Abstract: Transcription factor p53 has a powerful tumor
suppressing function that is associated with many cancers. However,
p53 of the molecular weight was higher make the limitation across to
skin or cell membrane. Thymidine dinucleotide (pTT), an
oligonucleotide, can activate the p53 transcription factor. pTT is a
hydrophilic and negative charge oligonucleotide, which delivery in to
cell membrane need an appropriate carrier. The aim of this study was
to improve the bioavailability of the nucleotide fragment, thymidine
dinucleotide (pTT), using elasic liposome carriers to deliver the drug
into the skin. The study demonstrate that dioleoylphosphocholine
(DOPC) incorporated with sodium cholate at molar ratio 1:1 can
archived the particle size about 220 nm. This elastic liposome could
penetration through skin from stratum corneum to whole epidermis by
confocal laser scanning microscopy (CLSM). Moreover, we observed
the the slight increase in generation of p53 by western blot.
Abstract: The Kumamoto area, Kyushu, Japan has 1,041km2 in
area and about 1milion in population. This area is a greatest area in Japan which depends on groundwater for all of drinking water. Quantity of this local groundwater use is about 200MCM during the
year. It is understood that the main recharging area of groundwater exist in the rice field zone which have high infiltrate height ahead of
100mm/ day of the irrigated water located in the middle area of the Shira-River Basin. However, by decrease of the paddy-rice planting
area by urbanization and an acreage reduction policy, the groundwater income and expenditure turned worse. Then Kumamoto city and four
companies expended financial support to increase recharging water to
underground by ponded water in the field from 2004.
In this paper, the author reported the situation of recovery of groundwater by recharge and estimates the efficiency of recharge by
statistical method.
Abstract: The purpose of this research is: a) to investigate how
the HR practices influence psychological contracts, b) to examine the
influence of psychological contracts to individual behavior and to
contribute individually, c) to study the psychological contact through
leadership. This research using mixed methods, qualitative and
quantitative research methods were utilized to gather the data
collected using a qualitative method by the HR Manager who is in
charge of the trainings from the staffs and quantitative method
(survey) by using questionnaire was utilized to draw upon and to
elaborate on the recurring themes present during the interviews. The
survey was done to 400 staffs of the company. The study found that
leadership styles supporting the firm’s HR strategy is the key in
making psychological contracts that benefit both the firm and its
members.
Abstract: The purpose of this study is to analyze the islands
tourist travel information sources, as well as for the satisfaction of the
tourist destination services. This study used questionnaires to the
island of Taiwan to the Penghu Islands to engage in tourism activities
tourist adopt the designated convenience sampling method, a total of
889 valid questionnaires were collected. After statistical analysis, this
study found that: 1. tourists to the Penghu Islands travel information
source for “friends and family came to Penghu". 2. Tourists feel the
service of the outlying islands of Penghu, the highest feelings of
“friendly local residents". 3. There are different demographic variables
affect the tourist travel information source and service satisfaction.
Based on the findings of this study not only for Penghu's tourism
industry with the unit in charge of the proposed operating and
suggestions for future research to other researchers.
Abstract: The Beshar River is one aquatic ecosystem, which is
located next to the city of Yasuj in southern Iran. The Beshar river
has been contaminated by industrial factories such as effluent of
sugar factory, agricultural and other activities in this region such as,
Imam Sajjad hospital, drainage from agricultural farms, Yasuj urban
surface runoff and effluent of wastewater treatment plants ,specially
Yasuj waste water treatment plant. In order to evaluate the effects of
these pollutants on the quality of the Beshar river, five monitoring
stations were selected along its course. The first station is located
upstream of Yasuj near the Dehnow village; stations 2 to 4 are
located east, south and west of city; and the 5th station is located
downstream of Yasuj. Several water quality parameters were
sampled. These include pH, dissolved oxygen, biological oxygen
demand (BOD), temperature, conductivity, turbidity, total dissolved
solids and discharge or flow measurements. Water samples from the
five stations were collected and analyzed to determine the following
physicochemical parameters: EC, pH, T.D.S, T.H, No2, DO, BOD5,
COD during 2008 to 2010. The study shows that the BOD5 value of
station 1 is at a minimum (1.7 ppm) and increases downstream from
stations 2 to 4 to a maximum (11.6 ppm), and then decreases at
station 5. The DO values of station 1 is a maximum (8.45 ppm),
decreases downstream to stations 2 - 4 which are at a minimum (3.1
ppm), before increasing at station 5. The amount of BOD and TDS
are highest at the 4th station and the amount of DO is lowest at this
station, marking the 4th station as more highly polluted than the
other stations .This study shows average amount of the water quality
parameters in first year of sampling (2008) have had a better quality
relation to third year in 2010 because of recent drought in this region
and pollutant increasing .As the Beshar river path after 5th station
goes through the mountain area with more slope and flow velocity
,so the physicochemical parameters improve at the 5th station due to
pollutant degradation and dilution. Finally the point and nonpoint
pollutant sources of Beshar river were determined and compared to
the monitoring results.
