Abstract: The fluid mechanics principle is used extensively in
designing axial flow fans and their associated equipment. This paper presents a computational fluid dynamics (CFD) modeling of air flow
distribution from a radiator axial flow fan used in an acid pump truck Tier4 (APT T4) Repower. This axial flow fan augments the transfer
of heat from the engine mounted on the APT T4.
CFD analysis was performed for an area weighted average static pressure difference at the inlet and outlet of the fan. Pressure contours, velocity vectors, and path lines were plotted for detailing
the flow characteristics for different orientations of the fan blade. The results were then compared and verified against known theoretical observations and actual experimental data. This study
shows that a CFD simulation can be very useful for predicting and understanding the flow distribution from a radiator fan for further
research work.
Abstract: Delayed wound healing in diabetes is primarily
associated with hyperglycemia, over-expression of inflammatory
marker, oxidative stress and delayed collagen synthesis. This
unmanaged wound is producing high economic burden on the
society. Thus research is required to develop new and effective
treatment strategies to deal with this emerging issue. Our present
study incorporates the evaluation of wound healing effects of 50%
ethanol extract of Ocimum sanctum (OSE) in streptozotocin
(45mg/kg)-induced diabetic rats with concurrent wound ulcer. The
animals showing diabetes (Blood glucose level >140 and
Abstract: Highly ordered TiO2 nanotube (TNT) arrays were
fabricated onto a pre-treated titanium foil by anodic oxidation with a
voltage of 20V in phosphoric acid/sodium fluoride electrolyte. A pretreatment
of titanium foil involved washing with acetone,
isopropanol, ethanol and deionized water. Carbon doped TiO2
nanotubes (C-TNT) was fabricated 'in-situ' with the same method in
the presence of polyvinyl alcohol and urea as carbon sources. The
affects of polyvinyl alcohol concentration and oxidation time on the
composition, morphology and structure of the C-TN were studied by
FE-SEM, EDX and XRD techniques. FESEM images of the
nanotubes showed uniform arrays of C-TNTs. The density and
microstructures of the nanotubes were greatly affected by the content
of PVA. The introduction of the polyvinyl alcohol into the electrolyte
increases the amount of C content inside TiO2 nanotube arrays
uniformly. The influence of carbon content on the photo-current of
C-TNT was investigated and the I-V profiles of the nanotubes were
established. The preliminary results indicated that the 'in-situ'
doping technique produced a superior quality nanotubes compared to
post doping techniques.
Abstract: Fermented beverages have high expression in the
market for beverages in general, is increasingly valued in situations
where the characteristic aroma and flavor of the material that gave
rise to them are kept after processing. This study aimed to develop a
distilled beverage from passion fruit, and assess, by sensory tests and
chromatographic profile, the influence of different treatments (FM1-
spirit with pulp addiction and FM2 – spirit with bigger ratio of pulp
in must) in the setting of volatiles in the fruit drink, and performing
chemical characterization taking into account the main parameters of
quality established by the legislation. The chromatograms and the
first sensorial tests had indicated that sample FM1 possess better
characteristics of aroma, as much of how much quantitative the
qualitative point of view. However, it analyzes it sensorial end
(preference test) disclosed the biggest preference of the cloth provers
for sample FM2-2 (note 7.93), being the attributes of decisive color
and flavor in this reply, confirmed for the observed values lowest of
fixed and total acidity in the samples of treatment FM2.
Abstract: In this paper we introduce the notion of protein interaction
network. This is a graph whose vertices are the protein-s
amino acids and whose edges are the interactions between them.
Using a graph theory approach, we identify a number of properties of
these networks. We compare them to the general small-world network
model and we analyze their hierarchical structure.
Abstract: The present work deals with the stabilisation of
organic clay using hydrated lime. Artificial organic clays were
prepared by adding kaolin and different humic acid contents. Results
given by physical testing show that the presence of humic acid has a
drawback effect on the untreated organic clay. The decrease in
specific gravity value was accompanied by a decrease in dry density
and plasticity of clay at higher humic acid contents. Significant
increase in shear strength at 7 days of curing period is observed in the
lime-treated samples up to 5% lime content. However shear strength
of lime-treated organic clay decreases at longer curing periods. The
results given by laboratory testing is further verified by
microstructure analysis. Based on the results obtained in this study, it
can be concluded that the presence of more than 1.5% humic acid
reduces significantly the efficiency of lime stabilization in organic
clays.
