Abstract: The 1:1 cocrystal of 2-amino-4-chloro-6-
methylpyrimidine (2A4C6MP) with 4-methylbenzoic acid (4MBA)
(I) has been prepared by slow evaporation method in methanol,
which was crystallized in monoclinic C2/c space group, Z = 8, and a
= 28.431 (2) Å, b = 7.3098 (5) Å, c = 14.2622 (10) Å and β =
109.618 (3)°. The presence of unionized –COOH functional group in
cocrystal I was identified both by spectral methods (1H and 13C
NMR, FTIR) and X-ray diffraction structural analysis. The
2A4C6MP molecule interact with the carboxylic group of the
respective 4MBA molecule through N—H⋯O and O—H⋯N
hydrogen bonds, forming a cyclic hydrogen–bonded motif R2
2(8).
The crystal structure was stabilized by Npyrimidine—H⋯O=C and
C=O—H⋯Npyrimidine types hydrogen bonding interactions.
Theoretical investigations have been computed by HF and density
function (B3LYP) method with 6–311+G (d,p)basis set. The
vibrational frequencies together with 1H and 13C NMR chemical
shifts have been calculated on the fully optimized geometry of
cocrystal I. Theoretical calculations are in good agreement with the
experimental results. Solvent–free formation of this cocrystal I is
confirmed by powder X-ray diffraction analysis.
Abstract: It is very important for a developing nation to
developing their infrastructure on the prime priority because their
infrastructure particularly their roads and transportation functions as a
blood in the system. Almost 1.1 billion populations share the travel
and transportation industry in India. On the other hand, the Pakistan
transportation industry is also extensive and elevating about 170
million users of transportation. Indian and Pakistani specifically
within bus industry are well connected within and between the urban
and rural areas. The transportation industry is radically helping the
economic alleviation of both countries. Due to high economic
instability, unemployment and poverty rate both countries
governments are very serious and committed to help for boosting
their economy. They believe that any form of transportation
development would play a vital role in the development of land,
infrastructure which could indirectly support many other industries’
developments, such as tourism, freighting and shipping businesses,
just to mention a few. However, it seems that their previous
transportation planning in the due course has failed to meet the fast
growing demand. As with the span of time, both the countries are
looking forward to a long-term, and economical solutions, because
the demand is from time to time keep appreciating and reacting
according to other key economic drivers. Content analysis method
and case study approach is used in this paper and secondary data
from the bureau of statistic is used for case analysis. The paper
focused on the mobility concerns of the lower and middle-income
people in India and Pakistan. The paper is aimed to highlight the
weaknesses, opportunities and limitations resulting from low priority
industry for a government, which is making the either country's
public suffer. The paper has concluded that the main issue is
identified as the slow, inappropriate, and unfavorable decisions which
are not in favor of long-term country’s economic development and
public interest. The paper also recommends to future research
avenues for public and private transportation, which is continuously
failing to meet the public expectations.
Abstract: A theoretical study of a humidification
dehumidification solar desalination unit has been carried out to
increase understanding the effect of weather conditions on the unit
productivity. A humidification-dehumidification (HD) solar
desalination unit has been designed to provide fresh water for
population in remote arid areas. It consists of solar water collector
and air collector; to provide the hot water and air to the desalination
chamber. The desalination chamber is divided into humidification
and dehumidification towers. The circulation of air between the two
towers is maintained by the forced convection. A mathematical
model has been formulated, in which the thermodynamic relations
were used to study the flow, heat and mass transfer inside the
humidifier and dehumidifier. The present technique is performed in
order to increase the unit performance. Heat and mass balance has
been done and a set of governing equations has been solved using the
finite difference technique. The unit productivity has been calculated
along the working day during the summer and winter sessions and
has compared with the available experimental results. The average
accumulative productivity of the system in winter has been ranged
between 2.5 to 4 (kg/m2)/day, while the average summer productivity
has been found between 8 to 12 (kg/m2)/day.