Abstract: The greenhouse effect and limitations on carbon
dioxide emissions concern engine maker and the future of the
internal combustion engines should go toward substantially and
improved thermal efficiency engine. Homogeneous charge
compression ignition (HCCI) is an alternative high-efficiency
technology for combustion engines to reduce exhaust emissions and
fuel consumption. However, there are still tough challenges in the
successful operation of HCCI engines, such as controlling the
combustion phasing, extending the operating range, and high
unburned hydrocarbon and CO emissions. HCCI and the exploitation
of ethanol as an alternative fuel is one way to explore new frontiers
of internal combustion engines with an eye towards maintaining its
sustainability. This study was done to extend database knowledge
about HCCI with ethanol a fuel.
Abstract: The charge-exchange xenon (CEX) ion generated by ion thruster can backflow to the surface of spacecraft and threaten to the safety of spacecraft operation. In order to evaluate the effects of the induced plasma environment in backflow regions on the spacecraft, we designed a spherical single Langmuir probe of 5.8cm in diameter for measuring low-density plasma parameters in backflow region of ion thruster. In practice, the tests are performed in a two-dimensional array (40cm×60cm) composed of 20 sites. The experiment results illustrate that the electron temperature ranges from 3.71eV to 3.96eV, with the mean value of 3.82eV and the standard deviation of 0.064eV. The electron density ranges from 8.30×1012/m3 to 1.66×1013/m3, with the mean value of 1.30×1013/m3 and the standard deviation of 2.15×1012/m3. All data is analyzed according to the “ideal" plasma conditions of Maxwellian distributions.
Abstract: Topical photodynamic therapy (PDT) with
5-aminolevulinic acid (ALA) is an alternative therapy for treating
superficial cancer, especially for skin or oral cancer. ALA, a precursor
of the photosensitizer protoporphyrin IX (PpIX), is present as
zwitterions and hydrophilic property which make the low permeability
through the cell membrane. Collagen is a traditional carrier; its
molecular composed various amino acids which bear positive charge
and negative charge. In order to utilize the ion-pairs with ALA and
collagen, the study employed various pH values adjusting the net
charge. The aim of this study was to compare a series collagen form,
including solution, gel and sponge to investigate the topical delivery
behavior of ALA. The in vivo confocal laser scanning microscopy
(CLSM) study demonstrated that PpIX generation ability was different
pattern after apply for 6 h. Gel type could generate high PpIX, and
archived more deep of skin depth.
Abstract: The utilize of renewable energy sources becomes
more crucial and fascinatingly, wider application of renewable
energy devices at domestic, commercial and industrial levels is not
only affect to stronger awareness but also significantly installed
capacities. Moreover, biomass principally is in form of woods and
converts to be energy for using by humans for a long time.
Gasification is a process of conversion of solid carbonaceous fuel
into combustible gas by partial combustion. Many gasified models
have various operating conditions because the parameters kept in
each model are differentiated. This study applied the experimental
data including three inputs variables including biomass consumption;
temperature at combustion zone and ash discharge rate and gas flow
rate as only one output variable. In this paper, response surface
methods were applied for identification of the gasified system
equation suitable for experimental data. The result showed that linear
model gave superlative results.
Abstract: The distribution, enrichment, accumulation, and potential ecological risk of copper (Cu) in the surface sediments of northern Kaohsiung Harbor, Taiwan were investigated. Sediment samples from 12 locations of northern Kaohsiung Harbor were collected and characterized for Cu, aluminum, water content, organic matter, total nitrogen, total phosphorous, total grease and grain size. Results showed that the Cu concentrations varied from 6.9–244 mg/kg with an average of 109±66 mg/kg. The spatial distribution of Cu reveals that the Cu concentration is relatively high in the river mouth region, and gradually diminishes toward the harbor entrance region. This indicates that upstream industrial and municipal wastewater discharges along the river bank are major sources of Cu pollution. Results from the enrichment factor and geo-accumulation index analyses imply that the sediments collected from the river mouth can be characterized between moderate and moderately severe degree enrichment and between none to medium and moderate accumulation of Cu, respectively. However, results of potential ecological risk index indicate that the sediment has low ecological potential risk.
