Abstract: Mendelian Disease Genes represent a collection of single points of failure for the various systems they constitute. Such genes have been shown, on average, to encode longer proteins than 'non-disease' proteins. Existing models suggest that this results from the increased likeli-hood of longer genes undergoing mutations. Here, we show that in saturated mutagenesis experiments performed on model organisms, where the likelihood of each gene mutating is one, a similar relationship between length and the probability of a gene being lethal was observed. We thus suggest an extended model demonstrating that the likelihood of a mutated gene to produce a severe phenotype is length-dependent. Using the occurrence of conserved domains, we bring evidence that this dependency results from a correlation between protein length and the number of functions it performs. We propose that protein length thus serves as a proxy for protein cardinality in different networks required for the organism's survival and well-being. We use this example to argue that the collection of Mendelian Disease Genes can, and should, be used to study the rules governing systems vulnerability in living organisms.
Abstract: Geopolymer cement was evaluated as wellbore sealing material for carbon dioxide geosequestration application. Curing of cement system in saline water and strength testing in triaxial stress state condition under lateral confinement is relevant to primary cementing in CO2 geosequestration wellbore in saline aquifer. Geopolymer cement was cured in saline water (both at ambient conditions for 28 days and heated (60°C) conditions for 12 hours) and tested for triaxial strength at different levels of lateral confinement. Normal water and few other curing techniques were also studied both for geopolymer and API ‘G’ cement. Results reported were compared to evaluate the suitability of saline water for curing of geopolymer cement. Unconfined compression test results showed higher strength for curing in saline water than normal water. Besides, testing strength under lateral confinement demonstrated the material failure behavior from brittle to plastic.
Abstract: Limited infrastructure development on peats and
organic soils is a serious geotechnical issues common to many
countries of the world especially Malaysia which distributed 1.5 mill
ha of those problematic soil. These soils have high water content and
organic content which exhibit different mechanical properties and
may also change chemically and biologically with time. Constructing
structures on peaty ground involves the risk of ground failure and
extreme settlement. Nowdays, much efforts need to be done in
making peatlands usable for construction due to increased landuse.
Deep mixing method employing cement as binders, is generally used
as measure again peaty/ organic ground failure problem. Where the
technique is widely adopted because it can improved ground
considerably in a short period of time. An understanding of
geotechnical properties as shear strength, stiffness and compressibility
behavior of these soils was requires before continues construction on
it. Therefore, 1- 1.5 meter peat soil sample from states of Johor and
an organic soil from Melaka, Malaysia were investigated. Cement
were added to the soil in the pre-mixing stage with water cement ratio
at range 3.5,7,14,140 for peats and 5,10,30 for organic soils,
essentially to modify the original soil textures and properties. The
mixtures which in slurry form will pour to polyvinyl chloride (pvc)
tube and cured at room temperature 250C for 7,14 and 28 days.
Laboratory experiments were conducted including unconfined
compressive strength and bender element , to monitor the improved
strength and stiffness of the 'stabilised mixed soils'. In between,
scanning electron miscroscopic (SEM) were observations to
investigate changes in microstructures of stabilised soils and to
evaluated hardening effect of a peat and organic soils stabilised
cement. This preliminary effort indicated that pre-mixing peat and
organic soils contributes in gaining soil strength while help the
engineers to establish a new method for those problematic ground
improvement in further practical and long term applications.
Abstract: Conventional approaches in the implementation of logic programming applications on embedded systems are solely of software nature. As a consequence, a compiler is needed that transforms the initial declarative logic program to its equivalent procedural one, to be programmed to the microprocessor. This approach increases the complexity of the final implementation and reduces the overall system's performance. On the contrary, presenting hardware implementations which are only capable of supporting logic programs prevents their use in applications where logic programs need to be intertwined with traditional procedural ones, for a specific application. We exploit HW/SW codesign methods to present a microprocessor, capable of supporting hybrid applications using both programming approaches. We take advantage of the close relationship between attribute grammar (AG) evaluation and knowledge engineering methods to present a programmable hardware parser that performs logic derivations and combine it with an extension of a conventional RISC microprocessor that performs the unification process to report the success or failure of those derivations. The extended RISC microprocessor is still capable of executing conventional procedural programs, thus hybrid applications can be implemented. The presented implementation is programmable, supports the execution of hybrid applications, increases the performance of logic derivations (experimental analysis yields an approximate 1000% increase in performance) and reduces the complexity of the final implemented code. The proposed hardware design is supported by a proposed extended C-language called C-AG.
