Abstract: Drought stress is a critical environmental factor that adversely affects crop productivity and quality. Because of their immobile nature, plants have evolved mechanisms to sense and respond to drought stress. We identified a novel locus of Arabidopsis, designated DRA1 (drought responsive ankyrin1), whose disruption leads to increased drought-stress tolerance. DRA1 encodes a transmembrane protein with an ankyrin-repeat motif that has been implicated in diverse cellular processes such as signal transduction. RT-PCR analysis revealed that there were at least two splicing variants of DRA1 transcripts in wild-type plants. In response to drought stress, the levels of DRA1 transcripts retaining second and third introns were increased, whereas these introns were removed under unstressed conditions. These results suggest that DRA1 protein may negatively regulate plant drought tolerance and that the expression of DRA1is regulated in response to drought stress by alternative splicing.
Abstract: People with hepatitis C are likely to experience psychological distress related to adjustment issues following diagnosis. Objective: The study was conducted to determine the psycho-social stressors accompanying Hepatitis C virus (HCV) chronic infection. The study focused on immediate and later on reactions to being diagnosed as infected HCV patients. Effect of HCV on disruption of patients’ relationships in term of family relationship and friendship, employment and financial status was assessed. The magnitude and causes of the social stigma and its relation to awareness about illness, level of education were also assessed. Methods: During this study the subjective experiences of people having HCV was explored through a designed questionnaire targeted 540 cases; 359 males and 181 females from ten out of 21 National Treatment Reference Centers of National Hepatology and Tropical Medicine Research Institutes of Ministry of Health (MOH) hospitals. The study was conducted along a period of six months from September 2011 to March 2012. Results: The study revealed that the financial problems are the commonest problems faced by 75.5% of the cases. More than 70% of the cases suffered from immediate sadness versus 67.4% suffered from worry. Social stigma was reported by 13 % of HCV +patients, the majority of which were females. Conclusions: Exploring the psychosocial consequences of HCV infection can act as pressing motivators for behavior change needed for limiting HCV endemicity in Egypt.
Abstract: Drought stress is a critical environmental factor that adversely affects crop productivity and quality. Because of their immobile nature, plants have evolved mechanisms to sense and respond to drought stress. We identified a novel locus of Arabidopsis, designated DRA1 (drought responsive ankyrin1), whose disruption leads to increased drought-stress tolerance. DRA1 encodes a transmembrane protein with an ankyrin-repeat motif that has been implicated in diverse cellular processes such as signal transduction. RT-PCR analysis revealed that there were at least two splicing variants of DRA1 transcripts in wild-type plants. In response to drought stress, the levels of DRA1 transcripts retaining second and third introns were increased, whereas these introns were removed under unstressed conditions. These results suggest that DRA1 protein may negatively regulate plant drought tolerance and that the expression of DRA1is regulated in response to drought stress by alternative splicing.
Abstract: The flow of suspensions of wood pulp fibers in circular pipes has been investigated experimentally. The flow characteristics of pulp suspensions are discussed with regard to five flow regimes designated by the author. In particular, the effects of the shear stress at the pipe wall on the disruption and dispersion of networks of pulp fibers are examined. The values of the disruptive and dispersive shear stresses are formulated as simple expressions depending on only the fiber concentration. Furthermore, the flow properties of the suspensions are described using the yield shear stress.
Abstract: The error monitoring and processing system, EMPS is
the system located in the substantia nigra of the midbrain, basal
ganglia and cortex of the forebrain, and plays a leading role in error
detection and correction. The main components of EMPS are the
dopaminergic system and anterior cingulate cortex. Although, recent
studies show that alcohol disrupts the EMPS, the ways in which
alcohol affects this system are poorly understood. Based on current
literature data, here we suggest a hypothesis of alcohol-related
glucose-dependent system of error monitoring and processing, which
holds that the disruption of the EMPS is related to the competency of
glucose homeostasis regulation, which in turn may determine the
dopamine level as a major component of EMPS. Alcohol may
indirectly disrupt the EMPS by affecting dopamine level through
disorders in blood glucose homeostasis regulation.