Abstract: This paper aims to (1) analyze the profiles of
transgressors (detected evaders); (2) examine reason(s) that triggered a
tax audit, causes of tax evasion, audit timeframe and tax penalty
charged; and (3) to assess if tax auditors followed the guidelines as
stated in the 'Tax Audit Framework' when conducting tax audits. In
2011, the Inland Revenue Board Malaysia (IRBM) had audited and
finalized 557 company cases. With official permission, data of all the
557 cases were obtained from the IRBM. Of these, a total of 421 cases
with complete information were analyzed. About 58.1% was small and
medium corporations and from the construction industry (32.8%). The
selection for tax audit was based on risk analysis (66.8%), information
from third party (11.1%), and firm with low profitability or fluctuating
profit pattern (7.8%). The three persistent causes of tax evasion by
firms were over claimed expenses (46.8%), fraudulent reporting of
income (38.5%) and overstating purchases (10.5%). These findings
are consistent with past literature. Results showed that tax auditors
took six to 18 months to close audit cases. More than half of tax
evaders were fined 45% on additional tax raised during audit for the
first offence. The study found tax auditors did follow the guidelines in
the 'Tax Audit Framework' in audit selection, settlement and penalty
imposition.
Abstract: The influence of axial magnetic field (B=0.48 T) on
the variation of ionization efficiency coefficient h and secondary
electron emission coefficient g with respect to reduced electric field
E/P is studied at a new range of plane-parallel electrode spacing (0<
d< 20 cm) and different nitrogen working pressure between 0.5-20
Pa. The axial magnetic field is produced from an inductive copper
coil of radius 5.6 cm. The experimental data of breakdown voltage is
adopted to estimate the mean Paschen curves at different working
features. The secondary electron emission coefficient is calculated
from the mean Paschen curve and used to determine the minimum
breakdown voltage. A reduction of discharge voltage of about 25% is
investigated by the applied of axial magnetic field. At high interelectrode
spacing, the effect of axial magnetic field becomes more
significant for the obtained values of h but it was less for the values
of g.
Abstract: The struggle between modern and postmodern
understanding is also displayed in terms of the superiorities of
quantitative and qualitative methods to each other which are
evaluated within the scope of these understandings. By way of
assuming that the quantitative researches (modern) are able to
account for structure while the qualitative researches (postmodern)
explain the process, these methods are turned into a means for
worldviews specific to a period. In fact, process is not a functioning
independent of structure. In addition to this issue, the ability of
quantitative methods to provide scientific knowledge is also
controversial so long as they exclude the dialectical method. For this
reason, the critiques charged against modernism in terms of
quantitative methods are, in a sense, legitimate. Nevertheless, the
main issue is in which parameters postmodernist critique tries to
legitimize its critiques and whether these parameters represent a point
of view enabling democratic solutions.
In this respect, the scientific knowledge covered in Turkish media
as a means through which ordinary people have access to scientific
knowledge will be evaluated by means of content analysis within a
new objectivity conception.
Abstract: PCCI engines can reduce NOx and PM emissions
simultaneously without sacrificing thermal efficiency, but a low
combustion temperature resulting from early fuel injection, and
ignition occurring prior to TDC, can cause higher THC and CO
emissions and fuel consumption. In conclusion, it was found that the
PCCI combustion achieved by the 2-stage injection strategy with
optimized calibration factors (e.g. EGR rate, injection pressure, swirl
ratio, intake pressure, injection timing) can reduce NOx and PM
emissions simultaneously. This research works are expected to
provide valuable information conducive to a development of an
innovative combustion engine that can fulfill upcoming stringent
emission standards.
Abstract: Chronic conditions carry with them strong emotions
and often lead to charged relationships between patients and their
health providers and, by extension, patients and health researchers.
Persons are both autonomous and relational and a purely cognitive
model of autonomy neglects the social and relational basis of chronic
illness. Ensuring genuine informed consent in research requires a
thorough understanding of how participants perceive a study and
their reasons for participation. Surveys may not capture the
complexities of reasoning that underlies study participation.