Abstract: In this study acoustic emission (AE) signals obtained during deformation and fracture of two types of ferrite-martensite dual phase steels (DPS) specimens have been analyzed in frequency domain. For this reason two low carbon steels with various amounts of carbon were chosen, and intercritically heat treated. In the introduced method, identifying the mechanisms of failure in the various phases of DPS is done. For this aim, AE monitoring has been used during tensile test of several DPS with various volume fraction of the martensite (VM) and attempted to relate the AE signals and failure mechanisms in these steels. Different signals, which referred to 2-3 micro-mechanisms of failure due to amount of carbon and also VM have been seen. By Fast Fourier Transformation (FFT) of signals in distinct locations, an excellent relationship between peak frequencies in these areas and micro-mechanisms of failure were seen. The results were verified by microscopic observations (SEM).
Abstract: Cities denote instantaneously a challenge and an
opportunity for climate change policy. Cities are the place where
most energy services are needed because urbanization is closely
linked to high population densities and concentration of economic
activities and production (Urban energy demand). Consequently, it is
critical to explain about the role of cities within the world-s energy
systems and its correlation with the climate change issue. With more
than half of the world-s population already living in urban areas, and
that percentage expected to rise to 75 per cent by 2050, it is clear that
the path to sustainable development must pass through cities. Cities
expanding in size and population pose increased challenges to the
environment, of which energy is part as a natural resource, and to the
quality of life. Nowadays, most cities have already understood the
importance of sustainability, both at their local scale as in terms of
their contribution to sustainability at higher geographical scales. It
requires the perception of a city as a complex and dynamic
ecosystem, an open system, or cluster of systems, where the energy
as well as the other natural resources is transformed to satisfy the
needs of the different urban activities. In fact, buildings and
transportation generally represent most of cities direct energy
demand, i.e., between 60 per cent and 80 per cent of the overall
consumption. Buildings, both residential and services are usually
influenced by the local physical and social conditions. In terms of
transport, the energy demand is also strongly linked with the specific
characteristics of a city (urban mobility).The concept of a “smart
city" builds on statistics as seven key axes of a city-s success in
moving towards common platform (brain nerve)of sustainable urban
energy systems.
With the aforesaid knowledge, the authors have suggested a frame
work to role of cities, as energy actors for smart city management.
The authors have discusses the potential elements needed for energy
in smart cities and also identified potential energy actions and
relevant barriers. Furthermore, three levels of city smartness in cities
actions to overcome market /institutional failures with a local
approach are distinguished. The authors have made an attempt to
conceive and implement concepts of city smartness by adopting the
city or local government as nerve center through an integrated
planning approach. Finally, concluding with recommendations for
the organization of the Smart Sustainable Cities for positive changes
of urban India.
Abstract: In the present research, two nutraceuticals made from
red grape and walnut that showed previously to improve kidney
dysfunction were incorporated separately into functional foods' bread
made from barley and rice bran. The functional foods were evaluated
in rats in which chronic renal failure was induced through feeding
diet rich in adenine and phosphate (APD). The evaluation based on
assessing kidney function, oxidative stress, inflammatory biomarkers
and body weight gain. Results showed induction of chronic kidney
failure reflected in significant increase in plasma urea, creatinine,
malondialdehyde, tumor necrosis factor- α and low density
lipoprotein cholesterol along with significant reduction of plasma
albumin, and total antioxidant and creatinine clearance and body
weight gain on feeding APD compared to control healthy group.
Feeding the functional foods produced amelioration in the different
biochemical parameters and body weight gain indicating
improvement in kidney function.
Abstract: The first and basic cause of the failure of concrete is repeated freezing (thawing) of moisture contained in the pores, microcracks, and cavities of the concrete. On transition to ice, water existing in the free state in cracks increases in volume, expanding the recess in which freezing occurs. A reduction in strength below the initial value is to be expected and further cycle of freezing and thawing have a further marked effect. By using some experimental parameters like nuclear magnetic resonance variation (NMR), enthalpy-temperature (or heat capacity) variation, we can resolve between the various water states and their effect on concrete properties during cooling through the freezing transition temperature range. The main objective of this paper is to describe the principal type of water responsible for the reduction in strength and structural damage (frost damage) of concrete following repeated freeze –thaw cycles. Some experimental work was carried out at the institute of cryogenics to determine what happens to water in concrete during the freezing transition.
Abstract: The clinical usefulness of heart rate variability is
limited to the range of Holter monitoring software available. These
software algorithms require a normal sinus rhythm to accurately
acquire heart rate variability (HRV) measures in the frequency
domain. Premature ventricular contractions (PVC) or more
commonly referred to as ectopic beats, frequent in heart failure,
hinder this analysis and introduce ambiguity. This investigation
demonstrates an algorithm to automatically detect ectopic beats by
analyzing discrete wavelet transform coefficients. Two techniques
for filtering and replacing the ectopic beats from the RR signal are
compared. One technique applies wavelet hard thresholding
techniques and another applies linear interpolation to replace ectopic
cycles. The results demonstrate through simulation, and signals
acquired from a 24hr ambulatory recorder, that these techniques can
accurately detect PVC-s and remove the noise and leakage effects
produced by ectopic cycles retaining smooth spectra with the
minimum of error.
