3D Liver Segmentation from CT Images Using a Level Set Method Based on a Shape and Intensity Distribution Prior

Liver segmentation from medical images poses more
challenges than analogous segmentations of other organs. This
contribution introduces a liver segmentation method from a series of
computer tomography images. Overall, we present a novel method for
segmenting liver by coupling density matching with shape priors.
Density matching signifies a tracking method which operates via
maximizing the Bhattacharyya similarity measure between the
photometric distribution from an estimated image region and a model
photometric distribution. Density matching controls the direction of
the evolution process and slows down the evolving contour in regions
with weak edges. The shape prior improves the robustness of density
matching and discourages the evolving contour from exceeding liver’s
boundaries at regions with weak boundaries. The model is
implemented using a modified distance regularized level set (DRLS)
model. The experimental results show that the method achieves a
satisfactory result. By comparing with the original DRLS model, it is
evident that the proposed model herein is more effective in addressing
the over segmentation problem. Finally, we gauge our performance of
our model against matrices comprising of accuracy, sensitivity, and
specificity.





References:
[1] S. Luo, X. Li, and J. Li, "Review on the Methods of Automatic Liver
Segmentation from Abdominal Images," Journal of Computer and
Communications, vol. 2, p. 1, 2014.
[2] R. Adams and L. Bischof, "Seeded region growing," Pattern Analysis and
Machine Intelligence, IEEE Transactions on, vol. 16, pp. 641-647, 1994.
[3] A. Beck and V. Aurich, "Hepatux–a semiautomatic liver segmentation
system," 3D Segmentation in The Clinic: A Grand Challenge, pp.
225-233, 2007.
[4] R. Pohle and K. D. Toennies, "Segmentation of medical images using
adaptive region growing," in Medical Imaging 2001, 2001, pp.
1337-1346. [5] K. J. Mortelé, V. Cantisani, R. Troisi, B. de Hemptinne, and S. G.
Silverman, "Preoperative liver donor evaluation: imaging and pitfalls,"
Liver Transplantation, vol. 9, pp. S6-S14, 2003.
[6] S. Kumar, R. Moni, and J. Rajeesh, "Automatic liver and lesion
segmentation: a primary step in diagnosis of liver diseases," Signal,
Image and Video Processing, vol. 7, pp. 163-172, 2013.
[7] C. Platero, J. M. Poncela, P. Gonzalez, M. C. Tobar, J. Sanguino, G.
Asensio, et al., "Liver segmentation for hepatic lesions detection and
characterisation," in Biomedical Imaging: From Nano to Macro, 2008.
ISBI 2008. 5th IEEE International Symposium on, 2008, pp. 13-16.
[8] D. A. B. Oliveira, R. Q. Feitosa, and M. M. Correia, "Liver Segmentation
using Level Sets and Genetic Algorithms," in VISAPP (2), 2009, pp.
154-159.
[9] H. Yang, Y. Wang, J. Yang, and Y. Liu, "A novel graph cuts based liver
segmentation method," in Medical Image Analysis and Clinical
Applications (MIACA), 2010 International Conference on, 2010, pp.
50-53.
[10] Y.-W. Chen, K. Tsubokawa, and A. H. Foruzan, "Liver segmentation
from low contrast open MR scans using k-means clustering and
graph-cuts," in Advances in Neural Networks-ISNN 2010, ed: Springer,
2010, pp. 162-169.
[11] A. H. Foruzan, C. Yen-Wei, R. A. Zoroofi, A. Furukawa, H. Masatoshi,
and N. TOMIYAMA, "Segmentation of Liver in Low-Contrast Images
Using K-Means Clustering and Geodesic Active Contour Algorithms,"
IEICE TRANSACTIONS on Information and Systems, vol. 96, pp.
798-807, 2013.
[12] J. Liu and J. K. Udupa, "Oriented active shape models," Medical Imaging,
IEEE Transactions on, vol. 28, pp. 571-584, 2009.
