Abstract: Sense-antisense gene pair (SAGP) is a pair of two oppositely transcribed genes sharing a common region on a chromosome. In the mammalian genomes, SAGPs can be organized in more complex sense-antisense gene architectures (CSAGA) in which at least one gene could share loci with two or more antisense partners. Many dozens of CSAGAs can be found in the human genome. However, CSAGAs have not been systematically identified and characterized in context of their role in human diseases including cancers. In this work we characterize the structural-functional properties of a cluster of 5 genes –TMEM97, IFT20, TNFAIP1, POLDIP2 and TMEM199, termed TNFAIP1 / POLDIP2 module. This cluster is organized as CSAGA in cytoband 17q11.2. Affymetrix U133A&B expression data of two large cohorts (410 atients, in total) of breast cancer patients and patient survival data were used. For the both studied cohorts, we demonstrate (i) strong and reproducible transcriptional co-regulatory patterns of genes of TNFAIP1/POLDIP2 module in breast cancer cell subtypes and (ii) significant associations of TNFAIP1/POLDIP2 CSAGA with amplification of the CSAGA region in breast cancer, (ii) cancer aggressiveness (e.g. genetic grades) and (iv) disease free patient-s survival. Moreover, gene pairs of this module demonstrate strong synergetic effect in the prognosis of time of breast cancer relapse. We suggest that TNFAIP1/ POLDIP2 cluster can be considered as a novel type of structural-functional gene modules in the human genome.
Abstract: Turbulence modeling of large-scale flow over a vegetated surface is complex. Such problems involve large scale computational domains, while the characteristics of flow near the surface are also involved. In modeling large scale flow, surface roughness including vegetation is generally taken into account by mean of roughness parameters in the modified law of the wall. However, the turbulence structure within the canopy region cannot be captured with this method, another method which applies source/sink terms to model plant drag can be used. These models have been developed and tested intensively but with a simple surface geometry. This paper aims to compare the use of roughness parameter, and additional source/sink terms in modeling the effect of plant drag on wind flow over a complex vegetated surface. The RNG k-ε turbulence model with the non-equilibrium wall function was tested with both cases. In addition, the k-ω turbulence model, which is claimed to be computationally stable, was also investigated with the source/sink terms. All numerical results were compared to the experimental results obtained at the study site Mason Bay, Stewart Island, New Zealand. In the near-surface region, it is found that the results obtained by using the source/sink term are more accurate than those using roughness parameters. The k-ω turbulence model with source/sink term is more appropriate as it is more accurate and more computationally stable than the RNG k-ε turbulence model. At higher region, there is no significant difference amongst the results obtained from all simulations.
Abstract: Aluminum alloy sheets have several advantages such
as the lightweight, high-specific strength and recycling efficiency.
Therefore, aluminum alloy sheets in sheet forming have been used in various areas as automotive components and so forth. During the
process of sheet forming, wrinkling which is caused by compression stress might occur and the formability of sheets was affected by
occurrence of wrinkling. A few studies of uniaxial compressive test by
using square tubes, pipes and sheets were carried out to clarify the each wrinkling behavior. However, on uniaxial compressive test,
deformation behavior of the sheets hasn-t be cleared. Then, it is necessary to clarify the relationship between the buckling behavior
and the forming conditions. In this study, the effect of dimension of the sheet in the buckling behavior on compression test of aluminum alloy sheet was cleared by experiment and FEA. As the results, the buckling
deformation was classified by three modes in terms of the distribution of equivalent plastic strain.
Abstract: To estimate the risks of dam failure phenomenon, it is necessary to understand this phenomenon and the involved governing factors. Overtopping and piping are the two main reasons of earthdam failures. In the piping context, the piping is determined as a phenomenon which is occurred between two phases, the water liquid and the solid soil. In this investigation, the onset of piping and its development, as well as the movement of water in soil, are numerically approached. In this regard, a one-dimensional numerical model based on the mass-conserving finite-volume method is developed and applied in order to simulate the piping phenomenon in a continuous circular tunnel of given initial length and radius, located between upstream and downstream. The simulation result includes the time-variations of radius along the tunnel until the radius value reaches its critical and the piping phenomenon converts to overtopping.
