Abstract: Persea declinata (Bl.) Kosterm is a member of the
Lauraceae family, widely distributed in Southeast Asia. It is from the
same genus with avocado (Persea americana Mill), which is widely
consumed as food and for medicinal purposes. In the present study,
we examined the anticancer properties of Persea declinata (Bl.)
Kosterm bark methanolic crude extract (PDM). PDM exhibited a
potent antiproliferative effect in MCF-7 human breast cancer cells,
with an IC50 value of 16.68 .g/mL after 48h of treatment. We
observed that PDM caused cell cycle arrest and subsequent apoptosis
in MCF-7 cells, as exhibited by increased population at G0/G1 phase,
higher lactate dehydrogenase (LDH) release, and DNA
fragmentation. Mechanistic studies showed that PDM caused
significant elevation in ROS production, leading to perturbation of
mitochondrial membrane potential, cell permeability, and activation
of caspases-3/7. On the other hand, real-time PCR and Western blot
analysis showed that PDM treatment increased the expression of the
proapoptotic molecule, Bax, but decreased the expression of
prosurvival proteins, Bcl-2 and Bcl-xL, in a dose-dependent manner.
These findings imply that PDM could inhibit proliferation in MCF-7
cells via cell cycle arrest and apoptosis induction, indicating its
potential as a therapeutic agent worthy of further development.
Abstract: The organizations of European and Czech critical
infrastructure have specific position, mission, characteristics and
behaviour in European Union and Czech state/business environments,
regarding specific requirements for regional and global security
environments. They must respect policy of national security and
global rules, requirements and standards in all their inherent and
outer processes of supply - customer chains and networks. A
controlling is generalized capability to have control over situational
policy. This paper aims and purposes are to introduce the controlling
as quite new necessary process attribute providing for critical
infrastructure is environment the capability and profit to achieve its
commitment regarding to the effectiveness of the quality
management system in meeting customer/ user requirements and also
the continual improvement of critical infrastructure organization’s
processes overall performance and efficiency, as well as its societal
security via continual planning improvement via DYVELOP
modelling.
Abstract: Well-designed composite steel and concrete structures
highlight the good material properties and lower the deficiencies of
steel and concrete, in particular they make use of high tensile strength
of steel and high stiffness of concrete. The most common composite
steel and concrete structure is a simply supported beam, which
concrete slab transferring the slab load to a beam is connected to the
steel cross-section. The aim of this paper is to find the most adequate
numerical model of a simply supported composite beam with the
cross-sectional and material parameters based on the results of a
processed parametric study and numerical analysis. The paper also
evaluates the suitability of using compact concrete with the
lightweight aggregates for composite steel and concrete beams. The
most adequate numerical model will be used in the resent future to
compare the results of laboratory tests.
Abstract: The fundamental issues in ICT Governance (ICTG)
implementation for Malaysian Public Sector (MPS) is how ICT be
applied to support improvements in productivity, management
effectiveness and the quality of services offered to its citizens. Our
main concern is to develop and adopt a common definition and
framework to illustrate how ICTG can be used to better align ICT
with government’s operations and strategic focus. In particular, we
want to identify and categorize factors that drive a successful ICTG
process. This paper presents the results of an exploratory study to
identify, validate and refine such Critical Success Factors (CSFs) and
confirmed seven CSFs and nineteen sub-factors as influential factors
that fit MPS after further validated and refined. The Delphi method
applied in validation and refining process before being endorsed as
appropriate for MPS. The identified CSFs reflect the focus areas that
need to be considered strategically to strengthen ICT Governance
implementation and ensure business success.
Abstract: Load Forecasting plays a key role in making today's
and future's Smart Energy Grids sustainable and reliable. Accurate
power consumption prediction allows utilities to organize in advance
their resources or to execute Demand Response strategies more
effectively, which enables several features such as higher
sustainability, better quality of service, and affordable electricity
tariffs. It is easy yet effective to apply Load Forecasting at larger
geographic scale, i.e. Smart Micro Grids, wherein the lower available
grid flexibility makes accurate prediction more critical in Demand
Response applications. This paper analyses the application of
short-term load forecasting in a concrete scenario, proposed within the
EU-funded GreenCom project, which collect load data from single
loads and households belonging to a Smart Micro Grid. Three
short-term load forecasting techniques, i.e. linear regression, artificial
neural networks, and radial basis function network, are considered,
compared, and evaluated through absolute forecast errors and training
time. The influence of weather conditions in Load Forecasting is also
evaluated. A new definition of Gain is introduced in this paper, which
innovatively serves as an indicator of short-term prediction
capabilities of time spam consistency. Two models, 24- and
1-hour-ahead forecasting, are built to comprehensively compare these
three techniques.
