Scholarly

Effect of Local Dual Frequency Sonication on Drug Distribution from Nanomicelles

Year: 2010 Volume: 4 Issue: 9 459 - 463 Pages

Abstract: The nanosized polymeric micelles release the drug due to acoustic cavitation, which is enhanced in dual frequency ultrasonic fields. In this study, adult female Balb/C mice were transplanted with spontaneous breast adenocarcinoma tumors and were injected with a dose of 1.3 mg/kg doxorubicin in one of three forms: free doxorubicin, micellar doxorubicin without sonication and micellar doxorubicin with sonication. To increase cavitation yield, the tumor region was sonicated with low level dual frequency of 3 MHz and 28 kHz. The animals were sacrificed 24 h after injection, and their tumor, heart, spleen, liver, kidneys and plasma were separated and homogenized. The drug content in their tumor, heart, spleen, liver, kidneys and plasma was determined using tissue fluorimetry. The results show that in the group that received micellar doxorubicin with sonication, the drug concentration in the tumor tissue was nine and three times higher than in the free doxorubicin group and the micellar doxorubicin without sonication group, respectively. In the micellar doxorubicin with sonication group, the drug concentration in other tissues was lower than other groups (p

Improving Co-integration Trading Rule Profitability with Forecasts from an Artificial Neural Network

Year: 2007 Volume: 1 Issue: 7 328 - 331 Pages

Abstract: Co-integration models the long-term, equilibrium relationship of two or more related financial variables. Even if cointegration is found, in the short run, there may be deviations from the long run equilibrium relationship. The aim of this work is to forecast these deviations using neural networks and create a trading strategy based on them. A case study is used: co-integration residuals from Australian Bank Bill futures are forecast and traded using various exogenous input variables combined with neural networks. The choice of the optimal exogenous input variables chosen for each neural network, undertaken in previous work [1], is validated by comparing the forecasts and corresponding profitability of each, using a trading strategy.

Entrepreneurial Characteristics and Attitude of Pineapple Growers

Year: 2008 Volume: 2 Issue: 10 197 - 201 Pages

Authors:
Kaushal Kumar Jha

Abstract: Nagaland, the 16th state of India in order of statehood, is situated between 25° 6' and 27° 4' latitude north and between 93º 20' E and 95º 15' E longitude of equator in the North Eastern part of the India. Endowed with varied topography, soil and agro climatic conditions it is known for its potentiality to grow all most all kinds of horticultural crops. Pineapple being grown since long organically by default is one of the most promising crops of the state with emphasis being laid for commercialization by the government of Nagaland. In light of commercialization, globalization and scope of setting small-scale industries, a research study was undertaken to examine the socio-economic and personal characteristics, entrepreneurial characteristics and attitude of the pineapple growers towards improved package of practices of pineapple cultivation. The study was conducted in Medziphema block of Dimapur district of the Nagaland state of India following ex post facto research design. Ninety pineapple growers were selected from four different villages of Medziphema block based on proportionate random selection procedure. Findings of the study revealed that majority of the respondents had medium level of entrepreneurial characteristics in terms of knowledge level, risk orientation, self confidence, management orientation, farm decision making ability and leadership ability and most of them had favourable attitude towards improved package of practices of pineapple cultivation. The variables age, education, farm size, risk orientation, management orientation and sources of information utilized were found important to influence the attitude of the respondents. The study revealed that favourable attitude and entrepreneurial characteristics of the pineapple cultivators might be harnessed for increased production of pineapple in the state thereby bringing socio economic upliftment of the marginal and small-scale farmers.

The Complementarities of Multi-Lateralism, Andregionalism and Income Convergence: ASEAN and SAARC

Year: 2008 Volume: 2 Issue: 12 1261 - 1270 Pages

Abstract: This paper proposes the hypothesis that multilateralism and regionalism are complementary, and that regional income convergence is likely with a like minded and committed regionalism that often has links geographically and culturally. The association between international trade, income per capita, and regional income convergence in founder members of ASEAN and SAARC, is explored by applying the Lumsdaine, and Papell approach. The causal relationships between the above variables are also studied in respective trade blocs by using Granger causality tests. The conclusion is that global reforms have had a greater impact on increasing trade for both trade blocs and induced convergence only in ASEAN-5 countries. The experience of ASEAN countries shows a two-way causal relationship between the flow from trade to regional income convergence, and vice versa. There is no evidence in SAARC countries for income convergence and causality.