Abstract: Recently, majors of doctors are divided into terribly lots of detailed areas. However, it is actually not a rare case that a doctor has a patient who is not in his/her major. He/She must judge an assessment and make a medical treatment plan for this patient. According to our investigation, conventional approaches such as image diagnosis cooperation are insufficient. This paper proposes an 'Assessment / Medical Treatment Plan Consulting System'. We have implemented a pilot system based on our proposition. Its effectiveness is clarified by an evaluation.
Abstract: This paper is a simple and systematic approaches to the design and analysis a pulse width modulation (PWM) based sliding mode controller for buck DC-DC Converters. Various aspects of the design, including the practical problems and the proposed solutions, are detailed. However, these control strategies can't compensate for large load current and input voltage variations. In this paper, a new control strategy by compromising both schemes advantages and avoiding their drawbacks is proposed, analyzed and simulated.
Abstract: The integral form of equations of motion of composite
beams subjected to varying time loads are discretized using a
developed finite element model. The model consists of a straight five
node twenty-two degrees of freedom beam element. The stability
analysis of the beams is studied by solving the matrix form
characteristic equations of the system. The principle of virtual work
and the first order shear deformation theory are employed to analyze
the beams with large deformation and small strains. The regions of
dynamic instability of the beam are determined by solving the
obtained Mathieu form of differential equations. The effects of nonconservative
loads, shear stiffness, and damping parameters on
stability and response of the beams are examined. Several numerical
calculations are presented to compare the results with data reported
by other researchers.
Abstract: In this paper we present a novel method, which
reduces the computational complexity of abrupt cut detection. We
have proposed fast algorithm, where the similarity of frames within
defined step is evaluated instead of comparing successive frames.
Based on the results of simulation on large video collection, the
proposed fast algorithm is able to achieve 80% reduction of needed
frames comparisons compared to actually used methods without the
shot cut detection accuracy degradation.
Abstract: The paper compares different channel models used for
modeling Broadband Power-Line Communication (BPLC) system.
The models compared are Zimmermann and Dostert, Philipps,
Anatory et al and Anatory et al generalized Transmission Line (TL)
model. The validity of each model was compared in time domain
with ATP-EMTP software which uses transmission line approach. It
is found that for a power-line network with minimum number of
branches all the models give similar signal/pulse time responses
compared with ATP-EMTP software; however, Zimmermann and
Dostert model indicates the same amplitude but different time delay.
It is observed that when the numbers of branches are increased only
generalized TL theory approach results are comparable with ATPEMTP
results. Also the Multi-Carrier Spread Spectrum (MC-SS)
system was applied to check the implication of such behavior on the
modulation schemes. It is observed that using Philipps on the
underground cable can predict the performance up to 25dB better
than other channel models which can misread the actual performance
of the system. Also modified Zimmermann and Dostert under
multipath can predict a better performance of about 5dB better than
the actual predicted by Generalized TL theory. It is therefore
suggested for a realistic BPLC system design and analyses the model
based on generalized TL theory be used.
Abstract: The paper reflects current state of popularization of
static elasticity modulus of concrete. This parameter is undoubtedly
very important for designing of concrete structures, and very often
neglected and rarely determined before designing concrete
technology itself. The paper describes assessment and comparison of
four mix designs with almost constant dosage of individual
components. The only difference is area of origin of small size
fraction of aggregate 0/4. Development of compressive strength and
static elasticity modulus at the age of 7, 28 and 180 days were
observed. As the experiment showed, designing of individual
components and their quality are the basic factor influencing
elasticity modulus of current concrete.
Abstract: A climate dependent model is proposed to simulate
the population of Aedes aegypti mosquito. In developing the model,
average temperature of Shah Alam, Malaysia was used to determine
the development rate of each stage of the life cycle of mosquito.
