Abstract: Yeast cells live in a constantly changing environment that requires the continuous adaptation of their genomic program in order to sustain their homeostasis, survive and proliferate. Due to the advancement of high throughput technologies, there is currently a large amount of data such as gene expression, gene deletion and protein-protein interactions for S. Cerevisiae under various environmental conditions. Mining these datasets requires efficient computational methods capable of integrating different types of data, identifying inter-relations between different components and inferring functional groups or 'modules' that shape intracellular processes. This study uses computational methods to delineate some of the mechanisms used by yeast cells to respond to environmental changes. The GRAM algorithm is first used to integrate gene expression data and ChIP-chip data in order to find modules of coexpressed and co-regulated genes as well as the transcription factors (TFs) that regulate these modules. Since transcription factors are themselves transcriptionally regulated, a three-layer regulatory cascade consisting of the TF-regulators, the TFs and the regulated modules is subsequently considered. This three-layer cascade is then modeled quantitatively using artificial neural networks (ANNs) where the input layer corresponds to the expression of the up-stream transcription factors (TF-regulators) and the output layer corresponds to the expression of genes within each module. This work shows that (a) the expression of at least 33 genes over time and for different stress conditions is well predicted by the expression of the top layer transcription factors, including cases in which the effect of up-stream regulators is shifted in time and (b) identifies at least 6 novel regulatory interactions that were not previously associated with stress-induced changes in gene expression. These findings suggest that the combination of gene expression and protein-DNA interaction data with artificial neural networks can successfully model biological pathways and capture quantitative dependencies between distant regulators and downstream genes.
Abstract: The aim of this study is to find out and analyze the
role of gender and age on the perceptions of students to the distant
online program offered by Vocational High School in Sakarya
University. The research is based on a questionnaire as a mean of
data collection method to find out the role of age and gender on the
student-s perceptions toward online education, and the study
progressed through finding relationships between the variables used
in the data collection instrument. The findings of the analysis
revealed that although the students registered to the online program
by will, they preferred the traditional face-to-face education due to
the difficulty of the nonverbal communication, their incompetence of
using the technology required, and their belief in traditional face-toface
learning more than online education.
Regarding gender, the results showed that the female students
have a better perception of the online education as opposed to the
male students. Regarding age, the results showed that the older the
students are the more is their preference towards attending face-toface
classes.
Abstract: A new OTA-based logarithmic-control variable gain
current amplifier (LCCA) is presented. It consists of two Operational
Transconductance Amplifier (OTA) and two PMOS transistors
biased in weak inversion region. The circuit operates from 0.6V DC
power supply and consumes 0.6 μW. The linear-dB controllable
output range is 43 dB with maximum error less than 0.5dB. The
functionality of the proposed design was confirmed using HSPICE in
0.35μm CMOS process technology.
Abstract: In blended learning environments, the Internet can be combined with other technologies. The aim of this research was to design, introduce and validate a model to support synchronous and asynchronous activities by managing content domains in an Adaptive Hypermedia System (AHS). The application is based on information recovery techniques, clustering algorithms and adaptation rules to adjust the user's model to contents and objects of study. This system was applied to blended learning in higher education. The research strategy used was the case study method. Empirical studies were carried out on courses at two universities to validate the model. The results of this research show that the model had a positive effect on the learning process. The students indicated that the synchronous and asynchronous scenario is a good option, as it involves a combination of work with the lecturer and the AHS. In addition, they gave positive ratings to the system and stated that the contents were adapted to each user profile.
Abstract: In the present work, study of the vibration of thin cylindrical shells made of a functionally gradient material (FGM) composed of stainless steel and nickel is presented. Material properties are graded in the thickness direction of the shell according to volume fraction power law distribution. The objective is to study the natural frequencies, the influence of constituent volume fractions and the effects of boundary conditions on the natural frequencies of the FG cylindrical shell. The study is carried out using third order shear deformation shell theory. The analysis is carried out using Hamilton's principle. The governing equations of motion of FG cylindrical shells are derived based on shear deformation theory. Results are presented on the frequency characteristics, influence of constituent volume fractions and the effects of clamped-free boundary conditions
Abstract: Many natural language expressions are ambiguous, and
need to draw on other sources of information to be interpreted.