Abstract: Possible advantages of technology in educational
context required the defining boundaries of formal and informal
learning. Increasing opportunity to ubiquitous learning by
technological support has revealed a question of how to discover
the potential of individuals in the spontaneous environments such as
social networks. This seems to be related with the question of what
purposes in social networks have been being used? Social networks
provide various advantages in educational context as collaboration,
knowledge sharing, common interests, active participation and
reflective thinking. As a consequence of these, the purpose of this
study is composed of proposing a new model that could determine
factors which effect adoption of social network applications for usage
in educational context. While developing a model proposal, the
existing adoption and diffusion models have been reviewed and they
are thought to be suitable on handling an original perspective instead
of using completely other diffusion or acceptance models because of
different natures of education from other organizations. In the
proposed model; social factors, perceived ease of use, perceived
usefulness and innovativeness are determined four direct constructs
that effect adoption process. Facilitating conditions, image,
subjective norms and community identity are incorporated to model
as antecedents of these direct four constructs.
Abstract: pH-sensitive drug targeting using nanoparticles for
cancer chemotherapy have been spotlighted in recent decades. Graft
copolymer composed of poly (L-histidine) (PHS) and dextran
(DexPHS) was synthesized and pH-sensitive nanoparticles were
fabricated for pH-responsive drug delivery of doxorubicin (DOX).
Nanoparticles of DexPHS showed pH-sensitive changes in particle
sizes and drug release behavior, i.e. particle sizes and drug release rate
were increased at acidic pH, indicating that DexPHS nanoparticles
have pH-sensitive drug delivery potentials. Antitumor activity of
DOX-incorporated DexPHS nanoparticles were studied using CT26
colorectal carcinoma cells. Results indicated that fluorescence
intensity was higher at acidic pH than basic pH. These results
indicated that DexPHS nanoparticles have pH-responsive drug
targeting.
Abstract: The presence of heavy metals in the environment
could constitute a hazard to food security and public health. These
can be accumulated in aquatic animals such as fish. Samples of four
popular brands of canned fish in the Iranian market (yellowfin tuna,
common Kilka, Kawakawa and longtail tuna) were analyzed for level
of Cr after wet digestion with acids using graphite furnace atomic
absorption spectrophotometry. The mean concentrations for Cr in the
different brands were: 2.57, 3.24, 3.16 and 1.65 μg/g for brands A, B,
C and D respectively. Significant differences were observed in the Cr
levels between all of the different brands of canned fish evaluated in
this study. The Cr concentrations for the varieties of canned fishes
were generally within the FAO/WHO, U.S. FDA and U.S. EPA
recommended limits for fish.
Abstract: Palm shell obtained from coastal part of southern
India was studied for the removal for the adsorption of Hg (II) ions.
Batch adsorption experiments were carried out as a function of pH,
concentration of Hg (II) ions, time, temperature and adsorbent dose.
Maximum removal was seen in the range pH 4.0- pH 7.0. The palm
shell powder used as adsorbent was characterized for its surface area,
SEM, PXRD, FTIR, ion exchange capacity, moisture content, and
bulk density, soluble content in water and acid and pH. The
experimental results were analyzed using Langmuir I, II, III, IV and
Freundlich adsorption isotherms. The batch sorption kinetics was
studied for the first order reversible reaction, pseudo first order;
pseudo second order reaction and the intra-particle diffusion reaction.
The biomass was successfully used for removal Hg (II) from
synthetic and industrial effluents and the technique appears
industrially applicable and viable.
Abstract: The literature reports a large number of approaches for
measuring the similarity between protein sequences. Most of these
approaches estimate this similarity using alignment-based techniques
that do not necessarily yield biologically plausible results, for two
reasons.
First, for the case of non-alignable (i.e., not yet definitively aligned
and biologically approved) sequences such as multi-domain, circular
permutation and tandem repeat protein sequences, alignment-based
approaches do not succeed in producing biologically plausible results.
This is due to the nature of the alignment, which is based on the
matching of subsequences in equivalent positions, while non-alignable
proteins often have similar and conserved domains in non-equivalent
positions.