Rainfall dependent function was proposed to simulate the hatching
rate of the eggs under several assumptions. The proposed transition
matrix was obtained and used to simulate the population of eggs,
larvae, pupae and adults mosquito. It was found that the peak of
mosquito abundance comes during a relatively dry period following a
heavy rainfall. In addition, lag time between the peaks of mosquito
abundance and dengue fever cases in Shah Alam was estimated.
Abstract: Meta-reasoning is essential for multi-agent communication. In this paper we propose a framework of multi-agent communication in which agents employ meta-reasoning to reason with agent and ontology locations in order to communicate semantic information with other agents on the semantic web and also reason with multiple distributed ontologies. We shall argue that multi-agent communication of Semantic Web information cannot be realized without the need to reason with agent and ontology locations. This is because for an agent to be able to communicate with another agent, it must know where and how to send a message to that agent. Similarly, for an agent to be able to reason with an external semantic web ontology, it must know where and how to access to that ontology. The agent framework and its communication mechanism are formulated entirely in meta-logic.
Abstract: In recent years, copulas have become very popular in
financial research and actuarial science as they are more flexible in
modelling the co-movements and relationships of risk factors as compared
to the conventional linear correlation coefficient by Pearson.
However, a precise estimation of the copula parameters is vital in
order to correctly capture the (possibly nonlinear) dependence structure
and joint tail events. In this study, we employ two optimization
heuristics, namely Differential Evolution and Threshold Accepting to
tackle the parameter estimation of multivariate t distribution models
in the EML approach. Since the evolutionary optimizer does not rely
on gradient search, the EML approach can be applied to estimation of
more complicated copula models such as high-dimensional copulas.
Our experimental study shows that the proposed method provides
more robust and more accurate estimates as compared to the IFM
approach.
Abstract: This experiment was conducted in attempt of
improving hydrodynamic efficiency of the propulsion mechanism by
installing a spring to the wing so that the opening angle of the wing in
one stroke can be changed automatically, compared to the existing
method of fixed maximum opening angle in Weis-Fogh type ship
propulsion mechanism. Average thrust coefficient was almost fixed
with all velocity ratio with the prototype, but with the spring type,
thrust coefficient increased sharply as velocity ratio increased.
Average propulsive efficiency was larger with bigger opening angle in
the prototype, but in the spring type, the one with smaller spring
coefficient had larger value. In the range over 1.0 in velocity ratio
where big thrust can be generated, spring type had more than twice of
propulsive efficiency increase compared to the prototype.
Abstract: This paper presents the theoretical investigation of a
slotted patch antenna. The main objective of proposed work is to
obtain a large bandwidth antenna with reduced size. The antenna has
a compact size of 21.1mm x 20.25mm x 8.5mm. Two designs with
minor variation are studied which provide wide impedance
bandwidths of 24.056% and 25.63% respectively with the use of
parasitic elements when excited by a probe feed. The advantages of
this configuration are its compact size and the wide range of
frequencies covered. A parametric study is also conducted to
investigate the characteristics of the antenna under different
conditions. The measured return loss and radiation pattern indicate
the suitability of this design for WLAN applications, namely, Wi-
Max, 802.11a/b/g and ISM bands.
Abstract: In this paper, we present a technical and an economic
assessment of several sources of renewable energy in Saudi Arabia;
mainly solar, wind, hydro and biomass. We analyze the
environmental and climatic conditions in relation to these sources
and give an overview of some of the existing clean energy
technologies. Using standardized cost and efficiency data, we carry
out a cost benefit analysis to understand the economic factors
influencing the sustainability of energy production from renewable
sources in light of the energy cost and demand in the Saudi market.
Finally, we take a look at the Saudi petroleum industry and the
existing sources of conventional energy and assess the potential of
building a successful market for renewable energy under the
constraints imposed by the flow of subsidized cheap oil. We show
that while some renewable energy resources are well suited for
distributed or grid connected generation in the kingdom, their
viability is greatly undercut by the well developed and well
capitalized oil industry.