Abstract: To maintain a healthy balanced loyalty, whether to art
or society, posits a debatable issue. The artist is always on the look
out for the potential tension between those two realms. Therefore,
one of the most painful dilemmas the artist finds is how to function in
a society without sacrificing the aesthetic values of his/her work. In
other words, the life-long awareness of failure which derives from the
concept of the artist as caught between unflattering social realities
and the need to invent genuine art forms becomes a fertilizing soil for
the artists to be tackled. Thus, within the framework of this dilemma,
the question of the responsibility of the artist and the relationship of
the art to politics will be illuminating. To a larger extent, however, in
drama, this dilemma is represented by the fictional characters of the
play. The present paper tackles the idea of the amorality of the artist in
selected plays by Tom Stoppard. However, Stoppard’s awareness of
his situation as a refugee has led him to keep at a distance from
politics. He tried hard to avoid any intervention into the realms of
political debate, especially in his earliest work. On the one hand, it is
not meant that he did not interest in politics as such, but rather he
preferred to question it than to create a fixed ideological position. On
the other hand, Stoppard’s refusal to intervene in politics is ascribed
to his feeling of gratitude to Britain where he settled. As a result,
Stoppard has frequently been criticized for a lack of political
engagement and also for not leaning too much for the left when he
does engage. His reaction to these public criticisms finds expression
in his self-conscious statements which defensively stressed the
artifice of his work. He, like Oscar Wilde thinks that the
responsibility of the artist is devoted to the realm of his/her art.
Consequently, his consciousness for the role of the artist is truly
reflected in his two plays, Artist Descending a Staircase (1972) and
Travesties (1974).
Abstract: In this paper, we calculate the two-photon ionization
(TPI) cross-section for pump-probe scheme in Ag neutral cluster. The
pump photon energy is assumed to be close to the surface plasmon
(SP) energy of cluster in dielectric media. Due to this choice, the
pump wave excites collective oscillations of electrons-SP and the
probe wave causes ionization of the cluster. Since the interband
transition energy in Ag exceeds the SP resonance energy, the main
contribution into the TPI comes from the latter. The advantage of Ag
clusters as compared to the other noble metals is that the SP
resonance in silver cluster is much sharper because of peculiarities of
its dielectric function. The calculations are performed by separating
the coordinates of electrons corresponding to the collective
oscillations and the individual motion that allows taking into account
the resonance contribution of excited SP oscillations. It is shown that
the ionization cross section increases by two orders of magnitude if
the energy of the pump photon matches the surface plasmon energy
in the cluster.
Abstract: Background: Breast milk may impact early brain
development, with potentially important biological, medical and
social implications. There is an important discussion on which is the
adequate breastfeeding extension to the development consolidation
and how the children breastfeeding affects their psychomotor
development, in the first year of life, and in following periods as
well. Some special fats (LC PUFA) contained in breast milk play a
key role in the brain’s maturation and cognitive development or
social skills. These capacities created during breastfeeding time
would be unfolded throughout all lifespan. Aim of the study: In our research, we have studied the effect of
breastfeeding in preschooler's psychomotor assessment.
Method: This study was conducted in a sample of 158 preschool
children in Vlorë, Albania. We have measured the psychometric
parameters of preschoolers with ASQ-3 (Age&Stage Questionnaires-
3). The studied sample was divided in three groups according to their
breastfeeding duration (3, 6 and 12 months). Results: Children breastfed for only 3 months have definitely
lower psychometric scores compared to the ones with 6 or more
months of breastfeeding (respectively 217 to 239 ASQ-3 scores). Six
and twelvemonth breastfed children have progressively more odds to
have high levels of psychomotor development comparing to those
with only 3 months of breastfeeding. The most affected psychometric
domains by shortness of breastfeeding are Communication and
Global motor. Conclusion: This leads to conclusion that to ensure high
psychomotor parameters during childhood is necessary breastfeeding
for at least 6 months.
Abstract: The Petri nets are the first standard for business
process modeling. Most probably, it is one of the core reasons why
all new standards created afterwards have to be so reformed as to
reach the stage of mapping the new standard onto Petri nets. The paper presents a business process repository based on a
universal database. The repository provides the possibility the data
about a given process to be stored in three different ways. Business
process repository is developed with regard to the reformation of a
given model to a Petri net in order to be easily simulated. Two different techniques for business process simulation based on
Petri nets - Yasper and Woflan are discussed. Their advantages and
drawbacks are outlined. The way of simulating business process
models, stored in the Business process repository is shown.
Abstract: In the vicinity of red sea about 15 fungi species were
isolated from oil contaminated sites. On the basis of aptitude to
degrade the crude oil and DCPIP assay, two fungal isolates were
selected amongst 15 oil degrading strains. Analysis of ITS-1, ITS-2
and amplicon pyrosequencing studies of fungal diversity revealed
that these strains belong to Penicillium and Aspergillus species. Two
strains that proved to be the most efficient in degrading crude oil was
Aspergillus niger (54%) and Penicillium commune (48%) Subsequent
to two weeks of cultivation in BHS medium the degradation rate
were recorded by using spectrophotometer and GC-MS. Hence, it is
cleared that these fungal strains has capability of degradation and can
be utilize for cleaning the Saudi Arabian environment.