Direction of Arrival Estimation Based on a Single Port Smart Antenna Using MUSIC Algorithm with Periodic Signals

Year: 2007 Volume: 1 Issue: 11 1628 - 1637 Pages

Abstract: A novel direction-of-arrival (DOA) estimation technique, which uses a conventional multiple signal classification (MUSIC) algorithm with periodic signals, is applied to a single RF-port parasitic array antenna for direction finding. Simulation results show that the proposed method gives high resolution (1 degree) DOA estimation in an uncorrelated signal environment. The novelty lies in that the MUSIC algorithm is applied to a simplified antenna configuration. Only one RF port and one analogue-to-digital converter (ADC) are used in this antenna, which features low DC power consumption, low cost, and ease of fabrication. Modifications to the conventional MUSIC algorithm do not bring much additional complexity. The proposed technique is also free from the negative influence by the mutual coupling between elements. Therefore, the technique has great potential to be implemented into the existing wireless mobile communications systems, especially at the power consumption limited mobile terminals, to provide additional position location (PL) services.

A Systematic Method for Performance Analysis of SOA Applications

Year: 2010 Volume: 4 Issue: 2 265 - 271 Pages

Abstract: The successful implementation of Service-Oriented Architecture (SOA) is not confined to Information Technology systems and required changes of the whole enterprise. In order to adapt IT and business, the enterprise requires adequate and measurable methods. The adoption of SOA creates new problem with regard to measuring and analysis the performance. In fact the enterprise should investigate to what extent the development of services will increase the value of business. It is required for every business to measure the extent of SOA adaptation with the goals of enterprise. Moreover, precise performance metrics and their combination with the advanced evaluation methodologies as a solution should be defined. The aim of this paper is to present a systematic methodology for designing a measurement system at the technical and business levels, so that: (1) it will determine measurement metrics precisely (2) the results will be analysed by mapping identified metrics to the measurement tools.

The Use of ICT and e-Learning in Higher Education in Japan

Year: 2010 Volume: 4 Issue: 6 1104 - 1108 Pages

Authors:
Kumiko Aoki

Abstract: Japan is known to be a technological powerhouse, being noted for its automobiles, consumer electronics, laptop computers, portable gaming devices, and more recently healing animal robots. Japan is also noted for its popular culture; manga, anime, novels, films, character goods, game programs, cosplay cafes, karaoke and so on. It may be natural for people outside Japan to assume that e-learning in Japan must be well advanced and innovative. In reality, the application of technologies in education in Japan is far behind of other developed countries. Especially in higher education, apathy of students towards their study prevails and teachers continue ignoring such student attitudes. E-learning, which is supposed to revolutionalize the way people learn as it has potentials to enable more student-centered learning, has not been realized in Japan and mostly used to perpetuate the teachercentered teaching in a different format.

Shape Memory alloy Actuator System Optimization for New Hand Prostheses

Year: 2012 Volume: 6 Issue: 1 9 - 14 Pages

Abstract: Shape memory alloy (SMA) actuators have found a wide range of applications due to their unique properties such as high force, small size, lightweight and silent operation. This paper presents the development of compact (SMA) actuator and cooling system in one unit. This actuator is developed for multi-fingered hand. It consists of nickel-titanium (Nitinol) SMA wires in compact forming. The new arrangement insulates SMA wires from the human body by housing it in a heat sink and uses a thermoelectric device for rejecting heat to improve the actuator performance. The study uses optimization methods for selecting the SMA wires geometrical parameters and the material of a heat sink. The experimental work implements the actuator prototype and measures its response.

GPS TEC Variation Affected by the Interhemispheric Conjugate Auroral Activity on 21 September 2009

Year: 2011 Volume: 5 Issue: 12 830 - 833 Pages

Abstract: This paper observed the interhemispheric conjugate auroral activity occurred on 21 September 2009. The GPS derived ionospheric total electron content (TEC) during a weak substorm interval recorded at interhemispheric conjugate points at Husafell in Iceland and Syowa in Antarctica is investigated to look at their signatures on the auroral features. Selection of all-sky camera (ASC) images and keogram at Tjörnes and Syowa during the interval 00:47:54 – 00:50:14 UT on 21 September 2009 found that the auroral activity had exerted their influence on the GPS TEC as a consequence of varying interplanetary magnetic field (IMF) By polarity.

Framework for Spare Inventory Management

Year: 2012 Volume: 6 Issue: 8 2189 - 2196 Pages

Abstract: Spare parts inventory management is one of the major areas of inventory research. Analysis of recent literature showed that an approach integrating spare parts classification, demand forecasting, and stock control policies is essential; however, adapting this integrated approach is limited. This work presents an integrated framework for spare part inventory management and an Excel based application developed for the implementation of the proposed framework. A multi-criteria analysis has been used for spare classification. Forecasting of spare parts- intermittent demand has been incorporated into the application using three different forecasting models; namely, normal distribution, exponential smoothing, and Croston method. The application is also capable of running with different inventory control policies. To illustrate the performance of the proposed framework and the developed application; the framework is applied to different items at a service organization. The results achieved are presented and possible areas for future work are highlighted.