Abstract: Virtualization and high performance computing have been discussed from a performance perspective in recent publications. We present and discuss a flexible and efficient approach to the management of virtual clusters. A virtual machine management tool is extended to function as a fabric for cluster deployment and management. We show how features such as saving the state of a running cluster can be used to avoid disruption. We also compare our approach to the traditional methods of cluster deployment and present benchmarks which illustrate the efficiency of our approach.
Abstract: Mitochondria are dynamic organelles, capable to
interact with each other. While the number of mitochondria in a cell
varies, their quality and functionality depends on the operation of
fusion, fission, motility and mitophagy. Nowadays, several
researches declare as an important factor in neurogenerative diseases
the disruptions in the regulation of mitochondrial dynamics. In this
paper a stochastic model in BioAmbients calculus is presented,
concerning mitochondrial fusion and its distribution in the renewal of
mitochondrial population in a cell. This model describes the
successive and dependent stages of protein synthesis, protein-s
activation and merging of two independent mitochondria.
Abstract: Producing companies aspire to high delivery
availability despite appearing disruptions. To ensure high delivery
availability safety stocksare required. Howeversafety stock leads to
additional capital commitment and compensates disruptions instead
of solving the reasons.The intention is to increase the stability in
production by configuring the production planning and control
systematically. Thus the safety stock can be reduced. The largest
proportion of inventory in producing companies is caused by batch
inventory, schedule deviations and variability of demand rates.These
reasons for high inventory levels can be reduced by configuring the
production planning and control specifically. Hence the inventory
level can be reduced. This is enabled by synchronizing the lot size
straightening the demand as well as optimizing the releasing order,
sequencing and capacity control.
Abstract: Retinoic acid is like a steroid hormone that plays a
role in embryo formation, proliferation of spermatogonia cells,
ephitelial cells differentiation and organogenesis. Retinoic acid can
influences seminiferous tubule formation during embryonic testis
development and also play a role in the regulation of ovarian function
and female reproductive tract by suppressing the hormones FSH
receptor expression. The excessive use of retinoic acid caused
abnormalities in the fetus. The result showed that there is the
influence of retinoic acid on the developmet of mice fetal testes, for
examples disruption of the formation of seminiferous tubules and
tubules seemed to be hollow, spermatogonia cells are relatively few
in number and caused Leydig cells count relatively more. While in
the female fetus does not caused the formation of primordial follicles
and disrupted the development of germinal ephitelial cells of fetal
ovaries of female mice (mus musculus) Swiss Webster.
Abstract: Since the beginning of human history, human
activities have caused many changes in the environment. Today, a
particular attention should be paid to gaining knowledge about water
quality of wetlands which are pristine natural environments rich in
genetic reserves. If qualitative conditions of industrial areas (in terms
of both physicochemical and biological conditions) are not addressed
properly, they could cause disruption in natural ecosystems,
especially in rivers. With regards to the quality of water resources,
determination of pollutant sources plays a pivotal role in engineering
projects as well as designing water quality control systems. Thus,
using different methods such as flow duration curves, dischargepollution
load model and frequency analysis by HYFA software
package, risk of various industrial pollutants in international and
ecologically important Gavkhoni wetland is analyzed. In this study, a
station located at Varzaneh City is used as the last station on
Zayanderud River, from where the river water is discharged into the
wetland. Results showed that elements- concentrations often
exceeded the allowed level and river water can endanger regional
ecosystem. In addition, if the river discharge is managed on Q25
basis, this basis can lower concentrations of elements, keeping them
within the normal level.
Abstract: The article deals with the classification of alternative water resources in terms of potential risks which is the prerequisite for incorporating these water resources to the emergency plans. The classification is based on the quantification of risks resulting from possible damage, disruption or total destruction of water resource caused by natural and anthropogenic hazards, assessment of water quality and availability, traffic accessibility of the assessed resource and finally its water yield. The aim is to achieve the development of an integrated rescue system, which will be capable of supplying the population with drinking water on the whole stricken territory during the states of emergency.
