Dextran/Poly(L-histidine) Graft Copolymer for pH-Responsive Drug Delivery
pH-sensitive drug targeting using nanoparticles for
cancer chemotherapy have been spotlighted in recent decades. Graft
copolymer composed of poly (L-histidine) (PHS) and dextran
(DexPHS) was synthesized and pH-sensitive nanoparticles were
fabricated for pH-responsive drug delivery of doxorubicin (DOX).
Nanoparticles of DexPHS showed pH-sensitive changes in particle
sizes and drug release behavior, i.e. particle sizes and drug release rate
were increased at acidic pH, indicating that DexPHS nanoparticles
have pH-sensitive drug delivery potentials. Antitumor activity of
DOX-incorporated DexPHS nanoparticles were studied using CT26
colorectal carcinoma cells. Results indicated that fluorescence
intensity was higher at acidic pH than basic pH. These results
indicated that DexPHS nanoparticles have pH-responsive drug
targeting.
<p>[1] C. He C, X. Zhuang, Z. Tang, H. Tian, X. Chen. "Stimuli-sensitive
synthetic polypeptide-based materials for drug and gene delivery," Adv.
Healthc. Mater. vol. 1, pp. 48-78, 2012.
[2] Y.L. Colson, M.W. Grinstaff, "Biologically responsive polymeric
nanoparticles for drug delivery," Adv. Mater. vol. 24, no. 28, pp.
3878-3886, 2012.
[3] R. Liu, D. Li, B. He, X. Xu, M. Sheng, Y. Lai, G. Wang, Z. Gu,
"Anti-tumor drug delivery of pH-sensitive poly(ethylene
glycol)-poly(L-histidine-)-poly(L-lactide) nanoparticles," J. Control.
Release, vol. 152, pp. 49-56, 2011.
[4] D. W. Pack, D. Putnam, R. Langer, "Design of imidazole-containing
endosomolytic biopolymers for gene delivery," Biotechnol. Bioeng. vol.
67, pp. 217-223, 2000.
[5] D. Putnam, A.N. Zelikin, V.A. Izumrudov, R. Langer,
"Polyhistidine-PEG:DNA nanocomposites for gene delivery,"
Biomaterials. vol. 24, pp. 4425-4433, 2003.
[6] R.P. Johnson, Y.I. Jeong, E. Choi, C.W. Chung, D.H. Kang, S.O. Oh, H.
Suh, I. Kim, "Biocompatible Poly(2-hydroxyethyl
methacrylate)-b-poly(L-histidine) Hybrid Materials for pH-Sensitive
Intracellular Anticancer Drug Delivery," Adv. Funct. Mater. vol. 22, pp.
1058–1068, 2012.
[7] Y.I. Jeong, C.W. Chung, D.H. Kang, "Fabrication of pH-sensitive
nanoparticles using dextran/poly(L-histidine) graft copolymers,"
Carbohydr. Polym. Preparation for submission.
[8] R.P. Johnson, C.W. Chung, Y.I. Jeong, D.H. Kang, H. Suh, I. Kim,
"Poly(L-histidine)-tagged 5-aminolevulinic acid prodrugs: new
photosensitizing precursors of protoporphyrin IX for photodynamic colon
cancer therapy," Int. J. Nanomedicine. vol. 7, pp. 2497-2512, 2012.
[9] I.F. Tannock, D. Rotin, "Acid pH in tumors and its potential for
therapeutic exploitation," Cancer Res. vol. 49, pp. 4373-4384, 1989.
[10] Q. Liu, Q.Q. Jiang, W.J. Yi, J. Zhang, X.C. Zhang, M.B. Wu, Y.M.
Zhang, W. Zhu, X.Q. Yu, "Novel imidazole-functionalized cyclen
cationic lipids: synthesis and application as non-viral gene vectors,"
Bioorg. Med. Chem. vol. 21, no. 11, pp. 3105-3113, 2013.