Coupled Dynamics in Host-Guest Complex Systems Duplicates Emergent Behavior in the Brain

Year: 2010 Volume: 4 Issue: 8 1157 - 1165 Pages

Authors:
Sergio Pissanetzky

Abstract: The ability of the brain to organize information and generate the functional structures we use to act, think and communicate, is a common and easily observable natural phenomenon. In object-oriented analysis, these structures are represented by objects. Objects have been extensively studied and documented, but the process that creates them is not understood. In this work, a new class of discrete, deterministic, dissipative, host-guest dynamical systems is introduced. The new systems have extraordinary self-organizing properties. They can host information representing other physical systems and generate the same functional structures as the brain does. A simple mathematical model is proposed. The new systems are easy to simulate by computer, and measurements needed to confirm the assumptions are abundant and readily available. Experimental results presented here confirm the findings. Applications are many, but among the most immediate are object-oriented engineering, image and voice recognition, search engines, and Neuroscience.

Evaluation and Preparation of Crystal Modifications of Artesunate: In vivo Studies

Year: 2013 Volume: 7 Issue: 7 376 - 382 Pages

Authors:
S. Gupta
R. Chadha

Abstract: Five crystal modifications of water insoluble artesunate were generated by recrystallizing it from various solvents with improved physicochemical properties. These generated crystal forms were characterized to select the most potent and soluble form. SEM of all the forms showed changes in external shape leading them to be different morphologically. DSC thermograms of Form III and Form V showed broad endotherm peaks at 83.04oC and 76.96oC prior to melting fusion of drug respectively. Calculated weight loss in TGA revealed that Form III and Form V are methanol and acetone solvates respectively. However, few additional peaks were appeared in XRPD pattern in these two solvate forms. All forms exhibit exothermic behavior in buffer and two solvates display maximum ease of molecular release from the lattice. Methanol and acetone solvates were found to be most soluble forms and exhibited higher antimalarial efficacy showing higher survival rate (83.3%) after 30 days.

Comparative Studies of Support Vector Regression between Reproducing Kernel and Gaussian Kernel

Year: 2010 Volume: 4 Issue: 5 560 - 568 Pages

Abstract: Support vector regression (SVR) has been regarded as a state-of-the-art method for approximation and regression. The importance of kernel function, which is so-called admissible support vector kernel (SV kernel) in SVR, has motivated many studies on its composition. The Gaussian kernel (RBF) is regarded as a “best" choice of SV kernel used by non-expert in SVR, whereas there is no evidence, except for its superior performance on some practical applications, to prove the statement. Its well-known that reproducing kernel (R.K) is also a SV kernel which possesses many important properties, e.g. positive definiteness, reproducing property and composing complex R.K by simpler ones. However, there are a limited number of R.Ks with explicit forms and consequently few quantitative comparison studies in practice. In this paper, two R.Ks, i.e. SV kernels, composed by the sum and product of a translation invariant kernel in a Sobolev space are proposed. An exploratory study on the performance of SVR based general R.K is presented through a systematic comparison to that of RBF using multiple criteria and synthetic problems. The results show that the R.K is an equivalent or even better SV kernel than RBF for the problems with more input variables (more than 5, especially more than 10) and higher nonlinearity.

Modeling and Control of Direct Driven PMSG for Ultra Large Wind Turbines

Year: 2011 Volume: 5 Issue: 11 1334 - 1340 Pages

Abstract: This paper focuses on developing an integrated reliable and sophisticated model for ultra large wind turbines And to study the performance and analysis of vector control on large wind turbines. With the advance of power electronics technology, direct driven multi-pole radial flux PMSG (Permanent Magnet Synchronous Generator) has proven to be a good choice for wind turbines manufacturers. To study the wind energy conversion systems, it is important to develop a wind turbine simulator that is able to produce realistic and validated conditions that occur in real ultra MW wind turbines. Three different packages are used to simulate this model, namely, Turbsim, FAST and Simulink. Turbsim is a Full field wind simulator developed by National Renewable Energy Laboratory (NREL). The wind turbine mechanical parts are modeled by FAST (Fatigue, Aerodynamics, Structures and Turbulence) code which is also developed by NREL. Simulink is used to model the PMSG, full scale back to back IGBT converters, and the grid.

Keywords:
FAST
Permanent Magnet Synchronous Generator(PMSG)
TurbSim
Vector Control and Pitch Control

A Standalone WebGL Supporting Architecture

Year: 2013 Volume: 7 Issue: 2 218 - 221 Pages

Authors:
Nakhoon Baek

Abstract: WebGL is typically used with web browsers. In this paper, we represent a standalone WebGL execution environment, where the original WebGL source codes show the same result to those of WebGL-capable web browsers. This standalone environment enables us to run WebGL programs without web browsers and/or internet connections. Our implementation shows the same rendering results with typical web browser outputs. This standalone environment is suitable for low-tier devices and/or debugging purposes.