Interpretation of the e word تعاون to be considered as a noun or a verb
depends on the presence of contextual cues. To interpret words we
need to be able to discriminate between different usages. This paper
proposes a hybrid of based- rules and a machine learning method for
tagging Arabic words. The particularity of Arabic word that may be
composed of stem, plus affixes and clitics, a small number of rules
dominate the performance (affixes include inflexional markers for
tense, gender and number/ clitics include some prepositions,
conjunctions and others). Tagging is closely related to the notion of
word class used in syntax. This method is based firstly on rules (that
considered the post-position, ending of a word, and patterns), and
then the anomaly are corrected by adopting a memory-based learning
method (MBL). The memory_based learning is an efficient method to
integrate various sources of information, and handling exceptional
data in natural language processing tasks. Secondly checking the
exceptional cases of rules and more information is made available to
the learner for treating those exceptional cases. To evaluate the
proposed method a number of experiments has been run, and in
order, to improve the importance of the various information in
learning.
Abstract: Expression data analysis is based mostly on the
statistical approaches that are indispensable for the study of
biological systems. Large amounts of multidimensional data resulting
from the high-throughput technologies are not completely served by
biostatistical techniques and are usually complemented with visual,
knowledge discovery and other computational tools. In many cases,
in biological systems we only speculate on the processes that are
causing the changes, and it is the visual explorative analysis of data
during which a hypothesis is formed. We would like to show the
usability of multidimensional visualization tools and promote their
use in life sciences. We survey and show some of the
multidimensional visualization tools in the process of data
exploration, such as parallel coordinates and radviz and we extend
them by combining them with the self-organizing map algorithm. We
use a time course data set of transitional cell carcinoma of the bladder
in our examples. Analysis of data with these tools has the potential to
uncover additional relationships and non-trivial structures.
Abstract: In mechanical and environmental engineering, mixed
convection is a frequently encountered thermal fluid phenomenon
which exists in atmospheric environment, urban canopy flows, ocean
currents, gas turbines, heat exchangers, and computer chip cooling
systems etc... . This paper deals with a numerical investigation of
mixed convection in a vertical heated channel. This flow results from
the mixing of the up-going fluid along walls of the channel with the
one issued from a flat nozzle located in its entry section. The fluiddynamic
and heat-transfer characteristics of vented vertical channels
are investigated for constant heat-flux boundary conditions, a
Rayleigh number equal to 2.57 1010, for two jet Reynolds number
Re=3 103 and 2104 and the aspect ratio in the 8-20 range. The system
of governing equations is solved with a finite volumes method and an
implicit scheme. The obtained results show that the turbulence and
the jet-wall interaction activate the heat transfer, as does the drive of
ambient air by the jet. For low Reynolds number Re=3 103, the
increase of the aspect Ratio enhances the heat transfer of about 3%,
however; for Re=2 104, the heat transfer enhancement is of about
12%. The numerical velocity, pressure and temperature fields are
post-processed to compute the quantities of engineering interest such
as the induced mass flow rate, and average Nusselt number, in terms
of Rayleigh, Reynolds numbers and dimensionless geometric
parameters are presented.
Abstract: There are many sources trough which the soil get
enriched and contaminated with REEs. The determination of REEs in
environmental samples has been limited because of the lack of
sensitive analytical techniques. Soil samples were collected from
four sites including open cast coal mine, natural coal burning, coal
washery and control in the coal field located in Dhanbad, India.