Second, the alignment-based approaches lead to similarity measures
that depend heavily on the parameters set by the user for the alignment
(e.g., gap penalties and substitution matrices). For easily alignable
protein sequences, it's possible to supply a suitable combination of
input parameters that allows such an approach to yield biologically
plausible results. However, for difficult-to-align protein sequences,
supplying different combinations of input parameters yields different
results. Such variable results create ambiguities and complicate the
similarity measurement task.
To overcome these drawbacks, this paper describes a novel and
effective approach for measuring the similarity between protein
sequences, called SAF for Substitution and Alignment Free. Without
resorting either to the alignment of protein sequences or to substitution
relations between amino acids, SAF is able to efficiently detect the
significant subsequences that best represent the intrinsic properties of
protein sequences, those underlying the chronological dependencies of
structural features and biochemical activities of protein sequences.
Moreover, by using a new efficient subsequence matching scheme,
SAF more efficiently handles protein sequences that contain similar
structural features with significant meaning in chronologically
non-equivalent positions. To show the effectiveness of SAF, extensive
experiments were performed on protein datasets from different
databases, and the results were compared with those obtained by
several mainstream algorithms.
Abstract: We have developed a database for membrane protein functions, which has more than 3000 experimental data on functionally important amino acid residues in membrane proteins along with sequence, structure and literature information. Further, we have proposed different methods for identifying membrane proteins based on their functions: (i) discrimination of membrane transport proteins from other globular and membrane proteins and classifying them into channels/pores, electrochemical and active transporters, and (ii) β-signal for the insertion of mitochondrial β-barrel outer membrane proteins and potential targets. Our method showed an accuracy of 82% in discriminating transport proteins and 68% to classify them into three different transporters. In addition, we have identified a motif for targeting β-signal and potential candidates for mitochondrial β-barrel membrane proteins. Our methods can be used as effective tools for genome-wide annotations.
Abstract: The methanolic extracts from seeds of tamarind
(Tamarindus indica) was prepared by Soxhlet apparatus extraction
and evaluated for total phenolic content by Folin-Ciocalteu method.
Then, methanolic extract was screened biological activities (In vitro)
for anti-melanogenic activity by tyrosinase inhibition test, antiinflammation
activity by cyclooxygenase 1 (COX-1) and
cyclooxygenase 2 (COX-2) inhibition test, and cytotoxic screening
test with Vero cells. The results showed that total phenolic content,
which contained in extract, was contained 27.72 mg of gallic acid
equivalent per g of dry weight. The ability to inhibit tyrosinase
enzyme, which exerted by Tamarind seed extracts (1 mg/ml) was
52.13 ± 0.42 %. The extract was not possessed inhibitory effect to
COX-1 and COX-2 enzymes and cytotoxic effect to Vero cells. The
finding is concludes that tested seed extract was possessed
antimelanogenic activity with non-toxic effects. However, there was
not exhibited anti-inflammatory activity. Further studies include the
use of advance biological models to confirm this biological activity,
as well as, the isolation and characterization of the purified
compounds that it was contained.
Abstract: Non-viral gene carriers composed of biodegradable
polymers or lipids have been considered as a safer alternative for gene
carriers over viral vectors. We have developed multi-functional
nano-micelles for both drug and gene delivery application.
Polyethyleneimine (PEI) was modified by grafting stearic acid (SA)
and formulated to polymeric micelles (PEI-SA) with positive surface
charge for gene and drug delivery. Our results showed that PEI-SA
micelles provided high siRNA binding efficiency. In addition, siRNA
delivered by PEI-SA carriers also demonstrated significantly high
cellular uptake even in the presence of serum proteins. The
post-transcriptional gene silencing efficiency was greatly improved by
the polyplex formulated by 10k PEI-SA/siRNA. The amphiphilic
structure of PEI-SA micelles provided advantages for multifunctional
tasks; where the hydrophilic shell modified with cationic charges can
electrostatically interact with DNA or siRNA, and the hydrophobic
core can serve as payloads for hydrophobic drugs, making it a
promising multifunctional vehicle for both genetic and chemotherapy
application.