Abstract: In this experimental investigation shake table tests
were conducted on two reduced models that represent normal single
room building constructed by Compressed Stabilized Earth Block
(CSEB) from locally available soil. One model was constructed with
earthquake resisting features (EQRF) having sill band, lintel band and
vertical bands to control the building vibration and another one was
without Earthquake Resisting Features. To examine the seismic
capacity of the models particularly when it is subjected to long-period
ground motion by large amplitude by many cycles of repeated
loading, the test specimen was shaken repeatedly until the failure.
The test results from Hi-end Data Acquisition system show that
model with EQRF behave better than without EQRF. This modified
masonry model with new material combined with new bands is used
to improve the behavior of masonry building.
Abstract: In the present article, a new method has been developed to enhance the application of equipment monitoring, which in turn results in improving condition-based maintenance economic impact in an automobile parts manufacturing factory. This study also describes how an effective software with a simple database can be utilized to achieve cost-effective improvements in maintenance performance. The most important results of this project are indicated here: 1. 63% reduction in direct and indirect maintenance costs. 2. Creating a proper database to analyse failures. 3. Creating a method to control system performance and develop it to similar systems. 4. Designing a software to analyse database and consequently create technical knowledge to face unusual condition of the system. Moreover, the results of this study have shown that the concept and philosophy of maintenance has not been understood in most Iranian industries. Thus, more investment is strongly required to improve maintenance conditions.
Abstract: Despite the strong and consistent increase in the use of
electronic payment methods worldwide, the diffusion of electronic
wallets is still far from widespread. Analysis of the failure of
electronic wallet uptake has either focused on technical issues or
chosen to analyse a specific scheme. This article proposes a joint
approach to analysing key factors affecting the adoption of e-wallets
by using the ‘Technology Acceptance Model” [1] which we have
expanded to take into account the cost of using e-wallets. We use this
model to analyse Monéo, the only French electronic wallet still in
operation.
Abstract: In this paper, the effect of bolt clamping force on the fatigue behavior of bolted single lap joints of aluminum alloy 2024- T3 have been studied using numerical finite element method. To do so, a three dimensional model according to the bolted single lap joint has been created and numerical analysis has been carried out using finite element based package. Then the stress distribution and also the slip amplitudes have been calculated in the critical regions and the outcome have been compared with the available experimental fatigue tests results. The numerical results show that in low applied clamping force, the fatigue failure of the specimens occur around the stress concentration location (the bolted hole edge) due to the tensile stresses and thus fatigue crack propagation, but with increase of the clamping force, the fatigue life increases and the cracks nucleate and propagate far from the hole edge because of fretting fatigue. In other words, with the further increase of clamping force value of the joint, the fatigue life reduces due to occurrence of the fretting fatigue in the critical location where the slip amplitude is within its critical occurs earlier.
Abstract: This paper focuses on the Mega-Sub Controlled
Structure Systems (MSCSS) performances and characteristics
regarding the new control principle contained in MSCSS subjected to
strong earthquake excitations. The adopted control scheme consists of
modulated sub-structures where the control action is achieved by
viscous dampers and sub-structure own configuration. The
elastic-plastic time history analysis under severe earthquake excitation
is analyzed base on the Finite Element Analysis Method (FEAM), and
some comparison results are also given in this paper. The result shows
that the MSCSS systems can remarkably reduce vibrations effects
more than the mega-sub structure (MSS). The study illustrates that the
improved MSCSS presents good seismic resistance ability even at 1.2g
and can absorb seismic energy in the structure, thus imply that
structural members cross section can be reduce and achieve to good
economic characteristics. Furthermore, the elasto-plastic analysis
demonstrates that the MSCSS is accurate enough regarding
international building evaluation and design codes. This paper also
shows that the elasto-plastic dynamic analysis method is a reasonable
and reliable analysis method for structures subjected to strong
earthquake excitations and that the computed results are more precise.
Abstract: The sand production problem has led researchers into making various attempts to understand the phenomenon. The generally accepted concept is that the occurrence of sanding is due to the in-situ stress conditions and the induced changes in stress that results in the failure of the reservoir sandstone during hydrocarbon production from wellbores. By using a hypothetical cased (perforated) well, an approach to the problem is presented here by using Finite Element numerical modelling techniques. In addition to the examination of the erosion problem, the influence of certain key parameters is studied in order to ascertain their effect on the failure and subsequent erosion process. The major variables investigated include: drawdown, perforation depth, and the erosion criterion. Also included is the determination of the optimal mud pressure for given operational and reservoir conditions. The improved understanding between parameters enables the choice of optimal values to minimize sanding during oil production.