Total concentrations of rare earth elements (REEs) were determined
using the inductively coupled plasma atomic absorption spectrometry
in order to assess enrichment status in the coal field. Results showed
that the mean concentrations of La, Pr, Eu, Tb, Ho, and Tm in open
cast mine and natural coal burning sites were elevated compared to
the reference concentrations, while Ce, Nd, Sm, and Gd were
elevated in coal washery site. When compared to reference soil,
heavy REEs (HREEs) were enriched in open cast mines and natural
coal burning affected soils, however, the HREEs were depleted in the
coal washery sites. But, the Chondrite-normalization diagram showed
significant enrichment for light REEs (LREEs) in all the soils. High
concentration of Pr, Eu, Tb, Ho, Tm, and Lu in coal mining and coal
burning sites may pose human health risks. Factor analysis showed
that distribution and relative abundance of REEs of the coal washery
site is comparable with the control. Eventually washing or cleaning
of coal could significantly decrease the emission of REEs from coal
into the environment.
Abstract: A camera in the building site is exposed to different
weather conditions. Differences between images of the same scene
captured with the same camera arise also due to temperature variations.
The influence of temperature changes on camera parameters
were modelled and integrated into existing analytical camera model.
Modified camera model enables quantitatively assessing the influence
of temperature variations.
Abstract: The ability of information systems to operate in conjunction with each other encompassing communication protocols, hardware, software, application, and data compatibility layers. There has been considerable work in industry on the development of component interoperability models, such as CORBA, (D)COM and JavaBeans. These models are intended to reduce the complexity of software development and to facilitate reuse of off-the-shelf components. The focus of these models is syntactic interface specification, component packaging, inter-component communications, and bindings to a runtime environment. What these models lack is a consideration of architectural concerns – specifying systems of communicating components, explicitly representing loci of component interaction, and exploiting architectural styles that provide well-understood global design solutions. The development of complex business applications is now focused on an assembly of components available on a local area network or on the net. These components must be localized and identified in terms of available services and communication protocol before any request. The first part of the article introduces the base concepts of components and middleware while the following sections describe the different up-todate models of communication and interaction and the last section shows how different models can communicate among themselves.
Abstract: The purpose of this study is to investigate the effects
of modality principles in instructional software among first grade
pupils- achievements in the learning of Arabic Language. Two modes
of instructional software were systematically designed and
developed, audio with images (AI), and text with images (TI). The
quasi-experimental design was used in the study. The sample
consisted of 123 male and female pupils from IRBED Education
Directorate, Jordan. The pupils were randomly assigned to any one of
the two modes. The independent variable comprised the two modes
of the instructional software, the students- achievement levels in the
Arabic Language class and gender. The dependent variable was the
achievements of the pupils in the Arabic Language test. The
theoretical framework of this study was based on Mayer-s Cognitive
Theory of Multimedia Learning. Four hypotheses were postulated
and tested. Analyses of Variance (ANOVA) showed that pupils using
the (AI) mode performed significantly better than those using (TI)
mode. This study concluded that the audio with images mode was an
important aid to learning as compared to text with images mode.
Abstract: This article considers the positional buckling of
composite thick plates under thermal loading . For this purpose , the
complex finite strip method is used . In analysis of complex finite
strip, harmonic complex function in longitudinal direction , cubic
functions in transversal direction and parabola distribution of
transverse shear strain in thickness of thick plate based on higherorder
shear deformation theory are used . In given examples , the
effect of angles of stratification , number of layers , dimensions ratio
and length – to – thick ratio across critical temperature are
considered.
Abstract: In this experimental investigation shake table tests
were conducted on two reduced models that represent normal single
room building constructed by Compressed Stabilized Earth Block
(CSEB) from locally available soil. One model was constructed with
earthquake resisting features (EQRF) having sill band, lintel band and
vertical bands to control the building vibration and another one was
without Earthquake Resisting Features. To examine the seismic
capacity of the models particularly when it is subjected to long-period
ground motion by large amplitude by many cycles of repeated
loading, the test specimen was shaken repeatedly until the failure.
The test results from Hi-end Data Acquisition system show that
model with EQRF behave better than without EQRF. This modified
masonry model with new material combined with new bands is used
to improve the behavior of masonry building.