Abstract: Artemisia species, which are medically beneficial, are
widespread in temperate regions of both Northern and Southern
hemispheres among which Iran is located. About 35 species of
Artemisia are indigenous in Iran among them some are widespread in
all or most provinces, yet some are restricted to some specific
regions. In this review paper, initially, GC-Mass results of some
experiments done in different provinces of Iran are mentioned among
them some compounds are common among species, some others are
mostly restricted to other species; after that, medical advantages
based on some researches on species of this genus are reviewed;
different qualities such as anti-leishmania, anti-bacteria, antiviral as
well as anti-proliferative could be mentioned.
Abstract: Nonalcoholic fatty liver disease (NAFLD) has
increased in conjunction with obesity. The accuracy of risk factors
for detecting NAFLD in obese adolescents has not undergone a
formal evaluation. The aim of this study was to evaluate predictors of
NAFLD among Egyptian female obese adolescents. The study
included 162 obese female adolescents. All were subjected to
anthropometry, biochemical analysis and abdominal ultrasongraphic
assessment. Metabolic syndrome (MS) was diagnosed according to
the IDF criteria. Significant association between presence of MS and
NAFLD was observed. Obese adolescents with NAFLD had
significantly higher levels of ALT, triglycerides, fasting glucose,
insulin, blood pressure and HOMA-IR, whereas decreased HDL-C
levels as compared with obese cases without NAFLD. Receiver–
operating characteristic (ROC) curve analysis shows that ALT is a
sensitive predictor for NAFLD, confirming that ALT can be used as a
marker of NAFLD.
Abstract: Due to reduced stiffness, research on second
generation titanium alloys for implant applications, like the
metastable β-titanium alloy Ti-15Mo, become more and more
important in the recent years. The machinability of these alloys is
generally poor leading to problems during implant production and
comparably large production costs. Therefore, in the present study,
Ti-15Mo was alloyed with 0.8 wt.-% of the rare earth metals
lanthanum (Ti-15Mo+0.8La) and neodymium (Ti-15Mo+0.8Nd) to
improve its machinability. Their microstructure consisted of a
titanium matrix and micrometer-size particles of the rare earth metals
and two of their oxides. The particles stabilized the microstructure as
grain growth was minimized. As especially the ductility might be
affected by the precipitates, the behavior of Ti-15Mo+0.8La and Ti-
15Mo+0.8Nd was investigated during static and dynamic
deformation at elevated temperature to develop a processing route.
The resulting mechanical properties (static strength and ductility)
were similar in all investigated alloys.
Abstract: The aim of the paper was to elaborate a novel calculator BasWilCalc, that allows to estimate the actual amount of biomass on the basket willow plantations. The proposed method is based on the results of field experiment conducted during years 2011-2013 on basket willow plantation in the south-western part of Poland. As input data the results of destructive measurements of the diameter, length and weight of willow stems and non-destructive biometric measurements of diameter in the middle of stems and their length during the growing season performed at weekly intervals were used. Performed analysis enabled to develop the algorithm which, due to the fact that energy plantations are of known and constant planting structure, allows to estimate the actual amount of willow basket biomass on the plantation with a given probability and accuracy specified by the model, based on the number of stems measured and the age of the plantation.
Abstract: This paper is about method to produce a stable and
accurate constant output pulse width regardless of the amplitude,
period and pulse width variation of the input signal source. The pulse
generated is usually being used in numerous applications as the
reference input source to other circuits in the system. Therefore, it is
crucial to produce a clean and constant pulse width to make sure the
system is working accurately as expected.
Abstract: Calcium phosphate coating (CaP) has been employed
for protein delivery, but the typical direct protein adsorption on the
coating led to low incorporation content and fast release of the
protein from the coating. By using bovine serum albumin (BSA) as a
model protein, rapid biomimetic co-precipitation between calcium
phosphate and BSA was employed to control the distribution of BSA
within calcium phosphate coating during biomimetic formation on
titanium surface for only 6 h at 50oC in an accelerated calcium
phosphate solution. As a result, the amount of BSA incorporation and
release duration could be increased by using a rapid biomimetic coprecipitation
technique. Up to 43 fold increases in the BSA
incorporation content and the increase from 6 h to more than 360 h in
release duration compared to typical direct adsorption technique were
observed depending on the initial BSA concentration used during coprecipitation
(1, 10 and 100 μg.ml-1). From x-ray diffraction and
Fourier transform infrared spectroscopy studies, the coating
composition was not altered with the incorporation of BSA by this
rapid biomimetic co-precipitation and mainly comprised octacalcium
phosphate and hydroxyapatite. However, the microstructure of
calcium phosphate crystals changed from straight, plate-like units to
curved, plate-like units with increasing BSA content.
Abstract: To mimic the natural circumstances of cell growth in an organism, we present three-dimensional (3D) scaffolds fabricated by microfluidics for cultivation. This work investigates the cellular behaviors of rat cardiomyocytes in gelatin 3D scaffolds compared to those on 2D control, such as proliferation, viability and morphology. We found that the scaffolds may induce skeletal differentiation of H9c2 cells.
Abstract: In Capitalism all economic activity rests upon a set of
core institutional foundations, main from which are privately owned
capital assets and profit. How these core institutional foundations are
working in former soviet countries, in particular in Travel and
Tourism Industry of Georgia?