Abstract: The floor beams of steel buildings, cold-formed steel
floor joists in particular, often require large web openings, which may
affect their shear capacities. A cost effective way to mitigate the
detrimental effects of such openings is to weld/fasten reinforcements.
A difficulty associated with an experimental investigation to establish
suitable reinforcement schemes for openings in shear zone is that
moment always coexists with the shear, and thus, it is impossible to
create pure shear state in experiments, resulting in moment
influenced results. However, Finite Element Method (FEM) based
analysis can be conveniently used to investigate the pure shear
behaviour of webs including webs with reinforced openings. This
paper presents the details associated with the finite element analysis
of thick/thin-plates (representing the web of hot-rolled steel beam,
and the web of a cold-formed steel member) having a large
reinforced opening. The study considered simply-supported
rectangular plates subjected to in-plane shear loadings until failure
(including post-buckling behaviour). The plate was modelled using
geometrically non-linear quadrilateral shell elements, and non-linear
stress-strain relationship based on experiments. Total Langrangian
with large displacement/small strain formulation was used for such
analyses. The model also considered the initial geometric
imperfections. This study considered three reinforcement schemes,
namely, flat, lip, and angle reinforcements. This paper discusses the
modelling considerations and presents the results associated with the
various reinforcement schemes under consideration.
Abstract: Within this paper, latest results on processing of energetic nanomaterials by means of the Spray Flash Evaporation technique are presented. This technology constitutes a highly effective and continuous way to prepare fascinating materials on the nano- and micro-scale. Within the process, a solution is set under high pressure and sprayed into an evacuated atomization chamber. Subsequent ultrafast evaporation of the solvent leads to an aerosol stream, which is separated by cyclones or filters. No drying gas is required, so the present technique should not be confused with spray dying. Resulting nanothermites, insensitive explosives or propellants and compositions are foreseen to replace toxic (according to REACH) and very sensitive matter in military and civil applications. Diverse examples are given in detail: nano-RDX (n-Cyclotrimethylentrinitramin) and nano-aluminum based systems, mixtures (n-RDX/n-TNT - trinitrotoluene) or even cocrystalline matter like n-CL-20/HMX (Hexanitrohexaazaisowurtzitane/ Cyclotetra-methylentetranitramin). These nanomaterials show reduced sensitivity by trend without losing effectiveness and performance. An analytical study for material characterization was performed by using Atomic Force Microscopy, X-Ray Diffraction, and combined techniques as well as spectroscopic methods. As a matter of course, sensitivity tests regarding electrostatic discharge, impact, and friction are provided.
Abstract: For the last decade, researchers have started to focus
their interest on Multicast Group Key Management Framework. The
central research challenge is secure and efficient group key
distribution. The present paper is based on the Bit model based
Secure Multicast Group key distribution scheme using the most
popular absolute encoder output type code named Gray Code. The
focus is of two folds. The first fold deals with the reduction of
computation complexity which is achieved in our scheme by
performing fewer multiplication operations during the key updating
process. To optimize the number of multiplication operations, an
O(1) time algorithm to multiply two N-bit binary numbers which
could be used in an N x N bit-model of reconfigurable mesh is used
in this proposed work. The second fold aims at reducing the amount
of information stored in the Group Center and group members while
performing the update operation in the key content. Comparative
analysis to illustrate the performance of various key distribution
schemes is shown in this paper and it has been observed that this
proposed algorithm reduces the computation and storage complexity
significantly. Our proposed algorithm is suitable for high
performance computing environment.
Abstract: Liver segmentation from medical images poses more
challenges than analogous segmentations of other organs. This
contribution introduces a liver segmentation method from a series of
computer tomography images. Overall, we present a novel method for
segmenting liver by coupling density matching with shape priors.
Density matching signifies a tracking method which operates via
maximizing the Bhattacharyya similarity measure between the
photometric distribution from an estimated image region and a model
photometric distribution. Density matching controls the direction of
the evolution process and slows down the evolving contour in regions
with weak edges. The shape prior improves the robustness of density
matching and discourages the evolving contour from exceeding liver’s
boundaries at regions with weak boundaries. The model is
implemented using a modified distance regularized level set (DRLS)
model. The experimental results show that the method achieves a
satisfactory result. By comparing with the original DRLS model, it is
evident that the proposed model herein is more effective in addressing
the over segmentation problem. Finally, we gauge our performance of
our model against matrices comprising of accuracy, sensitivity, and
specificity.