Contradictory reasons for participation, for instance an initial claim
of altruism as rationale and a subsequent claim of personal benefit
(therapeutic misconception), affect the quality of informed consent.
Individuals apply principles through the filter of personal values and
lived experience. Authentic autonomy, and hence authentic consent
to research, occurs within the context of patients- unique life
narratives and illness experiences.
Abstract: All around the world pulp and paper industries are the
biggest plant production with the environmental pollution as the
biggest challenge facing the pulp manufacturing operations. The
concern among these industries is to produce a high volume of papers
with the high quality standard and of low cost without affecting the
environment. This result obtained from this bleaching study show
that the activation of peroxide was an effective method of reducing
the total applied charge of chlorine dioxide which is harmful to our
environment and also show that softwood and hardwood Kraft pulps
responded linearly to the peroxide treatments. During the bleaching
process the production plant produce chlorines. Under the trial stages
chloride dioxide has been reduced by 3 kg/ton to reduce the
brightness from 65% ISO to 60% ISO of pulp and the dosing point
returned to the E stage charges by pre-treating Kraft pulps with
hydrogen peroxide. The pulp and paper industry has developed
elemental chlorine free (ECF) and totally chlorine free (TCF)
bleaching, in their quest for being environmental friendly, they have
been looking at ways to turn their ECF process into a TCF process
while still being competitive. This prompted the research to
investigate the capability of the hydrogen peroxide as catalyst to
reduce chloride dioxide.
Abstract: This paper analytically investigates the 3D flow
pattern at the confluences of two rectangular channels having 900
angles using Navier-Stokes equations based on Reynolds Stress
Turbulence Model (RSM). The equations are solved by the Finite-
Volume Method (FVM) and the flow is analyzed in terms of steadystate
(single-phased) conditions. The Shumate experimental findings
were used to test the validity of data. Comparison of the simulation
model with the experimental ones indicated a close proximity
between the flow patterns of the two sets. Effects of the discharge
ratio on separation zone dimensions created in the main-channel
downstream of the confluence indicated an inverse relation, where a
decrease in discharge ratio, will entail an increase in the length and
width of the separation zone. The study also found the model as a
powerful analytical tool in the feasibility study of hydraulic
engineering projects.
Abstract: This document details the process of developing a
wireless device that captures the basic movements of the foot (plantar
flexion, dorsal flexion, abduction, adduction.), and the knee
movement (flexion). It implements a motion capture system by using
a hardware based on optical fiber sensors, due to the advantages in
terms of scope, noise immunity and speed of data transmission and
reception. The operating principle used by this system is the detection
and transmission of joint movement by mechanical elements and
their respective measurement by optical ones (in this case infrared).
Likewise, Visual Basic software is used for reception, analysis and
signal processing of data acquired by the device, generating a 3D
graphical representation in real time of each movement. The result is
a boot in charge of capturing the movement, a transmission module
(Implementing Xbee Technology) and a receiver module for
receiving information and sending it to the PC for their respective
processing.
The main idea with this device is to help on topics such as
bioengineering and medicine, by helping to improve the quality of
life and movement analysis.
Abstract: Electrical Discharge Machine (EDM) is especially
used for the manufacturing of 3-D complex geometry and hard
material parts that are extremely difficult-to-machine by conventional
machining processes. In this paper authors review the research work
carried out in the development of die-sinking EDM within the past
decades for the improvement of machining characteristics such as
Material Removal Rate, Surface Roughness and Tool Wear Ratio. In
this review various techniques reported by EDM researchers for
improving the machining characteristics have been categorized as
process parameters optimization, multi spark technique, powder
mixed EDM, servo control system and pulse discriminating. At the
end, flexible machine controller is suggested for Die Sinking EDM to
enhance the machining characteristics and to achieve high-level
automation. Thus, die sinking EDM can be integrated with Computer
Integrated Manufacturing environment as a need of agile
manufacturing systems.
Abstract: This paper applies fuzzy set theory to evaluate the
service quality of online auction. Service quality is a composition of
various criteria. Among them many intangible attributes are difficult
to measure. This characteristic introduces the obstacles for respondent
in replying to the survey. So as to overcome this problem, we
invite fuzzy set theory into the measurement of performance. By
using AHP in obtaining criteria and TOPSIS in ranking, we found
the most concerned dimension of service quality is Transaction
Safety Mechanism and the least is Charge Item. Regarding to the
most concerned attributes are information security, accuracy and
information.