Abstract: To support mobility in ATM networks, a number of
technical challenges need to be resolved. The impact of handoff
schemes in terms of service disruption, handoff latency, cost
implications and excess resources required during handoffs needs to
be addressed. In this paper, a one phase handoff and route
optimization solution using reserved PVCs between adjacent ATM
switches to reroute connections during inter-switch handoff is
studied. In the second phase, a distributed optimization process is
initiated to optimally reroute handoff connections. The main
objective is to find the optimal operating point at which to perform
optimization subject to cost constraint with the purpose of reducing
blocking probability of inter-switch handoff calls for delay tolerant
traffic. We examine the relation between the required bandwidth
resources and optimization rate. Also we calculate and study the
handoff blocking probability due to lack of bandwidth for resources
reserved to facilitate the rapid rerouting.
Abstract: The 20th century has brought much development to the practice of Architecture worldwide, and technology has bridged inhabitation limits in many regions of the world with high levels of comfort and conveniences, most times at high costs to the environment. Throughout the globe, the tropical countries are being urbanized at an unprecedented rate and housing has become a major issue worldwide, in light of increased demand and lack of appropriate infra-structure and planning. Buildings and urban spaces designed in tropical cities have mainly adopted external concepts that in most cases do not fit the needs of the inhabitants living in such harsh climatic environment, and when they do, do so at high financial, environmental and cultural costs. Traditional architectural practices can provide valuable understanding on how self-reliance and autonomy of construction can be reinforced in rural-urban tropical environments. From traditional housing knowledge, it is possible to derive lessons for the development of new construction materials that are affordable, environmentally friendly, culturally acceptable and accesible to all.Specifically to the urban context, such solutions are of outmost importance, given the needs to a more democratic society, where access to housing is considered high in the agenda for development. Traditional or rural constructions are also ongoing through extensive changes eventhough they have mostly adopted climate-responsive building practices relying on local resources (with minimum embodied energy) and energy (for comfort and quality of life). It is important to note that many of these buildings can actually be called zero-energy, and hold potential answers to enable transition from high energy, high cost, low comfort urban habitations to zero/low energy habitations with high quality urban livelihood. Increasing access to modern urban lifestyels have also an effect on the aspirations from people in terms of performance, comfort and convenience in terms of their housing and the way it is produced and used. These aspirations are resulting in transitions from localresource dependent habitations- to non-local resource based highenergy urban style habitations. And such transitions are resulting in the habitations becoming increasingly unsuited to the local climatic conditions with increasing discomfort, ill-health, and increased CO2 emissions and local environmental disruption. This research studies one specific transition group in the context of 'water communities' in tropical-equatorial regions: Ribeirinhos housing typology (Amazonas, Brazil). The paper presents the results of a qualitative sustainability assessment of the housing typologies under transition, found at the Ribeirinhos communities.
Abstract: Next generation wireless/mobile networks will be IP based cellular networks integrating the internet with cellular networks. In this paper, we propose a new architecture for a high speed transport system and a mobile management protocol for mobile internet users in a transport system. Existing mobility management protocols (MIPv6, HMIPv6) do not consider real world fast moving wireless hosts (e.g. passengers in a train). For this reason, we define a virtual organization (VO) and proposed the VO architecture for the transport system. We also classify mobility as VO mobility (intra VO) and macro mobility (inter VO). Handoffs in VO are locally managed and transparent to the CH while macro mobility is managed with Mobile IPv6. And, from the features of the transport system, such as fixed route and steady speed, we deduce the movement route and the handoff disruption time of each handoff. To reduce packet loss during handoff disruption time, we propose pre-registration scheme using pre-registration. Moreover, the proposed protocol can eliminate unnecessary binding updates resulting from sequence movement at high speed. The performance evaluations demonstrate our proposed protocol has a good performance at transport system environment. Our proposed protocol can be applied to the usage of wireless internet on the train, subway, and high speed train.