[11] N. Toriyabe, Y. Hayashi, H. Harashima. "The transfection activity of
R8-modified nanoparticles and siRNA condensation using pH sensitive
stearylated-octahistidine," Biomaterials. vol. 34, no. 4, pp. 1337-1343,
2013.
[12] J.H. Hwang, C.W. Choi, H.W. Kim, D.H. Kim, T.W. Kwak, H.M. Lee,
C.H. Kim, C.W. Chung, Y.I. Jeong, D.H. Kang, "Nanoparticles of
dextran-b-poly(L-histidine) copolymer for pH-responsive drug delivery
to tumor cells," Int. J. Nanomedicine, Submitted for publication.
[13] R. Liu, B. He, D. Li, Y. Lai, J. Chang, J.Z. Tang, Z. Gu Z, "Effects of
pH-sensitive chain length on release of doxorubicin from
mPEG-b-PH-b-PLLA nanoparticles," Int. J. Nanomedicine, vol. 7, pp.
4433-4446, 2012.
[14] J.L. Wu, C.G. Liu, X.L. Wang, Z.H. Huang, "Preparation and
characterization of nanoparticles based on histidine-hyaluronic acid
conjugates as doxorubicin carriers," J. Mater. Sci. Mater. Med. vol. 23,
no. 8, pp. 1921-1929, 2012.
[15] B.S. Lee, K. Park, S. Park, G.C. Kim, H.J. Kim, S. Lee, H. Kil, S.J. Oh, D.
Chi, K. Kim, K. Choi, I.C. Kwon, S.Y. Kim, "Tumor targeting efficiency
of bare nanoparticles does not mean the efficacy of loaded anticancer
drugs: importance of radionuclide imaging for optimization of highly
selective tumor targeting polymeric nanoparticles with or without drug,"
J. Control. Release. vol. 147, pp. 253-260, 2010.</p>
<p>[1] C. He C, X. Zhuang, Z. Tang, H. Tian, X. Chen. "Stimuli-sensitive
synthetic polypeptide-based materials for drug and gene delivery," Adv.
Healthc. Mater. vol. 1, pp. 48-78, 2012.
[2] Y.L. Colson, M.W. Grinstaff, "Biologically responsive polymeric
nanoparticles for drug delivery," Adv. Mater. vol. 24, no. 28, pp.
3878-3886, 2012.
[3] R. Liu, D. Li, B. He, X. Xu, M. Sheng, Y. Lai, G. Wang, Z. Gu,
"Anti-tumor drug delivery of pH-sensitive poly(ethylene
glycol)-poly(L-histidine-)-poly(L-lactide) nanoparticles," J. Control.
Release, vol. 152, pp. 49-56, 2011.
[4] D. W. Pack, D. Putnam, R. Langer, "Design of imidazole-containing
endosomolytic biopolymers for gene delivery," Biotechnol. Bioeng. vol.
67, pp. 217-223, 2000.
[5] D. Putnam, A.N. Zelikin, V.A. Izumrudov, R. Langer,
"Polyhistidine-PEG:DNA nanocomposites for gene delivery,"
Biomaterials. vol. 24, pp. 4425-4433, 2003.
[6] R.P. Johnson, Y.I. Jeong, E. Choi, C.W. Chung, D.H. Kang, S.O. Oh, H.
Suh, I. Kim, "Biocompatible Poly(2-hydroxyethyl
methacrylate)-b-poly(L-histidine) Hybrid Materials for pH-Sensitive
Intracellular Anticancer Drug Delivery," Adv. Funct. Mater. vol. 22, pp.
1058–1068, 2012.
[7] Y.I. Jeong, C.W. Chung, D.H. Kang, "Fabrication of pH-sensitive
nanoparticles using dextran/poly(L-histidine) graft copolymers,"
Carbohydr. Polym. Preparation for submission.