[13] N. M. Altarawneh, S. Luo, B. Regan, and C. Sun, "A modified distance
reguularized level set model forl liver segmentation from CT images,"
Signal & Image Processing, vol. 6, p. 1, 2015.
[14] T. Heimann, I. Wolf, and H.-P. Meinzer, "Active shape models for a fully
automated 3D segmentation of the liver–an evaluation on clinical data,"
in Medical Image Computing and Computer-Assisted Intervention–
MICCAI 2006, ed: Springer, 2006, pp. 41-48.
[15] M. Erdt, S. Steger, M. Kirschner, and S. Wesarg, "Fast automatic liver
segmentation combining learned shape priors with observed shape
deviation," in Computer-Based Medical Systems (CBMS), 2010 IEEE
23rd International Symposium on, 2010, pp. 249-254.
[16] H. Badakhshannoory and P. Saeedi, "A model-based validation scheme
for organ segmentation in CT scan volumes," Biomedical Engineering,
IEEE Transactions on, vol. 58, pp. 2681-2693, 2011.
[17] W. Huang, Z. Tan, Z. Lin, G. Huang, J. Zhou, C. Chui, et al., "A
semi-automatic approach to the segmentation of liver parenchyma from
3D CT images with Extreme Learning Machine," in Engineering in
Medicine and Biology Society (EMBC), 2012 Annual International
Conference of the IEEE, 2012, pp. 3752-3755.
[18] S. Luo, Q. Hu, X. He, J. Li, J. S. Jin, and M. Park, "Automatic liver
parenchyma segmentation from abdominal CT images using support
vector machines," in Complex Medical Engineering, 2009. CME. ICME
International Conference on, 2009, pp. 1-5.
[19] S. Luo, X. Li, and J. Li, "Improvement of Liver Segmentation by
Combining High Order Statistical Texture Features with Anatomical
Structural Features," Engineering, vol. 5, p. 67, 2013.
[20] N. M. Altarawneh, S. Luo, B. Regan, C. Sun, and F. Jia, "global threshold
and region-based active contour model for accurate image segmentation."
[21] N. M. Altarawneh and B. Regan, "A novel global threshold-based active
contour model," Computer Science, 2014.
[22] C. Xu, d. l.pham, and j. l.prince, "Medical Image Segmentation Using
Deformable Models," in SPIE Handbook on Medical Imaging vol. 3, J.
M. Fitzpatrick and M. Sonka, Eds., ed, 2000, pp. 129-174.
[23] C. Li, C. Xu, C. Gui, and M. D. Fox, "Distance regularized level set
evolution and its application to image segmentation," Image Processing,
IEEE Transactions on, vol. 19, pp. 3243-3254, 2010.
[24] V. Caselles, R. Kimmel, and G. Sapiro, "Geodesic active contours,"
International journal of computer vision, vol. 22, pp. 61-79, 1997.
[25] D. Freedman and T. Zhang, "Active contours for tracking distributions,"
Image Processing, IEEE Transactions on, vol. 13, pp. 518-526, 2004.
[26] T. Georgiou, O. Michailovich, Y. Rathi, J. Malcolm, and A. Tannenbaum,
"Distribution metrics and image segmentation," Linear algebra and its
applications, vol. 425, pp. 663-672, 2007.
[27] Y. Rathi, O. Michailovich, J. Malcolm, and A. Tannenbaum, "Seeing the
unseen: Segmenting with distributions," in International conference on
signal and image processing, 2006.
[28] T. Zhang and D. Freedman, "Tracking objects using density matching and
shape priors," in Computer Vision, 2003. Proceedings. Ninth IEEE
International Conference on, 2003, pp. 1056-1062.
[29] I. B. Ayed, S. Li, and I. Ross, "A statistical overlap prior for variational
image segmentation," International journal of computer vision, vol. 85,
pp. 115-132, 2009.
[30] D. Cremers, N. Sochen, and C. Schnörr, "Towards recognition-based
variational segmentation using shape priors and dynamic labeling," in
Scale Space Methods in Computer Vision, 2003, pp. 388-400.