Abstract: True integration of multimedia services over wired or
wireless networks increase the productivity and effectiveness in
today-s networks. IP Multimedia Subsystems are Next Generation
Network architecture to provide the multimedia services over fixed
or mobile networks. This paper proposes an extended SIP-based QoS
Management architecture for IMS services over underlying IP access
networks. To guarantee the end-to-end QoS for IMS services in
interconnection backbone, SIP based proxy Modules are introduced
to support the QoS provisioning and to reduce the handoff disruption
time over IP access networks. In our approach these SIP Modules
implement the combination of Diffserv and MPLS QoS mechanisms
to assure the guaranteed QoS for real-time multimedia services. To
guarantee QoS over access networks, SIP Modules make QoS
resource reservations in advance to provide best QoS to IMS users
over heterogeneous networks. To obtain more reliable multimedia
services, our approach allows the use of SCTP protocol over SIP
instead of UDP due to its multi-streaming feature. This architecture
enables QoS provisioning for IMS roaming users to differentiate IMS
network from other common IP networks for transmission of realtime
multimedia services. To validate our approach simulation
models are developed on short scale basis. The results show that our
approach yields comparable performance for efficient delivery of
IMS services over heterogeneous IP access networks.
Abstract: This paper provides a framework in order to
incorporate reliability issue as a sign of disruption in distribution
systems and partial covering theory as a response to limitation in
coverage radios and economical preferences, simultaneously into the
traditional literatures of capacitated facility location problems. As a
result we develop a bi-objective model based on the discrete
scenarios for expected cost minimization and demands coverage
maximization through a three echelon supply chain network by
facilitating multi-capacity levels for provider side layers and
imposing gradual coverage function for distribution centers (DCs).
Additionally, in spite of objectives aggregation for solving the model
through LINGO software, a branch of LP-Metric method called Min-
Max approach is proposed and different aspects of corresponds
model will be explored.
Abstract: Nowadays for algae cell ultrasonication the
longitudinal ultrasonic piezosystems are used. In this paper a
possibility of creating unique ultrasonic piezoelectric system, which
would allow reducing energy losses and concentrating this energy to
a small closed volume are proposed. The current vibrating systems
whose ultrasonic energy is concentrated inside of hollow cylinder in
which water-algae mixture is flowing. Two, three or multiply
ultrasonic composite systems to concentrate total energy into a
hollow cylinder to creating strong algae cell ultrasonication are used.
The experiments and numerical FEM analysis results using diskshaped
transducer and the first biological test results on algae cell
disruption by ultrasonication are presented as well.
Abstract: As every system conceptions the concept of crisis is
based on the system of interdependent elements. These dialectic
elements occur in a majority of definitions even though called
differently. For further theoretical searching but also for practical
utilization it is necessary to understand these elements. The paper
stresses that the concept of crisis is ambiguous. There are identified
and explained the elements that are generally found in most crises
(disruption, precondition, triggers etc).
Abstract: Many firms implemented various initiatives such as outsourced manufacturing which could make a supply chain (SC) more vulnerable to various types of disruptions. So managing risk has become a critical component of SC management. Different types of SC vulnerability management methodologies have been proposed for managing SC risk, most offer only point-based solutions that deal with a limited set of risks. This research aims to reinforce SC risk management by proposing an integrated approach. SC risks are identified and a risk index classification structure is created. Then we develop a SC risk assessment approach based on the analytic network process (ANP) and the VIKOR methods under the fuzzy environment where the vagueness and subjectivity are handled with linguistic terms parameterized by triangular fuzzy numbers. By using FANP, risks weights are calculated and then inserted to the FVIKOR to rank the SC members and find the most risky partner.
Abstract: Supply chain networks are frequently hit by
unplanned events which lead to disruptions and cause operational and
financial consequences. It is neither possible to avoid disruption risk
entirely, nor are network members able to prepare for every possible
disruptive event. Therefore a continuity planning should be set up
which supports effective operational responses in supply chain
networks in times of emergencies. In this research network related
degrees of freedom which determine the options for responsive
actions are derived from interview data. The findings are further
embedded into a common risk management process. The paper
provides support for researchers and practitioners to identify the
network related options for responsive actions and to determine the
need for improving the reaction capabilities.