The role of Travel and Tourism as a key pillar of economic growth
is being increasingly recognized by governments in all regions of the
world. For the last few years Georgia succeeded in the World Bank
and IFC “Doing Business” rankings. Despite of that, during decades
totally different statistical data of the tourism sector were provided by
the different State bodies; economic parameters were published few,
or not published at all.
The frequency and extent of property rights violation in Georgia
has repeatedly been the subject of concern for the last decade. Total
value of abrogated by the former Georgian Government private
property is estimated approximately in US$4-5 billion.
Thus, if economic profitability is unknown and property rights are
not protected – that means that the main institutional foundations of
capitalism in Georgia, are not working properly yet, that cause
management problems at all levels of the national Travel and
Tourism industry of Georgia.
Abstract: Copper being one of the major intrinsic residual
impurities in steel possesses the tendency to induce severe
microstructural distortions if not controlled within certain limits.
Hence, this paper investigates the effect of this element on the
mechanical properties of construction steel with a view to ascertain
its safe limits for effective control. The experiment entails collection
of statistically scheduled samples of hot rolled profiles with varied
copper concentrations in the range of 0.12-0.39 wt. %. From these
samples were prepared standard test specimens subjected to tensile,
impact, hardness and microstructural analyses. Results show a rather
huge compromise in mechanical properties as the specimens
demonstrated 54.3%, 74.2% and 64.9% reduction in tensile strength,
impact energy and hardness respectively as copper content increases
from 0.12 wt. % to 0.39 wt. %. The steel’s abysmal performance is
due to the severe distortion of the microstructure occasioned by the
development of incoherent complex compounds which weaken the
pearlite reinforcing phase. It is concluded that the presence of copper
above 0.22 wt. % is deleterious to construction steel performance.
Abstract: The aim of this paper is to introduce the notions of
intuitionistic T-S fuzzy subalgebras and intuitionistic T-S fuzzy ideals
in BCI-algebras, and then to investigate their basic properties.
Abstract: Mass flow measurement is the basis of most technoeconomic
formulations in the chemical industry. This calls for
reliable and accurate detection of mass flow. Flow measurement
laboratory experiments were conducted using various instruments.
These consisted of orifice plates, various sized rotameters, wet gas
meter and soap bubble meter. This work was aimed at evaluating
appropriate operating conditions and accuracy of the aforementioned
devices. The experimental data collected were compared to
theoretical predictions from Bernoulli’s equation and calibration
curves supplied by the instrument’s manufacturers. The results
obtained showed that rotameters were more reliable for measuring
high and low flow rates; while soap-bubble meters and wet-gas
meters were found to be suitable for measuring low flow rates. The
laboratory procedures and findings of the actual work can assist
engineering students and professionals in conducting their flow
measurement laboratory test work.
Abstract: For a given a simple connected graph, we present
some new bounds via a new approach for a special topological index
given by the sum of the real number power of the non-zero
normalized Laplacian eigenvalues. To use this approach presents an
advantage not only to derive old and new bounds on this topic but
also gives an idea how some previous results in similar area can be
developed.
Abstract: An anthropometric study applied to 1,115 students of
the Faculty of Chemical Sciences and Engineering of the
Autonomous University of California. Thirteen individual
measurements were taken in a sitting position. The results obtained
allow forming a reliable anthropometric database for statistical
studies and analysis and inferences of specific distributions, so the
opinion of experts in occupational medicine recommendations may
emit to reduce risks resulting in an alteration of the vital signs during
the execution of their school activities. Another use of these analyses
is to use them as a reliable reference for future deeper research, to the
design of spaces, tools, utensils, workstations, with anthropometric
dimensions and ergonomic characteristics suitable to use.
Abstract: This paper presents an anthropometric study
conducted to 300 employees in a maquiladora industry that belongs
to the cluster of medical products as part of a research project to
pretend simulate workplace conditions under which operators
conduct their activities. This project is relevant because traditionally
performed a study to design ergonomic workspaces according to
anthropometric profile of users, however, this paper demonstrates the
importance of making decisions when the infrastructure cannot be
adapted for economic whichever put emphasis on user activity.
Abstract: Economic Dispatch (ED) is one of the most
challenging problems of power system since it is difficult to determine
the optimum generation scheduling to meet the particular load demand
with the minimum fuel costs while all constraints are satisfied. The
objective of the Economic Dispatch Problems (EDPs) of electric
power generation is to schedule the committed generating units
outputs so as to meet the required load demand at minimum operating
cost while satisfying all units and system equality and inequality
constraints. In this paper, an efficient and practical steady-state genetic
algorithm (SSGAs) has been proposed for solving the economic
dispatch problem. The objective is to minimize the total generation
fuel cost and keep the power flows within the security limits. To
achieve that, the present work is developed to determine the optimal
location and size of capacitors in transmission power system where,
the Participation Factor Algorithm and the Steady State Genetic
Algorithm are proposed to select the best locations for the capacitors
and determine the optimal size for them.