Abstract: Three alumina-supported Pt-Sn catalysts have been
prepared by means of co-impregnation and characterized by XRD and
N2 adsorption. The influence of catalyst composition and reaction
conditions on the conversion and selectivity were investigated in the
hydrogenation of acetic acid in an isothermal integral fixed bed
reactor. The experiments were performed on the temperature interval
468-548 K, liquid hourly space velocity (LHSV) of 0.3-0.7h-1,
pressures between 1.0 and 5.0Mpa. A good compromise of
0.75%Pt-1.5%Sn can act as an optimized acetic acid hydrogenation
catalyst, and the conversion and selectivity can be tuned through the
variation of reaction conditions.
Abstract: The effect of wheat flour extraction rates on flour
composition, farinographic characteristics and the quality of
sourdough naans was investigated. The results indicated that by
increasing the extraction rate, the amount of protein, fiber, fat and
ash increased, whereas moisture content decreased. Farinographic
characteristic like water absorption and dough development time
increased with an increase in flour extraction rate but the dough
stabilities and tolerance indices were reduced with an increase in
flour extraction rates. Titratable acidity for both sourdough and
sourdough naans also increased along with flour extraction rate. The
study showed that overall quality of sourdough naans were affected
by both flour extraction rate and starter culture used. Sensory
analysis of sourdough naans revealed that desirable extraction rate
for sourdough naan was 76%.
Abstract: In the past many uneconomic solutions for limitation
and interruption of short-circuit currents in low power applications
have been introduced, especially polymer switch based on the
positive temperature coefficient of resistance (PCTR) concept.
However there are many limitations in the active material, which
consists of conductive fillers. This paper presents a significantly
improved and simplified approach that replaces the existing current
limiters with faster switching elements. Its elegance lies in the
remarkable simplicity and low-cost processes of producing the device
using polyaniline (PANI) doped with methane-sulfonic acid (MSA).
Samples characterized as lying in the metallic and critical regimes of
metal insulator transition have been studied by means of electrical
performance in the voltage range from 1V to 5 V under different
environmental conditions. Moisture presence is shown to increase the
resistivity and also improved its current limiting performance.
Additionally, the device has also been studied for electrical resistivity
in the temperature range 77 K-300 K. The temperature dependence of
the electrical conductivity gives evidence for a transport mechanism
based on variable range hopping in three dimensions.
Abstract: For stricter drinking water regulations in the future, reducing the humic acid and disinfection byproducts in raw water, namely, trihalomethanes (THMs) and haloacetic acids (HAAs) is worthy for research. To investigate the removal of waterborne organic material using a lab-scale of bio-activated carbon filter under different EBCT, the concentrations of humic acid prepared were 0.01, 0.03, 0.06, 0.12, 0.17, 0.23, and 0.29 mg/L. Then we conducted experiments using a pilot plant with in-field of the serially connected bio-activated carbon filters and hollow fiber membrane processes employed in traditional water purification plants. Results showed under low TOC conditions of humic acid in influent (0.69 to 1.03 mg TOC/L) with an EBCT of 30 min, 40 min, and 50 min, TOC removal rates increases with greater EBCT, attaining about 39 % removal rate. The removal rate of THMs and HAAs by BACF was 54.8 % and 89.0 %, respectively.
Abstract: In this paper we introduce the notion of protein interaction network. This is a graph whose vertices are the protein-s amino acids and whose edges are the interactions between them. Using a graph theory approach, we observe that according to their structural roles, the nodes interact differently. By leading a community structure detection, we confirm this specific behavior and describe thecommunities composition to finally propose a new approach to fold a protein interaction network.
Abstract: Since hyaluronic acid (HA) receptor such as CD44 is
over-expressed at sites of cancer cells, HA can be used as a targeting
vehicles for anti-cancer drugs. The aim of this study is to synthesize
block copolymer composed of hyaluronic acid and
poly(ε-caprolactone) (HAPCL) and to fabricate polymeric micelles for
anticancer drug targeting against CD44 receptor of tumor cells.
Chemical composition of HAPCL was confirmed using 1H NMR
spectroscopy. Doxorubicin (DOX) was incorporated into polymeric
micelles of HAPCL. The diameters of HAPHS polymeric micelles
were changed around 80nm and have spherical shapes. Targeting
potential was investigated using CD44-overexpressing. When
DOX-incorporated polymeric micelles was added to KB cells, they
revealed strong red fluorescence color while blocking of CD44
receptor by pretreatment of free HA resulted in reduced intensity,
indicating that HAPCL polymeric micelles have targetability against
CD44 receptor.