Abstract: Calibration estimation is a method of adjusting the
original design weights to improve the survey estimates by using
auxiliary information such as the known population total (or mean)
of the auxiliary variables. A calibration estimator uses calibrated
weights that are determined to minimize a given distance measure to
the original design weights while satisfying a set of constraints
related to the auxiliary information. In this paper, we propose a new
multivariate calibration estimator for the population mean in the
stratified sampling design, which incorporates information available
for more than one auxiliary variable. The problem of determining the
optimum calibrated weights is formulated as a Mathematical
Programming Problem (MPP) that is solved using the Lagrange
multiplier technique.
Abstract: In this paper, we present the information life cycle, and analyze the importance of managing the corporate application portfolio across this life cycle. The approach presented here does not correspond just to the extension of the traditional information system development life cycle. This approach is based in the generic life cycle employed in other contexts like manufacturing or marketing. In this paper it is proposed a model of an information system life cycle, supported in the assumption that a system has a limited life. But, this limited life may be extended. This model is also applied in several cases; being reported here two examples of the framework application in a construction enterprise, and in a manufacturing enterprise.
Abstract: The purpose of present paper was to investigate
perceptions of Korean secondary school students about social issues
related to biological sciences. Twenty issues were selected based on
topics of articles in the newspaper from 2005 to 2010. The issues were
categorized into biotechnology, health-disease and environment
domains. Subjects were 541 high school students (male 253 and
female 288). On the survey, students were asked to answer on 5-point
Lickert scales how they thought of the effect of biological phenomena
or events related to biological issues on the individual life and the
society. They perceived that the biological issues would be more
effectible on the society than on the individual life. Female students
had a little more perceptions than males.
Abstract: In recent years image watermarking has become an
important research area in data security, confidentiality and image
integrity. Many watermarking techniques were proposed for medical
images. However, medical images, unlike most of images, require
extreme care when embedding additional data within them because
the additional information must not affect the image quality and
readability. Also the medical records, electronic or not, are linked to
the medical secrecy, for that reason, the records must be confidential.
To fulfill those requirements, this paper presents a lossless
watermarking scheme for DICOM images. The proposed a fragile
scheme combines two reversible techniques based on difference
expansion for patient's data hiding and protecting the region of
interest (ROI) with tamper detection and recovery capability.
Patient's data are embedded into ROI, while recovery data are
embedded into region of non-interest (RONI). The experimental
results show that the original image can be exactly extracted from the
watermarked one in case of no tampering. In case of tampered ROI,
tampered area can be localized and recovered with a high quality
version of the original area.
Abstract: This paper gives an overview of the mapping
mechanism of SEAM-a methodology for the automatic generation of
knowledge models and its mapping onto Java codes. It discusses the
rules that will be used to map the different components in the
knowledge model automatically onto Java classes, properties and
methods. The aim of developing this mechanism is to help in the
creation of a prototype which will be used to validate the knowledge
model which has been generated automatically. It will also help to
link the modeling phase with the implementation phase as existing
knowledge engineering methodologies do not provide for proper
guidelines for the transition from the knowledge modeling phase to
development phase. This will decrease the development overheads
associated to the development of Knowledge Based Systems.
Abstract: Bioleaching of spent catalyst using moderate thermophilic chemolithotrophic acidophiles in growth medium without Fe source was investigated with two different pulp densities and three different size fractions. All the experiments were conducted on shake flasks at a temperature of 65 °C. The leaching yield of Ni and Al was found to be promising with very high leaching yield of 92-96% followed by Al as 41-76%, which means both Ni and Al leaching were favored by the moderate thermophilic bioleaching compared to the mesophilic bioleaching. The acid consumption was comparatively higher for the 10% pulp density experiments. Comparatively minimal difference in the leaching yield with different size fractions and different pulp densities show no requirement of grinding and using low pulp density less than 10%. This process would rather be economical as well as eco-friendly process for future optimization of the recovery of metal values from spent catalyst.