[8] R.P. Johnson, C.W. Chung, Y.I. Jeong, D.H. Kang, H. Suh, I. Kim,
"Poly(L-histidine)-tagged 5-aminolevulinic acid prodrugs: new
photosensitizing precursors of protoporphyrin IX for photodynamic colon
cancer therapy," Int. J. Nanomedicine. vol. 7, pp. 2497-2512, 2012.
[9] I.F. Tannock, D. Rotin, "Acid pH in tumors and its potential for
therapeutic exploitation," Cancer Res. vol. 49, pp. 4373-4384, 1989.
[10] Q. Liu, Q.Q. Jiang, W.J. Yi, J. Zhang, X.C. Zhang, M.B. Wu, Y.M.
Zhang, W. Zhu, X.Q. Yu, "Novel imidazole-functionalized cyclen
cationic lipids: synthesis and application as non-viral gene vectors,"
Bioorg. Med. Chem. vol. 21, no. 11, pp. 3105-3113, 2013.
[11] N. Toriyabe, Y. Hayashi, H. Harashima. "The transfection activity of
R8-modified nanoparticles and siRNA condensation using pH sensitive
stearylated-octahistidine," Biomaterials. vol. 34, no. 4, pp. 1337-1343,
2013.
[12] J.H. Hwang, C.W. Choi, H.W. Kim, D.H. Kim, T.W. Kwak, H.M. Lee,
C.H. Kim, C.W. Chung, Y.I. Jeong, D.H. Kang, "Nanoparticles of
dextran-b-poly(L-histidine) copolymer for pH-responsive drug delivery
to tumor cells," Int. J. Nanomedicine, Submitted for publication.
[13] R. Liu, B. He, D. Li, Y. Lai, J. Chang, J.Z. Tang, Z. Gu Z, "Effects of
pH-sensitive chain length on release of doxorubicin from
mPEG-b-PH-b-PLLA nanoparticles," Int. J. Nanomedicine, vol. 7, pp.
4433-4446, 2012.
[14] J.L. Wu, C.G. Liu, X.L. Wang, Z.H. Huang, "Preparation and
characterization of nanoparticles based on histidine-hyaluronic acid
conjugates as doxorubicin carriers," J. Mater. Sci. Mater. Med. vol. 23,
no. 8, pp. 1921-1929, 2012.
[15] B.S. Lee, K. Park, S. Park, G.C. Kim, H.J. Kim, S. Lee, H. Kil, S.J. Oh, D.
Chi, K. Kim, K. Choi, I.C. Kwon, S.Y. Kim, "Tumor targeting efficiency
of bare nanoparticles does not mean the efficacy of loaded anticancer
drugs: importance of radionuclide imaging for optimization of highly
selective tumor targeting polymeric nanoparticles with or without drug,"
J. Control. Release. vol. 147, pp. 253-260, 2010.</p>
@article{"International Journal of Medical, Medicine and Health Sciences:51844", author = "Dae Hwan Kang and Young-IL Jeong and Chung-Wook Chung", title = "Dextran/Poly(L-histidine) Graft Copolymer for pH-Responsive Drug Delivery", abstract = "pH-sensitive drug targeting using nanoparticles for
cancer chemotherapy have been spotlighted in recent decades. Graft
copolymer composed of poly (L-histidine) (PHS) and dextran
(DexPHS) was synthesized and pH-sensitive nanoparticles were
fabricated for pH-responsive drug delivery of doxorubicin (DOX).
Nanoparticles of DexPHS showed pH-sensitive changes in particle
sizes and drug release behavior, i.e. particle sizes and drug release rate
were increased at acidic pH, indicating that DexPHS nanoparticles
have pH-sensitive drug delivery potentials. Antitumor activity of
DOX-incorporated DexPHS nanoparticles were studied using CT26
colorectal carcinoma cells. Results indicated that fluorescence
intensity was higher at acidic pH than basic pH. These results
indicated that DexPHS nanoparticles have pH-responsive drug
targeting.
", keywords = "pH-sensitive polymer, nanoparticles, block
copolymer, poly (L-histidine).", volume = "7", number = "7", pages = "349-4", }