Abstract: Throughout this paper, a relatively new technique, the Tabu search variable selection model, is elaborated showing how it can be efficiently applied within the financial world whenever researchers come across the selection of a subset of variables from a whole set of descriptive variables under analysis. In the field of financial prediction, researchers often have to select a subset of variables from a larger set to solve different type of problems such as corporate bankruptcy prediction, personal bankruptcy prediction, mortgage, credit scoring and the Arbitrage Pricing Model (APM). Consequently, to demonstrate how the method operates and to illustrate its usefulness as well as its superiority compared to other commonly used methods, the Tabu search algorithm for variable selection is compared to two main alternative search procedures namely, the stepwise regression and the maximum R 2 improvement method. The Tabu search is then implemented in finance; where it attempts to predict corporate bankruptcy by selecting the most appropriate financial ratios and thus creating its own prediction score equation. In comparison to other methods, mostly the Altman Z-Score model, the Tabu search model produces a higher success rate in predicting correctly the failure of firms or the continuous running of existing entities.
Abstract: The paper deals with calculation of the parameters of
ceramic material from a set of destruction tests of ceramic heads of
total hip joint endoprosthesis. The standard way of calculation of the
material parameters consists in carrying out a set of 3 or 4 point
bending tests of specimens cut out from parts of the ceramic material
to be analysed. In case of ceramic heads, it is not possible to cut out
specimens of required dimensions because the heads are too small (if
the cut out specimens were smaller than the normalised ones, the
material parameters derived from them would exhibit higher strength
values than those which the given ceramic material really has). On
that score, a special testing jig was made, in which 40 heads were
destructed. From the measured values of circumferential strains of the
head-s external spherical surface under destruction, the state of stress
in the head under destruction was established using the final elements
method (FEM). From the values obtained, the sought for parameters
of the ceramic material were calculated using Weibull-s weakest-link
theory.
Abstract: Dhaka, the capital city of Bangladesh, is one of the
densely populated cities in the world. Due to rapid urbanization 60%
of its population lives in slum and squatter settlements. The reason
behind this poverty is low economic growth, inequitable distribution
of income, unequal distribution of productive assets, unemployment
and underemployment, high rate of population growth, low level of
human resource development, natural disasters, and limited access to
public services. Along with poverty, creating pressure on urban land,
shelter, plots, open spaces this creates environmental and ecological
degradation. These constraints are mostly resulted from the failures
of the government policies and measures and only Government can
solve this problem. This is now prime time to establish planning and
environmental management policy and sustainable urban
development for the city and for the urban slum dwellers which are
free from eviction, criminals, rent seekers and other miscreants.
Abstract: Reinforced concrete has good durability and excellent structural performance. But there are cases of early deterioration due to a number of factors, one prominent factor being corrosion of steel reinforcement. The process of corrosion sets in due to ingress of moisture, oxygen and other ingredients into the body of concrete, which is unsound, permeable and absorbent. Cracks due to structural and other causes such as creep, shrinkage, etc also allow ingress of moisture and other harmful ingredients and thus accelerate the rate of corrosion. There are several interactive factors both external and internal, which lead to corrosion of reinforcement and ultimately failure of structures. Suitable addition of mineral admixture like silica fume (SF) in concrete improves the strength and durability of concrete due to considerable improvement in the microstructure of concrete composites, especially at the transition zone. Secondary reinforcement in the form of fibre is added to concrete, which provides three dimensional random reinforcement in the entire mass of concrete. Reinforced concrete beams of size 0.1 m X 0.15 m and length 1m have been cast using M 35 grade of concrete. The beams after curing process were subjected to corrosion process by impressing an external Direct Current (Galvanostatic Method) for a period of 15 days under stressed and unstressed conditions. The corroded beams were tested by applying two point loads to determine the ultimate load carrying capacity and cracking pattern and the results of specimens were compared with that of the companion specimens. Gravimetric method is used to quantify corrosion that has occurred.
Abstract: The great majority of the electric installations belong
to the first and second category. In order to ensure a high level of
reliability of their electric system feeder, two power supply sources
are envisaged, one principal, the other of reserve, generally a cold
reserve (electric diesel group).
The principal source being under operation, its control can be ideal
and sure, however for the reserve source being in stop, a preventive
maintenance-s which proceeds on time intervals (periodicity) and
for well defined lengths of time are envisaged, so that this source will
always available in case of the principal source failure.
The choice of the periodicity of preventive maintenance of the
source of reserve influences directly the reliability of the electric
feeder system. On the basis of the semi-markovians processes, the
influence of the periodicity of the preventive maintenance of the
source of reserve is studied and is given the optimal periodicity.