The Effect of Innovation Factors to Customer Loyalty by Structural Equation Model

Year: 2011 Volume: 5 Issue: 4 360 - 364 Pages

Abstract: Innovation is being view from four areas of innovation, product, service, technology, and marketing. Whereas customer loyalty is composed of customer expectation, perceived quality, perceived value, corporate image, customer satisfaction, customer trust/confidence, customer commitment, customer complaint, and customer loyalty. This study aimed to investigate the influence of innovation factors to customer loyalty to GSM in the telecom companies where use of products and services. Structural Equation Modeling (SEM) using to analyze innovation factors. It was found the factor of innovation have significant influence on customer loyalty.

SIP-Based QoS Management Architecture for IP Multimedia Subsystems over IP Access Networks

Year: 2010 Volume: 4 Issue: 4 748 - 755 Pages

Abstract: True integration of multimedia services over wired or wireless networks increase the productivity and effectiveness in today-s networks. IP Multimedia Subsystems are Next Generation Network architecture to provide the multimedia services over fixed or mobile networks. This paper proposes an extended SIP-based QoS Management architecture for IMS services over underlying IP access networks. To guarantee the end-to-end QoS for IMS services in interconnection backbone, SIP based proxy Modules are introduced to support the QoS provisioning and to reduce the handoff disruption time over IP access networks. In our approach these SIP Modules implement the combination of Diffserv and MPLS QoS mechanisms to assure the guaranteed QoS for real-time multimedia services. To guarantee QoS over access networks, SIP Modules make QoS resource reservations in advance to provide best QoS to IMS users over heterogeneous networks. To obtain more reliable multimedia services, our approach allows the use of SCTP protocol over SIP instead of UDP due to its multi-streaming feature. This architecture enables QoS provisioning for IMS roaming users to differentiate IMS network from other common IP networks for transmission of realtime multimedia services. To validate our approach simulation models are developed on short scale basis. The results show that our approach yields comparable performance for efficient delivery of IMS services over heterogeneous IP access networks.

Development of an Infrared Thermography Method with CO2 Laser Excitation, Applied to Defect Detection in CFRP

Year: 2013 Volume: 7 Issue: 8 589 - 593 Pages

Abstract: This paper presents a NDT by infrared thermography with excitation CO2 Laser, wavelength of 10.6 μm. This excitation is the controllable heating beam, confirmed by a preliminary test on a wooden plate 1.2 m x 0.9 m x 1 cm. As the first practice, this method is applied to detecting the defect in CFRP heated by the Laser 300 W during 40 s. Two samples 40 cm x 40 cm x 4.5 cm are prepared, one with defect, another one without defect. The laser beam passes through the lens of a deviation device, and heats the samples placed at a determinate position and area. As a result, the absence of adhesive can be detected. This method displays prominently its application as NDT with the composite materials. This work gives a good perspective to characterize the laser beam, which is very useful for the next detection campaigns.

Content Based Image Retrieval of Brain MR Images across Different Classes

Year: 2013 Volume: 7 Issue: 8 1021 - 1025 Pages

Abstract: Magnetic Resonance Imaging play a vital role in the decision-diagnosis process of brain MR images. For an accurate diagnosis of brain related problems, the experts mostly compares both T1 and T2 weighted images as the information presented in these two images are complementary. In this paper, rotational and translational invariant form of Local binary Pattern (LBP) with additional gray scale information is used to retrieve similar slices of T1 weighted images from T2 weighted images or vice versa. The incorporation of additional gray scale information on LBP can extract more local texture information. The accuracy of retrieval can be improved by extracting moment features of LBP and reweighting the features based on users feedback. Here retrieval is done in a single subject scenario where similar images of a particular subject at a particular level are retrieved, and multiple subjects scenario where relevant images at a particular level across the subjects are retrieved.

Cloud Computing: Changing Cogitation about Computing

Year: 2009 Volume: 3 Issue: 10 2401 - 2405 Pages

Abstract: Cloud Computing is a new technology that helps us to use the Cloud for compliance our computation needs. Cloud refers to a scalable network of computers that work together like Internet. An important element in Cloud Computing is that we shift processing, managing, storing and implementing our data from, locality into the Cloud; So it helps us to improve the efficiency. Because of it is new technology, it has both advantages and disadvantages that are scrutinized in this article. Then some vanguards of this technology are studied. Afterwards we find out that Cloud Computing will have important roles in our tomorrow life!

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