Abstract: Slash or Yaoi fan art is the artwork that contains a
homosexual relationship between fictional male characters, who were
heterosexual in the original media. Previous belief about Slash or
Yaoi fan art is that the fan fiction writers and the fan artists need to
see the equality in romantic relationship. They do not prefer the
pairing of man and woman, since both genders are not equal. The
objectives of the current study are to confirm this belief, and to
examine the relationship between equality found in Slash fan art,
friendship in original media, and violence contained in fan art. Mean
comparisons show that equality could be found in the pairing of hero
and hero, but rarely found in the pairing of hero and villain.
Regression analysis shows that the level of equality in fan art and
friendship in original media are significant predictors of violence
contained in fan art. Since villain-related pairings yield a high level
of violence in fan art and a low level of equality, researchers of future
studies should find the strategies to prevent fans to include villains in
their Slash or Yaoi fan art.
Abstract: Audio visual communication is a type of collective
expression. Due to inform the masses, give direction to opinions, and
establish public opinion, audio visual communication must be
subjected to special restrictions. This has been stipulated in both the
Constitution and the European Human Rights Agreement. This paper
aims to review freedom of expression and its restriction in audio
visual media. For this purpose, the authorization of the Radio and
Television Supreme Council to impose sanctions as an independent
administrative authority empowered to regulate the field of audio
visual communication has been reviewed with regard to freedom of
expression and its limits.
Abstract: The agenda of showing the scheduled time for
performing certain tasks is known as timetabling. It is widely used in
many departments such as transportation, education, and production.
Some difficulties arise to ensure all tasks happen in the time and
place allocated. Therefore, many researchers invented various
programming models to solve the scheduling problems from several
fields. However, the studies in developing the general integer
programming model for many timetabling problems are still
questionable. Meanwhile, this thesis describes about creating a
general model which solves different types of timetabling problems
by considering the basic constraints. Initially, the common basic
constraints from five different fields are selected and analyzed. A
general basic integer programming model was created and then
verified by using the medium set of data obtained randomly which is
much similar to realistic data. The mathematical software, AIMMS
with CPLEX as a solver has been used to solve the model. The model
obtained is significant in solving many timetabling problems easily
since it is modifiable to all types of scheduling problems which have
same basic constraints.
Abstract: Anogeissus leiocarpus (Combretaceae) is well known
for its medicinal uses in African traditional medicine, for treating
many human diseases mainly skin diseases and infections. Mycetoma
disease is a fungal and/ or bacterial skininfection, mainly cause by
Madurella mycetomatis fungus. This study was carried out in vitro to
investigate the antifungal activity of Anogeissus leiocarpus leaf
extracts against the isolated pathogenic Madurella mycetomatis, by
using the NCCLS modified method compared to Ketoconazole
standard drug, and MTT assay. The bioactive fraction was subjected
to chemical analysis implementing different chromatographic
analytical methods (TLC, HPLC, and LC-MS/MS). The results
showed significance antifungal activity of A. leiocarpus leaf extracts
against the isolated pathogenic M. mycetomatis, compared to negative
and positive controls. The chloroform fraction showed the highest
antifungal activity. The chromatographic analysis of the chloroform
fraction with the highest activity showed the presence of important
bioactive compounds such as ellagic and flavellagic acids derivatives,
flavonoids and stilbenoid, which are well known for their antifungal
activity.
Abstract: A field experiment was conducted in the Agricultural
Research Station, at El-Ghoraieb, Assiut to study dry seed yield
performance of two locally adapted cultivars (‘Azmerly’ and ‘Cream
7’) and two line introductions (IT81D-1032 and IT82D-812) of
common cowpea (Vigna unguiculata (L.) Walp) grown at three
different within-row spaces (20, 30 and 40 cm) and two planting
dates in the summer (April 15th and 30th) and in the fall season (Aug.
12th and 27th) of two successive seasons. The data showed that total
dry-seed yield produced by plants grown at 20 cm was greater than at
30 cm in all cvs/lines in both years. Increases in 1000-seed weight
were detected in cv ‘Azmerly’ and line IT82D-812 when they were
grown at 30 cm as compared with 20 cm in the summer season.
However, in the fall season such increases were found in all cvs/lines.
Planting at 40 cm produced seeds of greater weight than planting at
30 cm for all cvs/lines in the fall season and also in cv. Cream 7 and
line IT82D-812 in the summer season, while all cvs/lines in the fall
Planting on April 15th in the summer and also planting on Aug. 12th
in the fall had plants which showed increases in 1000-seed weight
and total dry-seed yield. The greatest 1000-seed weight was found in
the line IT81D-1032 in the summer season and in the line IT82D-812
in the fall season. The sum up results revealed that ‘Azmerly’
produced greater dry-seed yield than ‘Cream 7’ and both of them
were superior to the line IT82D-812 and IT81D-1032 in the summer
season. In the fall, however, the line IT82D-812 produced greater
dry-seed yield than the other cultivars/lines.
