the service consumer.
Business executives and policy makers in the west should not afraid
of outsourcing but they should choose the right strategy through the
use of emerging technology to significantly reduce the failure rate in
outsourcing.
Abstract: With optimized bandwidth and latency discrepancy ratios, Node Gain Scores (NGSs) are determined and used as a basis for shaping the max-heap overlay. The NGSs - determined as the respective bandwidth-latency-products - govern the construction of max-heap-form overlays. Each NGS is earned as a synergy of discrepancy ratio of the bandwidth requested with respect to the estimated available bandwidth, and latency discrepancy ratio between the nodes and the source node. The tree leads to enhanceddelivery overlay multicasting – increasing packet delivery which could, otherwise, be hindered by induced packet loss occurring in other schemes not considering the synergy of these parameters on placing the nodes on the overlays. The NGS is a function of four main parameters – estimated available bandwidth, Ba; individual node's requested bandwidth, Br; proposed node latency to its prospective parent (Lp); and suggested best latency as advised by source node (Lb). Bandwidth discrepancy ratio (BDR) and latency discrepancy ratio (LDR) carry weights of α and (1,000 - α ) , respectively, with arbitrary chosen α ranging between 0 and 1,000 to ensure that the NGS values, used as node IDs, maintain a good possibility of uniqueness and balance between the most critical factor between the BDR and the LDR. A max-heap-form tree is constructed with assumption that all nodes possess NGS less than the source node. To maintain a sense of load balance, children of each level's siblings are evenly distributed such that a node can not accept a second child, and so on, until all its siblings able to do so, have already acquired the same number of children. That is so logically done from left to right in a conceptual overlay tree. The records of the pair-wise approximate available bandwidths as measured by a pathChirp scheme at individual nodes are maintained. Evaluation measures as compared to other schemes – Bandwidth Aware multicaSt architecturE (BASE), Tree Building Control Protocol (TBCP), and Host Multicast Tree Protocol (HMTP) - have been conducted. This new scheme generally performs better in terms of trade-off between packet delivery ratio; link stress; control overhead; and end-to-end delays.
Abstract: Liposomal magnetofection is a simple, highly efficient
technology for cell transfection, demonstrating better outcome than a
number of other common gene delivery methods. However,
aggregate complexes distribution over the cell surface is non-uniform
due to the gradient of the permanent magnetic field. The aim of this
study was to estimate the efficiency of liposomal magnetofection for
prostate carcinoma PC3 cell line using newly designed device,
“DynaFECTOR", ensuring magnetofection in a dynamic gradient
magnetic field. Liposomal magnetofection in a dynamic gradient
magnetic field demonstrated the highest transfection efficiency for
PC3 cells – it increased for 21% in comparison with liposomal
magnetofection and for 42% in comparison with lipofection alone.
The optimal incubation time under dynamic magnetic field for PC3
cell line was 5 minutes and the optimal rotation frequency of
magnets – 5 rpm. The new approach also revealed lower cytotoxic
effect to cells than liposomal magnetofection.
Abstract: Opportunistic network is a kind of Delay Tolerant Networks (DTN) where the nodes in this network come into contact with each other opportunistically and communicate wirelessly and, an end-to-end path between source and destination may have never existed, and disconnection and reconnection is common in the network. In such a network, because of the nature of opportunistic network, perhaps there is no a complete path from source to destination for most of the time and even if there is a path; the path can be very unstable and may change or break quickly. Therefore, routing is one of the main challenges in this environment and, in order to make communication possible in an opportunistic network, the intermediate nodes have to play important role in the opportunistic routing protocols. In this paper we proposed an Adaptive Fuzzy Routing in opportunistic network (AFRON). This protocol is using the simple parameters as input parameters to find the path to the destination node. Using Message Transmission Count, Message Size and Time To Live parameters as input fuzzy to increase delivery ratio and decrease the buffer consumption in the all nodes of network.
Abstract: The performance of modified Fenton (MF) treatment
to promote PAH oxidation in artificially contaminated soil was
investigated in packed soil column with a hydrogen peroxide (H2O2)
delivery system simulating in situ injection. Soil samples were spiked
with phenanthrene (low molecular weight PAH) and fluoranthene
(high molecular weight PAH) to an initial concentration of 500
mg/kg dried soil each. The effectiveness of process parameters
H2O2/soil, iron/soil, chelating agent/soil weight ratios and reaction
time were studied using a 24 three level factorial design experiments.
Statistically significant quadratic models were developed using
Response Surface Methodology (RSM) for degrading PAHs from the
soil samples. Optimum operating condition was achieved at mild
range of H2O2/soil, iron/soil and chelating agent/soil weight ratios,
indicating cost efficient method for treating highly contaminated
lands.
Abstract: Biogas, a clean renewable energy, is attracting a growing
concern of researchers and professionals in many fields. Based
on the natural and climatic conditions in semi-arid regions of northwestern
China, the present study introduces a specifically-designed
family-size biogas plant (with a digester of 10m3) with manure
and urine of animals and humanity as raw materials. The biogas
plant is applicable to areas with altitudes of more than 2000 meters
in northwestern China. In addition to the installation cost, a little
operational expenditure, structure, characteristics, benefits of this
small-scale biogas plant, this article introduces a wide range of
specific popularization methods such as training, financial support,
guided tour to the biogas plant, community-based group study and
delivery of operational manuals. The feasibility of the biogas plant is
explored on the basis of the availability of the raw materials. Simple
operations contained in the current work increase the possibility of
the wide use of this small-scale biogas plant in similar regions of the
world.
Abstract: The focal spot of a high intensity focused ultrasound
transducer is small. To heat a large target volume, multiple treatment spots are required. If the power of each treatment spot is fixed, it could
results in insufficient heating of initial spots and over-heating of later ones, which is caused by the thermal diffusion. Hence, to produce a
uniform heated volume, the delivered energy of each treatment spot
should be properly adjusted. In this study, we proposed an iterative, extrapolation technique to adjust the required ultrasound energy of
each treatment spot. Three different scanning pathways were used to evaluate the performance of this technique. Results indicate that by using the proposed technique, uniform heating volume could be obtained.
Abstract: Delivering streaming video over wireless is an
important component of many interactive multimedia applications
running on personal wireless handset devices. Such personal devices
have to be inexpensive, compact, and lightweight. But wireless
channels have a high channel bit error rate and limited bandwidth.
Delay variation of packets due to network congestion and the high bit
error rate greatly degrades the quality of video at the handheld
device. Therefore, mobile access to multimedia contents requires
video transcoding functionality at the edge of the mobile network for
interworking with heterogeneous networks and services. Therefore,
to guarantee quality of service (QoS) delivered to the mobile user, a
robust and efficient transcoding scheme should be deployed in
mobile multimedia transporting network. Hence, this paper
examines the challenges and limitations that the video transcoding
schemes in mobile multimedia transporting network face. Then
handheld resources, network conditions and content based mobile
and wireless video transcoding is proposed to provide high QoS
applications. Exceptional performance is demonstrated in the
experiment results. These experiments were designed to verify and
prove the robustness of the proposed approach. Extensive
experiments have been conducted, and the results of various video
clips with different bit rate and frame rate have been provided.