Abstract: Voice over Internet Protocol (VoIP) application or commonly known as softphone has been developing an increasingly large market in today-s telecommunication world and the trend is expected to continue with the enhancement of additional features. This includes leveraging on the existing presence services, location and contextual information to enable more ubiquitous and seamless communications. In this paper, we discuss the concept of seamless session transfer for real-time application such as VoIP and IPTV, and our prototype implementation of such concept on a selected open source VoIP application. The first part of this paper is about conducting performance evaluation and assessments across some commonly found open source VoIP applications that are Ekiga, Kphone, Linphone and Twinkle so as to identify one of them for implementing our design of seamless session transfer. Subjective testing has been carried out to evaluate the audio performance on these VoIP applications and rank them according to their Mean Opinion Score (MOS) results. The second part of this paper is to discuss on the performance evaluations of our prototype implementation of session transfer using Linphone.
Abstract: Most of the academics connect a theory of
multiculturalism with globalization and limit it by last decades of
20th century. However, Kazakh society encountered with this
problem when the Soviet-s rule emerged. As a result of repression,
the Second World War, development of virgin lands representatives
of more than 100 nationalities lives in Kazakhstan. Communist
ideology propagandized internationalism, which would defined
principles of multicultural community but a common ideology
demands a single culture. As a result multicultural society in the
USSR developed under control of Russian culture. Education in the
USSR was conducted in two departments: autochthonous and
Russian. Autochthonous education narrowed student capabilities.
Also because of soviet ideology science was conducted in Russian
Universities provided education in Russian and all science literature
were in Russian. Exceptions were humanitarian fields where Kazakh
departments were admitted. Naturally non-Kazakhs studied in
Russian departments, moreover Kazakhs preferred to study in
Russian as most do nowadays preferring English. As a result Kazakh
society consisted of Kazakhs, Kazakhs who recognized Russian as a
mother tongue and other nationalities who were also Russian
speakers. This aspect continues to distinguish particular qualities of
multicultural community in Kazakhstan.
Abstract: Hazardous Material transportation by road is coupled
with inherent risk of accidents causing loss of lives, grievous injuries,
property losses and environmental damages. The most common type
of hazmat road accident happens to be the releases (78%) of
hazardous substances, followed by fires (28%), explosions (14%) and
vapour/ gas clouds (6 %.).
The paper is discussing initially the probable 'Impact Zones'
likely to be caused by one flammable (LPG) and one toxic (ethylene
oxide) chemicals being transported through a sizable segment of a
State Highway connecting three notified Industrial zones in Surat
district in Western India housing 26 MAH industrial units. Three
'hotspots' were identified along the highway segment depending on
the particular chemical traffic and the population distribution within
500 meters on either sides. The thermal radiation and explosion
overpressure have been calculated for LPG / Ethylene Oxide BLEVE
scenarios along with toxic release scenario for ethylene oxide.
Besides, the dispersion calculations for ethylene oxide toxic release
have been made for each 'hotspot' location and the impact zones
have been mapped for the LOC concentrations. Subsequently, the
maximum Initial Isolation and the protective zones were calculated
based on ERPG-3 and ERPG-2 values of ethylene oxide respectively
which are estimated taking the worst case scenario under worst
weather conditions. The data analysis will be helpful to the local
administration in capacity building with respect to rescue /
evacuation and medical preparedness and quantitative inputs to
augment the District Offsite Emergency Plan document.
Abstract: Amount of dissolve oxygen in a river has a great direct affect on aquatic macroinvertebrates and this would influence on the region ecosystem indirectly. In this paper it is tried to predict dissolved oxygen in rivers by employing an easy Fuzzy Logic Modeling, Wang Mendel method. This model just uses previous records to estimate upcoming values. For this purpose daily and hourly records of eight stations in Au Sable watershed in Michigan, United States are employed for 12 years and 50 days period respectively. Calculations indicate that for long period prediction it is better to increase input intervals. But for filling missed data it is advisable to decrease the interval. Increasing partitioning of input and output features influence a little on accuracy but make the model too time consuming. Increment in number of input data also act like number of partitioning. Large amount of train data does not modify accuracy essentially, so, an optimum training length should be selected.