Abstract: The aim of the study is to describe and analyze design
of mobile teaching for students collaborative learning in distance
higher education with a focus on mobile technologies as online
webinars (web-based seminars or conferencing) by using laptops,
smart phones, or tablets. These multimedia tools can provide face-toface
interactions, recorded flipped classroom videos and parallel chat
communications. The data collection consists of interviews with 22
students and observations of online face-to-face webinars, as well
two surveys. Theoretically, the study joins the research tradition of
Computer Supported Collaborative learning, CSCL, as well as
Computer Self-Efficacy, CSE concerned with individuals’ media and
information literacy. Important conclusions from the study
demonstrated mobile interactions increased student centered
learning. As the students were appreciating the working methods,
they became more engaged and motivated. The mobile technology
using among student also contributes to increased flexibility between
space and place, as well as media and information literacy.
Abstract: In order to investigate the prebiotic potential of
oligosaccharides prepared by chemical hydrolysis of water-soluble
polysaccharides (WSP) from Zizyphus lotus leaves, the effect of
oligosaccharides on bacterial growth was studied. The chemical
composition of WSP was evaluated by colorimetric assays revealed
the average values: 7.05±0.73% proteins and 86.21±0.74%
carbohydrates, among them 64.81±0.42% is neutral sugar and the rest
16.25±1.62% is uronic acids. The characterization of
monosaccharides was determined by high performance anion
exchange chromatography with pulsed amperometric detection
(HPAEC-PAD) was found to be composed of galactose (23.95%),
glucose (21.30%), rhamnose (20.28%), arabinose (9.55%), and
glucuronic acid (22.95%). The effects of oligosaccharides on the
growth of lactic acid bacteria were compared with those of fructooligosaccharide
(RP95). The oligosaccharides concentration was
1g/L of Man, Rogosa, Sharpe broth. Bacterial growth was assessed
during 2, 4.5, 6.5, 9, 12, 16 and 24 h by measuring the optical density
of the cultures at 600 nm (OD600) and pH values. During
fermentation, pH in broth cultures decreased from 6.7 to 5.87±0.15.
The enumeration of lactic acid bacteria indicated that
oligosaccharides led to a significant increase in bacteria (P≤0.05)
compared to the control. The fermentative metabolism appeared to be
faster on RP95 than on oligosaccharides from Zizyphus lotus leaves.
Both RP95 and oligosaccharides showed clear prebiotic effects, but
had differences in fermentation kinetics because of to the different
degree of polymerization. This study shows the prebiotic
effectiveness of oligosaccharides, and provides proof for the selection
of leaves of Zizyphus lotus for use as functional food ingredients.
Abstract: Lateral Geniculate Nucleus (LGN) is the relay center
in the visual pathway as it receives most of the input information
from retinal ganglion cells (RGC) and sends to visual cortex. Low
threshold calcium currents (IT) at the membrane are the unique
indicator to characterize this firing functionality of the LGN neurons
gained by the RGC input. According to the LGN functional
requirements such as functional mapping of RGC to LGN, the
morphologies of the LGN neurons were developed. During the
neurological disorders like glaucoma, the mapping between RGC and
LGN is disconnected and hence stimulating LGN electrically using
deep brain electrodes can restore the functionalities of LGN. A
computational model was developed for simulating the LGN neurons
with three predominant morphologies each representing different
functional mapping of RGC to LGN. The firings of action potentials
at LGN neuron due to IT were characterized by varying the
stimulation parameters, morphological parameters and orientation. A
wide range of stimulation parameters (stimulus amplitude, duration
and frequency) represents the various strengths of the electrical
stimulation with different morphological parameters (soma size,
dendrites size and structure). The orientation (0-1800) of LGN
neuron with respect to the stimulating electrode represents the angle
at which the extracellular deep brain stimulation towards LGN
neuron is performed. A reduced dendrite structure was used in the
model using Bush–Sejnowski algorithm to decrease the
computational time while conserving its input resistance and total
surface area. The major finding is that an input potential of 0.4 V is
required to produce the action potential in the LGN neuron which is
placed at 100 μm distance from the electrode. From this study, it can
be concluded that the neuroprostheses under design would need to
consider the capability of inducing at least 0.4V to produce action
potentials in LGN.